He aha ka Aminolevulinic Acid (Alae waha): Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

ʻO ka waikawa Aminolevulinic (ALA) he mea maoli i hana ʻia e kou kino ma ke ʻano he ʻāpana o ka hana ʻana i nā ʻulaʻula koko. Ke lawe ʻia ma ke ʻano he lāʻau lapaʻau, hana ia ma ke ʻano he mea photosensitizing, ʻo ia hoʻi, hoʻonui ia i kekahi mau cell i ka mālamalama. Hāʻawi kēia waiwai kūʻokoʻa i nā kauka e hoʻohana iā ia i kahi lapaʻau kūikawā i kapa ʻia ʻo photodynamic therapy, ma mua no kekahi mau ʻano o nā maʻi ʻili a me nā maʻi maʻi.

He aha ka Aminolevulinic Acid?

ʻO ka waikawa Aminolevulinic kahi hui i hana maoli ʻia e kou kino i nā mea liʻiliʻi i kēlā me kēia lā. Aia i loko o ka lāʻau lapaʻau waha kahi mana synthetic o kēia mea like, i hoʻolālā ʻia e hōʻiliʻili i nā cell abnormal ma kou kino. E noʻonoʻo iā ia he mea kōkua i manaʻo ʻia e hōʻailona i nā wahi pilikia no ka mālama ʻana.

Hana ka lāʻau lapaʻau ma ka lawe ʻia ʻana e nā cell e ulu wikiwiki ana a i ʻole nā cell abnormal, e like me nā cell maʻi a i ʻole nā ʻiʻo precancerous. Ke komo kēia mau cell i ka waikawa aminolevulinic, lilo lākou i mea naʻauao i nā nalu māmā kikoʻī, a laila hiki ke hoʻohana ʻia i ka lāʻau lapaʻau e luku iā lākou.

No ke aha e hoʻohana ʻia ai ka Aminolevulinic Acid?

ʻO ka hoʻohana mua ʻana o ka waikawa aminolevulinic waha i ka photodynamic therapy no kekahi mau maʻi olakino. Hiki i kāu kauka ke kuhikuhi iā ia e kōkua i ka ʻike a i ʻole ka mālama ʻana i nā ʻano kikoʻī o ka ulu ʻana o ka ʻiʻo abnormal, ʻoiai ma nā wahi paʻakikī ke kiʻi ʻia me nā lāʻau lapaʻau topical.

ʻO nā noi maʻamau e pili ana i ka mālama ʻana i kekahi mau maʻi ʻōpū, ʻo ia hoʻi ka maʻi maʻi ʻōpū non-muscle invasive a me ka carcinoma in situ. Hoʻohana kekahi mau kauka iā ia no ka ʻike ʻana i nā ʻiʻo abnormal i loko o ka ʻōpū i ka wā o nā hana ʻoki, no ka mea, ʻālohilohi nā wahi i mālama ʻia ma lalo o ke kukui uliuli kūikawā, e maʻalahi ai ka ʻike a me ka wehe ʻana.

I kekahi mau hihia, hiki i kāu mea mālama ola ke ʻōlelo aku i ka waikawa aminolevulinic no nā hoʻohana ʻole i ka lepili, e like me ka mālama ʻana i kekahi mau maʻi ʻili a i ʻole nā ʻano maʻi ʻaʻai superficial ʻē aʻe. Eia naʻe, ʻaʻole maʻamau kēia mau noi a pono e noʻonoʻo pono i nā pōmaikaʻi a me nā pilikia.

Pehea e hana ai ka waikawa Aminolevulinic?

Ua manaʻo ʻia ka waikawa Aminolevulinic he lāʻau lapaʻau ikaika waena e hana ana ma o ke kaʻina hana olaola hoihoi. Ke lawe ʻoe i ka waha, hele ia ma kou kahe koko a komo i loko o nā cell ma kou kino, me nā cell abnormal e lawe ana i ka nui o ia mea ma mua o nā cell olakino.

I loko o kēia mau cell i manaʻo ʻia, hoʻololi ka waikawa aminolevulinic i kahi mea i kapa ʻia ʻo protoporphyrin IX, e hana ana e like me ka antenna maoli no ka mālamalama. Ke hōʻike kāu kauka i ka wahi i mālama ʻia i nā nalu uliuli a ʻulaʻula paha, e komo ka protoporphyrin IX i kēia ikehu a hana i nā ʻano oxygen reactive e luku ai i nā cell abnormal.

He koho nui kēia kaʻina hana, ʻo ia hoʻi ka hopena nui i nā cell pilikia me ka waiho ʻana i ka ʻiʻo olakino i ka pōʻino nui. ʻO ka hana holoʻokoʻa e lawe maʻamau i kekahi mau hola mai ka manawa āu e lawe ai i ka lāʻau a hiki i ka hoʻomaka ʻana o ka mālama ʻana i ka mālamalama, e ʻae ana i ka hōʻiliʻili maikaʻi ʻana i nā cell i manaʻo ʻia.

Pehea wau e lawe ai i ka waikawa Aminolevulinic?

Pono ʻoe e lawe i ka waikawa aminolevulinic e like me ke kauoha a kāu kauka, maʻamau ma ke ʻano he hoʻokahi waha i hui pū ʻia me ka wai. He pauka ka lāʻau lapaʻau e pono e hoʻoheheʻe ʻia i loko o kahi wai kūikawā ma mua o ka inu ʻana, a e hoʻomākaukau kāu hui mālama ola i kēia huihuiu nāu.

Manaʻo ʻia ka lawe ʻana i ka lāʻau lapaʻau ma ka ʻōpū ʻole, no ka mea hiki i ka meaʻai ke keakea i kona komo ʻana. E noi paha kāu kauka iā ʻoe e pale i ka ʻai ʻana no ka liʻiliʻi o 2-3 mau hola ma mua o ka lawe ʻana i ka lāʻau. Hiki iā ʻoe ke hoʻomaka hou i ka ʻai ʻana ma kahi o 4-6 mau hola ma hope o ka lawe ʻana i ka lāʻau, ke ʻole kāu kauka e hāʻawi iā ʻoe i nā ʻōlelo ʻokoʻa.

He mea nui ka manawa e lawe ai ʻoe i ka waikawa aminolevulinic no ka mea pono ka manawa e hōʻiliʻili ai i loko o nā cell i manaʻo ʻia ma mua o ka hoʻomaka ʻana o ka mālama ʻana i ke kukui. Pono ka hapa nui o nā protocols e lawe ʻoe i ka lāʻau lapaʻau 1-3 mau hola ma mua o kāu kau photodynamic therapy, ma muli o ke kūlana kikoʻī e mālama ʻia nei.

Pehea ka lōʻihi e lawe ai au i ka waikawa Aminolevulinic?

Hāʻawi pinepine ʻia ka waikawa Aminolevulinic ma ke ʻano he hoʻokahi dose ma mua o ka lāʻau lapaʻau lōʻihi. ʻO ka hapa nui o nā protocols lapaʻau e pili ana i ka lawe ʻana i hoʻokahi dose ma mua o kēlā me kēia kau photodynamic therapy, a pono paha ʻoe i nā kau he nui i hoʻokaʻawale ʻia i nā pule a i ʻole nā mahina.

ʻO ka nui o nā lāʻau lapaʻau āu e pono ai e hilinaʻi ana i kou kūlana kikoʻī a me ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau. ʻIke kekahi poʻe i ka hoʻomaikaʻi nui ʻana ma hope o hoʻokahi kau, aʻo nā mea ʻē aʻe e pono paha i nā lāʻau lapaʻau 2-4 e loaʻa ai nā hopena i makemake ʻia. E nānā kāu kauka i kāu holomua a e hoʻoholo i ka papa hana lapaʻau maikaʻi loa no kou kūlana.

Ma waena o nā lāʻau lapaʻau, ʻaʻole ʻoe e lawe i ka waikawa aminolevulinic i kēlā me kēia lā. Akā, e lawe wale ʻoe ia i nā lā i hoʻonohonoho ʻia ai ʻoe no ka photodynamic therapy, e hana ana ia i mea ʻokoʻa loa mai ka hapa nui o nā lāʻau lapaʻau ʻē aʻe āu e kamaʻāina ai.

He aha nā hopena ʻaoʻao o ka waikawa Aminolevulinic?

E like me nā lāʻau lapaʻau, hiki i ka waikawa aminolevulinic ke hana i nā hopena ʻaoʻao, ʻoiai ua ʻae ka nui o nā kānaka iā ia. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hoʻopili ai i kāu hui mālama ola.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia ka nausea, ka luaʻi, a me ka ʻoluʻolu o ka ʻōpū, ʻoi aku hoʻi i nā hola ma hope o kāu dose. Hoʻoponopono maʻamau kēia mau hōʻailona digestive iā lākou iho i loko o 24-48 mau hola a hiki ke mālama ʻia me nā lāʻau anti-nausea inā pono.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia e nā maʻi:

• Ka luaʻi a me ka luaʻi ʻana (e pili ana i ka 10-30% o nā maʻi)
• ʻEha ʻōpū a i ʻole ka ʻūlū ʻana
• Pāpaʻa a i ʻole nā ʻōpū palupalu
• Luhi a i ʻole ka manaʻo maikaʻi ʻole
• Poʻo
• Pōniʻi a i ʻole ka māmā

He maʻalahi a maʻalahi kēia mau hopena ʻaoʻao maʻamau a he manawa pōkole. ʻO ka hapa nui o nā kānaka e ʻike i ka noho ʻana i ka wai a me ka hoʻomaha e kōkua i ka mālama ʻana i kēia mau hōʻailona.

ʻAʻole maʻamau nā hopena ʻaoʻao koʻikoʻi, akā pono e mālama koke ʻia. Pono ʻoe e hoʻokaʻaʻike i kāu kauka i kēia manawa inā loaʻa iā ʻoe nā hopena maʻi koʻikoʻi, me ka pilikia o ka hanu ʻana, ka pehu ʻana o kou maka a i ʻole ka ʻāʻī, a i ʻole ka ʻōpala ākea. Eia kekahi, ʻo ka luaʻi nui a mau paha e pale ai iā ʻoe mai ka mālama ʻana i nā wai e pono ai ka loiloi olakino.

ʻO kekahi mau hopena ʻaoʻao laha akā koʻikoʻi e pili ana i nā loli hana ate, ʻo ia ke kumu e nānā ai kāu kauka i kāu mau enzyme ate me nā hoʻokolohua koko. I kekahi manawa, hiki i nā maʻi ke ʻike i nā hopena cardiovascular nui aʻe a i ʻole nā hopena ʻili koʻikoʻi, ʻoiai inā ʻike lākou i ka mālamalama nui ma hope koke o ka mālama ʻana.

ʻO wai ka mea pono ʻole e lawe i ka Aminolevulinic Acid?

ʻAʻole pono kekahi poʻe e lawe i ka waikawa aminolevulinic ma muli o ka piʻi ʻana o ka pilikia o nā pilikia a i ʻole ka emi ʻana o ka pono. E nānā pono kāu kauka i kāu mōʻaukala olakino e hoʻoholo ai inā palekana kēia lāʻau lapaʻau iā ʻoe.

ʻAʻole pono ʻoe e lawe i ka waikawa aminolevulinic inā ʻike ʻoe i ka maʻi i ka lāʻau lapaʻau a i ʻole kekahi o kāna mau mea. Eia kekahi, ʻo nā poʻe me kekahi mau maʻi koko, ʻo ia hoʻi ka porphyria (he pūʻulu o nā maʻi laha e pili ana i ka kemika koko), pono e pale i kēia lāʻau lapaʻau no ka mea hiki ke hoʻonui i ko lākou kūlana.

Nui nā kūlana ʻē aʻe e hiki ai i ka waikawa aminolevulinic ke kūpono ʻole iā ʻoe:

• Ka maʻi kīkī nui a i ʻole ka hāʻule ʻana o ke kīkī
• Ka maʻi ate nui a i ʻole ka hāʻule ʻana o ke ate
• Hāpai a i ʻole ka hānai ʻana i ka waiū
• Ke kahe koko ʻana i loko o ka ʻōpū
• Nā maʻi puʻuwai nui a i ʻole ka loaʻa ʻana o ka puʻuwai i kēia manawa
• Nā maʻi autoimmune kekahi e pili ana i ka ʻike ʻana i ka mālamalama

E noʻonoʻo nō hoʻi kāu kauka i kāu mau lāʻau lapaʻau i kēia manawa, no ka mea, hiki i kekahi mau lāʻau ke launa pū me ka waikawa aminolevulinic a i ʻole e pili i ke ʻano o ka hana ʻana o kou kino. ʻO kēia loiloi akahele e hōʻoia i ka palekana a me ka pono o ka lāʻau lapaʻau no kou kūlana.

Nā inoa inoa o ka waikawa Aminolevulinic

Loaʻa ka waikawa Aminolevulinic ma lalo o nā inoa inoa like ʻole, ma muli o ka hoʻohuihui kikoʻī a me ka hoʻohana i manaʻo ʻia. ʻO ke ʻano waha i kauoha pinepine ʻia i ʻike ʻia ʻo Gleolan ma nā ʻāina he nui, ʻoiai ʻokoʻa ka loaʻa ʻana ma ka ʻāina.

Ma ʻAmelika Hui Pū ʻIa, loaʻa paha ka hoʻohuihui waha ma lalo o nā inoa inoa like ʻole a i ʻole he lāʻau lapaʻau maʻamau, ma muli o ka hōʻailona kikoʻī a me ka mea hana. E hāʻawi kāu hale kūʻai lāʻau lapaʻau iā ʻoe i ka inoa inoa pololei i kauoha ʻia e kāu kauka.

He mea pono e hoʻomaopopo aia kekahi mau mana topical (hoʻopili ʻia i ka ʻili) o ka waikawa aminolevulinic i loaʻa ma lalo o nā inoa inoa like ʻole, e like me Levulan Kerastick. Eia naʻe, he mau hoʻohuihui ʻokoʻa loa kēia a ʻaʻole pono e huikau me ka lāʻau waha.

Nā koho ʻē aʻe o ka waikawa Aminolevulinic

Inā ʻaʻole kūpono ka waikawa aminolevulinic iā ʻoe, hiki i kāu kauka ke noʻonoʻo i nā lāʻau lapaʻau ʻē aʻe ma muli o kou kūlana. No ka maʻi maʻi ʻōpū, hiki i nā koho ʻē aʻe ke komo i nā mea photosensitizing ʻē aʻe a i ʻole nā ala lapaʻau like ʻole.

ʻO kekahi mau lāʻau lapaʻau photosensitizing ʻē aʻe e komo pū ana me methyl aminolevulinate (MAL) a i ʻole nā mea hui ʻē aʻe i hoʻokumu ʻia i ka porphyrin, akā hoʻohana pinepine ʻia kēia mau mea no nā maʻi like ʻole a i ʻole nā ʻano hāʻawi. Hiki nō hoʻi i kāu kauka ke noʻonoʻo i nā lāʻau lapaʻau maʻamau e like me ka chemotherapy, immunotherapy, a i ʻole nā koho ʻoki.

Aia ke koho ʻana i ka lāʻau lapaʻau ʻē aʻe i kāu hōʻailona kikoʻī, ke olakino holoʻokoʻa, a me nā pahuhopu lapaʻau. E hana pū kāu hui mālama ola me ʻoe e ʻimi i ke koho kūpono loa inā ʻaʻole ʻo ka waikawa aminolevulinic ke koho kūpono no kou kūlana.

Ua ʻoi aku ka maikaʻi o ka waikawa Aminolevulinic ma mua o nā Photosensitizers ʻē aʻe?

He nui nā pōmaikaʻi o ka waikawa Aminolevulinic ma luna o nā lāʻau lapaʻau photosensitizing ʻē aʻe, ʻoiai i ka wikiwiki o ka hoʻomaʻemaʻe ʻana mai kou kino. ʻAʻole like me kekahi mau photosensitizers ʻē aʻe e hiki ke hoʻolilo iā ʻoe i mea naʻauao i ka mālamalama no nā pule, ʻo ka waikawa aminolevulinic ke kumu maʻamau i ka naʻau i ka mālamalama no 24-48 mau hola wale nō.

ʻO kēia manawa pōkole o ka naʻau i ka mālamalama e ʻoi aku ka maʻalahi no nā maʻi a hoʻemi i ka pilikia o nā pilikia hōʻike ʻana i ka mālamalama. Eia kekahi, loaʻa maoli ka waikawa aminolevulinic i kou kino, kahi e hōʻemi ai i ka pilikia o kekahi mau ʻano o nā hopena maʻi maʻi i hoʻohālikelike ʻia me nā mea pani synthetic.

Eia naʻe, pili loa ke koho

Hiki ke hoʻohana palekana ʻia ka waikawa Aminolevulinic i ka poʻe me ka maʻi diabetes, akā pono kāu kauka e nānā pono iā ʻoe. ʻAʻole pili pololei ka lāʻau lapaʻau i nā pae kōpaʻa koko, akā hiki i ke koʻikoʻi o ka mālama ʻana a me nā hopena ʻaoʻao e like me ka nausea a i ʻole ka luaʻi ʻana ke hoʻopilikia i kāu kaohi kōpaʻa koko.

Inā loaʻa iā ʻoe ka maʻi diabetes, e hōʻoia e haʻi i kāu hui mālama ola e hiki iā lākou ke hoʻoponopono i kāu nānā ʻana a me kāu mau lāʻau lapaʻau diabetes i ka manawa o ka mālama ʻana. Pono ʻoe e hoʻolālā e nānā i kāu kōpaʻa koko i nā manawa pinepine i nā lā lapaʻau.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka waikawa Aminolevulinic nui loa?

Inā lawe hewa ʻoe i ka waikawa aminolevulinic ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu kauka a i ʻole nā lawelawe pilikia. Hiki i ka overdose ke hoʻonui i ka pilikia o nā hopena ʻaoʻao koʻikoʻi, ʻo ia hoʻi ka hoʻonui ʻana i ka ʻike māmā a me ka nausea a i ʻole ka luaʻi ʻana.

Mai ho'āʻo e hoʻokomo i ka luaʻi ʻana ke ʻole i kauoha ʻia e nā poʻe loea lapaʻau. Akā, e ʻimi koke i ka lāʻau lapaʻau kahi e hiki ai i nā mea mālama ola ke nānā iā ʻoe no nā pilikia a hāʻawi i ka mālama kākoʻo kūpono inā pono.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele o ka waikawa Aminolevulinic?

No ka mea, hāʻawi ʻia ka waikawa aminolevulinic ma ke ʻano he mahele hoʻokahi ma mua o ka photodynamic therapy, ʻo ka haʻalele ʻana i kahi mahele ʻo ia hoʻi ka hoʻolālā hou ʻana i kāu kau lapaʻau holoʻokoʻa. E hoʻokaʻaʻike koke i kāu hui mālama ola inā haʻalele ʻoe i kāu mahele i hoʻonohonoho ʻia.

Pono kāu kauka e hoʻolālā hou i ka lāʻau lapaʻau a me ka mālama māmā, no ka mea, he mea nui ka manawa ma waena o kēia mau mea ʻelua no ka pono. Mai ho'āʻo e lawe i ka lāʻau lapaʻau iā ʻoe iho a i ʻole e hoʻoponopono i ka manawa me ka ʻole o ka mālama ʻana i ka lāʻau lapaʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka waikawa Aminolevulinic?

ʻAʻole ʻoe e “hooki” i ka lawe ʻana i ka waikawa aminolevulinic ma ke ʻano kuʻuna, no ka mea, hāʻawi pinepine ʻia ia ma ke ʻano he mau lāʻau pākahi ma mua o ka lāʻau hoʻomau. E pau ana kāu papa lapaʻau ke pau kāu mau kau lapaʻau photodynamic i hoʻonohonoho ʻia e kāu kauka.

Na kāu kauka e hoʻoholo i ka wā e pau ai kāu lapaʻau ma muli o ka maikaʻi o kāu pane ʻana i ka lāʻau a inā pono nā lāʻau lapaʻau e hahai ai. Pono kekahi poʻe i hoʻokahi kau wale nō, aʻo nā mea ʻē aʻe e pono paha i kekahi mau lāʻau lapaʻau i hohola ʻia ma luna o nā mahina.

Hiki iaʻu ke kalaiwa ma hope o ka lawe ʻana i ka waikawa Aminolevulinic?

Pono ʻoe e pale i ke kalaiwa ʻana ma hope o ka lawe ʻana i ka waikawa aminolevulinic, ʻoiai i ka lā o ka lapaʻau. Hiki i ka lāʻau lapaʻau ke hoʻoulu i ka noʻonoʻo, ka maʻi, a me ka luhi e hiki ke hoʻopilikia i kou hiki ke kalaiwa palekana.

Eia kekahi, pono ʻoe e pale i ka ʻike ʻana i ka mālamalama no 24-48 mau hola ma hope o ka lapaʻau, e komo pū ana me ka lā mālamalama e hiki ai iā ʻoe ke hālāwai i ke kalaiwa ʻana. E hoʻolālā e loaʻa i kekahi e kalaiwa iā ʻoe i a mai kāu mau manawa lapaʻau a no ka lā mua ma hope o kēlā me kēia kau.