He aha ka Antihemophilic Factor (Recombinant, Glycopegylated-exei)? Nā hoʻohana, nā hopena, & Ke alakaʻi lapaʻau

ʻO ka antihemophilic factor (recombinant, glycopegylated-exei) he mana i hana ʻia i loko o ka lab o ka clotting factor VIII e kōkua i kou koko e hana i nā clots pono. Ua hoʻolālā kūikawā ʻia kēia lāʻau lapaʻau no ka poʻe me ka hemophilia A, kahi maʻi kahi e hana ʻole ai kou kino i ka nui o kēia protein clotting koʻikoʻi. ʻO ka ʻāpana "glycopegylated" ʻo ia hoʻi ua hoʻololi ʻia e mau lōʻihi i loko o kou kino, no laila pono ʻoe i nā injections liʻiliʻi.

He aha ka Antihemophilic Factor (Recombinant, Glycopegylated-exei)?

ʻO kēia lāʻau lapaʻau he pani synthetic no ka factor VIII, kahi protein e pono ai kou koko e clot maʻamau. Ke loaʻa iā ʻoe kahi ʻoki a i ʻole ʻeha, kōkua ka factor VIII i ka hoʻomaka ʻana i ke kaʻina clotting e hoʻōki i ke kahe ʻana. ʻAʻole hana ka poʻe me ka hemophilia A i ka nui o ka factor VIII a i ʻole e hana i kahi mana i hana ʻole.

Hana ʻia ka mana recombinant i loko o kahi hale hana me ka hoʻohana ʻana i ka biotechnology kiʻekiʻe, ʻaʻole mai nā huahana koko kanaka. Hana kēia i mea palekana mai nā maʻi i lawe ʻia e ke koko. Hoʻohui ka hoʻololi glycopegylated i nā molekala kūikawā e kōkua i ka lāʻau lapaʻau e noho ikaika i loko o kou kahe koko no ka lōʻihi ma mua o nā huahana factor VIII maʻamau.

Pehea ke ʻano o ka lapaʻau ʻana me kēia lāʻau lapaʻau?

E loaʻa iā ʻoe kēia lāʻau lapaʻau ma o kahi injection IV, maʻamau i loko o kahi vein i kou lima. ʻO ka injection ponoʻī e like me ka loaʻa ʻana o ke koko a i ʻole ka loaʻa ʻana o kekahi lāʻau IV ʻē aʻe. ʻO ka hapa nui o ka poʻe e wehewehe iā ia he ʻoki wikiwiki a ukali ʻia e kahi manaʻo ʻoluʻolu i ke komo ʻana o ka lāʻau lapaʻau i loko o kou kahe koko.

Ma hope o ka injection, hiki iā ʻoe ke ʻoluʻolu i ka ʻike ʻana ua hoʻihoʻi ʻia kou hiki ke clotting. Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao maʻalahi e like me ke poʻo a i ʻole ka dizziness, akā ʻaʻole nui ka poʻe e manaʻo i kekahi mea ʻokoʻa. Hana mālie ka lāʻau lapaʻau i loko o kāu ʻōnaehana e pale a mālama paha i nā hanana kahe.

He aha ke kumu o ka pono o kēia lāʻau lapaʻau?

ʻO Hemophilia A ke kumu nui e pono ai ʻoe i kēia lāʻau lapaʻau. Hiki mai kēia maʻi genetic ke loaʻa i kou kino nā pilikia me ka gene e haʻi ana i kāu mau keena pehea e hana ai i ka factor VIII. Me ka lawa ʻole o ka factor VIII e hana ana, ʻaʻole hiki i kou koko ke paʻa pono, e alakaʻi ana i ke kahe ʻana o ke koko.

Nui nā mea hiki ke hana i ka pono no kēia lapaʻau kikoʻī:

• Hoʻoilina hemophilia A mai kou mau mākua
• Nā hanana kahe koko koʻikoʻi e pono ai ka lapaʻau koke
• Nā hana ʻoki i hoʻolālā ʻia a i ʻole nā hana niho
• Nā ʻeha e hana ai i ke kahe koko i loko a i waho paha
• Ke kahe koko hui e hiki ke hōʻino i ka cartilage a me ka iwi

I kekahi manawa, loaʻa i nā kānaka ka hemophilia A ma hope o ke ola ma muli o nā maʻi autoimmune kahi e hoʻouka ai ko lākou kino i kā lākou factor VIII ponoʻī. Pono kēia ʻano i loaʻa i ka therapy pani factor.

He aha nā maʻi e hoʻohana ʻia ai kēia lāʻau lapaʻau?

Hoʻomaʻamaʻa nui kēia lāʻau lapaʻau i ka hemophilia A, akā hoʻohana nā kauka iā ia i kekahi mau kūlana kikoʻī. ʻO ka pahuhopu nui ka hoʻihoʻi mau i ka hiki o kou koko ke paʻa maʻamau a pale i ke kahe koko weliweli.

Eia nā kūlana nui a me nā kūlana kahi e kōkua ai kēia lāʻau lapaʻau:

• Hemophilia A koʻikoʻi (ma lalo o 1% ka hana factor VIII maʻamau)
• Hemophilia A maʻalahi (1-5% ka hana factor VIII maʻamau)
• Hemophilia A maʻalahi i ka wā o nā hanana kahe koko nui
• Loaʻa ka hemophilia A mai nā maʻi autoimmune
• Lapaʻau prophylactic e pale i nā hanana kahe koko
• Hoʻomākaukau ma mua o ke ʻoki ʻana no ka poʻe me ka hemophilia A

Na kāu kauka e hoʻoholo i ka mahele kūpono a me ka papa manawa e pili ana i kāu mau pae factor VIII a me ka mōʻaukala kahe koko. Pono kekahi poʻe i nā mahele pale maʻamau, aʻo nā mea ʻē aʻe e pono wale i ka lapaʻau i ka wā o nā hanana kahe koko.

Hiki i nā hanana kahe koko ke hoʻoponopono me ka ʻole o kēia lāʻau lapaʻau?

No nā kānaka me ka hemophilia A, ʻaʻole e pau loa nā hanana koko ma ko lākou iho. ʻAʻole lawa ka factor VIII o kou kino e hana i nā clots kūpono, no laila e hoʻomau ka kahe koko no ka lōʻihi ma mua o ka maʻamau. Me ka ʻole o ka lapaʻau, hiki i nā ʻeha liʻiliʻi ke lilo i mea koʻikoʻi.

Hiki i nā ʻoki liʻiliʻi a me nā ʻōpala ke hoʻōki i ke kahe koko me ke kaomi a me ka manawa, akā ʻo ke kahe koko i loko a i ʻole ke kahe koko hui e koi pinepine i ka hoʻololi ʻana i ka factor. ʻO ka hoʻopaneʻe ʻana i ka lapaʻau hiki ke alakaʻi i ka pōʻino hui mau, ke kahe koko ʻiʻo, a i ʻole ke kahe koko i loko e hoʻoweliweli ana i ke ola.

ʻO ia ke kumu e hoʻohana ai ka poʻe he nui me ka hemophilia A i ka lapaʻau prophylactic, e loaʻa ana nā lāʻau maʻamau e pale ai i nā hanana koko ma mua o ka hoʻomaka ʻana. Ua hoʻomaikaʻi nui kēia ʻano hana i ka maikaʻi o ke ola a ua hōʻemi i nā pilikia lōʻihi.

Pehea e lawelawe ʻia ai kēia lāʻau lapaʻau?

Hāʻawi ʻia kēia lāʻau lapaʻau ma o ka intravenous injection wale nō, ʻo ia hoʻi, i loko pololei i kou kahe koko ma o ka vein. ʻAʻole hiki iā ʻoe ke lawe ma ka waha no ka mea e wāwahi ana kāu ʻōnaehana digestive i ka protein ma mua o ka hana ʻana. Hōʻoia ka ala IV i ka factor VIII e hele pololei i kahi e pono ai.

Nui ka poʻe e aʻo e hāʻawi iā lākou iho i nā injections ma ka home ma hope o ka hoʻomaʻamaʻa kūpono mai kā lākou hui mālama ola. Hāʻawi kēia kūʻokoʻa i ka lapaʻau koke ʻana i ka wā e hana ai nā hanana koko. Lawe ka hana injection i kekahi mau minuke wale nō ke ʻoluʻolu ʻoe me ka ʻenehana.

E helu kāu kauka i kāu mahele ma muli o kou kaumaha, ka paʻakikī o ke kahe koko, a me kāu mau pae factor VIII. Pono kekahi poʻe i nā injections i kēlā me kēia lā no ka pale ʻana, aʻo nā mea ʻē aʻe e pono wale nō iā lākou i ka wā o nā hanana koko.

He aha ke ʻano o ka lapaʻau lapaʻau no kēia lāʻau lapaʻau?

Aia nō ke ʻano o kāu lapaʻau i ka hoʻohana ʻana i kēia lāʻau no ka pale ʻana a i ʻole ka mālama ʻana i ke kahe ʻana o ke koko. No ka pale ʻana, e loaʻa iā ʻoe nā injections ʻelua a ʻekolu manawa i ka pule. No nā hanana kahe ʻana o ke koko, pono paha ʻoe i nā lāʻau pinepine a hiki i ka pau ʻana o ke kahe ʻana.

Eia ke ʻano o ka hana ʻana o ka lapaʻau olakino:

• Hoʻoholo ʻia ka lāʻau mua ma muli o kou kaumaha a me ka pae factor VIII i manaʻo ʻia
• Ke nānā ʻana i kāu mau pae factor VIII ma o nā hoʻokolohua koko
• Hoʻoponopono ʻia ka lāʻau ma muli o kou pane a me nā ʻano kahe ʻana o ke koko
• Nā manawa hālāwai maʻamau e loiloi i ka pono
• Nā protocols pilikia no nā hanana kahe ʻana o ke koko nui

E aʻo kāu hui mālama ola iā ʻoe pehea e ʻike ai i nā ʻano like ʻole o ke kahe ʻana o ke koko a i ka wā e ʻimi ai i ka lāʻau lapaʻau koke. E kōkua pū lākou iā ʻoe e hoʻomohala i kahi hoʻolālā lapaʻau pilikino e kūpono i kou ola a me nā ʻano kahe ʻana o ke koko.

I ka manawa hea wau e ʻimi ai i ka lāʻau lapaʻau i ka wā e hoʻohana ana i kēia lāʻau?

Pono ʻoe e hoʻokaʻaʻike koke i kāu kauka inā loaʻa iā ʻoe ke kahe ʻana o ke koko nui ʻaʻole e pane i kāu lāʻau maʻamau. Hōʻike paha kēia e hoʻomohala ana kou kino i nā antibodies e kūʻē i ka factor VIII, e koi ana i nā ʻano lapaʻau like ʻole.

E ʻimi i ka mālama olakino pilikia inā loaʻa iā ʻoe:

• Nā ʻeha poʻo a i ʻole ke kahe ʻana o ke koko i loko
• Ke kahe ʻana o ke koko hui nui me ka ʻeha nui a me ka pehu
• Ke kahe ʻana o ke koko e hoʻomau nei me ka lāʻau factor VIII kūpono
• Nā hōʻailona o ka hopena maʻi e like me ka pilikia o ka hanu ʻana a i ʻole ka pehu ʻana o ka maka
• Nā ʻano kahe ʻana o ke koko ʻokoʻa a i ʻole nā ʻano kahe ʻana o ke koko hou

Pono nō hoʻi ʻoe e hoʻokaʻaʻike i kāu mea mālama ola inā ʻike ʻoe i nā loli i ka maikaʻi o kāu lāʻau maʻamau e kāohi ai i ke kahe ʻana o ke koko. I kekahi manawa, loli nā pono o kou kino i ka manawa, a pono paha e hoʻoponopono ʻia kāu hoʻolālā lapaʻau.

He aha nā mea pilikia no ka pono o kēia lāʻau?

ʻO ka mea pilikia nui loa, ʻo ia ka loaʻa ʻana o ka hemophilia A, ka mea i hoʻoilina pinepine ʻia mai kou mau mākua. Hoʻopilikia ka hemophilia A i nā kāne nui loa no ka mea aia ka gene no ka factor VIII ma ka chromosome X. He hoʻokahi wale nō chromosome X o nā kāne, no laila inā loaʻa iā lākou ka gene hewa, e ulu lākou i ka hemophilia.

Nui nā mea e hoʻonui ai i kou kūlana e pono ai kēia lāʻau lapaʻau:

• ʻO ka moʻolelo o ka hemophilia A i loko o ka ʻohana
• Ke kāne kāne (ʻoiai hiki i nā wāhine ke lawe a i kekahi manawa e pili ana)
• Nā hanana koko mua e koi ana i ka hoʻololi ʻana o ka factor
• Nā pae haʻahaʻa o ka factor VIII
• Ke ola ikaika e hoʻonui ai i ka pilikia o ka ʻeha
• Nā maʻi autoimmune kekahi e hiki ke hana i ka hemophilia i loaʻa

Hiki i ka makahiki ke pāʻani i kahi hana, no ka mea, ʻoi aku ka nui o nā keiki ʻōpio a me nā mākua ikaika i nā hanana koko ma muli o ka hāʻule, nā ʻeha haʻuki, a i ʻole nā hana maʻamau o ka wā kamaliʻi. Hiki i kāu hui mālama ola ke kōkua iā ʻoe e hoʻomaopopo i kāu mau mea pilikia pilikino.

He aha nā pilikia hiki ke loaʻa i kēia lāʻau lapaʻau?

ʻO ka hapa nui o nā kānaka e ʻae maikaʻi i kēia lāʻau lapaʻau, akā e like me nā lāʻau lapaʻau a pau, hiki iā ia ke hana i nā hopena ʻaoʻao. He maʻalahi a he manawa pōkole nā hopena ʻaoʻao maʻamau, e like me ke poʻo, ka ʻūlū, a i ʻole ka nausea liʻiliʻi. Hoʻomaikaʻi maʻamau kēia mau mea i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau.

Eia nā pilikia hiki ke ʻike ʻia:

• Nā hopena maʻi mai ka ʻili ʻili maʻalahi a hiki i ka anaphylaxis koʻikoʻi
• Ka ulu ʻana o nā mea pale (nā antibodies e ālai i ka factor VIII)
• Nā hopena o ka pūnaewele injection e like me ka ʻeha, ka pehu, a i ʻole ka ʻeha
• Nā koko koko inā nui ka factor VIII i kūkulu ʻia i loko o kāu ʻōnaehana
• Fiva a i ʻole nā hōʻailona e like me ka maʻi ma hope o ka injection

ʻO ka ulu ʻana o nā mea pale ka pilikia lōʻihi loa, e hana ana ma kahi o 20-30% o nā kānaka me ka hemophilia A koʻikoʻi. E nānā kāu kauka i kēia ma o nā hoʻokolohua koko maʻamau a hoʻoponopono i kāu lāʻau lapaʻau inā pono.

He palekana anei kēia lāʻau lapaʻau no nā kānaka me nā maʻi ʻē aʻe?

He palekana maʻamau kēia lāʻau lapaʻau no ka hapa nui o nā kānaka me ka hemophilia A, akā pono kekahi mau maʻi i ka mālama kūikawā. E nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau e hōʻoia i ka palekana no kāu kūlana.

Pono ka poʻe me nā maʻi aʻe i ka nānā kūikawā:

• Maʻi puʻuwai a i ʻole ka pilikia o nā ʻōpū koko
• Maʻi ate e pili ana i nā mea clotting
• Maʻi kīkī e pili ana i ka hoʻomaʻemaʻe lāʻau lapaʻau
• Nā maʻi autoimmune
• Nā hopena maʻi ma mua i nā huahana factor VIII

Manaʻo ʻia ka hāpai ʻana a me ka hānai ʻana i ka waiū he palekana me kēia lāʻau lapaʻau, no ka mea, ʻaʻole i hele ka protein i ka placenta a i ʻole ke komo ʻana i ka waiū umauma i nā mea nui. Eia naʻe, e nānā pono kāu kauka iā ʻoe i kēia mau manawa.

He aha ka mea hiki ke kuhi hewa ʻia kēia lāʻau lapaʻau?

Hiki ke huikau kēia lāʻau lapaʻau me nā huahana koko ʻē aʻe a i ʻole nā ​​mea clotting factor concentrates. Hiki i ka inoa lōʻihi a me nā huaʻōlelo loea ke maʻalahi ke hui pū me nā lāʻau lapaʻau like. E hōʻoia mau e loaʻa ana iā ʻoe ka lāʻau lapaʻau kūpono ma ka nānā ʻana i ka inoa brand a me ka nīnau ʻana i kāu mea mālama ola.

I kekahi manawa ua kuhi hewa ʻia no:

• Nā huahana factor VIII ʻē aʻe me nā formulations like ʻole
• Factor IX concentrates i hoʻohana ʻia no ka hemophilia B
• Plasma paʻa hou a i ʻole cryoprecipitate
• Nā mea clotting recombinant ʻē aʻe
• Factor VIII maʻamau me ka ʻole o ka hoʻololi glycopegylated

ʻO ka ʻokoʻa nui, ʻo kēia lāʻau lapaʻau kikoʻī e mau ana i loko o kou kino, no laila pono ʻoe i nā injections liʻiliʻi i hoʻohālikelike ʻia me nā huahana factor VIII maʻamau. Hiki i kāu kauka lapaʻau a me ka hui mālama ola ke kōkua iā ʻoe e hoʻomaopopo pono i ka mea āu e loaʻa nei.

Nā nīnau i nīnau pinepine ʻia e pili ana i ka Antihemophilic Factor (Recombinant, Glycopegylated-exei)

Pehea ka lōʻihi o ka lōʻihi o kēlā me kēia mahele i loko o koʻu kino?

He lōʻihi ka lōʻihi o kēia lāʻau lapaʻau ma mua o nā huahana factor VIII maʻamau, e hāʻawi pinepine ana i ka pale no 3-4 mau lā ma kahi o 1-2 mau lā. Kōkua ka hoʻololi glycopegylated i ka noho ʻana i ka hana i loko o kou kahe koko no ka lōʻihi, ʻo ia hoʻi hiki iā ʻoe ke hoʻokaʻawale i kāu mau injections. E hoʻoholo kāu kauka i ka manawa kūpono e pili ana i kāu pane pilikino a me nā pae factor VIII.

Hiki iaʻu ke hele me kēia lāʻau lapaʻau?

ʻAe, hiki iā ʻoe ke hele me kēia lāʻau lapaʻau, akā pono ʻoe i nā palapala kūpono mai kāu kauka. Pono ka lāʻau lapaʻau i ka hoʻomaʻalili a me ka mālama pono ʻana, no laila pono ʻoe i kahi pahu hoʻoluʻu huakaʻi a me nā pūʻolo hau. ʻAe ka hapa nui o nā mokulele i nā lako lapaʻau e like me nā mea lawe, akā e nānā me kāu mokulele ma mua a lawe i kāu kauoha a me ka leka a ke kauka.

Pono anei au i kēia lāʻau lapaʻau no koʻu ola a pau?

Inā he hemophilia A kāu, pono paha ʻoe i kekahi ʻano o ka hoʻololi factor VIII i kou ola. Eia naʻe, ke hoʻomohala ʻia nei nā lāʻau lapaʻau hou e hiki ke hoʻololi i kēia i ka wā e hiki mai ana. Hiki i kekahi poʻe me ka hemophilia A i loaʻa ke hoʻōki i ka pono i ka lāʻau lapaʻau inā e hoʻomaikaʻi ko lākou kūlana kumu, akā pili kēia i kāu kūlana kikoʻī.

Hiki iaʻu ke hoʻoikaika kino a pāʻani i nā haʻuki i ka wā e hoʻohana ana i kēia lāʻau lapaʻau?

ʻAe, nui ka poʻe me ka hemophilia A e hoʻohana ana i ka hoʻololi factor VIII hiki ke komo i nā haʻuki a me ka hoʻoikaika kino. ʻO ka lāʻau lapaʻau prophylactic e ʻae pinepine ai i kahi nohona hana. Eia naʻe, pono ʻoe e pale i nā haʻuki pili kiʻekiʻe e lawe ana i ka pilikia nui o ka ʻeha. E hana pū me kāu hui mālama ola e hoʻomohala i kahi hoʻolālā hana e palekana ai no kāu kūlana kikoʻī.

He aha kaʻu e hana ai inā e hala wau i kahi lāʻau i hoʻonohonoho ʻia?

Inā e hala ʻoe i kahi mahele prophylactic, e lawe koke ia ke hoʻomanaʻo ʻoe, ke ʻole kokoke ka manawa no kāu mahele i hoʻonohonoho ʻia e hiki mai ana. Mai pāpālua i nā mahele. E kāhea aku i kāu mea mālama ola no ke alakaʻi ʻana i ka pehea e hoʻoponopono ai i kāu papa manawa. Hiki i ka hala ʻana i nā mahele ke hoʻonui i kou pilikia o nā hanana koko, no laila e hoʻāʻo e mālama i kāu papa manawa maʻamau e like me ka hiki.