He aha ka Anidulafungin: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau antifungal ikaika ka Anidulafungin a nā kauka e hāʻawi ai ma o ka IV e mālama i nā maʻi fungal koʻikoʻi. No ka hui ʻo echinocandins kēia lāʻau lapaʻau, e hana ana e like me nā missile i manaʻo ʻia e kūʻē i nā ʻano fungi weliweli e hiki ke hoʻoweliweli i kou olakino ke hoʻopilikia ʻia kāu ʻōnaehana pale.

He aha ka Anidulafungin?

He lāʻau lapaʻau antifungal kauoha ʻo Anidulafungin e hele mai ana ma ke ʻano IV wale nō. Ua hoʻolālā ʻia e hakakā i nā fungi Candida, he mau hū e hiki ke hoʻoulu i nā maʻi e hoʻoweliweli ana i ke ola i nā maʻi i ka haukapila.

Hana kēia lāʻau lapaʻau ma ka hoʻouka ʻana i nā paia cell o nā fungi, e hiki ʻole ai iā lākou ke ola a hana hou. E noʻonoʻo e like me ka wehe ʻana i ka pūpū pale e mālama ana i kēia mau meaola ʻino e ola ana. ʻAʻole like me nā lāʻau antifungal ʻē aʻe, ua manaʻo ʻia ʻo anidulafungin he mea maikaʻi loa me ka liʻiliʻi o nā pilina lāʻau.

E loaʻa wale iā ʻoe kēia lāʻau lapaʻau i loko o ka haukapila a i ʻole ke keʻena lapaʻau no ka mea e pono ai ka nānā pono ʻana a me ka lawelawe ʻana i ka ʻoihana. He pauka ka lāʻau lapaʻau e hui pū ai nā mea mālama ola me ka wai sterile ma mua o ka hāʻawi ʻana iā ʻoe ma o kāu laina IV.

No ke aha e hoʻohana ʻia ai ka Anidulafungin?

Hoʻomaʻamaʻa ʻo Anidulafungin i nā maʻi Candida koʻikoʻi i laha i kou kino a i ʻole i hoʻopilikia i kou kahe koko. Hoʻopaʻa nā kauka i kēia lāʻau lapaʻau ke loaʻa iā ʻoe ka candidemia (Candida i kou koko) a i ʻole ka candidiasis invasive e pili ana i kou mau ʻōpū.

He mea nui kēia lāʻau lapaʻau no nā maʻi i nā keʻena mālama koʻikoʻi, nā mea me nā ʻōnaehana pale i hoʻopilikia ʻia, a i ʻole nā ​​kānaka i hana i nā ʻoki nui. Hoʻohana ʻia nō hoʻi ke hana ʻole nā ​​lāʻau antifungal ʻē aʻe a i ʻole ke kūpaʻa ʻana o ke ʻano Candida i nā lāʻau ʻē aʻe.

Hiki i kāu kauka ke koho i ka anidulafungin inā loaʻa iā ʻoe nā maʻi Candida i loko o kou esophagus, ʻoiai ʻaʻole maʻamau kēia. He mea waiwai loa ka lāʻau lapaʻau no ka mea e hana wikiwiki a maikaʻi hoʻi i ka hapa nui o nā ʻano Candida e hoʻoulu ai i nā maʻi koʻikoʻi.

Pehea e hana ai ʻo Anidulafungin?

Ua manaʻo ʻia ʻo Anidulafungin he lāʻau antifungal ikaika e hana ana ma ka pale ʻana i kahi enzyme i kapa ʻia ʻo beta-glucan synthase. He mea nui kēia enzyme no nā fungi e kūkulu i ko lākou paia cell, e pale ana iā lākou a kōkua iā lākou e ola.

Ke ālai ʻo anidulafungin i kēia enzyme, nāwaliwali nā paia cell fungal a ma hope e wāwahi. ʻO kēia ke kumu e make ai nā mea ola Candida, e kōkua ana i kou kino e hoʻomaʻemaʻe i ka maʻi. He mea maikaʻi loa ka lāʻau lapaʻau no ka mea ʻaʻole loaʻa i nā cell kanaka kēia enzyme, no laila e kuhikuhi ana i nā fungi me ka ʻole e hōʻeha i kāu mau cell olakino.

Noho ka lāʻau lapaʻau i loko o kou kahe koko no kekahi mau hola ma hope o kēlā me kēia mahele, e hāʻawi ana iā ia i ka manawa e hiki ai i nā ʻiʻo i maʻi ʻia i loko o kou kino. Kōkua kēia hana mau i ka hōʻoia ʻana e hiki i ka lāʻau lapaʻau ke hoʻopau i nā fungi ʻoiai ma nā wahi paʻakikī e like me kou mau ʻōpū a i ʻole ke kahe koko.

Pehea wau e lawe ai i ka Anidulafungin?

E loaʻa iā ʻoe ka anidulafungin ma o ka laina IV wale nō i loko o kahi haukapila a i ʻole kahi hoʻonohonoho lapaʻau. E hāʻawi nā mea mālama ola iā ʻoe i kēia lāʻau lapaʻau lohi ma kahi o 90 mau minuke a 3 mau hola, ma muli o kāu mahele.

ʻAʻole pono ka lāʻau lapaʻau i kekahi hoʻomākaukau kūikawā ma kāu ʻaoʻao e pili ana i ka meaʻai a i ʻole ka inu. Hiki iā ʻoe ke ʻai maʻamau ma mua a ma hope o ka loaʻa ʻana o kāu mahele, no ka mea, ʻaʻole pili ka meaʻai i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau. Eia naʻe, e nānā pono kāu hui mālama ola iā ʻoe i ka wā o kēlā me kēia infusion.

E nānā kāu kahu hānai i kāu pūnaewele IV i nā manawa a pau e hōʻoia i ka holo pono ʻana o ka lāʻau lapaʻau a ʻaʻole ʻoe e ʻike i nā hopena. E nānā pū lākou i kāu mau hōʻailona koʻikoʻi a nānā i nā hōʻailona o nā hopena maʻi a i ʻole nā hopena ʻaoʻao i ka wā o ka infusion.

E hoʻolālā ʻia ka manawa o kāu mau lāʻau e kāu hui lapaʻau e pili ana i kou kūlana kikoʻī a me ka maikaʻi o kou pane ʻana i ka lāʻau. Mai hoʻāʻo e hoʻololi i ka manawa a i ʻole e hooki i ka lāʻau lapaʻau iā ʻoe iho.

Pehea ka lōʻihi e lawe ai au i ka Anidulafungin?

Aia ka lōʻihi o kāu lapaʻau anidulafungin ma ke koʻikoʻi o kāu maʻi a me ka wikiwiki o kou pane ʻana i ka lāʻau. Loaʻa ka lāʻau lapaʻau i ka hapa nui o nā maʻi no 14 a 21 mau lā, akā pono paha kekahi i nā papa lōʻihi.

E nānā kāu kauka i kāu mau hoʻokolohua koko a me nā hōʻailona lapaʻau e hoʻoholo ai i ka manawa e palekana ai ke hooki i ka lāʻau. E hoʻomau lākou i ka lāʻau lapaʻau no ka liʻiliʻi o 14 mau lā ma hope o kāu moʻomeheu koko maikaʻi hope loa a i ʻole a hiki i ka maikaʻi ʻana o kāu mau hōʻailona.

No kekahi poʻe maʻi me nā maʻi koʻikoʻi a i ʻole nā ​​pūnaehana pale i hoʻopilikia ʻia, hiki ke hoʻolōʻihi ʻia ka lāʻau lapaʻau no nā pule he nui. E loiloi mau kāu hui mālama ola inā e hana ana ka lāʻau a inā pono ʻoe e hoʻomau i ka lāʻau.

Mai hooki i ka lawe ʻana i ka anidulafungin i ka wā mua, ʻoiai inā hoʻomaka ʻoe e maikaʻi. ʻO ka hooki ʻana i ka wā mua hiki ke ʻae i ka maʻi e hoʻi mai, a hiki ke lilo i ʻano kūʻē i ʻoi aku ka paʻakikī o ka mālama ʻana.

He aha nā hopena ʻaoʻao o Anidulafungin?

Hoʻomanawanui ka hapa nui o nā kānaka i ka anidulafungin, akā e like me nā lāʻau lapaʻau a pau, hiki iā ia ke hana i nā hopena ʻaoʻao. ʻO ka lono maikaʻi, ʻaʻole maʻamau nā hopena ʻaoʻao koʻikoʻi, a e nānā pono kāu hui mālama ola iā ʻoe no nā pilikia.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike:

• ʻO ka nausea a i ʻole ka ʻōpū māmā
• ʻEha ke poʻo
• Pāpaʻa
• Fiva
• Nā pae potassium haʻahaʻa i kou koko
• ʻO ka ʻili māmā
• ʻEha a i ʻole ka huhū ma ka pūnaewele IV

He maʻalahi ka maʻamau o kēia mau hopena ʻaoʻao a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Hiki i kāu hui mālama ola ke kōkua i ka mālama ʻana i kēia mau hōʻailona inā lilo lākou i mea hoʻonāukiuki.

He maʻamau ʻole nā hopena ʻaoʻao koʻikoʻi, akā pono e mālama koke ʻia e ke kauka. Aia kēia mau mea i nā hopena maʻi maʻi koʻikoʻi, nā loli nui i nā hoʻokolohua hana ate, a i ʻole ke kahe ʻana o ke koko a i ʻole ka ʻeha ʻana. E nānā mau kāu hui lapaʻau i kāu hana koko e ʻike koke i nā loli e pili ana.

Hiki i kekahi poʻe ke ʻike i nā hopena pili i ka histamine i ka wā o ka hoʻokomo ʻana, hiki ke hoʻoulu i ka ʻulaʻula, ka ʻōpala, a i ʻole nā pilikia hanu māmā. Inā hiki kēia, hiki i kāu mea mālama ola ke hoʻolohi i ka wikiwiki o ka hoʻokomo ʻana a i ʻole e hāʻawi iā ʻoe i nā lāʻau lapaʻau e kōkua i ka mālama ʻana i kēia mau hōʻailona.

ʻO wai ka mea pono ʻole e lawe iā Anidulafungin?

ʻAʻole kūpono ʻo Anidulafungin no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. ʻO ka hopohopo nui inā ua loaʻa iā ʻoe kahi hopena maʻi i ka anidulafungin a i ʻole nā lāʻau antifungal echinocandin ʻē aʻe i ka wā ma mua.

Pono ka poʻe me nā pilikia ate koʻikoʻi i ka noʻonoʻo kūikawā, no ka mea, hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka hana ate. E kaupaona kāu kauka i nā pōmaikaʻi e kūʻē i nā pilikia a e nānā pono i kāu mau hoʻokolohua ate inā loaʻa iā ʻoe ka maʻi ate.

Pono nā wahine hāpai e loaʻa iā anidulafungin inā ʻoi aku ka nui o nā pōmaikaʻi ma mua o nā pilikia i ka pēpē e ulu ana. Hiki i ka lāʻau lapaʻau ke hele i loko o ka waiū umauma, no laila pono nā makuahine e hānai ana i ka umauma e kūkākūkā i nā pilikia a me nā pōmaikaʻi me kā lākou mea mālama ola.

ʻAʻole loaʻa i nā keiki ma lalo o 16 mau makahiki iā anidulafungin ke ʻole he mea pono loa, no ka mea, he palena ka ʻikepili palekana no kēia pūʻulu makahiki. E noʻonoʻo pono kāu loea pediatric i nā koho ʻē aʻe.

Nā inoa inoa o Anidulafungin

Loaʻa ʻo Anidulafungin ma lalo o ka inoa inoa Eraxis ma ʻAmelika Hui Pū ʻIa. ʻO kēia ka inoa inoa i ʻike nui ʻia no kēia lāʻau lapaʻau i nā wahi haukapila.

Hiki ke loaʻa ka lāʻau lapaʻau ma ke ʻano he anidulafungin generic ma kekahi mau keʻena mālama ola. Inā loaʻa iā ʻoe ka inoa inoa a i ʻole ka mana generic, ua like ka mea hana a me ka pono.

E hoʻohana kāu hui mālama ola i ka mana i loaʻa ma kāu haukapila a i ʻole ke keʻena lapaʻau. Ua like nā mana ʻelua i nā hoʻokolohua koʻikoʻi a me nā kūlana maikaʻi, no laila hiki iā ʻoe ke hilinaʻi i kekahi ʻano o ka lāʻau lapaʻau.

Nā Koho ʻē aʻe o Anidulafungin

Nui nā lāʻau lapaʻau antifungal ʻē aʻe e hiki ke mālama i nā maʻi Candida koʻikoʻi inā ʻaʻole kūpono ka anidulafungin iā ʻoe. ʻO nā koho maʻamau e pili ana i nā lāʻau lapaʻau echinocandin ʻē aʻe e like me caspofungin a me micafungin.

ʻO Fluconazole kekahi koho ʻē aʻe, ʻoi aku hoʻi no nā maʻi ʻaʻole koʻikoʻi a i ʻole ke hoʻololi ʻana mai IV i ka lāʻau lapaʻau waha. Eia naʻe, kūʻē kekahi ʻano Candida i ka fluconazole, ʻo ia ke kumu e koho ai kāu kauka i ka anidulafungin.

ʻO Amphotericin B kahi koho ʻē aʻe no nā maʻi koʻikoʻi, akā hiki iā ia ke hana i nā hopena ʻaoʻao ma mua o ka anidulafungin. E noʻonoʻo kāu kauka i kāu ʻano maʻi kikoʻī, ka hana o ka puʻupaʻa, a me ke olakino holoʻokoʻa i ke koho ʻana ma waena o kēia mau koho.

Aia ke koho ʻana i ka lāʻau lapaʻau antifungal i ke ʻano kikoʻī o Candida e hana ana i kāu maʻi, kāu hana puʻupaʻa a me ke ake, a me nā lāʻau lapaʻau ʻē aʻe āu e lawe nei. E koho kāu hui mālama ola i ke koho maikaʻi loa e pili ana i kāu mau kūlana pilikino.

Ua ʻoi aku ka maikaʻi o Anidulafungin ma mua o Fluconazole?

He mau lāʻau lapaʻau antifungal maikaʻi ʻo Anidulafungin a me fluconazole, akā hana lākou i nā kūlana like ʻole. ʻOi aku ka maikaʻi o Anidulafungin no nā maʻi Candida koʻikoʻi a me ka hoʻoweliweli ʻana i ke ola no ka mea hana wikiwiki a kūʻē i nā ʻano Candida kūʻē.

He koho maikaʻi ʻo Fluconazole no nā maʻi liʻiliʻi a i ʻole ke hiki iā ʻoe ke hoʻololi i ka lāʻau lapaʻau waha. He mea pono loa ia no ka mālama lōʻihi a i ʻole ka pale ʻana i nā maʻi fungal i nā maʻi pilikia nui.

ʻO ka pōmaikaʻi nui o ka anidulafungin ʻo ia kona pono e kūʻē i nā ʻano Candida i kūʻē i ka fluconazole. He liʻiliʻi nō hoʻi nā pilina lāʻau a ʻaʻole pono e hoʻoponopono i ka maʻi no nā pilikia o ka puʻupaʻa, ʻaʻole like me ka fluconazole.

E koho kāu kauka i ka lāʻau lapaʻau kūpono loa no kāu maʻi kikoʻī a me ke kūlana olakino. I kekahi manawa, hoʻomaka nā maʻi me ka anidulafungin a laila hoʻololi i ka fluconazole ke hoʻomalu ʻia ka maʻi.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana i ka Anidulafungin

Q1. Palekana anei ʻo Anidulafungin no ka maʻi puʻupaʻa?

ʻAe, palekana ka anidulafungin no ka poʻe me ka maʻi puʻupaʻa. ʻAʻole like me kekahi mau lāʻau lapaʻau antifungal ʻē aʻe, ʻaʻole pono ka anidulafungin e hoʻoponopono i ka maʻi ma muli o kāu hana puʻupaʻa.

ʻO kēia ka mea e lilo ai i koho maikaʻi loa no nā maʻi me nā pilikia puʻupaʻa e pono ai ka mālama ʻana i nā maʻi fungal koʻikoʻi. E nānā mau kāu kauka i kāu hana puʻupaʻa i ka wā o ka mālama ʻana, akā ʻaʻole maʻamau ka lāʻau lapaʻau i ka pōʻino o ka puʻupaʻa.

Q2. He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o ka Anidulafungin?

No ka mea, hāʻawi ʻia ka anidulafungin e nā poʻe loea mālama ola i kahi hoʻonohonoho i mālama ʻia, he mea maʻamau loa nā overdoses ulia. Hoʻomaopopo pono kāu hui lapaʻau a nānā i kēlā me kēia maʻi āu e loaʻa ai.

Inā hopohopo ʻoe e pili ana i kāu maʻi a i ʻole e ʻike i nā hōʻailona maʻamau i ka wā o ka mālama ʻana, e haʻi koke i kāu kahu hānai a i ʻole ke kauka. Hiki iā lākou ke loiloi wikiwiki i ke kūlana a hāʻawi i ka mālama kūpono inā pono.

Q3. He aha kaʻu e hana ai inā hala iaʻu kahi maʻi o Anidulafungin?

ʻAʻole paha e hala ka mahele o ka anidulafungin no ka mea e loaʻa ana iā ʻoe ma kahi haukapila me ka hoʻonohonoho pono. Akā, inā he lohi i kāu lapaʻau, e hoʻoholo ana kāu hui mālama ola i ke ala maikaʻi loa.

Hiki i kāu hui lapaʻau ke hoʻololi i ka manawa o nā mahele aʻe a i ʻole e hoʻolōʻihi i kāu manawa lapaʻau e hōʻoia ai e loaʻa iā ʻoe ka papa piha o ka lāʻau. E hana lākou i kēia mau hoʻoholo e pili ana i kāu kūlana kikoʻī a me ka pane ʻana i ka lapaʻau.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Anidulafungin?

Pono ʻoe e hooki i ka lawe ʻana i ka anidulafungin ke hoʻoholo kāu kauka he palekana ke hana pēlā. Hoʻokumu ʻia kēia hoʻoholo ma nā hopena o kāu hōʻike koko, nā hōʻailona lapaʻau, a me ka maikaʻi o kāu pane ʻana i ka lapaʻau.

ʻO ka maʻamau, hoʻomau ka lapaʻau no ka liʻiliʻi o 14 mau lā ma hope o ka lilo ʻana o kāu moʻomeheu koko i mea ʻole a i ʻole e hoʻomaikaʻi nui ai kāu mau hōʻailona. E nānā kāu hui mālama ola i kāu holomua i kēlā me kēia lā a e hana i kēia hoʻoholo nāu.

Q5. Hiki iaʻu ke lawe i nā lāʻau ʻē aʻe i ka wā e lawe ana i ka Anidulafungin?

He liʻiliʻi nā pilina lāʻau o ka Anidulafungin ma mua o nā lāʻau antifungal ʻē aʻe, akā he mea nui nō e haʻi i kāu hui mālama ola e pili ana i nā lāʻau a pau āu e lawe nei. Aia kēia i nā lāʻau lapaʻau, nā lāʻau lapaʻau ma luna o ka pāʻālua, a me nā mea hoʻohui.

E nānā kāu hui lapaʻau i kāu mau lāʻau a pau e hōʻoia ai he palekana ke hoʻohana pū. Pono paha lākou e hoʻololi i nā mahele o kekahi mau lāʻau a i ʻole e nānā pono iā ʻoe no nā hopena ʻaoʻao i ka wā e loaʻa ana iā ʻoe ka lapaʻau anidulafungin.