He aha ʻo Alirocumab: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Alirocumab e kōkua ana i ka hoʻohaʻahaʻa ʻana i kou pae cholesterol ke ʻaʻole lawa ka ʻai a me ka hoʻoikaika kino. He mea hana ikaika ia e hana ʻokoʻa mai nā lāʻau lapaʻau cholesterol kuʻuna e like me nā statins, e hāʻawi ana i ka manaʻolana no ka poʻe e pono ai ke kōkua hou i ka mālama ʻana i ko lākou olakino puʻuwai.

No kahi papa lāʻau lapaʻau hou aku kēia lāʻau lapaʻau i kapa ʻia ʻo PCSK9 inhibitors, a hele mai ia ma ke ʻano he injection āu e hāʻawi ai iā ʻoe iho ma lalo o ka ʻili. ʻOiai ʻo ka manaʻo o ka hoʻokomo ʻana iā ʻoe iho e manaʻo nui i ka wā mua, nui ka poʻe i ʻike he lilo ia i ʻāpana maʻalahi o kā lākou hana maʻamau me ke alakaʻi kūpono mai kā lākou hui mālama ola.

He aha ʻo Alirocumab?

He antibody i hana ʻia e ke kanaka ʻo Alirocumab e kuhikuhi ana i kahi protein kikoʻī i loko o kou kino i kapa ʻia ʻo PCSK9. E noʻonoʻo iā ia he mea kōkua kūikawā e hana pū me kou ate e wehe i ka cholesterol hou mai kou kahe koko.

ʻAʻole like me nā statins e hana ana i loko o kāu mau keena ate, hana ʻo alirocumab ma waho o nā keena ma ka ālai ʻana i ka protein PCSK9. ʻO kēia protein ka mea maʻamau e pale i kou ate mai ka hoʻomaʻemaʻe pono ʻana i ka cholesterol. Ke ālai ʻo alirocumab iā ia, hiki i kou ate ke hana maikaʻi i ka wehe ʻana i ka cholesterol LDL

Ua kuhikuhi ʻia nō hoʻi no ka poʻe i loaʻa i ka maʻi cardiovascular i hoʻokumu ʻia a pono e hōʻemi i ko lākou pilikia o ka loaʻa ʻana o ka puʻuwai, nā hahau, a i ʻole nā pilikia puʻuwai koʻikoʻi ʻē aʻe. Aia kēia i nā mea maʻi i loaʻa mua i ka puʻuwai, ka hahau, a i ʻole kekahi ʻano o ka ʻeha o ka umauma i kapa ʻia ʻo ka angina paʻa ʻole.

Hoʻokaʻawale ʻia ka lāʻau lapaʻau no ka poʻe i hiki ʻole i kā lākou pahuhopu cholesterol me ka lāʻau statin i ʻae ʻia. ʻAʻole hiki i kekahi poʻe ke lawe i nā statins ma muli o nā hopena ʻaoʻao e like me ka ʻeha o ka ʻiʻo, a hāʻawi ʻo alirocumab i kahi ala ʻē aʻe i ka mana cholesterol maikaʻi.

Pehea e hana ai ʻo Alirocumab?

Ua manaʻo ʻia ʻo Alirocumab he lāʻau lapaʻau hoʻohaʻahaʻa cholesterol ikaika e hana ana ma o kahi hana paʻakikī. He antibody monoclonal ia e kuhikuhi pono a paʻa i ka protein PCSK9 i loko o kou kahe koko.

Eia ke kōkua ʻana i kou kino: Loaʻa i kou ate nā mea hoʻokipa kūikawā e hopu i ka cholesterol mai kou koko a wāwahi iā ia. Hana ka protein PCSK9 e like me ka mea hoʻopilikia, e luku ana i kēia mau mea hoʻokipa kōkua. Ke ālai ʻo alirocumab iā PCSK9, ʻoi aku ka nui o nā mea hoʻokipa e ola a hiki ke hoʻomau i ka wehe ʻana i ka cholesterol mai kou koko.

Hiki i kēia hana ke hoʻohaʻahaʻa i kāu LDL cholesterol ma 45-60% a i ʻole ʻoi aku paha i kekahi poʻe. He ikaika loa nā hopena a hiki ke ʻike ʻia i loko o kekahi mau pule o ka hoʻomaka ʻana i ka lāʻau lapaʻau. ʻAʻole like me kekahi mau lāʻau lapaʻau e hana mālie, hāʻawi ʻo alirocumab i ka hoʻohaʻahaʻa cholesterol wikiwiki a koʻikoʻi.

Pehea wau e lawe ai iā Alirocumab?

Hāʻawi ʻia ʻo Alirocumab ma ke ʻano he injection ma lalo o kou ʻili i kēlā me kēia ʻelua pule. ʻO ka mahele maʻamau he 75 mg, akā hiki i kāu kauka ke hoʻonui iā ia i 150 mg inā pono. E hoʻokomo ʻoe iā ia i loko o kou ʻūhā, lima luna, a i ʻole ka ʻōpū, e hoʻololi ana i nā wahi injection e pale ai i ka huhū o ka ʻili.

Hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau me ka ʻai ʻole paha, no ka mea, ua hoʻokomo ʻia ma mua o ka ale ʻana. Eia naʻe, he mea nui e ʻae i ka lāʻau lapaʻau e hiki i ka mahana o ka lumi ma mua o ka hoʻokomo ʻana. E lawe iā ia mai loko mai o ka pahu hau ma kahi o 15-40 mau minuke ma mua o kou manawa hoʻokomo.

Na kāu mea mālama ola e aʻo iā ʻoe i ke ʻano hoʻokomo kūpono i kāu kipa mua. Hoʻomaʻamaʻa ka peni i hoʻopiha mua ʻia i ke kaʻina hana, akā ʻo ka hoʻomaʻamaʻa kūpono e hōʻoiaʻiʻo ai ua ʻoluʻolu ʻoe a ua hilinaʻi hoʻi i kēlā me kēia hoʻokomo. Nui ka poʻe i ʻike he mea kōkua ke hoʻonohonoho i kahi lā a me ka manawa maʻamau no kā lākou hoʻokomo ʻana e mālama i ka kūlike.

Pehea ka lōʻihi e lawe ai au i ka Alirocumab?

ʻO ka Alirocumab ka mea maʻamau he lapaʻau lōʻihi e hoʻomau ai ʻoe i ka wā e kōkua ana i kāu pae cholesterol a ʻōlelo kāu kauka. Lawe ka hapa nui o ka poʻe iā ia no nā makahiki ma mua o nā mahina, no ka mea, ʻo ka cholesterol kiʻekiʻe he maʻi maʻamau e pono ai ka mālama mau.

E nānā mau kāu kauka i kāu pae cholesterol, e nānā maʻamau iā lākou ma hope o 4-8 mau pule o ka lapaʻau a laila i kēlā me kēia mau mahina. Kōkua kēia mau hoʻokolohua i ka hoʻoholo ʻana inā e hana pono ana ka lāʻau lapaʻau a inā pono e hoʻoponopono i ka dosage.

Aia ka lōʻihi o ka lapaʻau i kāu kūlana pilikino, me kāu pae cholesterol, ka pilikia o ka maʻi puʻuwai, a me ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau. Hiki i kekahi poʻe ke hōʻemi i kā lākou dosage i ka manawa, ʻoiai pono paha kekahi e hoʻomau i ka regimen like no ka manawa pau ʻole.

He aha nā hopena ʻaoʻao o Alirocumab?

ʻO ka hapa nui o ka poʻe e ʻae maikaʻi i ka alirocumab, akā e like me nā lāʻau lapaʻau a pau, hiki iā ia ke hana i nā hopena ʻaoʻao. ʻO nā hopena ʻaoʻao maʻamau ka maʻamau a hiki ke mālama ʻia me ka mālama kūpono a me ka nānā ʻana.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike:

• Nā hopena ma ke kahua o ka pahu, e like me ka ʻulaʻula, ka pehu, a i ʻole ka ʻeha
• Nā hōʻailona e like me ke anu, me ka ihu e kahe ana a i ʻole ka ʻeha o ka ʻāʻī
• Nā hōʻailona e like me ka maʻi flu, e like me ka luhi a i ʻole ka ʻeha o nā ʻiʻo
• Ka ʻū a i ʻole ka ʻōpala o ka ʻili
• Nā maʻi o ka ʻōnaehana urinary
• Ka maʻi palahē a i ʻole ka pilikia o ka ʻōpū

Hoʻomaikaʻi pinepine kēia mau hopena ʻaoʻao i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Hiki i ka hoʻololi ʻana i nā kahua o ka pahu a me ka hana pahu kūpono ke kōkua i ka hōʻemi ʻana i nā hopena o ka ʻili.

ʻOiai ʻaʻole maʻamau, hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi e koi ai i ka mālama olakino koke:

• Nā hopena maʻi maʻi koʻikoʻi me ka pilikia o ka hanu ʻana, ka pehu ʻana o ka maka a i ʻole ka ʻāʻī
• Ka ʻeha mau o nā ʻiʻo a i ʻole ka nāwaliwali
• Nā hōʻailona o nā pilikia o ke akepaʻa e like me ka melemele o ka ʻili a i ʻole nā maka
• Nā hopena ma ke kahua o ka pahu koʻikoʻi ʻaʻole e hoʻomaikaʻi

E kāhea i kāu mea mālama ola inā ʻike ʻoe i nā hōʻailona e pili ana a i ʻole inā e hoʻopilikia nā hopena ʻaoʻao i kou ola i kēlā me kēia lā.

ʻO wai ka mea pono ʻole e lawe iā Alirocumab?

ʻAʻole kūpono ʻo Alirocumab no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia iā ʻoe. Pono nā poʻe i ʻike i nā maʻi maʻi iā alirocumab a i ʻole kekahi o kāna mau mea pono e pale i kēia lāʻau.

E makaʻala loa kāu kauka inā he moʻolelo kou o nā hopena maʻi maʻi koʻikoʻi i nā lāʻau ʻē aʻe a i ʻole inā he mau maʻi olakino kou. ʻAʻole pono nā wahine hāpai e lawe iā alirocumab ke ʻole e ʻoi aku ka maikaʻi o nā pōmaikaʻi i nā pilikia, no ka mea, ʻaʻole i ʻike ʻia kona hopena i nā pēpē e ulu ana.

Inā ʻoe e hānai ana i ka waiū, e kūkākūkā i kēia me kāu kauka, no ka mea, ʻaʻole maopopo inā hele ka lāʻau i loko o ka waiū umauma. Pono paha nā poʻe me ka maʻi kīkī a i ʻole ke akepaʻa koʻikoʻi i ka nānā kūikawā a i ʻole nā hoʻoponopono ʻana i ka lāʻau.

ʻAʻole pono nā keiki a me nā ʻōpio e lawe i ka alirocumab ke ʻole lākou i ka hypercholesterolemia ʻohana koʻikoʻi a ʻaʻole i hana nā lāʻau lapaʻau ʻē aʻe. Ke aʻo ʻia nei ka palekana a me ka pono i nā maʻi pediatric.

Nā inoa inoa o Alirocumab

Kūʻai ʻia ʻo Alirocumab ma lalo o ka inoa inoa ʻo Praluent ma ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe. ʻO kēia ka inoa maʻamau āu e ʻike ai ma nā kauoha a me nā hale kūʻai lāʻau lapaʻau.

Hana ʻia ka lāʻau lapaʻau e Regeneron Pharmaceuticals a me Sanofi, a loaʻa wale nō ma ke ʻano he lāʻau inoa inoa. I kēia manawa, ʻaʻohe mana generic o alirocumab i loaʻa, ʻo ia hoʻi he pipiʻi loa ia me ka ʻole o ka ʻinikua.

Hiki i kekahi mau hoʻolālā ʻinikua ke koi i ka ʻae mua ma mua o ka uhi ʻana iā Praluent, a pono paha kāu kauka e hōʻike ʻaʻole i kūpono nā lāʻau lapaʻau cholesterol ʻē aʻe iā ʻoe.

Nā koho ʻē aʻe o Alirocumab

Inā ʻaʻole kūpono ka alirocumab iā ʻoe, hiki i kekahi mau koho ʻē aʻe ke kōkua i ka mālama ʻana i kāu pae cholesterol. ʻO Evolocumab (Repatha) kekahi mea hoʻopaʻa PCSK9 e hana like me alirocumab akā ʻoi aku ka maikaʻi o ka ʻae ʻia e kekahi poʻe.

ʻO nā lāʻau statin kuʻuna e like me atorvastatin (Lipitor) a i ʻole rosuvastatin (Crestor) ka lāʻau lapaʻau mua no ka hapa nui o ka poʻe me ka cholesterol kiʻekiʻe. He maikaʻi kēia mau lāʻau lapaʻau waha a ʻoi aku ka liʻiliʻi ma mua o nā mea hoʻopaʻa PCSK9.

ʻO nā koho ʻē aʻe e pili ana i ka ezetimibe (Zetia), e ālai ana i ka absorption cholesterol i loko o kou ʻōpū, a me nā mea hoʻokaʻawale waika bile e like me cholestyramine. No ka poʻe me nā triglycerides kiʻekiʻe loa, hiki ke kōkua nā lāʻau lapaʻau e like me icosapent ethyl (Vascepa).

ʻO nā koho hou aku e pili ana i ka bempedoic acid (Nexletol) a me inclisiran (Leqvio), e hana ana ma nā ʻano hana like ʻole e hoʻohaʻahaʻa i ka cholesterol. E kōkua kāu kauka iā ʻoe e ʻimi i ka hui maikaʻi loa o nā lāʻau lapaʻau e pili ana i kāu mau pono a me nā kūlana.

ʻOi aku ka maikaʻi o Alirocumab ma mua o Evolocumab?

ʻO Alirocumab a me evolocumab nā mea pale PCSK9 e hana like ana a he like ka maikaʻi i ka hoʻohaʻahaʻa ʻana i nā pae cholesterol. Hōʻike nā haʻawina hiki i nā lāʻau ʻelua ke hoʻohaʻahaʻa i ka LDL cholesterol ma 50-60% a ʻoi aku paha ke hoʻohui ʻia i ka lāʻau statin.

ʻO ke koho ma waena o lākou e pili pinepine ana i nā mea pilikino e like me nā ʻano hopena ʻaoʻao, nā papa hana dosing, a me ka uhi ʻinikua. Hāʻawi ʻia ʻo Alirocumab i kēlā me kēia pule ʻelua, a hiki ke hāʻawi ʻia ʻo evolocumab i kēlā me kēia pule ʻelua a i ʻole i kēlā me kēia mahina, ma muli o ka mahele.

Hiki i kekahi poʻe ke ʻae i kekahi ma mua o kekahi, a hiki i kāu kauka ke hoʻololi i nā lāʻau lapaʻau inā loaʻa iā ʻoe nā hopena ʻaoʻao. Loaʻa i nā mea ʻelua nā ʻano palekana like, akā hiki ke ʻokoʻa nā pane pilikino.

He mea nui ka uku a me ka uhi ʻinikua i ka hoʻoholo ʻana, no ka mea, he kumukūʻai nā lāʻau ʻelua. Hiki i kāu kauka a me ka lāʻau lapaʻau ke kōkua iā ʻoe e hoʻokele i kēia mau mea e noʻonoʻo ai i ka wā e hōʻoiaʻiʻo ana ʻoe e loaʻa ana ka mālama cholesterol maikaʻi.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Alirocumab

He Palekana ʻo Alirocumab no ka poʻe me ka maʻi diabetes?

ʻAe, palekana ʻo alirocumab no ka poʻe me ka maʻi diabetes a hiki ke pono loa no ka mea e hoʻonui ai ka maʻi diabetes i ka pilikia o ka maʻi puʻuwai. Hōʻike nā haʻawina ʻaʻole pili nui ʻo alirocumab i nā pae kōpaʻa koko, e lilo ia i koho maikaʻi no nā maʻi diabetic e pono ai ka mālama cholesterol ikaika.

Loaʻa pinepine i ka poʻe me ka maʻi diabetes nā mea pilikia cardiovascular he nui, a hiki i nā hopena hoʻohaʻahaʻa cholesterol ikaika o alirocumab ke kōkua i ka hōʻemi ʻana i ko lākou pilikia maʻi puʻuwai holoʻokoʻa. E nānā kāu kauka i kāu cholesterol a me nā pae kōpaʻa koko i kēlā me kēia manawa e hōʻoia i ka mālama maikaʻi ʻana i nā kūlana ʻelua.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o Alirocumab?

Inā ua hoʻokomo ʻoe i ka alirocumab ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu mea mālama ola a i ʻole ke kikowaena hoʻomalu lāʻau make. ʻOiai he kakaikahi nā mea i loaʻa i ka lāʻau nui me kēia lāʻau, he mea nui e loaʻa ke alakaʻi ʻoihana e pili ana i nā hana e hiki mai ana.

Mai hoʻāʻo e "hoʻoponopono" i ka lāʻau nui ma ka haʻalele ʻana i kāu mahele e hiki mai ana. Akā, e hahai i nā ʻōlelo a kāu kauka e pili ana i ka manawa e hoʻomaka hou ai i kāu papa hana maʻamau. E mālama i ka pūʻolo lāʻau i ka wā e kāhea ai ʻoe i ke kōkua, no ka mea, e pono kēia ʻike no nā mea mālama ola.

He aha kaʻu e hana ai inā ua hala wau i kahi mahele o Alirocumab?

Inā ua hala ʻoe i kāu mahele alirocumab i hoʻonohonoho ʻia, e hoʻokomo iā ia i ka wā e hoʻomanaʻo ai ʻoe, inā aia i loko o ʻehiku lā o kāu mahele i hala. A laila e hoʻomau me kāu papa hana ʻelua pule mai ia manawa.

Inā ua hala ma mua o ʻehiku lā mai kāu mahele i hala, e haʻalele loa iā ia a kali no kāu injection i hoʻonohonoho ʻia e hiki mai ana. Mai pāpālua i nā mahele e hoʻoponopono ai i ka mea i hala, no ka mea, hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Alirocumab?

Pono ʻoe e hooki i ka lawe ʻana i ka alirocumab ma lalo o ka nānā ʻana a kāu kauka. ʻO ka cholesterol kiʻekiʻe he maʻi maʻamau e pono ai ka mālama mau ʻana, a ʻo ka hooki ʻana i ka lāʻau e hoʻonui hou i kāu pae cholesterol i loko o kekahi mau pule.

Hiki i kāu kauka ke noʻonoʻo e hooki a hoʻemi paha i ka mahele inā ua mālama maikaʻi ʻia kāu pae cholesterol no ka manawa lōʻihi a ua hoʻomaikaʻi ʻia nā mea pilikia ʻē aʻe. Eia naʻe, pono e hana mau kēia hoʻoholo me kāu mea mālama ola e pili ana i kou kūlana pilikino.

Hiki iaʻu ke hele me Alirocumab?

ʻAe, hiki iā ʻoe ke hele me alirocumab, akā pono ia i kekahi hoʻolālā ʻana no ka mea pono e hoʻomaʻalili ʻia ka lāʻau. Ke lele nei, e lawe iā ia i loko o kāu ʻeke lima me kahi lepili kauoha a me kahi leka mai kāu kauka e wehewehe ana i ka pono o ka lāʻau.

No ka huakaʻi lōʻihi, e noʻonoʻo e hoʻohana i kahi pahu hoʻoluʻu lāʻau lapaʻau i hoʻolālā ʻia no nā lāʻau lapaʻau injectable. Hiki i ka lāʻau lapaʻau ke waiho i ka mahana o ka lumi a hiki i 30 mau lā, akā ʻoi aku ka maikaʻi o ka mālama ʻana i loko o ka pahu hau ke hiki ke mālama i kona pono.