He aha ʻo Belimumab: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Belimumab i kuhikuhi ʻia e kōkua i ka hoʻomaha ʻana i kāu ʻōnaehana pale i ka wā e hoʻouka hewa ai i kou kino ponoʻī. Ua hoʻolālā kūikawā ʻia ia e mālama i nā maʻi autoimmune e like me ka lupus, kahi e pono ai kāu ʻōnaehana pale i ke alakaʻi mālie e hooki i ka hakakā ʻana iā ʻoe.

Hana kēia lāʻau lapaʻau ma ka pale ʻana i kahi protein i kapa ʻia ʻo BLyS (B-lymphocyte stimulator) e haʻi ana i kekahi mau pūnaewele pale e lilo i mea hana nui. E noʻonoʻo e like me ka hoʻohaʻahaʻa ʻana i ka leo ma kahi ʻōnaehana pale i pāʻani nui loa.

No ke aha e hoʻohana ʻia ai ʻo Belimumab?

Hoʻohana nui ʻia ʻo Belimumab e mālama i ka systemic lupus erythematosus (SLE), i ʻike nui ʻia ʻo lupus. Hiki i kāu kauka ke kuhikuhi iā ia ke loaʻa iā ʻoe ka lupus hana ʻaʻole i pane maikaʻi i nā lāʻau lapaʻau maʻamau e like me nā antimalarials, corticosteroids, a i ʻole immunosuppressants.

Ua ʻae ʻia ka lāʻau lapaʻau no ka mālama ʻana i ka lupus nephritis, e hana ʻia ana i ka wā e pili ai ka lupus i kou mau puʻupaʻa. He ʻano koʻikoʻi kēia o ka lupus e pono ai ka mālama pono ʻana e pale i kāu hana puʻupaʻa.

Eia kekahi, hiki i ka belimumab ke kōkua me ka systemic lupus erythematosus hana i nā keiki 5 makahiki a ʻoi aku. E ana pono kāu kauka i nā pōmaikaʻi a me nā pilikia ma mua o ka ʻōlelo ʻana iā ia no nā maʻi ʻōpio.

Pehea e hana ai ʻo Belimumab?

Hana ʻo Belimumab ma ka hoʻopaʻa ʻana i nā pūnaewele B, ʻo ia nā pūnaewele pale e hana ai i nā antibodies. I ka lupus, lilo kēia mau pūnaewele B i mea hana nui a hana i nā antibodies e hoʻouka i kou mau ʻiʻo olakino ponoʻī ma mua o ka pale ʻana iā ʻoe mai nā maʻi.

Pale ka lāʻau lapaʻau i ka BLyS, kahi protein e hana ana e like me ka wahie no kēia mau pūnaewele B hana nui. Ma ka hoʻemi ʻana i kēia kumu wahie, kōkua ʻo belimumab i ka hoʻemi ʻana i ka helu o nā pūnaewele B pilikia i kāu ʻōnaehana, hiki ke hōʻemi i nā hōʻailona lupus a me nā ahi.

He manaʻo ʻia he lāʻau lapaʻau i manaʻo ʻia ma mua o ka mea e pale ai i ka pale ʻana, ʻo ia hoʻi, ʻoi aku ka pololei o ka hopena i kāu ʻōnaehana pale. Eia naʻe, he lāʻau ikaika nō ia e pono ai ka nānā pono ʻana e kāu hui mālama ola.

Pehea e lawe ai au i ka Belimumab?

Loaʻa ka Belimumab i nā ʻano ʻelua: intravenous (IV) infusion a me ka subcutaneous (ma lalo o ka ʻili) injection. E hoʻoholo kāu kauka i ke ʻano kūpono loa iā ʻoe e pili ana i kou kūlana a me nā pono o ke ola.

No nā infusions IV, e loaʻa iā ʻoe ka lāʻau lapaʻau ma kahi hale mālama ola i kēlā me kēia ʻehā pule. Ma kahi o hoʻokahi hola ka infusion, a e nānā ʻia ʻoe i ka wā a ma hope o ka mālama ʻana no nā hopena koke.

Inā ʻoe e hoʻohana ana i ke ʻano subcutaneous, e hoʻokomo paha ʻoe i hoʻokahi manawa i ka pule ma ka home ma hope o ke aʻo kūpono. E aʻo kāu hui mālama ola iā ʻoe i ke ʻano hoʻokomo pololei a kōkua iā ʻoe e ʻoluʻolu i ke kaʻina hana.

ʻAʻole pono ʻoe e lawe i ka belimumab me ka meaʻai, akā he mea nui e mālama i kahi papa manawa paʻa. Manaʻo kekahi poʻe he mea kōkua ke kaha i kā lākou kalena a i ʻole ke hoʻonohonoho ʻana i nā mea hoʻomanaʻo kelepona e noho ma ke ala.

Pehea ka lōʻihi e lawe ai au i ka Belimumab?

ʻO ka Belimumab ka mea maʻamau he lapaʻau lōʻihi e hoʻomau ʻoe i ka wā e kōkua ana i kāu lupus a ke ʻae maikaʻi nei ʻoe. Nui ka poʻe e lawe iā ia no nā makahiki e mālama i ka mana o kā lākou mau hōʻailona a pale i nā ahi.

Hiki iā ʻoe ke hoʻomaka e ʻike i nā hoʻomaikaʻi ʻana ma hope o kekahi mau mahina, ʻoiai hiki ke lawe i ʻeono mahina e ʻike i nā pōmaikaʻi piha. Hana ʻia kēia hoʻomaikaʻi ʻana no ka mea e hana ana ka belimumab ma ka hoʻemi mālie ʻana i nā cell immune overactive ma mua o ka hāʻawi ʻana i ke kōkua koke.

E loiloi mau kāu kauka i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau ma o nā hoʻokolohua koko, ka nānā ʻana i nā hōʻailona, ​​a me ka nānā ʻana i nā hopena ʻaoʻao. E kōkua lākou iā ʻoe e hoʻoholo i ka manawa kūpono e hoʻomau, hoʻoponopono, a i ʻole e hoʻōki i ka lāʻau lapaʻau.

He aha nā hopena ʻaoʻao o Belimumab?

E like me nā lāʻau lapaʻau a pau e pili ana i kou ʻōnaehana pale, hiki i ka belimumab ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole nā mea a pau e ʻike iā lākou. ʻO ka ʻike i ka mea e nānā ai e kōkua iā ʻoe e noho palekana a loaʻa ka mālama wikiwiki inā pono.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia ka nausea, ka maʻi maʻi, ke kuni, ka ihu paʻa, ka bronchitis, ka hiamoe ʻole, a me ka ʻeha ma kou mau lima a i ʻole nā wāwae. He maʻalahi ka maʻi maʻamau a maʻa mau e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau.

ʻO nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau e komo pū ana:

• Hoʻonui i ka pilikia o nā maʻi ma muli o ka hoʻopaʻa ʻana o ka ʻōnaehana pale
• Nā hopena maʻi maʻi koʻikoʻi, ʻoi loa i ka wā o nā infusions IV
• Ka kaumaha a i ʻole nā loli o ka naʻau
• Nā maʻi koʻikoʻi e koi ai i ka haukapila

No ka mea e pili ana ka belimumab i kou ʻōnaehana pale, e loaʻa iā ʻoe ka pilikia nui o ka loaʻa ʻana o nā maʻi. ʻO ia hoʻi, pono ʻoe e hoʻokaʻaʻike i kāu kauka inā loaʻa iā ʻoe ke kuni, nā hōʻailona e like me ka maʻi flu, a i ʻole nā hōʻailona o ka maʻi.

ʻO nā hopena ʻaoʻao kakaʻikahi akā koʻikoʻi e komo pū ana i ke kaumaha nui, nā manaʻo o ka hōʻeha iā ia iho, ka progressive multifocal leukoencephalopathy (PML), a me ka hoʻāla hou ʻana o ka hepatitis B i ka poʻe i loaʻa mua kēia maʻi.

ʻO wai ka mea ʻaʻole pono e lawe i ka Belimumab?

ʻAʻole kūpono ka Belimumab no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. ʻAʻole pono ʻoe e lawe i kēia lāʻau inā ua loaʻa iā ʻoe kahi hopena maʻi maʻi koʻikoʻi i ka belimumab a i ʻole kekahi o kāna mea i hala.

Pono ka poʻe me nā maʻi koʻikoʻi, ikaika e kali a hiki i ka mālama ʻia ʻana o ka maʻi ma mua o ka hoʻomaka ʻana i ka belimumab. Aia kēia i nā maʻi koʻikoʻi bacterial, viral, fungal, a i ʻole nā maʻi ʻē aʻe e hiki ke hōʻino me ka hoʻopaʻa ʻana i ka pale.

E akahele loa kāu kauka inā loaʻa iā ʻoe:

• He mōʻaukala o nā maʻi maʻi mau a i ʻole nā maʻi pinepine
• HIV, hepatitis B, a i ʻole hepatitis C
• He mōʻaukala o ke kaumaha a i ʻole nā manaʻo e pepehi iā ia iho
• Ka maʻi ʻaʻai ma mua a i ʻole ka mālama ʻana i ka maʻi ʻaʻai i kēia manawa
• Nā hoʻolālā e loaʻa nā lāʻau lapaʻau ola

Inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, pono ʻoe e kūkākūkā i nā pilikia a me nā pōmaikaʻi me kāu kauka. Hiki i ka Belimumab ke hele i ka placenta a hiki ke hoʻopilikia i ka ʻōnaehana pale o kāu pēpē e ulu ana.

Nā inoa inoa Belimumab

Loaʻa ka Belimumab ma lalo o ka inoa inoa Benlysta. ʻO kēia wale nō ka inoa inoa i loaʻa i kēia manawa no kēia lāʻau lapaʻau, i hana ʻia e GSK (GlaxoSmithKline).

Inā loaʻa iā ʻoe ka IV a i ʻole ke ʻano subcutaneous, ua kūʻai ʻia nā mea ʻelua ma lalo o ka inoa inoa Benlysta like. E kuhikuhi kāu kauoha i ke ʻano a me ka ikaika āu e pono ai.

Nā koho ʻē aʻe o Belimumab

Inā ʻaʻole kūpono ka belimumab iā ʻoe a i ʻole ʻaʻole e hāʻawi ana i ka mana kūpono o kāu lupus, aia kekahi mau lāʻau lapaʻau ʻē aʻe. Hiki i kāu kauka ke noʻonoʻo i nā lāʻau lapaʻau biologic ʻē aʻe e like me rituximab, e manaʻo pū ana i nā pūnaewele B-cell akā hana ʻokoʻa.

He mea nui nā lāʻau lapaʻau immunosuppressive kuʻuna, me ka methotrexate, mycophenolate, azathioprine, a me cyclophosphamide. He moʻolelo lōʻihi ko kēia mau lāʻau lapaʻau a kūpono paha no kekahi mau kūlana.

Hāʻawi nā lāʻau lapaʻau hou e like me anifrolumab (Saphnelo) i kahi ala i manaʻo ʻia no ka mālama ʻana i ka lupus. E noʻonoʻo kāu kauka i nā mea e like me kāu mau hōʻailona kikoʻī, nā lāʻau lapaʻau ma mua, a me ke olakino holoʻokoʻa i ke koho ʻana i ke koho maikaʻi loa iā ʻoe.

I kekahi manawa, ʻoi aku ka kūpono o ka lāʻau lapaʻau hui pū me nā antimalarials e like me hydroxychloroquine a i ʻole ka mālama ʻana i ka corticosteroid ma mua o ka hoʻololi ʻana i kahi lāʻau lapaʻau biologic ʻē aʻe.

Ua ʻoi aku ka maikaʻi o Belimumab ma mua o Rituximab?

ʻAʻole maʻalahi ka hoʻohālikelike ʻana i ka belimumab me ka rituximab no ka mea he ʻokoʻa ko lākou hana a hoʻohana ʻia i nā kūlana like ʻole. Hoʻopā nā mea ʻelua i nā B-cells, akā hoʻopau ʻo rituximab i kēia mau cell me ka piha loa aʻo belimumab e hōʻemi mālie i ko lākou hoʻāla ʻana.

Loaʻa i ka Belimumab ka ʻikepili hoʻokolohua lapaʻau ikaika no ka mālama ʻana i ka lupus, me ka ʻae ʻia e ka FDA e pili ana i nā haʻawina nui a maikaʻi. ʻOiai he pono ka rituximab no nā maʻi lupus he nui, hoʻohana ʻia ia

No ka hoʻokomo ʻana i ka IV, ʻaʻole paha e loaʻa ka overdose no ka mea e hāʻawi ana nā poʻe loea mālama ola i ka lāʻau. Eia naʻe, inā manaʻo ʻoe ua hana hewa ʻia i ka wā o kāu hoʻokomo ʻana, e haʻi koke i kāu hui mālama ola i hiki iā lākou ke hana i nā hana nānā kūpono.

He aha kaʻu e hana ai inā e poina iaʻu kahi mahele o Belimumab?

Inā poina iā ʻoe kahi injection subcutaneous, e lawe koke iā ia ke hoʻomanaʻo ʻoe, a laila e hoʻi i kāu papa hana pule maʻamau. Mai pāpālua i nā mahele e uku ai i ka mea i poina.

No nā hoʻokomo IV, e hoʻokaʻaʻike i kāu mea mālama ola e hoʻonohonoho hou i ka hiki wawe. E hoʻāʻo e mālama i ka manawa ʻehā pule ma waena o nā mahele, akā mai hopohopo inā pono ʻoe e hoʻoponopono i kekahi mau lā ma muli o nā palena hoʻonohonoho.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Belimumab?

Mai hooki i ka lawe ʻana iā belimumab me ka ʻole e kūkākūkā mua me kāu kauka. ʻO ka hooki ʻana i ka pōkole hiki ke alakaʻi i nā hōʻailona lupus a i ʻole ka hōʻino ʻana o kāu mau hōʻailona, ​​no ka mea, e pau mālie nā hopena pale o ka lāʻau.

Hiki i kāu kauka ke noʻonoʻo e hooki i ka belimumab inā ua loaʻa iā ʻoe ka remission paʻa no ka manawa lōʻihi, inā ʻoe e ʻike nei i nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia, a i ʻole inā ʻaʻole e hāʻawi ana ka lāʻau i ka pono kūpono. E kōkua lākou iā ʻoe e hoʻololi palekana i nā lāʻau lapaʻau ʻē aʻe inā pono.

Hiki iaʻu ke kiʻi i nā lāʻau lapaʻau i ka wā e lawe ana iā Belimumab?

Pono ʻoe e pale i nā lāʻau lapaʻau ola i ka wā e lawe ana iā belimumab, no ka mea, hiki iā lākou ke hoʻoulu i nā maʻi i ka poʻe me nā ʻōnaehana pale i hoʻopaʻa ʻia. Aia kēia i nā lāʻau lapaʻau e like me MMR, varicella (chickenpox), a me nā lāʻau lapaʻau flu nasal.

ʻO nā lāʻau lapaʻau i hoʻopau ʻia (e like me ka pana flu, nā lāʻau lapaʻau COVID-19, a me ka lāʻau lapaʻau pneumonia) palekana a paipai ʻia. Eia nō naʻe, ʻaʻole paha lākou e hana maikaʻi i ka wā e lawe ana ʻoe iā belimumab, no laila e kūkākūkā i ka manawa a me nā mea i manaʻo ʻia me kāu kauka.