He aha ka mea Antihemophilic Factor: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

ʻO ka antihemophilic factor he lāʻau lapaʻau e hoʻopakele ai i ke ola e pani ana i ka protein clotting i nalowale i ka poʻe me ka hemophilia A. E noʻonoʻo e like me ka hāʻawi ʻana i kou koko i ka mea nui e pono ai e hana i nā clots a hoʻōki i ke kahe ʻana.

Aia i loko o kēia lāʻau lapaʻau ka Factor VIII, kahi protein e kōkua i kou koko e clot maʻamau. Ke loaʻa iā ʻoe ka hemophilia A, ʻaʻole hana kou kino i ka nui o kēia protein a i ʻole e hana i kahi mana ʻaʻole hana maikaʻi. Hoʻokomo ka antihemophilic factor injection i kēia āpau, e kōkua ana i ka pale ʻana i nā hanana kahe koko weliweli.

He aha ka mea Antihemophilic Factor?

ʻO ka antihemophilic factor he ʻano i hoʻopaʻa ʻia o Factor VIII, ka protein clotting koko i nele i ka poʻe me ka hemophilia A. Hāʻawi ʻia ma o ka IV e hoʻihoʻi koke i ka hiki o kou koko ke clot.

Hele mai kēia lāʻau lapaʻau i ʻelua ʻano nui: plasma-derived (hana ʻia mai ke koko kanaka i hāʻawi ʻia) a me ka recombinant (hana ʻia i loko o kahi lab me ka hoʻohana ʻana i ka ʻenekinia genetic). Hana like nā ʻano ʻelua i kou kino. E koho kāu kauka i ke koho maikaʻi loa e pili ana i kāu mau pono kikoʻī a me ka mōʻaukala olakino.

Hoʻoponopono ʻia a hoʻāʻo ʻia ka lāʻau lapaʻau e hōʻoia i ka palekana a me ka maikaʻi. Ua hana nā ʻenehana hana hou i kēia mau huahana i ʻoi aku ka palekana ma mua o nā makahiki i hala aku nei, me ka nānā nui ʻana i nā maʻi maʻi.

No ke aha e hoʻohana ʻia ai ka Antihemophilic Factor?

Hoʻomaʻamaʻa ka antihemophilic factor a pale i ke kahe ʻana i ka poʻe me ka hemophilia A, kahi maʻi genetic kahi e clot ʻole ai ke koko. ʻO ia ka ʻōnaehana hoʻihoʻi o kou kino ke hāʻule ka clotting maoli.

Hoʻonohonoho nā kauka i kēia lāʻau lapaʻau no kekahi mau kūlana koʻikoʻi. Pono paha ʻoe e hoʻōki i nā hanana kahe koko ikaika, inā mai kahi ʻeha, ke ʻoki ʻana, a i ʻole ke kahe ʻana i loko o nā hono a me nā ʻiʻo. Hoʻohana ʻia nō hoʻi ma mua o nā ʻoki i hoʻolālā ʻia a i ʻole nā kaʻina hana niho e hōʻemi i ka pilikia o ke kahe ʻana.

Ke lawe nei kekahi poʻe me ka hemophilia koʻikoʻi i nā lāʻau maʻamau e pale loa i nā hanana koko. Hiki i kēia ala, i kapa ʻia he lapaʻau prophylactic, ke kōkua i ka pale ʻana i kou mau hono a me nā ʻiʻo mai ka pōʻino e hiki ai ke kahe koko pinepine i ka manawa.

Pehea e hana ai ka Antihemophilic Factor?

Hana ka antihemophilic factor ma ka pani ʻana i ka protein Factor VIII i nalowale i loko o kou koko. Ke hoʻokomo ʻia, hoʻomaka koke ia e kōkua i kou koko e hana i nā clots maʻamau.

Ke hōʻeha ʻoe, hoʻomaka kou kino i kahi kaʻina hana paʻakikī i kapa ʻia ʻo ka clotting cascade. He mea nui ka Factor VIII i kēia kaʻina hana, e kōkua ana i ka hoʻololi ʻana i nā protein clotting ʻē aʻe i ko lākou mau ʻano hana. Me ka lawa ʻole o ka Factor VIII, paʻa kēia cascade, a hoʻomau ke kahe koko ma mua o ka mea e pono ai.

Holoholo ka lāʻau lapaʻau i loko o kou kahe koko no kekahi mau hola a i ʻole mau lā, ma muli o ka wikiwiki o kou kino e wāwahi iā ia. I kēia manawa, hiki i kou koko ke clot ʻoi aku ka maikaʻi, e pale ana iā ʻoe mai ke kahe koko weliweli.

Pehea wau e lawe ai i ka Antihemophilic Factor?

Hāʻawi mau ʻia ka antihemophilic factor ma ke ʻano he intravenous (IV) injection, e kekahi mea mālama ola a i ʻole e ʻoe iho inā ua aʻo ʻia ʻoe. Pono e hele pololei ka lāʻau lapaʻau i loko o kou kahe koko e hana pono ai.

Ma mua o kēlā me kēia injection, pono ʻoe e hui i ka lāʻau lapaʻau inā hele mai ma ke ʻano he pauka. E hahai pono i nā ʻōlelo hui e like me kāu kauka a i ʻole ka mea lapaʻau i hōʻike iā ʻoe. E hoʻohana wale i ka wai kūikawā (diluent) e hele mai me ka lāʻau lapaʻau, ʻaʻole loa i ka wai paʻi a i ʻole nā ​​wai ʻē aʻe.

Pono e hāʻawi ʻia ka injection mālie no kekahi mau minuke. Hiki i ka wikiwiki ke hoʻoulu i nā hopena ʻaoʻao ʻoluʻolu ʻole e like me ka ʻulaʻula a i ʻole ka puʻuwai wikiwiki. E mālama i ka lāʻau lapaʻau i loko o ka pahu hau akā e hoʻokuʻu iā ia i ka mahana o ka lumi ma mua o ka hui ʻana a me ka hoʻokomo ʻana.

He nui ka poʻe e aʻo ana e hāʻawi iā lākou iho i nā injections ma ka home, e hāʻawi ana i ka maʻalahi a me ka wikiwiki o ka lapaʻau i ka wā o nā hanana koko. E aʻo kāu hui mālama ola iā ʻoe i nā ʻenehana injection kūpono a kōkua iā ʻoe e manaʻoʻiʻo i ke kaʻina hana.

Pehea ka lōʻihi e pono ai iaʻu ke lawe i ka Antihemophilic Factor?

ʻO ka lōʻihi o ka lapaʻau antihemophilic factor e hilinaʻi loa i kou kūlana pilikino a me ke kumu e lawe nei ʻoe. No nā hanana koko ikaika, pono paha ʻoe i nā mahele no kekahi mau lā a hiki i ka pau ʻana o ke koko.

Inā e hana ana ʻoe i ke ʻoki a i ʻole ke kaʻina hana niho, hoʻomaka maʻamau ka lapaʻau ma mua o ke kaʻina hana a hoʻomau no kekahi mau lā ma hope. E nānā kāu kauka i kāu mau pae Factor VIII a hoʻoponopono i ka papa hana lapaʻau e pili ana i kāu holomua hoʻōla.

No ka lapaʻau pale, lawe kekahi poʻe i nā mahele maʻamau no nā mahina a i ʻole nā makahiki. Hiki i kēia ala lōʻihi ke hōʻemi nui i nā hanana koko a pale i kou mau hono mai ka pōʻino. E loiloi mau kāu kauka inā kūpono kēia ala no ʻoe.

Mai hooki i ka lapaʻau me ka ʻole e kamaʻilio mua me kāu kauka. Hiki i ka hoʻōki koke ʻana ke waiho iā ʻoe i ka pilikia i ke koko koʻikoʻi, ʻoiai inā he hemophilia koʻikoʻi kāu.

He aha nā hopena ʻaoʻao o Antihemophilic Factor?

ʻO ka hapa nui o ka poʻe e ʻae maikaʻi i ka antihemophilic factor, akā e like me nā lāʻau lapaʻau, hiki iā ia ke hana i nā hopena ʻaoʻao. ʻO ka lono maikaʻi ʻaʻole maʻamau nā hopena koʻikoʻi, a ʻo ka hapa nui o nā hopena ʻaoʻao he maʻalahi a he manawa pōkole.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia nā hopena maʻalahi ma ke kahua injection e like me ka ʻulaʻula, ka pehu, a i ʻole ke akahai. ʻIke kekahi poʻe i nā poʻo, ka ʻūlū, a i ʻole ka ʻono metala i ko lākou waha i ka wā a i ʻole ma hope o ka injection.

Eia nā hopena ʻaoʻao maʻamau e hiki ke hana:

• Nā hopena ma ke kahua o ka pahu (ʻulaʻula, pehu, ʻeha)
• ʻEhaʻeha a i ʻole ka wili
• Nausea a i ʻole ka ʻōpū
• Hoʻomaʻemaʻe a i ʻole ka mahana i kou maka
• Ka puʻuwai wikiwiki i ka wā o ka pahu
• Luhi a i ʻole nāwaliwali

Hoʻoponopono pinepine kēia mau hopena iā lākou iho a ʻaʻole pono e hoʻōki i ka mālama ʻana.

ʻAʻole maʻamau, hoʻomohala kekahi poʻe i nā hopena ʻaoʻao e pono ai ka nānā ʻana i ke olakino. Hiki ke loaʻa nā hopena maʻi, ʻoiai he kakaikahi me nā hoʻomākaukau hou. ʻO nā hōʻailona e pili ana i ka pilikia o ka hanu ʻana, ka pehu ʻana o kou maka a i ʻole ka ʻāʻī, a i ʻole ka ʻōpala ākea.

Eia nā hopena ʻaoʻao kakaikahi akā koʻikoʻi e nānā ai:

• Nā hopena maʻi koʻikoʻi (pilikia o ka hanu ʻana, pehu, ʻōpala koʻikoʻi)
• Nā koko koko i nā wāwae a i ʻole nā māmā
• ʻEhaʻeha o ka umauma a i ʻole ka hanu pōkole
• ʻEhaʻeha koʻikoʻi a i ʻole nā loli ʻike
• Nā hōʻailona o ka maʻi (fiva, anu, luhi ʻole)

E kelepona koke i kāu kauka inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona koʻikoʻi.

ʻO kahi pilikia kakaikahi akā koʻikoʻi ka hoʻomohala ʻana o nā mea pale - nā antibodies e hoʻopau i ka Factor VIII. Hana kēia ma kahi o 15-30% o nā kānaka me ka hemophilia A koʻikoʻi, maʻamau i loko o nā lā 75 mua o ka hōʻike ʻana i ka mālama ʻana.

ʻO wai ka mea ʻaʻole pono e lawe i ka Antihemophilic Factor?

He kakaikahi loa nā kānaka me ka hemophilia A ʻaʻole hiki ke lawe i ka antihemophilic factor, akā pono kekahi mau kūlana i ka mālama hou a i ʻole nā lāʻau lapaʻau ʻē aʻe. E loiloi pono kāu kauka i kāu moʻolelo olakino ma mua o ka kau ʻana i kēia lāʻau.

Pono nā kānaka me nā maʻi maʻi koʻikoʻi i nā huahana Factor VIII a i ʻole kekahi o nā meaʻai e pale i kēia lāʻau. Inā loaʻa iā ʻoe nā hopena maʻi koʻikoʻi i nā huahana koko i ka wā i hala, pono kāu kauka e noʻonoʻo i nā lāʻau lapaʻau ʻē aʻe.

Pono ka poʻe me nā koko koko ikaika a i ʻole ka mōʻaukala o nā maʻi koko e nānā pono ʻia. ʻOiai he mea maʻamau ʻole, hiki i ka Factor VIII ke kōkua i ka hana ʻana i nā koko, ʻoi aku hoʻi i ka poʻe i loaʻa mua nā mea pilikia o ka koko.

Hiki i ka poʻe me kekahi mau maʻi ʻōnaehana pale a i ʻole ka poʻe e lawe ana i nā lāʻau lapaʻau immunosuppressive ke piʻi aʻe ka pilikia o ka hoʻomohala ʻana i nā mea pale. E loiloi kāu kauka i nā pōmaikaʻi a me nā pilikia me ka akahele i kēia mau kūlana.

Nā inoa inoa o ka Antihemophilic Factor

Loaʻa ka antihemophilic factor ma lalo o nā inoa inoa like ʻole, me nā ʻano like ʻole. E koho kāu kauka i ke koho maikaʻi loa e pili ana i kāu mau pono kikoʻī a me ka mōʻaukala olakino.

ʻO nā hōʻailona plasma maʻamau e pili ana iā Humate-P, Koate-HP, a me Monoclate-P. Hana ʻia kēia mau mea mai ke koko plasma kanaka i hāʻawi ʻia a hele i nā hana hoʻomaʻemaʻe a me ka hoʻopau ʻana i ka maʻi.

ʻO nā hōʻailona recombinant e pili ana iā Advate, Helixate FS, Kogenate FS, Novoeight, a me Nuwiq. Hana ʻia kēia mau mea me ka hoʻohana ʻana i nā ʻenehana ʻenekinia genetic a ʻaʻole i loaʻa nā huahana koko kanaka, kahi mea a kekahi poʻe e makemake ai.

ʻO nā huahana hapalua ola lōʻihi e like me Adynovate, Eloctate, a me Jivi e mau ana i kou kino, e hōʻemi ana i ke alapine o ka injection. E kōkua kāu kauka iā ʻoe e hoʻomaopopo i nā ʻokoʻa a koho i ka mea e hana maikaʻi loa no kou ola.

Nā koho ʻē aʻe o ka Antihemophilic Factor

Nui nā koho ʻē aʻe no ka poʻe hiki ʻole ke hoʻohana i ka antihemophilic factor maʻamau a i ʻole ka poʻe e hoʻomohala i nā mea pale. Ua hoʻonui nui kēia mau koho i nā mea hiki ke mālama ʻia i nā makahiki i hala iho nei.

No ka poʻe me nā mea pale, hiki i nā mea e pale ana e like me Factor VIIa (NovoSeven) a i ʻole ka concentrate prothrombin complex activated (FEIBA) ke kōkua i ke koko e paʻa me ka ʻole o ka pono o Factor VIII. Hana kēia mau mea ma ka hoʻāla ʻana i nā ʻāpana ʻē aʻe o ka cascade clotting.

ʻO Emicizumab (Hemlibra) he lāʻau lapaʻau hou e hoʻohālike ana i ka hana o Factor VIII akā ʻaʻole ʻo Factor VIII maoli nō. Hāʻawi ʻia ia ma ke ʻano he injection subcutaneous ma mua o IV, a he mea maʻalahi ia no nā kānaka he nui.

No ka hemophilia A maʻalahi, hiki i ka desmopressin (DDAVP) i kekahi manawa ke hoʻoulu i kou kino e hoʻokuʻu i ka Factor VIII i mālama ʻia. He kūpono kēia i nā kānaka i loaʻa kekahi hana o ka hana ʻana o Factor VIII.

Ua ʻoi aku ka maikaʻi o ka Antihemophilic Factor ma mua o nā lāʻau lapaʻau hemophilia ʻē aʻe?

Ke noho nei ka antihemophilic factor i ka lāʻau lapaʻau maʻamau no ka hemophilia A, akā pili ka

Pono paha nā keiki i nā ʻano lāʻau like ʻole ma mua o nā mākua ma muli o ko lākou kaumaha a me nā pae Factor VIII. E helu ke kauka o kāu keiki i ka lāʻau kūpono a hiki ke hoʻoponopono iā ia i ka wā e ulu ana kāu keiki. Nui nā keiki a me ko lākou mau ʻohana e aʻo e hāʻawi i nā injections ma ka home, e hāʻawi ana i ka maʻalahi no nā nohona hana.

He mea nui ka nānā mau ʻana no nā keiki, no ka mea, ʻoi aku ka nui o ka hoʻomohala ʻana i nā mea pale ma mua o nā mākua. E nānā ke kime mālama ola o kāu keiki i nā hōʻailona o ka hoʻomohala ʻana i nā mea pale a hoʻoponopono i ka lāʻau e like me ka mea e pono ai.

He aha kaʻu e hana ai inā ua hoʻohana hewa au i ka nui o ka Antihemophilic Factor?

Inā hāʻawi hewa ʻoe iā ʻoe iho i ka nui o ka antihemophilic factor, mai hopohopo. ʻAʻole pilikia ka nui o nā lāʻau, akā pono ʻoe e hoʻokaʻaʻike i kāu kauka a i ʻole ke kikowaena lapaʻau no ke alakaʻi.

ʻO ka hopohopo nui me ka nui o ka Factor VIII, ʻo ia ka piʻi ʻana o ka pilikia o nā koko koko, ʻoiai ʻaʻole maʻamau kēia. E nānā i nā hōʻailona e like me ka ʻeha wāwae a i ʻole ka pehu ʻana, ka ʻeha o ka umauma, a i ʻole ka pōkole o ka hanu, a e ʻimi koke i ka lāʻau lapaʻau inā loaʻa kēia mau mea.

E mālama i kahi moʻolelo o ka mea i hana ʻia, me ka nui o ka lāʻau i lawe ʻia a me ka manawa. E kōkua kēia ʻike i kāu hui mālama ola e loiloi i ke kūlana a hāʻawi i ke alakaʻi kūpono. Makemake paha lākou e nānā iā ʻoe i ka pili ʻana a i ʻole e hoʻoponopono i kāu lāʻau aʻe.

He aha kaʻu e hana ai inā ua hala au i kahi lāʻau o Antihemophilic Factor?

Inā ua hala ʻoe i kahi lāʻau i hoʻonohonoho ʻia o ka antihemophilic factor, e lawe iā ia i ka wā e hoʻomanaʻo ai ʻoe, ke ʻole kokoke ka manawa no kāu lāʻau aʻe. Mai pāpālua i nā lāʻau e hoʻoponopono ai i kahi mea i hala.

No ka poʻe ma ka lāʻau prophylactic, ʻo ka hala ʻana i kahi lāʻau i kekahi manawa ʻaʻole ia e hoʻopilikia koke, akā e hoʻāʻo e hoʻi i ka papa manawa i ka hiki. E emi mālie ana kāu mau pae Factor VIII, e waiho ana iā ʻoe i ka pilikia o ke kahe ʻana.

Inā e mālama ana ʻoe i kahi hanana kahe koko ikaika a nalo i kahi mahele, e kelepona koke i kāu kauka. Pono paha ka kahe koko ikaika i ka hoʻohana pinepine ʻana, a hiki i nā lohi ke alakaʻi i nā pilikia koʻikoʻi.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Antihemophilic Factor?

ʻAʻole pono ʻoe e hooki i ka lawe ʻana i ka antihemophilic factor me ka ʻole e kūkākūkā mua i kāu kauka. No ka poʻe me ka hemophilia A, he lāʻau lapaʻau kēia lāʻau lapaʻau i ke ola holoʻokoʻa e pono ai no ka pale ʻana i ke kahe koko weliweli.

Inā e lawe ana ʻoe no kahi hanana kahe koko kikoʻī a i ʻole ke ʻoki ʻana, e haʻi aku kāu kauka iā ʻoe i ka wā e palekana ai ke hooki ʻana ma muli o kāu pae Factor VIII a me ka holomua o ka hoʻōla. Pono e hana mau ʻia kēia hoʻoholo me ka mālama olakino.

No ka poʻe ma ka lāʻau lapaʻau prophylactic, hiki i ka hooki ʻana ke hoʻonui nui i kou pilikia o nā hanana kahe koko a me ka pōʻino hui. Inā ʻoe e noʻonoʻo ana i nā loli i kāu hoʻolālā lapaʻau, e kūkākūkā i nā pilikia a me nā pōmaikaʻi me kāu hui mālama ola.

Hiki iaʻu ke hele me Antihemophilic Factor?

ʻAe, hiki iā ʻoe ke hele me ka antihemophilic factor, akā pono ia i kekahi hoʻolālā. Pono e mālama ʻia ka lāʻau lapaʻau i loko o ka pahu hau, no laila pono ʻoe i kahi pahu anuanu me nā pūʻolo hau no ka lawe ʻana.

E lawe mai i kahi leka mai kāu kauka e wehewehe ana i kou maʻi olakino a no ke aha ʻoe e pono ai e lawe i kēia lāʻau lapaʻau. Pono ka palekana o ke kahua mokulele e ʻae iā ʻoe e lawe mai, akā ʻo ka loaʻa ʻana o nā palapala e kōkua i ka pale ʻana i nā lohi a i ʻole nā pilikia.

E ʻōpala i nā lāʻau lapaʻau keu inā loaʻa nā lohi huakaʻi, a e noiʻi i nā kikowaena lapaʻau hemophilia ma kāu huakaʻi. Nui ka poʻe i ʻike he mea kōkua ke kelepona ʻana i ka World Federation of Hemophilia no ka ʻike e pili ana i nā keʻena lapaʻau ma nā ʻāina ʻē.