He aha ʻo Belatacept: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i kauoha ʻia ʻo Belatacept i hāʻawi ʻia ma o ka IV e kōkua i ka pale ʻana i kou kino mai ka hōʻole ʻana i kahi puʻupaʻa i hoʻololi ʻia. Hana ia ma ka hoʻomaha ʻana i kou ʻōnaehana pale e pale ai i ka hoʻouka ʻana i kāu ʻōkana hou e like me ka mea komo malihini.

Hoʻohana pinepine ʻia kēia lāʻau lapaʻau ma ke ʻano he ʻāpana o kahi hoʻolālā lapaʻau piha ma hope o ke ʻoki ʻana i ka puʻupaʻa. E nānā pono kāu hui transplant iā ʻoe i ka wā e loaʻa ai iā ʻoe kēia lāʻau lapaʻau e hōʻoia i ka hana pono a me ka palekana no kāu kūlana kikoʻī.

He aha ʻo Belatacept?

ʻO Belatacept kahi lāʻau lapaʻau immunosuppressive e pili ana i kahi papa o nā lāʻau i kapa ʻia he selective T-cell costimulation blockers. E noʻonoʻo iā ia he mea hana kūikawā e kōkua i kāu ʻōnaehana pale e aʻo e ʻae i kāu puʻupaʻa i hoʻololi ʻia.

ʻAʻole like me kekahi mau lāʻau lapaʻau anti-rejection ʻē aʻe āu e lawe ai ma ka waha, hāʻawi pololei ʻia ʻo belatacept i loko o kou kahe koko ma o ka infusion IV. Hiki i kēia i ka lāʻau lapaʻau ke hana pololei a kōkua i kāu hui lapaʻau e kāohi pono i ka nui o kāu e loaʻa ai.

Ua hoʻomohala kūikawā ʻia ka lāʻau lapaʻau no ka poʻe i loaʻa i nā transplants puʻupaʻa. Hōʻike ia i kahi ala hou e pale ai i ka hōʻole ʻana i nā ʻōkana i hoʻohālikelike ʻia me kekahi mau lāʻau immunosuppressive kuʻuna.

No ke aha e hoʻohana ʻia ai ʻo Belatacept?

Hoʻohana nui ʻia ʻo Belatacept e pale i ka hōʻole ʻana i nā ʻōkana i nā pākeke i loaʻa i ka transplant puʻupaʻa. Hoʻāʻo maoli kāu ʻōnaehana pale e pale iā ʻoe mai nā mea a pau i ʻike ʻia he malihini, me kāu puʻupaʻa hou.

He ʻāpana maʻamau kēia lāʻau lapaʻau i kahi ala lapaʻau hui pū. E kauoha maʻamau kāu mau kauka iā ia me nā lāʻau lapaʻau ʻē aʻe e like me mycophenolate a me corticosteroids e hana i kahi hoʻolālā pale piha no kāu ʻōkana i hoʻololi ʻia.

Ua ʻae ʻia ka lāʻau lapaʻau no ka poʻe i loaʻa i ka transplant ʻāpana puʻupaʻa a ʻaʻole hoʻohana ʻia no nā ʻano transplant ʻē aʻe. Ua koho kāu hui transplant i kēia lāʻau lapaʻau no ka mea manaʻo lākou e hāʻawi ana i ke kaulike maikaʻi loa o ka pono a me ka palekana no kou kūlana.

Pehea e hana ai ʻo Belatacept?

Hana ʻo Belatacept ma ka pale ʻana i nā hōʻailona kikoʻī e haʻi maʻamau i kou ʻōnaehana pale e hoʻouka i kāu ʻāpana puʻupaʻa i hoʻololi ʻia. Hoʻopaʻa ia i nā T-cells, he mau mea nui i ka pane ʻana o kou kino.

Ua manaʻo ʻia kēia lāʻau lapaʻau he immunosuppressant ikaika. He ikaika ia e pale pono ai i ka hōʻole ʻana i ka wā e hana ana i nā hopena ʻaoʻao liʻiliʻi ma mua o kekahi mau koho ʻē aʻe, ʻoi aku hoʻi e pili ana i ka hana ʻāpana puʻupaʻa a me ke olakino cardiovascular.

ʻAʻole e pani loa ka lāʻau lapaʻau i kāu ʻōnaehana pale. Akā, hoʻemi ʻo ia i ka pane ʻana o ka pale ʻana i kāu ʻāpana puʻupaʻa i hoʻololi ʻia i ka wā e ʻae ana i kou kino e hakakā i nā maʻi a me nā mea hoʻoweliweli ʻē aʻe, ʻoiai e hoʻemi ʻia kāu pane pale holoʻokoʻa.

Pehea wau e lawe ai iā Belatacept?

Hāʻawi ʻia ʻo Belatacept ma ke ʻano he infusion intravenous, ʻo ia hoʻi, hāʻawi pololei ʻia i loko o kou kahe koko ma o kahi paipu liʻiliʻi i waiho ʻia i loko o kou vein. E loaʻa iā ʻoe kēia lapaʻau ma kahi keʻena lapaʻau kahi e hiki ai i nā poʻe loea mālama ola i hoʻomaʻamaʻa ʻia ke nānā iā ʻoe.

ʻO ka maʻamau, e lawe ana ka infusion ma kahi o 30 mau minuke e hoʻopau. E loaʻa iā ʻoe i ka wā mua, a laila e liʻiliʻi pinepine i ka wā e hala ai ka manawa. E hāʻawi kāu hui mālama ola iā ʻoe i kahi papa manawa kikoʻī i kūpono i kāu mau pono.

ʻAʻole pono ʻoe e hana i kekahi mea kūikawā ma mua o kāu infusion e pili ana i ka meaʻai a i ʻole ka inu. Eia naʻe, he mea nui e hōʻea mai me ka wai maikaʻi a e haʻi i kāu hui mālama ola inā ʻaʻole ʻoe maikaʻi a i ʻole he hopohopo ma mua o ka hoʻomaka ʻana i ka lapaʻau.

Pehea ka lōʻihi e lawe ai au iā Belatacept?

ʻO ka hapa nui o nā kānaka e loaʻa ana iā belatacept e pono e hoʻomau i kēia lāʻau no ka lōʻihi o ko lākou puʻupaʻa i hoʻololi ʻia. He hana ola kēia, no ka mea, ʻo ka hooki ʻana i nā lāʻau anti-rejection hiki ke alakaʻi i ka hōʻole ʻana o ke kino.

E loli ana kāu papa hana lāʻau i ka manawa. I ka wā mua, e loaʻa iā ʻoe nā infusions pinepine e hoʻokumu i ka pale no kāu puʻupaʻa hou. Ma hope o kekahi mau mahina, e hoʻokaʻawale ʻia nā infusions, akā e hoʻomau mau lākou.

E loiloi mau kāu hui transplant i ka maikaʻi o ka hana ʻana o ka lāʻau a inā pono e hana i nā hoʻoponopono. E noʻonoʻo lākou i nā mea e like me kāu hana puʻupaʻa, nā hopena ʻaoʻao āu e ʻike nei, a me kou olakino holoʻokoʻa i ka wā e hoʻoholo ai i kāu hoʻolālā lapaʻau e hiki mai ana.

He aha nā hopena ʻaoʻao o Belatacept?

E like me nā lāʻau lapaʻau a pau e pili ana i kāu ʻōnaehana pale, hiki i ka belatacept ke hana i nā hopena ʻaoʻao. ʻO ka hapa nui o nā kānaka e ʻae maikaʻi iā ia, akā he mea nui e ʻike i ka mea e nānā ai i hiki iā ʻoe ke loaʻa ke kōkua inā pono.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia ka piʻi ʻana o ka maʻi, ke koko kiʻekiʻe, a me nā loli i kāu helu koko. Hiki nō hoʻi iā ʻoe ke ʻike i nā poʻo, ka nausea, a i ʻole ka luhi, ʻoi aku ka nui o kou kino e hoʻoponopono ana i ka lāʻau.

Eia nā hopena ʻaoʻao maʻamau i hōʻike ʻia e nā kānaka:

• Hoʻonui ʻia ka pilikia o nā maʻi ma muli o ka hoʻemi ʻia ʻana o ka hana pale
• Ke koko kiʻekiʻe e pono ai ka nānā ʻana a me ka mālama ʻana
• Anemia a i ʻole nā loli i nā helu keʻokeʻo koko
• Nā poʻo a me ka luhi maʻamau
• Nausea a i ʻole ka hōʻoluʻolu ʻana o ka ʻai
• Ka pehu ʻana i nā lima, nā wāwae, a i ʻole nā wāwae

Hiki ke mālama ʻia kēia mau hopena ʻaoʻao me ka mālama olakino kūpono a me ka nānā ʻana. E nānā kāu hui mālama ola i kēia mau pilikia a kōkua iā ʻoe e hoʻoponopono iā lākou inā loaʻa.

Aia kekahi mau hopena ʻē aʻe i ʻike ʻole ʻia akā ʻoi aku ka koʻikoʻi e pono e ʻike. ʻOiai ʻaʻole hiki kēia mau mea i ka hapa nui o nā kānaka, he mea nui e ʻike e pili ana iā lākou i hiki iā ʻoe ke ʻimi i ka lāʻau lapaʻau koke inā pono.

ʻO nā hopena ʻaoʻao maʻamau akā koʻikoʻi e komo pū ana:

• Nā maʻi koʻikoʻi e koi ai i ka haukapila
• Hoʻonui ʻia ka pilikia o kekahi mau maʻi maʻi, ʻo ia hoʻi ka maʻi ʻili a me nā lymphomas
• ʻO ka progressive multifocal leukoencephalopathy (PML), he maʻi lolo laha ʻole
• Nā hopena maʻi maʻi koʻikoʻi i ka wā o ka hoʻokomo ʻana
• Post-transplant lymphoproliferative disorder (PTLD)

E nānā pono kāu hui lapaʻau iā ʻoe no kēia mau pilikia koʻikoʻi a e hana i nā hana e pale ai iā lākou i ka hiki. ʻO nā loiloi maʻamau a me nā hoʻokolohua koko e kōkua i ka hopu ʻana i nā pilikia i ka wā mua.

ʻO wai ka mea pono ʻole e lawe iā Belatacept?

ʻAʻole kūpono ʻo Belatacept no nā mea a pau e loaʻa ana i ka transplant kidney. E loiloi pono kāu hui transplant inā kūpono kēia lāʻau lapaʻau iā ʻoe ma muli o kekahi mau mea nui.

ʻAʻole pono ʻoe e loaʻa iā belatacept inā he maikaʻi ʻole ʻoe no ka Epstein-Barr virus (EBV) a i ʻole inā ʻaʻole ʻike ʻia kāu kūlana EBV. ʻO kēia no ka mea ʻo ka poʻe me ka ʻole o ka hōʻike EBV mua he kiʻekiʻe ka pilikia o ka hoʻomohala ʻana i nā lymphomas koʻikoʻi i ka wā e lawe ana i kēia lāʻau.

ʻO nā kūlana ʻē aʻe kahi i ʻōlelo ʻole ʻia ai ʻo belatacept e komo pū ana:

• Inā loaʻa iā ʻoe kahi maʻi hana ʻole, ʻaʻole i mālama ʻia
• Inā loaʻa iā ʻoe kekahi mau ʻano maʻi maʻi i kēia manawa
• Inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai
• Inā he moʻolelo kou o nā hopena maʻi maʻi koʻikoʻi i nā lāʻau lapaʻau like
• Inā ʻaʻole hiki iā ʻoe ke hele i nā koho lapaʻau maʻamau no ka nānā ʻana

E kūkākūkā kāu hui transplant i kēia mau mea me ʻoe a kōkua i ka hoʻoholo ʻana i ke ʻano immunosuppressive maikaʻi loa no kāu kūlana kikoʻī. Aia nā lāʻau lapaʻau ʻē aʻe inā ʻaʻole kūpono ʻo belatacept iā ʻoe.

Nā inoa inoa Belatacept

Loaʻa ʻo Belatacept ma lalo o ka inoa inoa Nulojix. ʻO kēia ka inoa kalepa nui āu e ʻike ai ke loaʻa iā ʻoe kāu mau infusions ma ke keʻena lapaʻau.

Mai ka wā i hāʻawi ʻia ai ʻo belatacept he lāʻau lapaʻau kūikawā wale nō i nā wahi mālama ola, ʻaʻole pono ʻoe e hopohopo e pili ana i ka lawe ʻana mai kahi hale kūʻai lāʻau lapaʻau a i ʻole ka mālama ʻana i nā inoa inoa like ʻole. E mālama kāu kikowaena transplant i nā mea a pau o ka loaʻa ʻana a me ka hoʻomākaukau ʻana i kāu lāʻau lapaʻau.

Nā Koho ʻē aʻe o Belatacept

Inā ʻaʻole kūpono ʻo belatacept iā ʻoe, aia kekahi mau lāʻau lapaʻau immunosuppressive ʻē aʻe e hiki ke pale pono i ka hōʻole ʻana i ka transplant kidney. E hana pū kāu hui transplant me ʻoe e ʻimi i ke koho maikaʻi loa no kāu mau pono kikoʻī.

ʻO nā koho maʻamau e pili ana iā tacrolimus, i lawe ʻia e ka waha a he mea maikaʻi loa i ka pale ʻana i ka hōʻole ʻana. ʻO Cyclosporine kekahi koho i hoʻohana maikaʻi ʻia no nā makahiki he nui i nā mea loaʻa transplant.

ʻO nā koho ʻē aʻe e pili ana i nā ʻano hui like ʻole e hoʻohana ana i nā lāʻau lapaʻau e like me mycophenolate, azathioprine, a i ʻole sirolimus. Loaʻa i kēlā me kēia koho kona mau pono a me nā hopena ʻaoʻao, a e kōkua kāu hui lapaʻau iā ʻoe e hoʻomaopopo i ke ala e hana maikaʻi ai iā ʻoe.

Ua ʻoi aku ka maikaʻi o Belatacept ma mua o Tacrolimus?

He mea maikaʻi ʻo Belatacept a me tacrolimus i ka pale ʻana i ka hōʻole ʻana i ka transplant kidney, akā hana lākou i nā mea like ʻole a loaʻa nā pōmaikaʻi like ʻole. ʻO ke koho ma waena o lākou e pili ana i kāu ʻikepili olakino a me nā kūlana.

Hiki i ka Belatacept ke hāʻawi i kekahi mau pōmaikaʻi no ka hana kidney lōʻihi a me ke olakino cardiovascular i hoʻohālikelike ʻia me tacrolimus. Hōʻike kekahi mau haʻawina e loaʻa paha i ka poʻe e lawe ana i ka belatacept ka hana kidney i mālama ʻia i ka manawa a me nā pilikia e pili ana i ka naʻau.

Akā, lawe ʻia ʻo tacrolimus ma ke ʻano he pila, a he mea maʻalahi ka nui o nā kānaka ma mua o ka hoʻokomo ʻana i ka IV maʻamau. He moʻolelo lōʻihi nō hoʻi ko Tacrolimus o ka hoʻohana ʻana a makemake ʻia paha i kekahi mau kūlana, e like me ka wā e piʻi ai ka pilikia o ka hōʻole ʻana.

E noʻonoʻo kāu hui transplant i nā mea e like me kou makahiki, nā maʻi olakino ʻē aʻe, ke ʻano o ke ola, a me nā makemake pilikino i ka wā e ʻōlelo ai i ka lāʻau lapaʻau maikaʻi loa nāu. Hiki i nā koho ʻelua ke maikaʻi loa ke hoʻohana pono ʻia.

Nā Nīnau i Nīnau pinepine ʻia e pili ana iā Belatacept

He palekana anei ʻo Belatacept no ka poʻe me ka maʻi diabetes?

ʻAe, hiki ke hoʻohana palekana ʻia ʻo belatacept i ka poʻe me ka maʻi diabetes i loaʻa i nā transplant puʻupaʻa. ʻO ka ʻoiaʻiʻo, hiki iā ia ke hāʻawi i kekahi mau mea maikaʻi no nā maʻi diabetic i hoʻohālikelike ʻia me nā lāʻau immunosuppressive ʻē aʻe.

ʻAʻole like me kekahi mau lāʻau anti-rejection ʻē aʻe, ʻaʻole maʻamau ka belatacept e hoʻonui i ka mana o ke kō koko. Hiki i kēia ke kōkua nui i ka poʻe me ka maʻi diabetes e pono e mālama i nā pae glucose paʻa. E hoʻomau kāu hui lapaʻau i ka nānā ʻana i kāu mālama ʻana i ka maʻi diabetes i ka wā e loaʻa ai iā ʻoe ka belatacept.

He aha kaʻu e hana ai inā e poina iaʻu kahi mahele o Belatacept?

Inā e poina iā ʻoe kāu hoʻokomo ʻana i ka belatacept i hoʻonohonoho ʻia, e hoʻokaʻaʻike koke i kāu hui transplant. No ka mea, hāʻawi ʻia kēia lāʻau lapaʻau ma kahi keʻena lapaʻau, ʻo ka poina ʻana i kahi mahele ʻo ia ka hoʻonohonoho hou ʻana i kāu manawa i ka hiki wawe.

Mai kali a hiki i kāu manawa i hoʻonohonoho ʻia e hiki mai ana inā ua poina iā ʻoe kahi mahele. Pono kāu hui transplant e loiloi i ka lōʻihi o ka hala ʻana mai kāu hoʻokomo hope loa a pono paha e hoʻoponopono i kāu hoʻolālā lapaʻau e hōʻoia i ka pale ʻana o kou puʻupaʻa mai ka hōʻole ʻana.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Belatacept?

ʻAʻole pono ʻoe e hooki i ka lawe ʻana iā belatacept me ka ʻole o nā ʻōlelo kuhikuhi mai kāu hui transplant. He mea nui kēia lāʻau lapaʻau no ka pale ʻana i kou kino mai ka hōʻole ʻana i kāu puʻupaʻa i hoʻololi ʻia, a ʻo ka hooki ʻana iā ia hiki ke alakaʻi i nā pilikia koʻikoʻi.

ʻO ka hapa nui o nā kānaka e loaʻa ana i nā mea kanu kīkī e pono e lawe i nā lāʻau lapaʻau immunosuppressive no ke ola. E loiloi mau kāu hui transplant i kāu hoʻolālā lapaʻau a hana i nā hoʻoponopono e pono ai, akā e hōʻoia mau lākou iā ʻoe i ka pale kūpono mai ka hōʻole ʻana.

Hiki iaʻu ke hele i ka wā e lawe ana i ka Belatacept?

Hiki iā ʻoe ke hele maʻamau i ka wā e lawe ana i ka belatacept, akā pono ʻoe e hoʻolālā pono a puni kāu papa manawa infusion. Ma muli o ka hāʻawi ʻia ʻana o ka lāʻau lapaʻau i nā manawa kikoʻī, pono ʻoe e hoʻopili me kāu hui transplant ma mua o ka hana ʻana i nā hoʻolālā huakaʻi.

No nā huakaʻi lōʻihi, hiki i kāu hui transplant ke hoʻonohonoho iā ʻoe e loaʻa i kāu infusion ma kahi keʻena lapaʻau kokoke i kāu huakaʻi. Pono lākou i ka hoʻolaha mua e hoʻopili i kēia mālama a hōʻoia i ka hoʻomau ʻana o kāu lapaʻau.

E pili anei ka Belatacept i koʻu hiki ke hakakā i nā maʻi?

ʻAe, e hōʻemi ka belatacept i ka hiki o kāu ʻōnaehana pale e hakakā i nā maʻi, ʻo ia ka hopena i manaʻo ʻia o nā lāʻau lapaʻau immunosuppressive. Pono kēia e pale i ka hōʻole ʻana i kāu kīkī i kanu ʻia.

ʻOiai ua hoʻonui ʻia kāu pilikia maʻi, ʻaʻole ʻike ka hapa nui o ka poʻe e lawe ana i ka belatacept i nā maʻi koʻikoʻi. E nānā pono kāu hui mālama ola iā ʻoe a hiki ke ʻōlelo i nā hana pale e like me kekahi mau lāʻau lapaʻau a i ʻole nā lāʻau lapaʻau e hōʻemi i kou pilikia maʻi. He mea nui e hoʻomaʻamaʻa i ka maʻemaʻe maikaʻi a pale i ka hōʻike ʻana i nā maʻi i ka wā hiki.