He aha ʻo Alendronate: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

ʻO Alendronate he lāʻau lapaʻau hoʻoikaika iwi e kōkua ana i ka pale ʻana i nā haʻihaʻi i nā poʻe me ka osteoporosis a i ʻole ka nalowale o ka iwi. No kahi pūʻulu lāʻau lapaʻau i kapa ʻia ʻo bisphosphonates, e hana ana ma ka hoʻolohi ʻana i ke kaʻina hana maoli e wāwahi i ka ʻiʻo iwi. Hāʻawi kēia i kou kino i ka manawa hou e kūkulu ai i ka iwi hou a ikaika, e kōkua ana i ka hōʻemi ʻana i kou pilikia o nā haʻihaʻi a me nā haʻihaʻi i kou wā ʻelemakule.

He aha ʻo Alendronate?

ʻO Alendronate he lāʻau lapaʻau i kauoha ʻia e mālama a pale i ka osteoporosis, kahi maʻi e nāwaliwali a palupalu ai nā iwi. E noʻonoʻo iā ia he pale pale no kou mau iwi - kōkua ia i ka mālama ʻana i ka nui o ka iwi ma ka hoʻopilikia ʻana i nā cell e wāwahi maʻamau i ka ʻiʻo iwi.

Hele mai ka lāʻau lapaʻau i ke ʻano papa a lawe ʻia e ka waha, maʻamau i hoʻokahi manawa i ka pule a i ʻole hoʻokahi manawa i ka lā e pili ana i ka ʻōlelo aʻoaʻo a kāu kauka. Ua hoʻohana ʻia me ka palekana no nā makahiki he nui e kōkua i nā miliona o nā kānaka e mālama i nā iwi ikaika a hōʻemi i ko lākou pilikia haʻihaʻi.

Ua manaʻo ʻia ʻo Alendronate he lapaʻau laina mua no ka osteoporosis, ʻo ia hoʻi, koho pinepine nā kauka iā ia ma ke ʻano he ʻōlelo mua ma muli o kona pono i hōʻoia ʻia a me ka palekana i hoʻokumu ʻia.

No ke aha e hoʻohana ʻia ai ʻo Alendronate?

Hoʻomaʻamaʻa ʻo Alendronate i ka osteoporosis i nā kāne a me nā wahine, ʻoi aku ka poʻe i pilikia nui i nā haʻihaʻi iwi. He mea kōkua nui ia no nā wahine postmenopausal, no ka mea, hiki i nā loli hormone i ka wā menopause ke wikiwiki i ka nalowale o ka iwi.

Hiki i kāu kauka ke kauoha iā alendronate inā loaʻa iā ʻoe kekahi mau maʻi pili iwi e pono ai ka nānā ʻana:

• Osteoporosis me ka mōʻaukala o nā haʻihaʻi
• ʻO ka haʻahaʻa haʻahaʻa o ka iwi (osteopenia) e holomua ana i ka osteoporosis
• ʻO ka osteoporosis i hoʻokomo ʻia e ka steroid mai ka hoʻohana ʻana i ka corticosteroid lōʻihi
• ʻO ka maʻi o Paget, kahi e ulu ai nā iwi i ka nui a me ka nāwaliwali
• Ka pale ʻana i ka nalowale o ka iwi i nā poʻe e lawe ana i nā lāʻau lapaʻau e nāwaliwali ai nā iwi

He mea waiwai loa ka lāʻau lapaʻau no ka poʻe i loaʻa i ka haʻihaʻi i hoʻokahi manawa, no ka mea, hoʻemi nui ia i ka hiki ʻana mai o nā haʻihaʻi e hiki mai ana. Hoʻohana ʻia nō hoʻi e pale aku i ka poʻe me nā mea pilikia he nui no ka osteoporosis.

Pehea e hana ai ʻo Alendronate?

Hana ʻo Alendronate ma ka pale ʻana i nā pūnaewele kūikawā i kapa ʻia ʻo osteoclasts e wāwahi maʻamau i ka ʻiʻo iwi kahiko. He lāʻau lapaʻau ikaika kēia e hana ana i kahi loli nui i ke kaʻina hana hoʻohālike maoli o kou iwi.

Ke kūkulu mau nei kou mau iwi iā lākou iho ma o ke kaulike o ka wāwahi a me ke kūkulu ʻana. Ke huli kēia kaulike i ka wāwahi nui loa, nāwaliwali nā iwi a maʻalahi i nā haʻihaʻi. Hoʻohuli ʻo Alendronate i nā unahi ma ka hoʻemi ʻana i ka ʻaoʻao wāwahi o ka hoohalike.

Hoʻopili ʻia ka lāʻau lapaʻau i loko o kāu ʻiʻo iwi a noho ma laila no nā mahina a i ʻole nā makahiki, e hāʻawi ana i ka pale lōʻihi. ʻO ia ke kumu e hoʻomau ai nā hopena ʻoiai ma hope o kou hooki ʻana i ka lawe ʻana, ʻoiai e emi mālie ana ka pale i ka manawa.

E ʻike maʻamau ʻoe i nā hoʻomaikaʻi ʻana i ka paʻa o ka iwi i loko o 6 a 12 mau mahina o ka hoʻomaka ʻana i ka lāʻau lapaʻau, me nā pōmaikaʻi kiʻekiʻe i loaʻa ma hope o 2 a 3 mau makahiki o ka hoʻohana mau.

Pehea wau e lawe ai iā Alendronate?

Pono ʻo Alendronate i ka manawa kikoʻī a me ka hoʻomākaukau ʻana e hana pono a pale i ka huhū o ka ʻōpū. Pono ʻoe e lawe mua i ke kakahiaka ma ka ʻōpū ʻole me ke aniani wai maʻemaʻe.

Eia ke kaʻina hana i kēlā me kēia ʻanuʻu e ʻōlelo ai kāu kauka:

1. E lawe i ka papa i ka wā e ala ai, ma mua o ka ʻai ʻana a i ʻole ka inu ʻana i kekahi mea
2. E ale i ka mea holoʻokoʻa me 6 a 8 auneke o ka wai maʻemaʻe (ʻaʻole wai mineral, kofe, a i ʻole wai)
3. E noho pololei (e noho ana a i ʻole e kū ana) no ka liʻiliʻi o 30 mau minuke ma hope o ka lawe ʻana
4. E kali ma kahi o 30 mau minuke ma mua o ka ʻai ʻana, ka inu ʻana, a i ʻole ka lawe ʻana i nā lāʻau lapaʻau ʻē aʻe
5. Mai moe i lalo, kulou, a i ʻole e hoʻoikaika ikaika i kēia manawa kali

ʻAʻole he mau ʻōlelo paipai wale nō kēia mau kuhikuhi - he mea nui lākou no ka pale ʻana i nā hopena ʻaoʻao koʻikoʻi a me ka hōʻoia ʻana e hana pono ka lāʻau lapaʻau. Kōkua ke kūlana kūpono i ka pale ʻana i ka papa mai ka hoʻonāukiuki ʻana i kou esophagus.

Inā ʻoe e lawe i nā mea hoʻohui calcium a i ʻole antacids, e kali ma ka liʻiliʻi he 2 hola ma hope o kāu mahele alendronate, no ka mea, hiki i kēia mau mea ke keakea i ka absorption.

Pehea ka lōʻihi e lawe ai au i ka Alendronate?

Lawe ka hapa nui o nā kānaka i ka alendronate no 3 a 5 mau makahiki i ka wā mua, ʻoiai paha e pono kekahi i ka lōʻihi o ka mālama ʻana ma muli o ko lākou pilikia haʻihaʻi. E loiloi mau kāu kauka inā pono ʻoe e hoʻomau, e hoʻomaha, a i ʻole e hoʻololi i kahi lāʻau lapaʻau ʻē aʻe.

Ma hope o 5 mau makahiki o ka mālama ʻana, hiki i nā kānaka he nui ke lawe i ka mea i kapa ʻia he

Hōʻike pinepine ʻia kēia mau hōʻailona i nā pule mua o ka mālama ʻana a pinepine e hoʻoponopono iā lākou iho. ʻO ka lawe ʻana i ka lāʻau lapaʻau e like me ke kuhikuhi ʻana e hōʻemi nui i ka pilikia o nā hopena ʻaoʻao e pili ana i ka ʻōpū.

Aia kekahi mau hopena ʻaoʻao laha akā koʻikoʻi e koi ana i ka lāʻau lapaʻau koke, ʻoiai e pili ana lākou i ka liʻiliʻi ma mua o 1 i ka 1,000 poʻe:

• ʻEha āwae nui a i ʻole ka paʻakikī o ka wehe ʻana i kou waha (osteonecrosis o ka āwae)
• ʻEha ʻūhā maʻamau a i ʻole ka ʻeha ʻaʻole e pau
• ʻO ka puʻuwai nui a i ʻole ka paʻakikī o ka ale ʻana
• ʻEha umauma hou a i ʻole ka ʻino
• ʻO ka ʻeha ʻiʻo, iwi, a i ʻole hui nui e ʻokoʻa mai kou ʻoluʻolu maʻamau

I kekahi manawa, hiki i kekahi poʻe ke ʻike i nā haʻihaʻi atypical o ka iwi ʻūhā ma hope o ka hoʻohana ʻana i ka wā lōʻihi. Hiki i kēia mau haʻihaʻi maʻamau ke hana me ka liʻiliʻi o ka trauma a hiki ke hele mua ʻia e ka ʻeha ʻūhā no nā pule a i ʻole nā mahina.

ʻO wai ka mea pono ʻole e lawe iā Alendronate?

ʻAʻole kūpono ʻo Alendronate no nā mea a pau, a ʻo kekahi mau maʻi olakino e palekana ʻole a i ʻole ka liʻiliʻi o ka maikaʻi. E nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana i kēia lāʻau lapaʻau.

ʻAʻole pono ʻoe e lawe iā alendronate inā loaʻa iā ʻoe kekahi o kēia mau maʻi e hiki ai i ka lāʻau lapaʻau ke pilikia:

• Nā pilikia me kou esophagus, me ka hoʻopaʻa ʻana a i ʻole ka paʻakikī o ka ale ʻana
• ʻAʻole hiki ke noho a kū pololei no ka liʻiliʻi o 30 mau minuke
• Nā pae calcium koko haʻahaʻa loa (hypocalcemia)
• Maʻi kīkī koʻikoʻi
• Nā maʻi maʻi i ʻike ʻia iā alendronate a i ʻole nā lāʻau lapaʻau like

Pono kekahi mau maʻi olakino i ka mālama kūikawā a me ka nānā ʻana, ʻoiai ʻaʻole lākou e pale iā ʻoe mai ka lawe ʻana iā alendronate. E kaupaona kāu kauka i nā pōmaikaʻi e kūʻē i nā pilikia hiki ke loaʻa inā loaʻa iā ʻoe nā pilikia o ka ʻōpū, nā pilikia niho, a i ʻole ka hemahema o ka huaora D.

ʻAʻole pono nā wāhine hāpai a me nā wāhine e hānai ana i ka waiū e lawe i ka alendronate, no ka mea, hiki ke hōʻeha i ka pēpē e ulu ana. Hiki ke noho ka lāʻau lapaʻau i loko o ka ʻiʻo iwi no nā makahiki, no laila, pono nā wāhine e hoʻolālā ana e hāpai e kūkākūkā i ka manawa me kā lākou mea mālama ola.

Nā inoa inoa o Alendronate

Loaʻa ka Alendronate ma lalo o nā inoa inoa like ʻole, ʻo Fosamax ka mea i ʻike nui ʻia. Loaʻa i ka mana generic ka mea hana like a hana like me nā mana inoa inoa.

ʻO nā inoa inoa maʻamau e komo pū ana me Fosamax, Fosamax Plus D (aia i loko o ka huaora D), a me Binosto (he papa effervescent e hoʻoheheʻe ʻia i ka wai). Hiki i kāu hale kūʻai lāʻau lapaʻau ke lawe i nā inoa inoa like ʻole, akā loaʻa nā lāʻau lapaʻau like.

ʻO ke koho ma waena o nā mana generic a me nā inoa inoa e pili pinepine ana i ke kumukūʻai a me ka ʻinikua. ʻOi aku ka liʻiliʻi o ka alendronate generic a hana like me nā mana inoa inoa.

Nā koho ʻē aʻe o Alendronate

Inā ʻaʻole hana maikaʻi ka alendronate iā ʻoe a i ʻole e hana i nā hopena ʻaoʻao e hoʻopilikia ai, hiki i kekahi mau lāʻau lapaʻau ʻē aʻe ke kōkua i ka hoʻoikaika ʻana i kou mau iwi. Hiki i kāu kauka ke kōkua iā ʻoe e ʻimi i ke koho maikaʻi loa e pili ana i kāu mau pono a me nā kūlana olakino.

Hana like nā lāʻau bisphosphonate ʻē aʻe me ka alendronate akā hiki ke maʻalahi ke ʻae ʻia:

• Risedronate (Actonel) - lawe ʻia i kēlā me kēia pule a i ʻole i kēlā me kēia mahina
• Ibandronate (Boniva) - loaʻa ma ke ʻano he mau pila i kēlā me kēia mahina a i ʻole nā ​​injections i kēlā me kēia hapahā
• Zoledronic acid (Reclast) - hāʻawi ʻia ma ke ʻano he infusion intravenous i kēlā me kēia makahiki

ʻO nā koho ʻē aʻe ʻaʻole bisphosphonate e komo pū ana me denosumab (Prolia), i hāʻawi ʻia ma ke ʻano he injection i kēlā me kēia 6 mahina, a me teriparatide (Forteo), e hoʻoulu maoli ai i ka hana ʻana o ka iwi hou ma mua o ka pale ʻana i ka nalowale o ka iwi.

No kekahi poʻe, hiki i ka lāʻau lapaʻau hoʻololi hormone, nā mea hoʻololi receptor estrogen koho, a i ʻole calcitonin ke kūpono. ʻO ke koho maikaʻi loa e pili ana i kou makahiki, ke kāne, ka pilikia o ka haki, a me nā mea olakino ʻē aʻe.

Ua ʻOi aku ka Maikaʻi o Alendronate ma mua o Risedronate?

He mau lāʻau bisphosphonate maikaʻi ʻo Alendronate a me Risedronate e hana like ana e pale i nā haki a e hoʻoikaika i nā iwi. Hōʻike nā haʻawina he like lāua i ka maikaʻi, me ka hoʻēmi ʻana o ka pilikia o ka haki ma kahi o 30-50%.

ʻO nā ʻokoʻa nui ma ka hoʻonohonoho ʻana i nā lāʻau a me ka maikaʻi o ka poʻe e ʻae i kēlā me kēia lāʻau. Lawe ʻia ʻo Alendronate i hoʻokahi manawa i ka pule, a hiki ke lawe ʻia ʻo Risedronate i kēlā me kēia pule a i ʻole i kēlā me kēia mahina. Manaʻo kekahi poʻe he maʻalahi kekahi e ʻae ma mua o kekahi ma ke ʻano o nā hopena ʻaoʻao o ka ʻōpū.

He ʻoluʻolu iki paha ʻo Risedronate i ka ʻōpū no kekahi poʻe, akā pono nā lāʻau ʻelua i ka lawelawe ʻana me ka mālama ʻana ma ka ʻōpū ʻole me ka nui o ka wai. Ke hilinaʻi pinepine nei ke koho i kāu pane pilikino a me nā makemake.

E noʻonoʻo kāu kauka i kāu kūlana olakino kikoʻī, nā lāʻau ʻē aʻe āu e lawe nei, a me nā ʻike mua me nā bisphosphonates i ka wā e hoʻoholo ai ma waena o kēia mau koho.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Alendronate

He Palekana ʻo Alendronate no ka poʻe me ka maʻi kīkī?

Hiki ke hoʻohana ʻia ʻo Alendronate me ka akahele i ka poʻe me nā pilikia kīkī māmā, akā ʻaʻole ia i ʻōlelo ʻia no ka poʻe me ka maʻi kīkī koʻikoʻi. E nānā kāu kauka i kāu hana kīkī me nā hoʻokolohua koko ma mua o ke kau ʻana iā alendronate a hiki ke nānā iā ia i kēlā me kēia manawa i ka wā o ka mālama ʻana.

Inā loaʻa iā ʻoe ka maʻi kīkī, hiki i kāu kauka ke koho i kahi lāʻau iwi ʻē aʻe a i ʻole e hoʻoponopono i kāu hoʻolālā lapaʻau. ʻAʻole pono ka poʻe me ka maʻi kīkī koʻikoʻi e lawe iā alendronate no ka mea hiki ke kūkulu i loko o ke kino a hiki ke hoʻopilikia.

He aha kaʻu e hana ai inā ua hoʻohana au i ka nui o Alendronate?

Inā lawe ʻoe i ka nui o kāu lāʻau i kauoha ʻia, mai hopohopo, akā e hoʻokaʻaʻike koke i kāu kauka a i ʻole ka mana hoʻomalu lāʻau. Mai ho'āʻo e luaʻi, no ka mea, hiki i kēia ke hoʻonāukiuki i ka lāʻau i kou ʻāʻī a me ka esophagus i ke ala e piʻi ai.

E inu i ka waiū a i ʻole ka wai nui e kōkua i ka hoʻoheheʻe ʻana i ka lāʻau lapaʻau i loko o kou ʻōpū. E noho kū pololei a pale i ka moe ʻana. ʻAʻole nui ka poʻe i lawe hewa i nā lāʻau hou aʻe i loaʻa nā pilikia nui, akā he mea nui ke alakaʻi lapaʻau e hōʻoia i kou palekana.

He aha kaʻu e hana ai inā ua hala wau i kahi lāʻau Alendronate?

Inā ua hala ʻoe i kāu lāʻau i kēlā me kēia pule a hoʻomanaʻo i loko o hoʻokahi a ʻelua paha lā, e lawe koke iā ia ke hoʻomanaʻo ʻoe, e hahai ana i nā ʻōlelo aʻoaʻo maʻamau. A laila, e hoʻi i kāu papa manawa maʻamau i ka pule e hiki mai ana.

Inā ua hala kekahi mau lā mai kāu lāʻau i hala, e lele loa iā ia a lawe i kāu lāʻau e hiki mai ana i ka lā i hoʻonohonoho ʻia. Mai lawe i ʻelua lāʻau i ka pule hoʻokahi e uku ai i kahi lāʻau i hala, no ka mea, e hoʻonui ana kēia i kou pilikia o nā hopena ʻaoʻao.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Alendronate?

Mai hooki koke i ka lawe ʻana iā alendronate me ka ʻole e kūkākūkā mua me kāu kauka. Hiki i ka hapa nui o nā kānaka ke lawe palekana i nā hoʻomaha i hoʻolālā ʻia mai ka lāʻau lapaʻau ma hope o 3 a 5 mau makahiki o ka mālama ʻana, akā pono e hana mau kēia hoʻoholo me ke alakaʻi lapaʻau.

E loiloi kāu kauka i kou paʻa iwi o kēia manawa, ka pilikia o ka haki, a me ke olakino holoʻokoʻa ma mua o ka ʻōlelo ʻana inā e hoʻomau i ka mālama ʻana, e hoʻomaha, a i ʻole e hoʻololi i kahi lāʻau lapaʻau ʻē aʻe. Pono paha kekahi poʻe e hoʻomau i ka mālama ʻana no ka lōʻihi ma muli o kā lākou mau mea pilikia.

Hiki iaʻu ke lawe iā Alendronate me nā lāʻau lapaʻau ʻē aʻe?

Hiki i ka Alendronate ke launa pū me kekahi mau lāʻau lapaʻau, no laila he mea nui e haʻi i kāu kauka e pili ana i nā mea a pau āu e lawe nei. Hiki i nā mea hoʻohui calcium, antacids, a me nā mea hoʻohui hao ke keakea i ka absorption alendronate inā lawe ʻia kokoke loa.

Pono ʻoe e kali ma ka liʻiliʻi he 2 mau hola ma hope o ka lawe ʻana iā alendronate ma mua o ka lawe ʻana i ka calcium, antacids, a i ʻole nā lāʻau lapaʻau ʻē aʻe. Hiki i kekahi mau lāʻau lapaʻau e like me kekahi mau antibiotics a i ʻole nā lāʻau anti-inflammatory ke hoʻonui i ka pilikia o ka huhū o ka ʻōpū ke hui pū ʻia me alendronate.