He aha ʻo Bevacizumab: Nā Hoʻohana, Ka Leka, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i manaʻo ʻia ʻo Bevacizumab e kōkua ana i ka hoʻolohi ʻana i ka ulu ʻana o ka maʻi maʻi ma ka pale ʻana i ka hana ʻana o nā kīʻaha koko. Hana kēia lapaʻau kūikawā ma ka ʻoki ʻana i ka lako koko e pono ai nā maʻi maʻi e ulu a laha i loko o kou kino.

Ma ke ʻano he monoclonal antibody, hōʻike ʻo bevacizumab i kahi ala pololei i ka mālama ʻana i ka maʻi maʻi i hoʻohālikelike ʻia me ka chemotherapy kuʻuna. Hiki i kāu oncologist ke ʻōlelo aku i kēia lāʻau lapaʻau ma ke ʻano he ʻāpana o kāu hoʻolālā mālama maʻi maʻi ākea, pinepine me nā lāʻau lapaʻau ʻē aʻe e hāʻawi iā ʻoe i ka hopena maikaʻi loa.

He aha ʻo Bevacizumab?

He protein i hana ʻia i loko o ka hale hana ʻo Bevacizumab e hoʻohālike i nā antibodies o ka ʻōnaehana pale o kou kino. Hoʻopili pono ia i kahi protein i kapa ʻia ʻo VEGF (vascular endothelial growth factor) e hoʻohana ai nā maʻi maʻi e hana i nā kīʻaha koko hou.

E noʻonoʻo iā VEGF ma ke ʻano he hōʻailona e haʻi ana i kou kino e kūkulu i nā alaloa no ke kahe koko. Hoʻouna nā pūnaewele maʻi maʻi i ka nui o kēia mau hōʻailona e loaʻa ai nā meaʻai e pono ai lākou e ulu. Pale ʻo Bevacizumab i kēia mau hōʻailona, ​​e ʻoki ana i ka lako meaʻai o ka maʻi maʻi.

No ka papa i kapa ʻia ʻo angiogenesis inhibitors kēia lāʻau lapaʻau, ʻo ia hoʻi ka pale ʻana i ka hana ʻana o nā kīʻaha koko hou. Ma ka hana ʻana i kēia, hiki iā ia ke kōkua i ka hoʻolohi ʻana i ka ulu ʻana o ka maʻi maʻi a hana i nā lāʻau lapaʻau maʻi maʻi ʻē aʻe e hana ʻoi aku ka maikaʻi.

No ke aha e hoʻohana ʻia ai ʻo Bevacizumab?

Hoʻomaʻamaʻa ʻo Bevacizumab i kekahi mau ʻano maʻi maʻi holomua, ʻoiai ke laha a hoʻi mai paha ma hope o ka mālama mua ʻana. Kauoha kāu kauka iā ia i ka wā i hoʻomohala ai nā pūnaewele maʻi maʻi i kā lākou pūnaewele lako koko ponoʻī.

ʻO nā maʻi maʻi maʻamau i mālama ʻia me bevacizumab me ka maʻi maʻi colorectal, ka maʻi maʻi maʻi, ka maʻi maʻi kīkī, a me kekahi mau maʻi maʻi lolo i kapa ʻia ʻo glioblastomas. Hoʻohana ʻia nō hoʻi ia no kekahi mau maʻi maʻi gynecologic e like me ka maʻi maʻi ovarian a me ka maʻi maʻi cervical.

Hoʻohui maʻamau kāu kauka oncology i ka bevacizumab me ka chemotherapy ma mua o ka hoʻohana ʻana iā ia wale nō. ʻOi aku ka maikaʻi o kēia hui pū ʻana ma mua o kekahi lapaʻau, e hāʻawi ana i kou kino i nā ala he nui e hakakā ai i ka maʻi kanesa.

I kekahi mau hihia, hoʻohana nā kauka i ka bevacizumab no nā maʻi maka e like me ka degeneration macular pili i ka makahiki, akā pono kēia i kahi formulation ʻokoʻa a me ka papa hana dosing ma mua o ka lapaʻau maʻi kanesa.

Pehea e Hana ai ʻo Bevacizumab?

Hana ʻo Bevacizumab ma ka hoʻopaʻa ʻana i nā protein VEGF i loko o kou kahe koko, e pale ana iā lākou mai ka hoʻopili ʻana i nā mea hoʻokipa ma nā cell koko. Pale kēia i ka hōʻailona e haʻi maʻamau i kou kino e ulu i nā kīʻaha koko hou i ke tumora.

Ma ke ʻano he therapy i manaʻo ʻia, ua manaʻo ʻia ʻo bevacizumab he lāʻau lapaʻau ikaika waena e hana ʻokoʻa mai ka chemotherapy kuʻuna. Ma kahi o ka pepehi pololei ʻana i nā cell maʻi kanesa, hoʻopau ia iā lākou ma ka ʻoki ʻana i kā lākou lako koko.

Holoholo ka lāʻau lapaʻau ma kou kahe koko no kekahi mau pule ma hope o kēlā me kēia infusion. I kēia manawa, pale mau ia i nā hōʻailona VEGF, e kōkua ana i ka hoʻoponopono ʻana i nā pūnaewele kīʻaha koko chaotic e hana ai nā tumora.

Hiki i kēia ala ke hoʻolilo i nā tumora i mea maʻalahi i nā lapaʻau ʻē aʻe e like me ka chemotherapy a i ʻole ka radiation, ʻo ia ke kumu e hoʻohana pinepine ai nā kauka i ka bevacizumab ma ke ʻano he ʻāpana o ka therapy hui pū ʻana ma mua o ka hoʻokahi.

Pehea wau e lawe ai i ka Bevacizumab?

Hāʻawi ʻia ʻo Bevacizumab ma o ka intravenous (IV) infusion wale nō ma kahi kikowaena lapaʻau maʻi kanesa a i ʻole ka haukapila. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka waha a i ʻole e hoʻokomo iā ʻoe iho ma ka home.

Lawe maʻamau kāu infusion mua ma kahi o 90 mau minuke, e ʻae ana i kāu hui lapaʻau e nānā i ka pane ʻana o kou kino. Inā ʻoe e ʻae maikaʻi iā ia, hiki ke hoʻopōkole ʻia nā infusions ma hope i 60 mau minuke, a ma hope i 30 mau minuke.

ʻAʻole pono ʻoe e hoʻokē ʻai ma mua o ka mālama ʻana, akā ʻo ka ʻai ʻana i ka meaʻai māmā ma mua e kōkua iā ʻoe e ʻoluʻolu i ka wā o ka hoʻokomo ʻana. E lawe mai i ka wai a me nā mea ʻai māmā, no ka mea, e noho ana ʻoe no ka manawa lōʻihi.

E nānā mau kāu kahu hānai i nā hōʻailona koʻikoʻi a nānā i nā hopena koke. Hoʻohui ʻia ka lāʻau lapaʻau me ka wai paʻakai a hāʻawi mālie ʻia ma o kāu laina IV e hōʻemi i nā hopena ʻaoʻao.

Pehea ka lōʻihi e lawe ai au i ka Bevacizumab?

He ʻokoʻa loa ka lōʻihi o ka mālama ʻana i ka bevacizumab ma muli o kāu ʻano maʻi maʻi, ke kahua, a me ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau. Loaʻa ka hapa nui o nā maʻi i nā infusions i kēlā me kēia 2-3 pule no kekahi mau mahina.

E nānā kāu oncologist i kāu maʻi maʻi ma o nā scans maʻamau a me nā hoʻokolohua koko e hoʻoholo ai inā e hana ana ka lāʻau lapaʻau. Inā pane maikaʻi kāu maʻi maʻi a ke ʻae nei ʻoe i ka lāʻau lapaʻau, hiki ke hoʻomau ʻia ka mālama ʻana no 6-12 mau mahina a ʻoi aku paha.

Hoʻomau kekahi poʻe maʻi i ka bevacizumab ma ke ʻano he lāʻau lapaʻau mālama ʻoiai ma hope o ka mana ʻia ʻana o kā lākou maʻi maʻi. Kōkua kēia lāʻau lapaʻau e pale i ka maʻi maʻi mai ka hoʻomohala ʻana i nā kīʻaha koko hou a me ka ulu hou ʻana.

E kūkākūkā kāu kauka i ka hoʻōki ʻana i ka lāʻau lapaʻau inā holomua kāu maʻi maʻi me ka lāʻau lapaʻau, inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, a i ʻole inā pono ʻoe i ke ʻoki e pono ai ka manawa hoʻōla.

He aha nā hopena ʻaoʻao o Bevacizumab?

ʻO ka hoʻomaopopo ʻana i nā hopena ʻaoʻao e kōkua iā ʻoe e ʻike i ka mea e manaʻo ai a i ka manawa e hoʻopili ai i kāu hui mālama ola. ʻO ka hapa nui o nā kānaka e ʻike i kekahi mau hopena ʻaoʻao, akā hiki ke mālama ʻia me ke kākoʻo kūpono a me ka nānā ʻana.

ʻO nā hopena ʻaoʻao maʻamau e ʻike ai ka nui o nā maʻi e pili ana i ke koko kiʻekiʻe, ka luhi, a me ka ihu. Hiki nō hoʻi iā ʻoe ke ʻike i nā loli i kou ʻano o ka ʻono, ka nausea māmā, a i ʻole ka piʻi ʻana o ka ʻeha mai nā puʻupuʻu liʻiliʻi.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia:

• Ke koko kiʻekiʻe e pono ai ka hoʻoponopono ʻana i ka lāʻau lapaʻau
• Luhi a me ka nāwaliwali e hiki ke ʻino i ka wā
• Ka ihu e kahe ana a i ʻole nā hanana koko liʻiliʻi ʻē aʻe
• Protein i loko o kāu mimi i ʻike ʻia ma o ka hoʻāʻo maʻamau
• Nā loli ʻono e pili ana i kou makemake
• ʻO ka nausea māmā a i ʻole ka waena
• Hoʻonui ʻia ka ʻeha a i ʻole ka lohi o ka hoʻōla ʻana i ka ʻeha

Pono nā hopena ʻaoʻao koʻikoʻi i ka lāʻau lapaʻau koke, ʻoiai e hana pinepine ʻole lākou. Hiki i kēia mau pilikia ke hoʻoweliweli i ke ola inā ʻaʻole i mālama koke ʻia e kāu hui mālama ola.

ʻO nā hopena ʻaoʻao laha akā koʻikoʻi e komo pū ana:

• Ke kahe nui ʻana i loko o kou ʻōpū, nā māmā, a i ʻole ka lolo
• Nā koko koko i loko o kou mau wāwae, nā māmā, a i ʻole ka puʻuwai
• Nā puka a i ʻole nā waimaka i loko o kou pā ʻōpū (perforation)
• Ka pilikia koko kiʻekiʻe koʻikoʻi
• Nā pilikia o ka puʻuwai me ka hāʻule ʻana o ka puʻuwai
• ʻO ka pōʻino o ka puʻupaʻa me ka nalowale o ka protein
• Nā hopena maʻi koʻikoʻi i ka wā o ka infusion

Nānā kāu hui lapaʻau i kēia mau pilikia koʻikoʻi ma o nā hoʻāʻo koko maʻamau, nā loiloi koko, a me nā hoʻokolohua kino. Hiki i ka ʻike mua a me ka mālama ʻana i nā hopena ʻaoʻao ke pale i ka hapa nui o nā pilikia mai ka lilo ʻana i mea weliweli.

ʻO wai ka mea ʻaʻole pono e lawe iā Bevacizumab?

ʻO kekahi mau maʻi a me nā kūlana e palekana ʻole ai ka bevacizumab a i ʻole e koi i nā hana kūikawā. E nānā pono kāu oncologist i kāu mōʻaukala olakino ma mua o ka ʻōlelo ʻana i kēia lapaʻau.

ʻAʻole pono ʻoe e loaʻa iā bevacizumab inā hāpai ʻoe i kēia manawa a i ʻole e hoʻolālā ana e hāpai, no ka mea, hiki iā ia ke hana i nā kīnā hānau koʻikoʻi. Pono nā wahine o ka makahiki hānau ke hoʻohana i ka contraception maikaʻi i ka wā o ka lapaʻau a no ʻeono mahina ma hope.

ʻAʻole hiki i nā poʻe i loaʻa i ke ʻoki nui ʻana a i ʻole nā kaʻina hana ʻoki i hoʻolālā ʻia ke loaʻa iā bevacizumab. Hoʻopilikia ka lāʻau lapaʻau i ka hoʻōla ʻana i ka ʻeha, no laila pono ʻoe e hoʻōki i ka lapaʻau ma ka liʻiliʻi he 28 mau lā ma mua o kekahi ʻoki i hoʻolālā ʻia.

Nā kūlana hou aʻe e pale ai i ka hoʻohana ʻana i ka bevacizumab:

• Ke koko kiʻekiʻe ʻaʻole i mālama ʻia me ka lāʻau lapaʻau
• Mōʻaukala hou o nā hanana koko nui
• Nā maʻi koko i kēia manawa
• Maʻi puʻuwai koʻikoʻi a i ʻole ka puʻuwai i loaʻa i kēia manawa
• Nā maʻi e hana nei ʻaʻole e pane i ka lāʻau lapaʻau
• Maʻi kīkī koʻikoʻi me ka nalowale o ka protein
• ʻO ka hahau hou a i ʻole ke koko i ka lolo

E loiloi kāu kauka i nā pōmaikaʻi e kūʻē i kēia mau pilikia no kou kūlana kikoʻī. I kekahi manawa, hiki i nā hoʻololi i kāu hoʻolālā lapaʻau a i ʻole ka nānā ʻana ke palekana i ka bevacizumab no ka poʻe me kekahi mau maʻi.

Nā inoa inoa o Bevacizumab

Loaʻa ka Bevacizumab ma lalo o nā inoa inoa like ʻole, ʻo Avastin ka mea i ʻike nui ʻia. Ua hoʻohana ʻia kēia mana inoa inoa i ka mālama ʻana i ka maʻi kanesa no nā makahiki he nui me ka noiʻi nui e kākoʻo ana i kona pono.

Loaʻa nā mana biosimilar o bevacizumab i kēia manawa, e hāʻawi ana i nā pōmaikaʻi therapeutic like ma nā kumukūʻai haʻahaʻa. Aia kēia mau mea iā Mvasi, Zirabev, a me Alymsys, ua ʻae ʻia lākou a pau e like me ka Avastin kumu.

Hiki i kāu ʻinikua ke hoʻopili i ka inoa inoa e kauoha ai kāu kauka, akā aia nā mana i ʻae ʻia i ka mea hana like a hana like i loko o kou kino. ʻO ke koho ma waena o nā inoa inoa e pili ana i ka loaʻa a me nā kumukūʻai ma mua o nā ʻokoʻa olakino.

Nā koho ʻē aʻe o Bevacizumab

Nui nā lāʻau lapaʻau ʻē aʻe e hana like me ka bevacizumab ma ka hoʻopaʻa ʻana i ka hana ʻana o nā kīʻaha koko, ʻoiai he mau ʻano kū hoʻokahi a me nā hoʻohana i ʻae ʻia. Hiki i kāu oncologist ke noʻonoʻo i kēia mau koho ʻē aʻe e pili ana i kāu ʻano maʻi kanesa a me ka mōʻaukala olakino.

ʻO Ramucirumab (Cyramza) kekahi lāʻau lapaʻau e kuhikuhi ana i ka VEGF i hoʻohana nui ʻia no ka maʻi ʻōpū a me ka maʻi maʻi māmā. Hana ia ma o kahi ʻano hana ʻokoʻa iki akā loaʻa nā hopena like i ka pale ʻana i ka ulu ʻana o nā kīʻaha koko tumora.

ʻO nā mea pale angiogenesis ʻē aʻe e komo pū ana me aflibercept (Zaltrap) no ka maʻi maʻi colorectal a me regorafenib (Stivarga) no ka maʻi maʻi colorectal a me ke ake. Hāʻawi kēia mau lāʻau lapaʻau i nā koho hoʻokele waha, kahi e makemake ai kekahi poʻe maʻi ma mua o nā infusions IV.

No kekahi mau maʻi maʻi, hiki ke noʻonoʻo ʻia nā lāʻau lapaʻau immunotherapy e like me pembrolizumab (Keytruda) a i ʻole nivolumab (Opdivo) ma kahi o a i ʻole me bevacizumab, ma muli o nā ʻano kikoʻī a me nā biomarkers o kāu maʻi maʻi.

Ua ʻoi aku ka maikaʻi o Bevacizumab ma mua o nā lāʻau lapaʻau like ʻē aʻe?

ʻO Bevacizumab ka mea pale VEGF i ʻae mua ʻia a loaʻa ka ʻikepili noiʻi nui e kākoʻo ana i kāna hoʻohana ʻana ma nā ʻano maʻi maʻi he nui. Kōkua kēia moʻolelo lōʻihi i nā kauka e wānana pehea ʻoe e pane ai i ka lāʻau lapaʻau.

I ka hoʻohālikelike ʻana me nā mea ʻē aʻe hou e like me ramucirumab, ʻoi aku ka nui o nā hui lapaʻau i loaʻa iā bevacizumab a me ka ʻae ākea no nā ʻano maʻi maʻi like ʻole. Eia naʻe, pili loa ke koho

Hiki i ka bevacizumab ke hoʻopilikia i kāu ʻōnaehana cardiovascular, no laila, pono nā kānaka me nā maʻi puʻuwai i ka nānā ʻana a me nā hana mālama hou. E hana pū kāu cardiologist a me ka oncologist e hoʻoholo inā ʻoi aku ka maikaʻi ma mua o nā pilikia.

Inā he maʻi puʻuwai maʻalahi kāu i mālama maikaʻi ʻia, hiki nō paha iā ʻoe ke loaʻa ka bevacizumab me ka nānā pinepine ʻana i ka puʻuwai. Aia kēia i nā ECG maʻamau, echocardiograms, a me ka mālama pono ʻana i ke koko i ka wā o ka mālama ʻana.

ʻAʻole hiki i nā kānaka me ka maʻi puʻuwai koʻikoʻi, nā puʻuwai i loaʻa i kēia manawa, a i ʻole ke koko kiʻekiʻe ʻole ke loaʻa palekana i ka bevacizumab. Hiki i ka lāʻau lapaʻau ke hoʻonui i kēia mau maʻi a hoʻonui i ka pilikia o nā pilikia cardiovascular koʻikoʻi.

He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o ka Bevacizumab?

He mea maʻamau loa ka overdose bevacizumab no ka mea e lawelawe ʻia e nā poʻe lapaʻau i aʻo ʻia i nā wahi mālama ola i mālama ʻia. Hoʻoholo pono ʻia ka lāʻau lapaʻau e pili ana i ke kaumaha o kou kino a hāʻawi mālie ʻia ma o ka infusion IV i nānā ʻia.

Inā manaʻo ʻoe ua loaʻa iā ʻoe kahi mahele hewa, e hoʻomaopopo koke i kāu kahu hānai infusion a i ʻole ke kauka. Hiki iā lākou ke nānā i kāu mau moʻolelo lapaʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao maʻamau.

ʻO nā hōʻailona e hōʻike ana i nā pilikia dosing e pili ana i ke poʻo koʻikoʻi, ke koko kiʻekiʻe loa, ke kahe ʻana o ke koko, a i ʻole ka nausea koʻikoʻi. ʻIke kāu hui mālama ola pehea e mālama ai i kēia mau kūlana a hāʻawi i ka mālama kākoʻo kūpono.

He aha kaʻu e hana ai inā hala iaʻu kahi mahele o Bevacizumab?

E hoʻokaʻaʻike i kāu hui oncology i ka wā hiki wawe inā hala ʻoe i kahi infusion bevacizumab i hoʻonohonoho ʻia. E hoʻonohonoho hou lākou iā ʻoe no ka manawa kūpono mua e mālama i ka pono o kāu lapaʻau.

Hiki i kāu kauka ke hoʻololi iki i kāu papa hana lapaʻau e kūpono i ka mahele i hala, akā, mai hoʻāʻo e \

E makaʻala i ke ʻano o ka waiʻona e pili ana iā ʻoe i ka wā e mālama ʻia ai, no ka mea, hiki i nā lāʻau lapaʻau maʻi ʻaʻai ke hoʻololi i kou ʻae ʻana. ʻIke kekahi poʻe maʻi i ka manaʻo ikaika o ka waiʻona a i ʻole ka piʻi ʻana o ka luhi i ka hui pū ʻana me ka bevacizumab.