He aha ʻo Bevacizumab: Nā Hoʻohana, Nā Kumu, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i manaʻo ʻia ʻo Bevacizumab e kōkua ana i ka hakakā ʻana i kekahi mau ʻano maʻi maʻi ma ka ʻoki ʻana i ko lākou lako koko. Hana kēia lāʻau lapaʻau ma ka pale ʻana i kahi protein i kapa ʻia ʻo VEGF e kōkua ana i nā maʻi e ulu i nā moku koko hou e hānai iā lākou iho.

Hiki i kāu kauka ke ʻōlelo aku iā bevacizumab inā loaʻa iā ʻoe nā maʻi maʻi e like me ka colorectal, ka māmā, ka puʻupaʻa, a i ʻole nā maʻi lolo. Hāʻawi mau ʻia ma o ka IV i loko o kahi haukapila a i ʻole ke keʻena lapaʻau, kahi e hiki ai i nā poʻe loea lapaʻau ke nānā pono iā ʻoe i ka wā o ka mālama ʻana.

He aha ʻo Bevacizumab?

He antibody i hana ʻia i ka hale hana ʻo Bevacizumab e manaʻo ana i nā sela maʻi ma ke ʻano kūikawā loa. E noʻonoʻo iā ia he kiaʻi i hoʻomaʻamaʻa nui ʻia e ʻike a pale i kekahi mau hōʻailona e hoʻohana ai nā sela maʻi e ulu a laha.

No kēia lāʻau lapaʻau i kahi papa o nā lāʻau i kapa ʻia he angiogenesis inhibitors, ʻo ia hoʻi, ke kāohi nei ia i ka hana ʻana o nā moku koko hou. Pono nā sela maʻi i ka lako mau o nā meaʻai a me ka oxygen ma o nā moku koko e ola a hoʻonui. Ma ka pale ʻana i kēia lako koko, hoʻopau maoli ʻo bevacizumab i ka maʻi.

Ua ʻike ʻia ka lāʻau lapaʻau e kona inoa inoa ʻo Avastin a hele mai ma ke ʻano he wai maopopo e hui pū ai nā mea mālama ola me ka hopena saline. Manaʻo ʻia he monoclonal antibody, ʻo ia hoʻi, ua hoʻolālā ʻia e manaʻo i hoʻokahi protein kikoʻī i kou kino.

No ke aha e hoʻohana ʻia ai ʻo Bevacizumab?

Hoʻomaʻamaʻa ʻo Bevacizumab i kekahi mau ʻano maʻi maʻi holomua, pinepine i ka hui pū ʻana me nā lāʻau lapaʻau maʻi maʻi ʻē aʻe. E hoʻoholo kāu oncologist inā kūpono kēia lapaʻau no kāu kūlana kikoʻī e pili ana i kāu ʻano maʻi a me ke kahua.

Eia nā maʻi maʻi nui kahi e kōkua ai ʻo bevacizumab:

• Ka maʻi ʻaʻai kolorectal i laha i nā wahi ʻē aʻe o kou kino
• Ka maʻi ʻaʻai māmā non-small cell i nā pae kiʻekiʻe
• Ka maʻi ʻaʻai puʻupaʻa (renal cell carcinoma)
• Nā ʻōpū lolo, ʻo glioblastoma
• Ka maʻi ʻaʻai ʻāʻī i hoʻi mai a i laha paha
• Ka maʻi ʻaʻai ovarian i hoʻi mai ma hope o ka mālama mua ʻana

Hiki i kāu kauka ke noʻonoʻo i ka bevacizumab no nā ʻano maʻi ʻaʻai ʻē aʻe i nā hoʻokolohua lapaʻau a i ʻole nā kūlana kūikawā. Hoʻohana ʻia ka lāʻau lapaʻau i kekahi manawa wale nō a hana maʻamau me nā lāʻau chemotherapy e hoʻonui i ko lākou pono.

Pehea e hana ai ʻo Bevacizumab?

Hana ʻo Bevacizumab ma ka ʻimi ʻana i kahi protein i kapa ʻia ʻo vascular endothelial growth factor, a i ʻole VEGF no ka pōkole. Hana kēia protein e like me ka hōʻailona e haʻi ana i kou kino e hana i nā kīʻaha koko hou, he hana maʻamau a olakino.

Hoʻopili nā pūnaewele maʻi ʻaʻai i kēia hana maoli ma ka hana ʻana i ka nui o VEGF e kūkulu i kā lākou pūnaewele kīʻaha koko ponoʻī. Hāʻawi kēia mau kīʻaha hou i ka oxygen a me nā meaʻai e kōkua i nā ʻōpū e ulu nui a laha paha i nā wahi ʻē aʻe o kou kino.

Ke komo ʻo bevacizumab i kāu ʻōnaehana, pili ia i nā protein VEGF a pale iā lākou mai ka hoʻouna ʻana i kā lākou hōʻailona kūkulu kīʻaha koko. ʻO kēia hana e ʻoki i ka lako meaʻai o ka ʻōpū, e hoʻemi a hoʻōki paha i ka ulu ʻana.

Manaʻo ʻia ka lāʻau lapaʻau he ikaika a hōʻike maʻamau i nā hopena i loko o kekahi mau pōʻai lapaʻau. Eia naʻe, hana ʻokoʻa ia ma mua o nā lāʻau chemotherapy kuʻuna e pepehi pololei i nā pūnaewele maʻi ʻaʻai.

Pehea wau e lawe ai iā Bevacizumab?

Hāʻawi mau ʻia ʻo Bevacizumab ma o ka laina intravenous (IV) i loko o ka haukapila, ka lāʻau lapaʻau, a i ʻole ke kikowaena lapaʻau maʻi ʻaʻai. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka home a i ʻole ma ka waha, no ka mea, pono e hoʻomākaukau pono ʻia a nānā ʻia e nā poʻe loea mālama ola.

E hahai ana kāu lapaʻau i kēia kaʻina hana: ʻO ka mea mua, e hoʻokomo kahi kahu maʻi i kahi laina IV i loko o kou lima a i ʻole e komo i kāu awa inā loaʻa iā ʻoe kekahi. A laila, e hui pū ʻia ka lāʻau lapaʻau me ka wai paʻakai a hāʻawi mālie ʻia ma luna o 30 a 90 mau minuke.

Ma mua o kēlā me kēia hoʻokomo ʻana, ʻaʻole pono ʻoe e pale i ka ʻai a i ʻole ka inu ʻana ke ʻole e hāʻawi kāu kauka iā ʻoe i nā ʻōlelo kikoʻī. Eia naʻe, ʻo ka noho ʻana i ka wai maikaʻi ma ka inu ʻana i ka wai nui i nā lā e alakaʻi ana i ka lapaʻau hiki ke kōkua i kou kino e hana maikaʻi i ka lāʻau lapaʻau.

E loaʻa iā ʻoe ka bevacizumab i kēlā me kēia 2 a 3 pule, ma muli o kāu hoʻolālā lapaʻau. Hiki i kēlā me kēia kau ke lawe i 2 a 4 mau hola, me ka manawa hoʻomākaukau a me ka nānā ʻana ma hope.

Pehea ka lōʻihi e lawe ai au i ka Bevacizumab?

ʻO ka lōʻihi o kāu lapaʻau bevacizumab e hilinaʻi ana i ka maikaʻi o ka pane ʻana o kāu maʻi maʻi a me ke ʻano o kou kino e ʻae ai i ka lāʻau lapaʻau. Loaʻa ka hapa nui o nā kānaka i ka lapaʻau no kekahi mau mahina, ʻoiai paha e pono kekahi no hoʻokahi makahiki a ʻoi aku paha.

E nānā kāu oncologist i kāu holomua ma o nā scans maʻamau a me nā hoʻokolohua koko e hoʻoholo ai i ka manawa e hoʻomau ai, hoʻoponopono, a i ʻole e hoʻōki i ka lapaʻau. Inā e emi a kū paha kāu maʻi maʻi me ka ʻole o nā hopena ʻaoʻao koʻikoʻi, hiki iā ʻoe ke hoʻomau i ka lapaʻau no ka manawa lōʻihi.

Pono paha kekahi poʻe e hoʻomaha i ka lapaʻau no ka manawa pōkole inā loaʻa iā lākou kekahi mau hopena ʻaoʻao, a laila e hoʻomau i ka wā e hoʻoponopono ai kēia mau pilikia. E hana kāu kauka me ʻoe e ʻimi i ke kaulike kūpono ma waena o ka hakakā ʻana i kāu maʻi maʻi a me ka mālama ʻana i kou ola maikaʻi.

He aha nā hopena ʻaoʻao o ka Bevacizumab?

E like me nā lāʻau lapaʻau maʻi maʻi a pau, hiki i ka bevacizumab ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole i loaʻa nā mea a pau iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ka mālama olakino kūpono a me ka nānā ʻana.

ʻO nā hopena ʻaoʻao maʻamau i loaʻa i nā kānaka he nui, ʻo ia:

• Ke koko kiʻekiʻe e nānā pono ʻia e kāu kauka
• Luhi e hiki ke hoʻoluhi iā ʻoe ma mua o ka maʻamau
• ʻEha poʻo i hiki ke mālama ʻia me nā mea hōʻoluʻolu ʻeha ma luna o ke kūʻai
• Nausea e hiki ke hoʻopilikia i kou ʻai
• Pāpaʻa a i ʻole nā loli i nā neʻe ʻana o ka ʻōpū
• Nā kahe koko ihu a i ʻole ke kahe koko liʻiliʻi e kū maʻalahi
• Nā loli i ka ʻono e hiki ke hoʻololi i ka ʻono o ka meaʻai

Hoʻomaikaʻi maʻamau kēia mau hopena ʻaoʻao i kēlā me kēia lā i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau, a he nui nā ala e kōkua ai kāu hui mālama ola e mālama iā lākou.

ʻO nā hopena ʻaoʻao maʻamau ʻole akā ʻoi aku ka koʻikoʻi e koi i ka lāʻau lapaʻau koke a komo pū:

• Ke kahe koko koʻikoʻi ʻaʻole e kū maʻalahi
• Nā koko koko e hiki ke hoʻoulu i ka ʻeha wāwae a i ʻole nā pilikia hanu
• Ke koko kiʻekiʻe koʻikoʻi me nā hōʻailona e like me ka ʻeha poʻo koʻikoʻi a i ʻole nā loli ʻike
• Nā pilikia kīkī e hiki ke hoʻoulu i ka pehu a i ʻole nā loli i ka mimi
• Nā pilikia puʻuwai e hiki ke hoʻoulu i ka ʻeha umauma a i ʻole ka pōkole o ka hanu
• ʻO ka perforation ʻōpū, e hoʻoulu ai i ka ʻeha ʻōpū nui

E nānā pono kāu hui lapaʻau iā ʻoe no kēia mau hopena koʻikoʻi a e aʻo iā ʻoe i nā hōʻailona ʻōlelo aʻo e nānā ai ma waena o nā lāʻau lapaʻau.

ʻO nā pilikia maʻamau akā koʻikoʻi e kū mai ana i kahi pākēneka liʻiliʻi o nā maʻi e komo pū:

• Nā pilikia hoʻōla ʻeha koʻikoʻi e hiki ke hoʻopaneʻe i ke ʻoki
• Reversible posterior leukoencephalopathy syndrome (RPLS), e hoʻopilikia i ka lolo
• Protein koʻikoʻi i ka mimi (proteinuria)
• ʻO ka puʻuwai puʻuwai congestive i ka poʻe me nā maʻi puʻuwai
• Nā hopena maʻi maʻi koʻikoʻi i ka wā o ka hoʻokomo ʻana

ʻOiai ke kani nei kēia mau hopena maʻamau, ua aʻo ʻia kāu hui mālama ola e ʻike a mālama iā lākou me ka wikiwiki inā loaʻa lākou.

ʻO wai ka mea pono ʻole e lawe iā Bevacizumab?

ʻAʻole palekana ʻo Bevacizumab no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ka ʻōlelo ʻana i kēia lapaʻau. ʻO kekahi mau maʻi olakino a i ʻole nā kūlana e hoʻoweliweli loa ai kēia lāʻau.

ʻAʻole pono ʻoe e loaʻa iā bevacizumab inā loaʻa iā ʻoe:

• Ka ʻoki ʻana i nā lā 28 i hala, no ka mea, hiki iā ia ke keakea i ka hoʻōla ʻana i ka ʻeha
• Ke kahe koko ikaika a i ʻole ka moʻolelo o nā maʻi kahe koko koʻikoʻi
• Ke koko kiʻekiʻe koʻikoʻi, ʻaʻole i mālama ʻia
• Ka puʻuwai a i ʻole ka hahau ʻana i ka lolo i hala
• Maʻi kīkī koʻikoʻi a i ʻole proteinuria
• ʻIke ʻia ka maʻi i ka bevacizumab a i ʻole nā lāʻau lapaʻau like

E mālama pū kāu kauka i ka mālama nui inā loaʻa iā ʻoe ka maʻi puʻuwai, nā maʻi hoʻopaʻa koko, a i ʻole ka moʻolelo o nā pilikia ʻōpū. ʻAʻole kēia mau kūlana e kāpae ʻakomi iā ʻoe mai ka lapaʻau ʻana, akā pono lākou i ka nānā ʻana.

Inā hāpai ʻoe a i ʻole e hānai ana i ka waiū, ʻaʻole ʻōlelo ʻia ʻo bevacizumab no ka mea hiki iā ia ke hōʻeha i kāu pēpē e ulu ana. E kūkākūkā kāu hui mālama ola i nā ʻano hana palekana inā he makahiki hānau keiki ʻoe.

Nā inoa inoa inoa o Bevacizumab

ʻIke nui ʻia ʻo Bevacizumab e kona inoa inoa ʻo Avastin, ʻo ia ka mana mua i hoʻomohala ʻia e Genentech. ʻO kēia ka inoa āu e lohe nui ai mai kāu hui mālama ola a ʻike ma kāu palapala lapaʻau.

Ua ʻae ʻia kekahi mau mana biosimilar o bevacizumab a loaʻa paha ma kāu kikowaena lapaʻau. Aia kēia mau mea iā Mvasi, Zirabev, a me Alymsys, e hana like ana me ka Avastin kumu.

Ua like loa nā Biosimilars me ka lāʻau lapaʻau kumu a loaʻa ka hopena a me ka palekana like. Hiki i kāu kauka a i ʻole ka mea kūʻai lāʻau lapaʻau ke hoʻohana i kekahi o kēia mau inoa i ke kūkākūkā ʻana i kāu lapaʻau, akā pili lākou a pau i ke ʻano like o ka lāʻau lapaʻau.

Nā koho ʻē aʻe o Bevacizumab

Inā ʻaʻole kūpono ʻo bevacizumab iā ʻoe a i ʻole e pau ka hana pono ʻana, he nui nā koho lapaʻau ʻē aʻe a kāu oncologist. ʻO ke koho maikaʻi loa e hilinaʻi ana i kāu ʻano maʻi maʻi kikoʻī a me kou kūlana olakino holoʻokoʻa.

ʻO nā mea pale angiogenesis ʻē aʻe e hana like ana, penei:

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• Ramucirumab (Cyramza) no nā maʻi maʻi ʻōpū a me ka māmā
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• Sunitinib (Sutent) no ka maʻi maʻi puʻupaʻa
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• Sorafenib (Nexavar) no nā maʻi maʻi ate a me ka puʻupaʻa
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• Pazopanib (Votrient) no ka maʻi maʻi puʻupaʻa
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Hiki nō hoʻi i kāu kauka ke noʻonoʻo i nā lāʻau immunotherapy, nā hui chemotherapy like ʻole, a i ʻole nā ​​pills therapy i manaʻo ʻia e pili ana i kou kūlana. He mau pōmaikaʻi a me nā hopena ʻaoʻao ko kēlā me kēia koho ʻē aʻe.

Hāʻawi pinepine nā hoʻokolohua lapaʻau i ke komo ʻana i nā lāʻau lapaʻau hou ʻaʻole i loaʻa ākea. Hiki i kāu oncologist ke kōkua iā ʻoe e ʻimi i kēia mau koho inā ʻaʻole kūpono nā lāʻau lapaʻau maʻamau.

Ua ʻoi aku ka maikaʻi o Bevacizumab ma mua o nā lāʻau maʻi maʻi ʻē aʻe?

ʻAʻole pono ʻo Bevacizumab i ʻoi aku ka maikaʻi a i ʻole ka ʻino ma mua o nā lāʻau maʻi maʻi ʻē aʻe, akā lawelawe ʻo ia i kahi kumu ʻokoʻa i kāu hoʻolālā lapaʻau. ʻOi aku ka maikaʻi o ka hui pū ʻana me nā lāʻau chemotherapy kuʻuna ma mua o ka hoʻohana ʻana wale nō.

I ka hoʻohālikelike ʻana me ka chemotherapy wale nō, hiki i ka hoʻohui ʻana i ka bevacizumab ke kōkua i ka hōʻemi ʻana i nā ʻōpū me ka ʻoi aku ka maikaʻi a i kekahi manawa e kōkua i nā kānaka e ola lōʻihi. Eia naʻe, hoʻohui pū ia i nā hopena ʻaoʻao e pono ai kāu hui lapaʻau e mālama pono.

ʻO ka lapaʻau

He Palekana anei ʻo Bevacizumab no ka poʻe me ka maʻi puʻuwai?

Pono ʻo Bevacizumab i ka mālama nui ʻana i ka poʻe me nā maʻi puʻuwai, akā ʻaʻole ia e kāpae ʻia. E hana pū kāu cardiologist a me ka oncologist e hoʻoholo inā ʻoi aku ka maikaʻi ma mua o nā pilikia no kāu kūlana.

Inā loaʻa iā ʻoe ka maʻi puʻuwai, e nānā pono kāu hui lapaʻau i kāu hana puʻuwai i ka wā o ka mālama ʻana. Hiki iā lākou ke hoʻoponopono i kāu dosage, hoʻonohonoho i nā nānā pinepine, a i ʻole e ʻōlelo i nā lāʻau lapaʻau e pale ai i ka puʻuwai me kāu mālama ʻana i ka maʻi maʻi.

He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o Bevacizumab?

He mea liʻiliʻi loa ka overdose o bevacizumab no ka mea e helu pono nā poʻe loea mālama ola a hāʻawi i kēlā me kēia mahele. Hāʻawi ʻia ka lāʻau lapaʻau me ka lohi ma o ka IV i ka wā e nānā ʻia nei ʻoe, e hana ana i ka overdose ulia pōpilikia kokoke i ka hiki ʻole.

Inā hopohopo ʻoe e pili ana i kāu dosage a i ʻole e ʻike i nā hōʻailona maʻamau ma hope o ka mālama ʻana, e hoʻokaʻaʻike koke i kāu hui oncology. Hiki iā lākou ke loiloi i kāu mau hōʻailona a hāʻawi i ka mālama kūpono inā pono.

He aha kaʻu e hana ai inā hala iaʻu kahi mahele o Bevacizumab?

Inā hala ʻoe i kahi manawa bevacizumab i hoʻonohonoho ʻia, e hoʻokaʻaʻike i kāu hui oncology i ka hiki wawe e hoʻonohonoho hou. E hoʻoholo lākou i ka manawa maikaʻi loa no kāu mahele aʻe e pili ana i kāu papa hana lapaʻau a me ka nui o ka manawa i hala.

Mai ho'āʻo e hoʻoponopono i nā mahele i hala ma ka hoʻonohonoho ʻana i nā lāʻau lapaʻau kokoke. E hoʻoponopono kāu hui lapaʻau i kāu hoʻolālā lapaʻau me ka palekana e hoʻihoʻi iā ʻoe i ke ala i ka wā e mālama ana i ka pono o ka lāʻau lapaʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Bevacizumab?

Pono ʻoe e hooki i ka mālama ʻana iā bevacizumab ma lalo o ke alakaʻi a kāu oncologist, ʻoiai inā ʻoe e ʻoi aku ka maikaʻi. He paʻakikī nā hoʻoholo lapaʻau maʻi maʻi a ua hoʻokumu ʻia ma nā hopena scan, nā hoʻokolohua koko, a me kāu pane holoʻokoʻa i ka therapy.

E loiloi mau kāu kauka inā e hoʻomau, hoʻololi, a i ʻole e hoʻōki i kāu lapaʻau ma muli o ka maikaʻi o kāna hana a me kou ʻae ʻana iā ia. Pono paha kekahi poʻe e hoʻōki ma muli o nā hopena ʻaoʻao, aʻo nā mea ʻē aʻe e hoʻomau no nā mahina he nui inā he maikaʻi ka lapaʻau.

Hiki iaʻu ke loaʻa nā lāʻau lapaʻau i ka wā e lawe ana i ka Bevacizumab?

He palekana ka hapa nui o nā lāʻau lapaʻau maʻamau i ka wā e loaʻa ana ka bevacizumab, akā pono ʻoe e nānā mau me kāu hui oncology mua. Hiki iā lākou ke ʻōlelo i ka manawa o nā lāʻau lapaʻau ma waena o nā pōʻai lapaʻau a i ʻole e pale i nā lāʻau lapaʻau ola i ka wā o kāu lapaʻau.

ʻAʻole paha e pane ikaika kou ʻōnaehana pale i nā lāʻau lapaʻau i ka wā e loaʻa ana ka lapaʻau maʻi maʻi, no laila e ʻōlelo paha kāu kauka i nā hana hou a i ʻole nā pana booster. E mālama i kāu hui lapaʻau i ka ʻike e pili ana i nā lāʻau lapaʻau āu e noʻonoʻo nei.