He aha ka Arsenic Trioxide: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi ʻaʻai ikaika ka arsenic trioxide e kōkua ana i ka mālama ʻana i kekahi mau ʻano maʻi ʻaʻai koko, ʻo ia hoʻi ka leukemia promyelocytic acute (APL). ʻOiai he mea hoʻoweliweli paha ka inoa no ka mea ua ʻike ʻia ka arsenic he mea ʻawaʻawa, ua hoʻomākaukau pono ʻia kēia lāʻau a ua ana pono ʻia e hakakā i nā sela maʻi ʻaʻai i ka wā e nānā pono ʻia e kāu hui lapaʻau.

Hōʻike kēia lapaʻau i kahi holomua lapaʻau kupaianaha kahi i hoʻololi ʻia ai kahi mea ʻawaʻawa i ka mōʻaukala i kahi lāʻau lapaʻau e ola ai. Hoʻomaopopo maoli kāu poʻe mālama ola pehea e hoʻohana ai i kēia lāʻau lapaʻau me ka palekana a me ka pono no kou kūlana kikoʻī.

He aha ka Arsenic Trioxide?

ʻO ka arsenic trioxide he lāʻau chemotherapy e hana ana ma ka ʻimi ʻana a me ka luku ʻana i nā sela maʻi ʻaʻai i kou koko. Hāʻawi ʻia ma o ka laina intravenous (IV) pololei i loko o kou kahe koko, e ʻae ana iā ia e hōʻea i nā sela maʻi ʻaʻai ma kou kino a wikiwiki a maikaʻi.

No ka papa o nā lāʻau i kapa ʻia ʻo antineoplastics ka lāʻau lapaʻau, ʻo ia hoʻi ke kaua nei lākou i ka maʻi ʻaʻai. ʻOiai kona inoa hoʻoweliweli, ua aʻo nui ʻia kēia lapaʻau a ua hōʻoia ʻia he palekana ke hoʻohana ʻia ma lalo o ka mālama olakino kūpono.

E hoʻomākaukau a lawelawe kāu hui lapaʻau i kēia lāʻau lapaʻau i kahi haukapila i mālama ʻia a i ʻole ke keʻena lapaʻau. Hoʻoholo pololei ʻia ka dosing e pili ana i kou kaumaha kino a me ke kūlana olakino kikoʻī, e hōʻoia ana e loaʻa iā ʻoe ka nui kūpono no ka pōmaikaʻi nui.

No ke aha e hoʻohana ʻia ai ka Arsenic Trioxide?

Hoʻohana nui ʻia ka arsenic trioxide e mālama i ka leukemia promyelocytic acute (APL), kahi ʻano maʻi ʻaʻai koko. Hiki mai ka APL ke hana kou iwi iwi i nā keʻokeʻo keʻokeʻo keʻokeʻo he nui ʻole e hiki ʻole ke hana pono, e hoʻopilikia ana i nā sela koko olakino.

Hoʻohana pinepine ʻia kēia lāʻau lapaʻau ke hoʻi mai ka APL ma hope o ka mālama mua ʻana a i ʻole ʻaʻole i pane maikaʻi i nā lāʻau lapaʻau ʻē aʻe. He mea maikaʻi loa ia no ka mea hiki iā ia ke hoʻoikaika i nā pūnaewele maʻamau e oʻo i loko o nā pūnaewele maʻamau a i ʻole e make maoli lākou.

Hiki i kekahi mau kauka ke hoʻohana i ka arsenic trioxide no nā ʻano maʻi koko ʻē aʻe i nā hoʻokolohua lapaʻau a i ʻole nā kūlana kūikawā. Eia naʻe, ʻo APL ka mea i hoʻokumu ʻia a kūleʻa loa, me ka nui o nā maʻi e loaʻa ana ka remission piha.

Pehea e hana ai ka Arsenic Trioxide?

Hana ʻo Arsenic trioxide ma o nā ʻano hana nui ʻelua e hakakā i nā pūnaewele maʻi maʻi. ʻO ka mea mua, kōkua ia i nā pūnaewele maʻamau e oʻo i loko o nā pūnaewele maʻamau, hana ma o ke kaʻina hana i kapa ʻia ʻo ka differentiation. ʻO ka lua, hoʻoulu ia i nā pūnaewele maʻi maʻi e make maoli ma o ka make ʻana o ka cell i hoʻolālā ʻia.

Ua manaʻo ʻia kēia lāʻau lapaʻau he ikaika ma waena o nā lāʻau chemotherapy. He ikaika ia e kūʻē loa i ka APL, akā ua ʻoi aku ka pahuhopu ma mua o kekahi mau mea chemotherapy ākea, hiki ke manaʻo i nā hopena ʻaoʻao liʻiliʻi no kekahi mau maʻi.

Hoʻopā pololei ka lāʻau i nā protein maʻamau e hana ai i nā pūnaewele APL e hana pono ʻole. Ma ka hoʻopilikia ʻana i kēia mau protein, aʻo maoli ka arsenic trioxide i nā pūnaewele maʻi maʻi e ulu a hana maʻamau a i ʻole e make maluhia.

Pehea wau e lawe ai i ka Arsenic Trioxide?

Hāʻawi mau ʻia ka arsenic trioxide ma o ka laina IV i loko o kahi haukapila a i ʻole kahi keʻena loea. ʻAʻole ʻoe e lawe i kēia lāʻau lapaʻau ma ka home, no ka mea, pono ia i ka nānā pono ʻana a me ka hoʻokele ʻoihana e nā limahana mālama ola i hoʻomaʻamaʻa ʻia.

Ma mua o kēlā me kēia lapaʻau, e loaʻa iā ʻoe ka lāʻau lapaʻau ma o kahi laina waena a i ʻole peripheral IV ma luna o 1-4 mau hola. E nānā pono kāu kahu iā ʻoe i kēia manawa, e nānā ana i kāu mau hōʻailona koʻikoʻi a e nānā ana i nā hopena koke.

ʻAʻole pono ʻoe e hahai i nā ʻōlelo aʻoaʻo ʻai kūikawā ma mua o ka mālama ʻana, akā he mea kōkua mau ka noho ʻana i ka wai. Manaʻo kekahi poʻe maʻi he maʻalahi ka ʻai ʻana i ka meaʻai māmā ma mua o ka hele ʻana mai, a ʻo nā mea ʻē aʻe makemake e ʻai ma hope. E haʻi aku kāu hui mālama ola iā ʻoe i ka mea e hana maikaʻi ai no kāu papa hana lapaʻau.

He ʻoluʻolu ka hana hoʻokomo ʻana, a heluhelu ka nui o nā maʻi, nānā i nā kiʻiʻoniʻoni, a kamaʻilio paha me ka ʻohana i ka wā o ka mālama ʻana. Inā ʻike ʻoe i kekahi ʻoluʻolu ʻole i ka wā o ka lawelawe ʻana i ka IV, e haʻi koke i kāu kahu hānai i hiki iā lākou ke hoʻoponopono i ka helu hoʻokomo a i ʻole e hāʻawi i nā ana hōʻoluʻolu hou.

Pehea ka lōʻihi e lawe ai au i ka Arsenic Trioxide?

He ʻokoʻa ka lōʻihi o ka mālama ʻana i ka arsenic trioxide ma muli o kou kūlana kikoʻī a me ka maikaʻi o kāu pane ʻana i ka lāʻau lapaʻau. Loaʻa i ka hapa nui o nā maʻi ka lāʻau lapaʻau no kekahi mau pule a i ʻole mau mahina, e hahai ana i kahi papa hana i hoʻoholo ʻia e kāu oncologist.

No APL, hana pinepine ka lāʻau lapaʻau i ʻelua mau ʻāpana: kahi ʻāpana induction e hoʻokō i ka remission, a ukali ʻia e kahi ʻāpana consolidation e mālama i kēlā remission. ʻO ka maʻamau ka lōʻihi o ka induction phase 4-6 pule, a hiki ke hoʻomau ka consolidation no kekahi mau mahina.

E nānā kāu kauka i kāu helu koko a me ke olakino holoʻokoʻa i ka wā o ka mālama ʻana. Kōkua kēia mau hoʻokolohua e hoʻoholo i ka wā i loaʻa ai iā ʻoe ka pane maikaʻi loa a i ka wā e palekana ai e hoʻopau i ka lāʻau lapaʻau.

Mai hooki i ka lāʻau lapaʻau ma mua o kou manawa, ʻoiai inā ʻoe e ʻoi aku ka maikaʻi. ʻO ka hoʻopau ʻana i ka papa piha e hāʻawi iā ʻoe i ka manawa maikaʻi loa o ka remission lōʻihi a pale i ka maʻi maʻi mai ka hoʻi ʻana mai me ka ikaika ma mua.

He aha nā hopena ʻaoʻao o ka Arsenic Trioxide?

E like me nā lāʻau lapaʻau maʻi maʻi a pau, hiki i ka arsenic trioxide ke hoʻoulu i nā hopena ʻaoʻao, ʻoiai e ʻae maikaʻi ka nui o nā maʻi. ʻO ka maʻamau ka maʻalahi o nā hopena ʻaoʻao maʻamau me ke kākoʻo olakino kūpono a me ka nānā ʻana.

Eia nā hopena ʻaoʻao maʻamau e hiki ai iā ʻoe ke ʻike i ka wā o ka mālama ʻana:

• Ka luhi a me ka nāwaliwali, e maikaʻi pinepine ana i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau
• Ka luaʻi a me ka luaʻi ʻana, i mālama maikaʻi ʻia me nā lāʻau anti-nausea
• ʻEha poʻo e pane maʻamau i nā mea hōʻoluʻolu ʻeha ma luna o ka counter
• Ka maʻi palahī, hiki ke mālama ʻia me nā loli meaʻai a me nā lāʻau lapaʻau
• ʻO ka ʻili ʻulaʻula a i ʻole ka ʻūlū, he maʻalahi a he manawa pōkole
• Nā loli i ka puʻuwai, e nānā pono ana kāu hui lapaʻau
• Nā helu koko haʻahaʻa, e koi ana i nā hoʻokolohua koko maʻamau

ʻO ka hapa nui o kēia mau hopena ʻaoʻao he manawa pōkole a e hoʻomaikaʻi i ka pau ʻana o ka lāʻau lapaʻau. He mau hoʻolālā maikaʻi kāu hui mālama ola e kōkua i ka mālama ʻana i kēlā me kēia o kēia mau hōʻailona a e hōʻoluʻolu iā ʻoe i ka wā o ka lāʻau lapaʻau.

Hiki i kekahi poʻe maʻi ke ʻike i nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau e koi ana i ka nānā koke:

• ʻO ka maʻi differentiation, e hoʻoulu ana i ke kuni, ka pilikia o ka hanu ʻana, a me ka mālama wai
• Nā loli puʻuwai koʻikoʻi e hiki ke pilikia
• Nā loli hana ate e pono ai ka nānā ʻana
• Nā hāʻule nui i nā helu koko e alakaʻi ana i ka maʻi a i ʻole nā pilikia koko
• Nā pilikia nerve e hoʻoulu ana i ka ʻūlū a i ʻole ka ʻūlū ʻana i nā lima a me nā wāwae

Ke nānā pono ʻia nei kēia mau hopena ʻaoʻao koʻikoʻi ma o nā hoʻokolohua a me nā hoʻokolokolo maʻamau. Ua ʻike kāu hui lapaʻau i ka ʻike ʻana a me ka mālama ʻana i kēia mau pilikia me ka wikiwiki a me ka maikaʻi.

I nā manawa kakaʻikahi loa, hiki i kekahi poʻe maʻi ke hoʻomohala i nā hopena lōʻihi e like me nā maʻi maʻi lua a i ʻole nā pilikia puʻuwai mau. ʻOiai aia kēia mau pilikia, ʻaʻole maʻamau loa lākou, a ke kau nei kāu hui lapaʻau i kēia mau pilikia kūpono e kūʻē i nā pōmaikaʻi e ola ai ke ola o ka mālama ʻana i kāu maʻi maʻi i kēia manawa.

ʻO wai ka mea ʻaʻole pono e lawe i ka Arsenic Trioxide?

ʻAʻole kūpono ka arsenic trioxide no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia nāu. Pono paha nā kānaka me kekahi mau maʻi puʻuwai i ka nānā kūikawā a i ʻole nā lapaʻau ʻē aʻe no ka mea hiki i kēia lāʻau lapaʻau ke hoʻopilikia i ka puʻuwai.

Inā loaʻa iā ʻoe ka maʻi ate a i ʻole ka maʻi kīkī, pono paha kāu kauka e hoʻoponopono i kāu hoʻolālā lapaʻau a i ʻole e koho i nā lāʻau lapaʻau ʻē aʻe. Kōkua kēia mau ʻōkana i ka hana ʻana i ka lāʻau lapaʻau, no laila he mea nui ka hana kūpono no ka lapaʻau palekana.

ʻAʻole pono nā wahine hāpai e loaʻa i ka arsenic trioxide no ka mea hiki iā ia ke hōʻeha i ka pēpē e ulu ana. Inā ʻoe i ka makahiki hānau keiki, e kūkākūkā kāu kauka i nā ʻano hana pale hāpai maikaʻi e hoʻohana ʻia i ka wā a ma hope o ka lapaʻau.

Pono paha nā kānaka me kekahi mau maʻi genetic e pili ana i ka puʻuwai i nā lapaʻau ʻē aʻe. E nānā kāu kauka i kāu mōʻaukala olakino piha a hiki ke kauoha i nā hoʻokolohua puʻuwai kūikawā ma mua o ka hoʻomaka ʻana i ka lapaʻau.

Nā inoa inoa o Arsenic Trioxide

Loaʻa pinepine ka arsenic trioxide ma lalo o ka inoa inoa ʻo Trisenox, ʻo ia ka mea i hoʻohana nui ʻia. Ua aʻo nui ʻia kēia brand a ua hōʻoia ʻia he maikaʻi no ka mālama ʻana i ka APL.

Hiki i kekahi mau halemai a me nā keʻena lapaʻau ke hoʻohana i nā mana generic o arsenic trioxide, aia ka mea hana like a hana like. E hōʻoia kāu hui mālama ola e loaʻa iā ʻoe ka hoʻomākaukau kūpono loa no kāu mau pono.

Me ka nānā ʻole i ka inoa inoa, hoʻokō nā lāʻau lapaʻau arsenic trioxide a pau i hoʻohana ʻia i ka mālama ʻana i ka maʻi kanesa i nā kūlana palekana a me ka pono. E koho kāu oncologist i ke koho maikaʻi loa ma muli o ka loaʻa a me kāu hoʻolālā lapaʻau.

Nā koho ʻē aʻe o Arsenic Trioxide

ʻOiai he maikaʻi loa ka arsenic trioxide no ka APL, aia nā koho lapaʻau ʻē aʻe e pili ana i kāu kūlana. ʻO ka waikawa all-trans retinoic (ATRA) kekahi lāʻau lapaʻau i hoʻohana pinepine ʻia wale nō a i hui pū ʻia me ka arsenic trioxide.

Hiki ke noʻonoʻo ʻia nā lāʻau chemotherapy kuʻuna e like me daunorubicin a i ʻole cytarabine i kekahi mau hihia, akā ʻoi aku ka nui o nā hopena ʻaoʻao ma mua o ka arsenic trioxide. Hana ʻokoʻa kēia mau lāʻau lapaʻau akā hiki ke kūpono i ka APL.

No kekahi poʻe maʻi, hāʻawi ka hui pū ʻana me ka arsenic trioxide me ATRA i nā hopena maikaʻi loa. Ua hōʻike kēia ʻano hui pū i nā hopena maikaʻi loa i nā hoʻokolohua lapaʻau a ua manaʻo pinepine ʻia ʻo ia ke kūlana gula no ka mālama ʻana i ka APL.

Na kāu oncologist e hoʻoholo i ke ala lapaʻau maikaʻi loa e pili ana i kāu ʻano APL, ke olakino holoʻokoʻa, a me nā mea pilikino ʻē aʻe. Loaʻa i kēlā me kēia koho lapaʻau kona mau pono a me nā mea e noʻonoʻo ai.

Ua ʻoi aku ka maikaʻi o ka Arsenic Trioxide ma mua o ATRA?

He mau lapaʻau maikaʻi loa ʻo Arsenic trioxide a me ATRA (all-trans retinoic acid) no ka APL, a ʻoi aku ka maikaʻi o ka hoʻohana pū ʻana. Ma mua o ka hoʻokūkū ʻana kekahi i kekahi, hana kēia mau lāʻau lapaʻau ma nā ʻano hana like ʻole e hāʻawi i ka mālama ʻana i ka maʻi kanesa.

Kōkua ʻo ATRA i nā cell abnormal e oʻo i nā cell maʻamau, ʻoiai ʻo ka arsenic trioxide e paipai i ka oʻo ʻana a me ka make ʻana o nā cell maʻi kanesa. Hoʻouka kēia ʻano hui pū i ka maʻi kanesa mai nā kihi he nui, e alakaʻi pinepine ana i nā hopena maikaʻi aʻe ma mua o kekahi lāʻau lapaʻau.

Hiki i kekahi poʻe maʻi ke loaʻa i ka arsenic trioxide wale nō, ʻoiai inā ua loaʻa iā lākou nā lāʻau lapaʻau ma mua a i ʻole nā ​​maʻi olakino kikoʻī. E noʻonoʻo pono kāu oncologist i kou kūlana pilikino e hoʻoholo ai inā ʻoi aku ka maikaʻi o ka lāʻau lapaʻau hoʻokahi a i ʻole ka hui pū.

Ua hōʻike nā haʻawina lapaʻau i ka hui pū ʻana o kēia mau lāʻau lapaʻau e hāʻawi pinepine i nā helu hoʻōla kiʻekiʻe loa no ka APL. Aia ke koho ma waena o ka lāʻau lapaʻau hoʻokahi a i ʻole ka hui pū ʻana i nā mea e like me kou olakino holoʻokoʻa, nā lāʻau lapaʻau ma mua, a me ke ʻano kikoʻī o APL.

Nā nīnau i nīnau pinepine ʻia e pili ana i ka Arsenic Trioxide

He palekana anei ka Arsenic Trioxide no ka poʻe me nā pilikia o ka naʻau?

Hiki i ka arsenic trioxide ke hoʻopilikia i ka puʻuwai, no laila, pono ka poʻe me nā maʻi puʻuwai i ka nānā kūikawā i ka wā e mālama ʻia ai. E kauoha paha kāu kauka i ka electrocardiogram (EKG) ma mua o ka hoʻomaka ʻana i ka mālama ʻana a e nānā mau i kou puʻuwai i ka wā o ka lāʻau lapaʻau.

Nui nā maʻi me nā maʻi puʻuwai maʻalahi e hiki nō ke loaʻa i ka arsenic trioxide me ka palekana me ka nānā pono. E hana pū kāu cardiologist a me ka oncologist e hōʻoia i ka olakino o kou puʻuwai i ka wā o ka mālama ʻana i ka maʻi kanesa.

Inā he pilikia nui kou puʻuwai, hiki i kāu kauka ke ʻōlelo i nā lāʻau lapaʻau ʻē aʻe a i ʻole e hoʻoponopono i kāu papa hana. ʻO ka pahuhopu ka mālama pono ʻana i kāu maʻi kanesa me ka mālama ʻana i kou puʻuwai i ka palekana.

He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o ka Arsenic Trioxide?

He mea maʻamau loa nā kūlana overdose no ka mea e hāʻawi mau ʻia ka arsenic trioxide e nā poʻe lapaʻau i aʻo ʻia i nā wahi i mālama ʻia. Eia naʻe, inā manaʻo ʻoe ua hana hewa, e hoʻomaopopo koke i kāu hui mālama ola.

E nānā pono kāu hui lapaʻau iā ʻoe a hiki ke hāʻawi i ka mālama kākoʻo e kōkua i kou kino e hana i ka lāʻau lapaʻau me ka palekana. Loaʻa iā lākou nā protocols e mālama i nā pilikia i hiki ke kū mai mai nā hewa dosing.

Ua lako ka haukapila kahi e loaʻa ai iā ʻoe ka lāʻau lapaʻau e mālama i nā pilikia e pili ana i ka lāʻau lapaʻau. ʻO kou palekana ka mea nui, a ua aʻo ʻia kāu hui mālama ola e pane wikiwiki i nā hopohopo.

He aha kaʻu e hana ai inā hala iaʻu kahi mahele o Arsenic Trioxide?

No ka mea e hāʻawi ʻia ka arsenic trioxide i kahi hoʻonohonoho lapaʻau, mālama ʻia nā mahele i hala e kāu hui mālama ola. Inā hala ʻoe i kahi manawa, e hoʻokaʻaʻike koke i ke keʻena o kāu oncologist e hoʻonohonoho hou.

Hoʻolālā ʻia kāu papa hana lapaʻau e hoʻonui i ka pono, no laila he mea nui e mālama i nā manawa dosing maʻamau ke hiki. E aʻo aku kāu hui lapaʻau iā ʻoe pehea e hoʻoponopono ai i kāu papa hana inā hala ʻoe i kahi lāʻau lapaʻau.

Mai hoʻāʻo e hoʻoponopono i nā lāʻau i hala ma ka pāpālua ʻana i nā lāʻau. Na kāu kauka e hoʻoholo i ke ala palekana loa e hoʻihoʻi ai i kāu lāʻau lapaʻau me ka hoʻopilikia ʻole i kou olakino.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Arsenic Trioxide?

Hoʻoholo mau ʻia ka hoʻoholo e hooki i ka lāʻau arsenic trioxide e kāu oncologist ma muli o kāu pane ʻana i ka lāʻau lapaʻau a me nā hoʻokolohua nānā maʻamau. Hoʻopau ka hapa nui o nā maʻi i kā lākou papa lāʻau lapaʻau i hoʻolālā ʻia, e mau ana no kekahi mau mahina.

E hoʻohana kāu kauka i nā hoʻokolohua koko, nā biopsies iwi iwi, a me nā loiloi ʻē aʻe e hoʻoholo ai i ka wā i loaʻa ai iā ʻoe ka pane maikaʻi loa. ʻO ka hooki ʻana i ka wā mua e hiki ai i nā sela maʻi ʻaʻai ke hoʻi a ulu ikaika.

ʻOiai ma hope o ka pau ʻana o ka lāʻau arsenic trioxide, e hoʻomau ʻoe i nā manawa hulina maʻamau e nānā i kou olakino a nānā i nā hōʻailona o ka maʻi ʻaʻai e hoʻi mai ana. He ʻāpana nui kēia mālama mau i kāu hoʻolālā lapaʻau holoʻokoʻa.

Hiki iaʻu ke hana i ka wā e loaʻa ana iaʻu ka lāʻau Arsenic Trioxide?

Hiki i nā maʻi he nui ke hoʻomau i ka hana i ka wā e loaʻa ana ka lāʻau arsenic trioxide, akā pono paha ʻoe e hoʻoponopono i kāu papa hana a puni nā lā lapaʻau a hoʻokō i nā luhi a i ʻole nā hopena ʻaoʻao āu e ʻike ai.

ʻO ka papa hana lapaʻau e ʻae maʻamau i nā hana maʻamau ma waena o nā manawa, a ʻike ka nui o nā maʻi i ka noho ʻana a me ka mālama ʻana i nā hana maʻamau e kōkua iā lākou e ʻoi aku ka maikaʻi. Eia naʻe, e hoʻolohe i kou kino a hoʻomaha i ka wā e pono ai.

E kūkākūkā i kāu kūlana hana me kāu hui mālama ola, no ka mea, hiki iā lākou ke hāʻawi i ke alakaʻi ʻana i ka mālama ʻana i nā hopena ʻaoʻao lapaʻau i ka wā e mālama ana i kāu mau kuleana ʻoihana. Hiki nō hoʻi i kāu mea hana ke hāʻawi i nā hoʻokō e kōkua iā ʻoe e kaulike i ka lāʻau lapaʻau a me ka hana.