He aha ʻo Amifostine: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau pale ʻo Amifostine e kōkua ana i ka pale ʻana i nā keena olakino mai ka pōʻino i ka wā o ka mālama ʻana i ka maʻi kanesa. Hana ia e like me ke kiaʻi kino kelepona, e komo ana e hōʻemi i nā hopena ʻino o ka chemotherapy a me ka radiation ma nā ʻiʻo maʻamau a ʻoiai e ʻae ana i kēia mau lāʻau e hoʻomau i ka hakakā ʻana i nā keena maʻi kanesa.

He mea waiwai kēia lāʻau lapaʻau i ka mālama ʻana i ka maʻi kanesa no nā makahiki he nui, e hāʻawi ana i ka manaʻolana i nā maʻi e pono ai i nā lāʻau lapaʻau ikaika akā makemake e pale i ko lākou mau ʻōkana olakino. ʻO ka hoʻomaopopo ʻana i ka hana ʻana o amifostine hiki ke kōkua iā ʻoe e manaʻoʻiʻo i kāu mau hoʻoholo lapaʻau.

He aha ʻo Amifostine?

He lāʻau cytoprotective ʻo Amifostine, ʻo ia hoʻi e pale ana i nā keena olakino mai ka pōʻino ʻona. Hoʻololi ʻia ka lāʻau lapaʻau i kahi ʻano hana i loko o kou kino e hana ana ma ke ʻano he scavenger, e hoʻopau ana i nā radical manuahi ʻino i hana ʻia e nā lāʻau lapaʻau maʻi kanesa.

E noʻonoʻo iā amifostine ma ke ʻano he pale e pale nui ai i nā keena maʻamau a waiho i nā keena maʻi kanesa i ka lāʻau. Hana ʻia kēia pale koho no ka mea he ʻoi aku ka maikaʻi o ke kahe koko o nā keena olakino a hiki ke komo i ka lāʻau lapaʻau ʻoi aku ka maikaʻi ma mua o nā keena maʻi kanesa.

Ua hoʻomohala mua ʻia ka lāʻau e ka U.S. Army ma ke ʻano he pale i ka radiation. I kēia lā, hoʻohana nā oncologists iā ia e kōkua i nā maʻi e ʻae i nā kiʻekiʻe kiʻekiʻe o nā lāʻau lapaʻau maʻi kanesa e ola ana me nā hopena ʻaoʻao liʻiliʻi.

No ke aha i hoʻohana ʻia ai ʻo Amifostine?

Hana ʻo Amifostine ma ke ʻano he hoa pale i ka wā o nā lāʻau lapaʻau maʻi kanesa. Hiki i kāu kauka ke ʻōlelo iā ia e hōʻemi i ka pōʻino o ka puʻupaʻa mai ka chemotherapy cisplatin a i ʻole e pale i ka waha maloʻo nui i ka wā o ka radiation therapy no nā maʻi kanesa o ke poʻo a me ka ʻāʻī.

Kōkua ka lāʻau lapaʻau i ka pale ʻana i nā pilikia o ka puʻupaʻa i hoʻokumu ʻia e ka cisplatin, hiki ke koʻikoʻi a i kekahi manawa mau loa. Ke loaʻa iā ʻoe ka cisplatin no nā maʻi kanesa e like me ka ovarian, ka māmā, a i ʻole ka maʻi kanesa testicular, hiki i ka amifostine ke hōʻemi nui i kou pilikia o ka pōʻino o ka puʻupaʻa.

No nā maʻi maʻi maʻi poʻo a me ka ʻāʻī e loaʻa ana i ka radiation, kōkua ʻo amifostine i ka pale ʻana i nā ʻōpū salivary. Hiki i kēia pale ke pale i ka waha maloʻo mau e pinepine ai i ka ʻai ʻana, ka ʻōlelo ʻana, a me ka hiamoe ʻana ma hope o ka mālama ʻana i ka radiation.

Hoʻohana kekahi mau kauka i ka amifostine e pale aku i nā hopena ʻē aʻe e pili ana i ka chemotherapy, ʻoiai ʻaʻole maʻamau kēia mau hoʻohana a hilinaʻi i kāu kūlana kikoʻī.

Pehea e hana ai ʻo Amifostine?

Hana ʻo Amifostine ma ka lilo ʻana i mea pale cellular ke komo i kou kino. Ua wāwahi ʻia ka lāʻau lapaʻau e kahi enzyme i kapa ʻia ʻo alkaline phosphatase, ʻoi aku ka hana i nā ʻiʻo olakino ma mua o nā cell cancer.

Hoʻokumu kēia wāwahi i kahi hui hana e hana ana e like me ka sponge molecular, e omo ana i nā radical manuahi ʻona i hana ʻia e ka chemotherapy a me ka radiation. ʻO kēia mau radical manuahi nā mea nui ma hope o ka pōʻino o nā ʻōpū e pili ana i ka mālama ʻana.

Aia ka nani o amifostine i kona koho. Hiki i nā cell olakino me ke kahe koko maikaʻi ke lawe a hoʻāla i ka lāʻau lapaʻau me ka maikaʻi, ʻoiai ʻaʻole hiki i nā cell cancer me ke kahe koko maikaʻi ʻole. ʻO ia hoʻi, loaʻa i kāu mau ʻōpū maʻamau ka pale ʻana aʻo nā cell cancer e noho nāwaliwali i ka mālama ʻana.

Hana wikiwiki ka lāʻau lapaʻau, me ka pale kiʻekiʻe e hana ana i loko o 15-30 mau minuke ma hope o ka lawelawe ʻana. Hāʻawi kēia manawa i kāu hui lapaʻau e hoʻonohonoho pono me kāu papa hana mālama maʻi maʻi.

Pehea wau e lawe ai i ka Amifostine?

Hāʻawi mau ʻia ʻo Amifostine intravenously (ma o ka IV) i loko o kahi haukapila a i ʻole ke keʻena lapaʻau. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka home no ka mea pono ia i ka mālama ʻana i ka lāʻau lapaʻau a me ka manawa kikoʻī me kāu mālama maʻi maʻi.

E hāʻawi kāu hui mālama ola iā ʻoe i ka lāʻau lapaʻau ma kahi o 30 mau minuke ma mua o kāu chemotherapy a i ʻole ka mālama ʻana i ka radiation. Hōʻoia kēia manawa i ka piʻi ʻana o nā hopena pale ke loaʻa iā ʻoe kāu mālama maʻi maʻi.

Ma mua o ka loaʻa ʻana o ka amifostine, pono ʻoe e inu i ka wai nui a loaʻa paha i ka lāʻau anti-nausea. E nānā pono ʻia kou koko no ka mea hiki i ka lāʻau lapaʻau ke hoʻohaʻahaʻa i ka manawa.

Lawe maʻamau ka infusion ma kahi o 15 mau minuke. E noho ʻoe ma kahi o ka mālama ʻana no ka nānā ʻana e hōʻoia e maikaʻi ana ʻoe ma mua o ka hoʻomau ʻana me kāu mālama ʻana i ka maʻi maʻi.

Pehea ka lōʻihi e lawe ai au i ka Amifostine?

E loaʻa iā ʻoe ka amifostine no ka lōʻihi e loaʻa ana iā ʻoe ka mālama ʻana i ka maʻi maʻi e pale nei iā ʻoe. Inā loaʻa iā ʻoe ka chemotherapy cisplatin, e loaʻa iā ʻoe ka amifostine ma mua o kēlā me kēia mahele cisplatin i kāu mau pōʻai lapaʻau.

No nā maʻi radiation therapy, hāʻawi ʻia ka lāʻau lapaʻau i kēlā me kēia lā ma mua o kēlā me kēia kau radiation. E hoʻoholo kāu radiation oncologist i ka papa manawa pololei e pili ana i kāu hoʻolālā lapaʻau a me ka maikaʻi o kou ʻae ʻana i ka lāʻau lapaʻau.

Aia ka lōʻihi i kāu protocol lapaʻau maʻi maʻi. Loaʻa i kekahi poʻe maʻi no kekahi mau pule, a pono paha nā mea ʻē aʻe no kekahi mau mahina. E loiloi mau kāu hui lapaʻau inā e hoʻomau nā pōmaikaʻi i ka lanakila ʻana i nā hopena ʻaoʻao.

E hoʻōki kāu kauka i ka amifostine inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi a i ʻole e loli kāu hoʻolālā lapaʻau maʻi maʻi. E hāʻawi mau lākou i ka palekana a me ka pono o ka mālama ʻana i ka wā e hana ai i kēia mau hoʻoholo.

He aha nā hopena ʻaoʻao o Amifostine?

E like me ka hapa nui o nā lāʻau lapaʻau, hiki i ka amifostine ke hoʻoulu i nā hopena ʻaoʻao, ʻoiai ua ʻae maikaʻi ka nui o nā maʻi. ʻO nā hopena ʻaoʻao maʻamau ka hiki ke mālama ʻia a me ka manawa, e hana nui ana i ka wā a i ʻole ma hope koke o ka infusion.

Eia nā hopena ʻaoʻao āu e ʻike ai, e hoʻomaka ana me nā mea maʻamau:

• Ka luaʻi a me ka luaʻi (e pili ana i ka 60% o nā maʻi)
• Ke koko haʻahaʻa i ka wā e hoʻokomo ʻia ai
• Luhi a me ka nāwaliwali
• ʻAʻaʻa a i ʻole ka manaʻo palupalu
• ʻUlaʻula a i ʻole ka mahana i kou maka a me kou ʻāʻī
• He ʻono metala i kou waha
• Hāʻule a i ʻole hiccups
• Ka hiamoe

ʻO ka hapa nui o kēia mau hopena he maʻalahi a hoʻoponopono i loko o kekahi mau hola. E nānā pono kāu hui mālama ola iā ʻoe a hiki ke hāʻawi i nā lāʻau lapaʻau e kōkua i ka mālama ʻana i ka luaʻi a kākoʻo i kou koko inā pono.

ʻO kekahi poʻe maʻi e ʻike i nā hopena ʻaoʻao maʻamau ʻole akā ʻoi aku ka hopohopo e koi ana i ka lāʻau lapaʻau koke:

• Nā hopena maʻi koʻikoʻi me ka pilikia o ka hanu ʻana a i ʻole ka pehu ʻana
• Ke koko haʻahaʻa weliweli ʻaʻole e pane i ka lāʻau lapaʻau
• Nā pilikia kīkī koʻikoʻi
• Ka puʻuwai puʻuwai ʻole
• Nā hopu (maʻamau loa)

ʻAʻole maʻamau kēia mau hopena ʻaoʻao koʻikoʻi, akā ua aʻo ʻia kāu hui lapaʻau e ʻike a mālama koke iā lākou. Hōʻoia ka hoʻonohonoho lapaʻau i hoʻomalu ʻia e loaʻa iā ʻoe ka mālama wikiwiki inā e ulu kekahi mau hōʻailona e pili ana.

ʻO wai ka mea pono ʻole e lawe iā Amifostine?

ʻAʻole kūpono ʻo Amifostine no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia iā ʻoe. ʻO kekahi mau maʻi lapaʻau a me nā kūlana e hana i ka lāʻau lapaʻau i mea pilikia loa e hoʻohana.

ʻAʻole pono ʻoe e loaʻa iā amifostine inā loaʻa iā ʻoe kekahi o kēia mau maʻi:

• ʻIke ʻia ka maʻi i ka amifostine a i ʻole kāna mau mea
• Ke koko kiʻekiʻe ʻaʻole i hoʻomalu ʻia
• Maʻi puʻuwai koʻikoʻi a i ʻole nā pilikia puʻuwai hou
• Maʻi kīkī koʻikoʻi
• ʻO kekahi mau ʻano maʻi maʻi i hiki ke pale ʻia e ka lāʻau lapaʻau
• Hāpai a hānai paha

E makaʻala nō hoʻi kāu kauka i ka ʻōlelo ʻana iā amifostine inā he mōʻaukala kou o ka hahau ʻana, nā pilikia o ka puʻuwai, a i ʻole inā ʻoe e lawe i nā lāʻau lapaʻau e pili ana i ke koko. ʻAʻole he mea keakea ka makahiki wale nō, akā pono paha nā mākua kahiko i ka nānā hou.

ʻAʻole paha he mau maʻi ʻaʻai kekahi, ʻo ia hoʻi nā mea e pili ana i ka iwi iwi a i ʻole nā ​​pūnaewele koko, i nā moho no ka amifostine no ka mea hiki i ka pale ʻana i kēia mau wahi ke keakea i ka pono o ka lapaʻau.

Nā inoa inoa o Amifostine

Loaʻa ka Amifostine ma lalo o ka inoa inoa Ethyol ma ʻAmelika Hui Pū ʻIa. ʻO kēia ke ʻano i kauoha pinepine ʻia e ʻike ʻoe i nā kikowaena lapaʻau maʻi ʻaʻai.

Ua kapa ʻia ka mana generic ʻo amifostine a hana like me ka inoa inoa. Hiki i kāu ʻinikua ke makemake i kekahi mana ma luna o kekahi, akā aia nā mea hana like i loko o lāua ʻelua a hāʻawi i nā pōmaikaʻi pale like.

Hiki i kekahi mau mākeke honua ke loaʻa nā inoa inoa like ʻole, akā like ka lāʻau lapaʻau. E hōʻoia kāu hui mālama ola e loaʻa iā ʻoe ka hoʻomākaukau kūpono me ka nānā ʻole i ka inoa inoa.

Nā koho ʻē aʻe o Amifostine

I kēia manawa, ʻaʻohe koho pololei i ka amifostine e hana like. Eia naʻe, loaʻa i kāu kauka nā hoʻolālā ʻē aʻe e pale i kou mau ʻōkana i ka wā o ka lapaʻau maʻi ʻaʻai.

No ka pale ʻana i nā puʻupaʻa i ka wā o ka lapaʻau cisplatin, nā koho ʻē aʻe e pili ana i ka hoʻohana ʻana i ka carboplatin ma kahi o ka cisplatin, ʻoiai ʻaʻole paha kēia e pono no kekahi mau maʻi ʻaʻai. Hiki i ka hydration ikaika a me nā lāʻau lapaʻau e like me ka mannitol ke kōkua i ka pale ʻana i ka hana o nā puʻupaʻa.

No ka waha maloʻo i hoʻokumu ʻia e ka radiation, nā koho ʻē aʻe e pili ana i ka therapy radiation intensity-modulated (IMRT) e kuhikuhi maikaʻi i ka maʻi ʻaʻai me ka mālama ʻana i nā ʻōpū salivary, a i ʻole nā ​​lāʻau lapaʻau e like me ka pilocarpine e hiki ke hoʻoulu i ka hana saliva ma hope o ka lapaʻau.

E kūkākūkā kāu oncologist i kēia mau koho ʻē aʻe inā ʻaʻole kūpono ka amifostine iā ʻoe a i ʻole inā ʻoe e ʻike i nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia. Aia ke koho i kāu ʻano maʻi ʻaʻai, ka hoʻolālā lapaʻau, a me ke olakino holoʻokoʻa.

Ua ʻoi aku ka maikaʻi o ka Amifostine ma mua o nā lāʻau lapaʻau pale ʻē aʻe?

He kūlana koʻikoʻi ko Amifostine ma ke ʻano he lāʻau lapaʻau i ʻae ʻia e ka FDA i hoʻolālā ʻia e pale i nā cell olakino i ka wā o ka mālama ʻana i ka maʻi ʻaʻai. ʻAʻohe lāʻau lapaʻau hoʻokahi e hāʻawi i nā pōmaikaʻi pale ākea like e kūʻē i ka chemotherapy a me ka pōʻino radiation.

I ka hoʻohālikelike ʻana me nā hoʻolālā pale ʻē aʻe, he mau mea maikaʻi ʻo Amifostine. Hana ia ma ke kiʻekiʻe cellular e hoʻopau i ka pōʻino ma mua o ka hiki ʻana mai, ma mua o ka mālama ʻana i nā hōʻailona ma hope. Hāʻawi pinepine kēia ala hana i ka pale maikaʻi ma mua o nā lāʻau lapaʻau.

Eia naʻe, pili ka

Inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi e like me ka pilikia o ka hanu ʻana, ka ʻeha o ka umauma, a i ʻole ka wili nui i ka wā o ka hoʻokomo ʻana i ka amifostine, e hoʻomaopopo koke i kāu hui mālama ola. Mai kali a hoʻāʻo paha e hoʻomanawanui.

Ua aʻo ʻia kāu hui lapaʻau e mālama i kēia mau kūlana me ka wikiwiki. Hiki iā lākou ke hoʻōki i ka hoʻokomo ʻana, hāʻawi i nā lāʻau lapaʻau kākoʻo, a hōʻoia i kou palekana. ʻO ka hapa nui o nā hopena koʻikoʻi e hoʻoponopono koke ʻia ke hoʻōki ʻia ka hoʻokomo ʻana.

Ma hope o kahi hopena koʻikoʻi, e loiloi hou kāu kauka inā kūpono ka amifostine iā ʻoe. Hiki iā lākou ke hoʻoponopono i ka mahele, hoʻololi i ka helu hoʻokomo, a i ʻole e ʻōlelo i nā hoʻolālā pale ʻē aʻe no nā lāʻau lapaʻau e hiki mai ana.

Hiki iaʻu ke hoʻomau i ka amifostine inā ua hala wau i kahi mahele i hoʻonohonoho ʻia?

No ka mea, hāʻawi ʻia ka amifostine i loko o kahi keʻena lapaʻau ma mua o ka mālama ʻana i ka maʻi kanesa, ʻaʻole maʻamau nā mahele i hala. Inā hoʻopaneʻe ʻia a hoʻonohonoho hou ʻia kāu mālama ʻana i ka maʻi kanesa, e hoʻonohonoho hou ʻia kāu amifostine.

ʻAʻole pono ʻoe e hopohopo e pili ana i ka hana ʻana i nā mahele i hala a i ʻole ka mālama ʻana i kahi papa manawa kikoʻī ma waho o kāu mau manawa lapaʻau maʻi kanesa. He mea pono wale nō ka lāʻau lapaʻau ke hāʻawi ʻia ma mua koke o ka chemotherapy a i ʻole ka radiation.

Inā hala ʻoe i kahi manawa lapaʻau maʻi kanesa, e kūkākūkā me kāu hui lapaʻau inā pono kekahi hoʻoponopono ʻana i kāu hoʻolālā lapaʻau holoʻokoʻa. E hōʻoia lākou e pili ana kāu papa manawa lāʻau lapaʻau pale me kāu papa manawa lapaʻau maʻi kanesa.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka amifostine?

E hooki ʻoe i ka lawe ʻana i ka amifostine ke hoʻopau ʻoe i kāu chemotherapy cisplatin a i ʻole ka papa lapaʻau radiation. ʻAʻole pono e hoʻemi mālie i ka lāʻau lapaʻau no ka mea ʻaʻole ia he mea e hilinaʻi ai kou kino.

Hiki nō hoʻi i kāu kauka ke hoʻōki i ka amifostine inā loaʻa iā ʻoe nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia a i ʻole inā hoʻololi kāu hoʻolālā lapaʻau maʻi kanesa. E hana lākou i kēia hoʻoholo e pili ana i kāu mau pahuhopu lapaʻau holoʻokoʻa a me ka maikaʻi o ke ola.

Hopohopo kekahi poʻe maʻi no ka nalowale ʻana o ka pale ke hooki ʻia ka amifostine, akā e hoʻomanaʻo e pono ana ʻoe i ka pale i ka wā e mālama ʻia ai ka maʻi maʻi. Ke pau kāu chemotherapy a i ʻole radiation, hiki i kou mau ʻōkana ke hoʻomaka i kā lākou hana hoʻōla maoli.

Hoʻopilikia anei ka Amifostine i ka pono o ka mālama ʻana i ka maʻi maʻi?

Hōʻike ka noiʻi nui e pale ana ka amifostine i nā cell olakino me ka ʻole e hōʻemi i ka pono o ka mālama ʻana i ka maʻi maʻi. ʻO ke ʻano koho o ka lāʻau lapaʻau, ʻo ia hoʻi, e mau ana nā cell maʻi maʻi i ka nāwaliwali ʻoiai e loaʻa ana ka pale i kou mau ʻōkana olakino.

Ua hōʻike nā hoʻokolohua lapaʻau i ka loaʻa ʻana o nā hopena like o ka mālama ʻana i ka maʻi maʻi i nā poʻe maʻi e loaʻa ana ka amifostine i ka hoʻohālikelike ʻana i ka poʻe i loaʻa ʻole. Kākoʻo kēia hōʻike i kāna hoʻohana ʻana ma ke ʻano he ana pale ʻaʻole e hōʻino i kāu mālama ʻana i ka maʻi maʻi.

E ʻōlelo wale kāu oncologist i ka amifostine inā maopopo iā lākou ʻaʻole ia e hoʻopilikia i kāu mālama ʻana i ka maʻi maʻi. Inā he hopohopo e pili ana i ka hōʻemi ʻia o ka pono, e hāʻawi lākou i ka mea nui i kāu mālama ʻana i ka maʻi maʻi ma mua o ka pale ʻana i nā ʻōkana.