He aha ʻo Bevacizumab-tnjn: Nā Hoʻohana, Ka Leka, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

ʻO Bevacizumab-tnjn kahi lāʻau lapaʻau i manaʻo ʻia no ka maʻi ʻaʻai e kōkua ana i ka hoʻolohi ʻana i ka ulu ʻana o ka maʻi maʻi ma o ka pale ʻana i ka hana ʻana o nā kīʻaha koko. No ka papa o nā lāʻau lapaʻau i kapa ʻia he monoclonal antibodies kēia lāʻau lapaʻau, e hana ana e like me nā pōkā alakaʻi e ʻimi a hoʻouka i nā protein kikoʻī e pono ai nā sela maʻi ʻaʻai e ola a laha.

Hiki paha iā ʻoe ke manaʻo ua piha ʻoe i ka ʻike e pili ana i kēia lapaʻau, a he mea maʻamau loa ia. ʻO ka hoʻomaopopo ʻana i ka hana ʻana o kāu lāʻau lapaʻau hiki ke kōkua iā ʻoe e ʻoi aku ka hilinaʻi e pili ana i kāu hoʻolālā lapaʻau a me ka mea e manaʻo ai ma ke ala.

He aha ʻo Bevacizumab-tnjn?

ʻO Bevacizumab-tnjn kahi mana biosimilar o ka lāʻau lapaʻau bevacizumab mua. ʻO ka biosimilar ke ʻano he like loa ia me ka lāʻau mua e pili ana i ka palekana a me ka pono, akā ua hana ʻia e kahi mea hana ʻē aʻe e hoʻohana ana i nā kaʻina hana like ʻole.

ʻO kēia lāʻau lapaʻau he antibody i hana ʻia i ka hale hana e hoʻohālike i ka ʻōnaehana pale o kou kino. Hoʻopili pono ia i kahi protein i kapa ʻia ʻo VEGF (vascular endothelial growth factor), a nā maʻi e hoʻohana ai e hana i nā kīʻaha koko hou. Ma ka pale ʻana i kēia protein, hiki i ka lāʻau lapaʻau ke kōkua i ka pōloli ʻana i nā maʻi i nā meaʻai e pono ai lākou e ulu.

ʻO ka ʻāpana "-tnjn" o ka inoa he suffix wale nō e kōkua ana i ka hoʻokaʻawale ʻana i kēia biosimilar mai nā mea ʻē aʻe. E noʻonoʻo e like me ka inoa hope e kōkua ana i ka ʻike ʻana i ke ʻano kikoʻī o ka lāʻau lapaʻau āu e loaʻa nei.

No ke aha e hoʻohana ʻia ai ʻo Bevacizumab-tnjn?

Hoʻomaʻamaʻa ʻo Bevacizumab-tnjn i nā ʻano maʻi ʻaʻai like ʻole ma ka hoʻopā ʻana i ka lako koko e hānai ana i nā maʻi. Ua kauoha kāu kauka i kēia lāʻau lapaʻau no ka mea hiki ke kōkua i ka hoʻolohi ʻana i ka ulu ʻana o ka maʻi ʻaʻai a hiki ke hōʻemi i nā maʻi e kū nei.

Hoʻohana pinepine ʻia ka lāʻau lapaʻau no kēia mau ʻano maʻi ʻaʻai:

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• Ka maʻi 'aʻai kolorectal (ka maʻi 'aʻai o ka ʻōpū nui a i ʻole ka ʻōpū liʻiliʻi)
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• Ka maʻi 'aʻai o ka māmā, ʻoi loa ka maʻi 'aʻai o ka māmā ʻaʻole liʻiliʻi
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• Ka maʻi 'aʻai o ka puʻupaʻa (renal cell carcinoma)
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• Ka maʻi 'aʻai o ka ʻāʻī o ka ʻōpū
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• Ka maʻi 'aʻai o ka ʻōpū
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• Glioblastoma (he ʻano maʻi ʻaʻai lolo)
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E hui pinepine kāu kauka oncologist i ka bevacizumab-tnjn me nā lāʻau lapaʻau maʻi 'aʻai ʻē aʻe e like me ka chemotherapy. Hiki i kēia hui ʻana ke ʻoi aku ka maikaʻi ma mua o ka hoʻohana ʻana i kekahi lāʻau lapaʻau hoʻokahi wale nō, e hāʻawi ana iā ʻoe i ka manawa maikaʻi loa no ka hopena maikaʻi.

Pehea e hana ai ʻo Bevacizumab-tnjn?

Hana ʻo Bevacizumab-tnjn ma ka ʻoki ʻana i ka lako koko e pono ai nā ʻōpū e ulu a laha. ʻO kēia ka mea e lilo ai i lāʻau lapaʻau ikaika e hiki ke hoʻopilikia nui i ka holomua o ka maʻi 'aʻai ke hoʻohana pono ʻia.

Eia ke ʻano o ka hana ʻana o ke kaʻina hana ma nā huaʻōlelo maʻalahi. Hoʻokuʻu nā sela maʻi 'aʻai i kahi protein i kapa ʻia ʻo VEGF, e hōʻailona ana i kou kino e hana i nā kīʻaha koko hou a puni ka ʻōpū. Hana kēia mau kīʻaha koko hou e like me nā alaloa, e hāʻawi ana i ka oxygen a me nā meaʻai e kōkua i ka maʻi 'aʻai e ulu a laha i nā ʻāpana ʻē aʻe o kou kino.

Pale ʻo Bevacizumab-tnjn iā VEGF mai ka hoʻouna ʻana i kēia mau hōʻailona. Ke paʻa ka lāʻau lapaʻau i ka VEGF, pale ia i nā kīʻaha koko hou mai ka hana ʻana a puni ka ʻōpū. Me ka ʻole o kēia lako koko, paʻakikī ka ʻōpū i ka loaʻa ʻana o nā meaʻai e pono ai e hoʻomau i ka ulu.

Kapa ʻia kēia kaʻina hana he anti-angiogenesis, ʻo ia hoʻi ka

E hoʻokomo kāu hui mālama ola i kahi paipu liʻiliʻi (laina IV) i loko o kahi aa i kou lima a i ʻole e hoʻohana i kahi laina waena inā loaʻa iā ʻoe kekahi. Hoʻohui ʻia ka lāʻau lapaʻau me kahi wai paʻakai a hoʻokuʻu mālie ʻia i loko o kou kahe koko ma luna o 30 a 90 mau minuke. ʻO ka maʻamau, ʻoi aku ka lōʻihi o kāu hoʻokomo mua ʻana i ka wā e nānā ai kāu hui lapaʻau i ke ʻano o kou pane ʻana i ka lāʻau lapaʻau.

ʻAʻole pono ʻoe e lawe i kēia lāʻau lapaʻau me ka meaʻai a i ʻole e pale i ka ʻai ʻana ma mua. Eia naʻe, he mea kōkua ke noho maikaʻi i ka wai ma ka inu ʻana i ka wai nui ma mua a ma hope o kāu lapaʻau. Manaʻo kekahi poʻe he mea hōʻoluʻolu ke lawe mai i kahi mea ʻai, puke, a i ʻole papa e kōkua i ka hala ʻana o ka manawa i ka wā o ka hoʻokomo ʻana.

E hilinaʻi kāu papa hana lapaʻau i kāu ʻano maʻi maʻi kikoʻī a me ka hoʻolālā lapaʻau holoʻokoʻa. Loaʻa ka hapa nui o nā kānaka i nā infusions i kēlā me kēia 2 a 3 pule, akā e hoʻoholo kāu oncologist i ka manawa kūpono no kou kūlana.

Pehea ka lōʻihi e lawe ai au i ka Bevacizumab-tnjn?

ʻO ka lōʻihi o kāu lapaʻau bevacizumab-tnjn e hilinaʻi ana i ka maikaʻi o ka pane ʻana o kāu maʻi maʻi a me ke ʻano o kou kino e ʻae ai i ka lāʻau lapaʻau. Hoʻomau ka hapa nui o nā kānaka i ka lapaʻau no kekahi mau mahina, ʻoiai paha e pono kekahi no hoʻokahi makahiki a ʻoi aku paha.

E nānā mau kāu oncologist i kāu holomua ma o nā hoʻokolohua koko, nā kiʻi kiʻi, a me nā hoʻokolohua kino. Kōkua kēia mau loiloi e hoʻoholo inā e hana pono ana ka lāʻau lapaʻau a inā e ʻike nei ʻoe i nā hopena ʻaoʻao e pili ana.

Hoʻomau ka lapaʻau i ka wā e paʻa ai kāu maʻi maʻi a i ʻole e hoʻomaikaʻi a ʻaʻole ʻoe e ʻike i nā hopena ʻaoʻao koʻikoʻi. Hiki i kāu kauka ke ʻōlelo e hoʻōki i ka lāʻau lapaʻau inā hōʻike nā scans e holomua ana kāu maʻi maʻi me ka mālama ʻana, a i ʻole inā paʻakikī loa nā hopena ʻaoʻao e mālama.

He mea nui e hele i nā manawa a pau i hoʻonohonoho ʻia a mai hooki i ka lapaʻau ma kāu iho. Inā he mau hopohopo kāu e pili ana i ka hoʻomau ʻana i ka lapaʻau, e kūkākūkā ākea me kāu hui mālama ola. Hiki iā lākou ke kōkua i ka hoʻoponopono ʻana i kāu hoʻolālā lapaʻau a i ʻole e hāʻawi i ke kākoʻo hou e kōkua iā ʻoe i nā wā paʻakikī.

He aha nā hopena ʻaoʻao o Bevacizumab-tnjn?

Hiki i ka Bevacizumab-tnjn ke hana i nā hopena ʻaoʻao no ka mea e pili ana i ka hana ʻana o nā kīʻaha koko ma kou kino a pau, ʻaʻole wale nō a puni nā ʻōpū. ʻO ka hapa nui o nā kānaka e ʻike i kekahi mau hopena ʻaoʻao, akā hiki ke mālama ʻia ka nui me ka mālama kūpono a me ka nānā ʻana.

ʻO nā hopena ʻaoʻao maʻamau i ʻike ʻia e nā kānaka he nui, ʻo ia:

• Ke koko kiʻekiʻe (hypertension)
• Luhi a me ka nāwaliwali
• Pāpaʻa
• Hoʻemi ʻia ka ʻai
• Poʻo
• Nausea
• Protein i loko o ka mimi
• Nā kahe koko i ka ihu
• Nā loli i ka ʻono

E nānā pono kāu hui mālama ola i kou koko a hiki ke kauoha i ka lāʻau lapaʻau e mālama iā ia. E nānā mau lākou i kāu mimi e nānā i ka protein, hiki ke hōʻike i nā hopena o ka puʻupaʻa mai ka lapaʻau.

Pono kekahi mau hopena ʻaoʻao koʻikoʻi i ka lāʻau lapaʻau koke, ʻoiai ʻaʻole maʻamau. ʻO kēia mau mea e pili ana i ke kahe koko nui, nā koko koko, nā pilikia o ka naʻau, a me ka lohi o ka hoʻōla ʻana i ka ʻeha. E kūkākūkā kāu hui lapaʻau i kēia mau pilikia me ʻoe a wehewehe i nā hōʻailona e nānā ai.

Hiki i nā pilikia kakaʻikahi akā koʻikoʻi ke komo i ka perforation bowel (he lua i ka paia o ka ʻōpū), ke koko kiʻekiʻe nui, a i ʻole nā pilikia me ka hoʻōla ʻana i ka ʻeha ma hope o ke ʻoki ʻana. ʻOiai he mea weliweli kēia mau mea, ua ʻike kāu hui mālama ola i ka mālama ʻana i kēia mau pilikia a e nānā pono iā ʻoe i ka wā o ka lapaʻau.

ʻO wai ka mea pono ʻole e lawe iā Bevacizumab-tnjn?

ʻAʻole palekana ʻo Bevacizumab-tnjn no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. ʻO kekahi mau maʻi olakino a i ʻole nā kūlana e hoʻoweliweli loa ai kēia lāʻau lapaʻau.

ʻAʻole pono ʻoe e loaʻa i ka bevacizumab-tnjn inā loaʻa iā ʻoe kekahi o kēia mau maʻi:

• Ka ʻoki nui hou (i loko o nā lā 28 i hala)
• Nā pilikia koko nui a i ʻole nā maʻi koko
• ʻAʻole i mālama ʻia nā metastases lolo
• ʻO ka maʻi puʻuwai nui
• Ka puʻuwai puʻuwai a i ʻole ka hahau ʻana
• Hāpai a hānai ʻana paha
• ʻO ka maʻi kīkī nui

E makaʻala nō hoʻi kāu kauka i ka kuhikuhi ʻana i kēia lāʻau lapaʻau inā loaʻa iā ʻoe ke koko kiʻekiʻe i paʻakikī ke kāohi, ka mōʻaukala o nā koko koko, a i ʻole inā e hoʻolālā ana ʻoe e hana i ke ʻoki ʻana. ʻAʻole kēia mau maʻi e kāpae ʻakomi i ka mālama ʻana, akā pono lākou i ka nānā ʻana a me nā hana mālama.

Inā hāpai ʻoe a i ʻole hiki ke hāpai, he mea nui e kūkākūkā i nā koho hoʻomalu hānau me kāu hui mālama ola. Hiki i ka Bevacizumab-tnjn ke kumu i nā kīnā hānau koʻikoʻi, no laila he mea nui ka pale ʻana i ka hāpai ʻana i ka wā o ka mālama ʻana a no kekahi mau mahina ma hope.

Nā inoa inoa o Bevacizumab-tnjn

Kūʻai ʻia ʻo Bevacizumab-tnjn ma lalo o ka inoa inoa Mvasi ma ʻAmelika Hui Pū ʻIa. ʻO kēia ka mana biosimilar o ka lāʻau lapaʻau bevacizumab kumu, i kūʻai ʻia ma lalo o ka inoa inoa Avastin.

Hana like nā lāʻau lapaʻau ʻelua a loaʻa nā ʻano like a me nā palekana. ʻO ka ʻokoʻa nui ʻo ka Mvasi ka mea maʻamau i emi ke kumukūʻai ma mua o Avastin, hiki ke kōkua i ka hōʻemi ʻana i nā kumukūʻai lapaʻau.

Hiki i kāu hoʻolālā ʻinikua a i ʻole ke kikowaena lapaʻau ke makemake i kekahi mana ma luna o kekahi ma muli o ke kumukūʻai a i ʻole ka loaʻa. Hiki iā ʻoe ke manaʻoʻiʻo ua hala nā mana ʻelua i nā hoʻokolohua koʻikoʻi e hōʻoia i ka palekana a me ka pono no ka mālama ʻana i ka maʻi kanesa.

Nā koho ʻē aʻe o Bevacizumab-tnjn

Nui nā lāʻau lapaʻau ʻē aʻe e hana like me ka bevacizumab-tnjn ma ka hoʻopaʻa ʻana i ka hana ʻana o nā kīʻaha koko a puni nā ʻōpū. Hiki i kāu oncologist ke noʻonoʻo i kēia mau koho ʻē aʻe inā ʻaʻole kūpono ka bevacizumab-tnjn no kou kūlana.

ʻO nā lāʻau anti-angiogenesis ʻē aʻe e komo pū ana:

• Ramucirumab (Cyramza) - hoʻohana ʻia no ka maʻi ʻōpū, ka maʻi ʻāʻī, a me ka maʻi ate
• Aflibercept (Zaltrap) - hoʻohana ʻia no ka maʻi ʻaʻai kolorectal
• Sorafenib (Nexavar) - hoʻohana ʻia no ka maʻi kīkī a me ka maʻi ate
• Sunitinib (Sutent) - hoʻohana ʻia no ka maʻi kīkī a me kekahi mau ʻōpū ʻōpū

He ʻokoʻa nā ʻano hopena ʻaoʻao o kēlā me kēia lāʻau lapaʻau a ua ʻae ʻia no nā ʻano maʻi ʻaʻai like ʻole. E koho kāu oncologist i ke koho maikaʻi loa e pili ana i kāu ʻano maʻi ʻaʻai, ke olakino holoʻokoʻa, a me ka maikaʻi o kāu pane ʻana i nā lāʻau lapaʻau ma mua.

ʻO ke koho ʻana ma waena o kēia mau lāʻau lapaʻau e pili pinepine ana i nā mea e like me kāu hana kīkī, ke koko, a me ka pilikia o ke kahe ʻana. E hana pū kāu hui mālama ola me ʻoe e ʻimi i ka lāʻau lapaʻau e hāʻawi ana i ke kaulike maikaʻi loa o ka pono a me nā hopena ʻaoʻao hiki ke mālama ʻia.

Ua ʻoi aku ka maikaʻi o Bevacizumab-tnjn ma mua o Avastin?

Ua manaʻo ʻia ʻo Bevacizumab-tnjn (Mvasi) a me Avastin he mea pono like no ka mālama ʻana i ka maʻi ʻaʻai. Loaʻa i nā lāʻau lapaʻau ʻelua ka mea hana like a hana like i ke ala like e ālai i ka hana ʻana o nā kīʻaha koko a puni nā ʻōpū.

Ua hoʻoholo ka FDA he biosimilar ʻo bevacizumab-tnjn iā Avastin, ʻo ia hoʻi ʻaʻohe ʻokoʻa koʻikoʻi i ka palekana a i ʻole ka pono. Ua hōʻike nā haʻawina i ka poʻe e loaʻa ana i kekahi lāʻau lapaʻau he hopena like a me nā ʻano hopena ʻaoʻao.

ʻO ka pōmaikaʻi nui o bevacizumab-tnjn ʻo ke kumukūʻai. Ma ke ʻano he biosimilar, ʻoi aku ka liʻiliʻi o ke kumukūʻai ma mua o ka Avastin kumu, hiki ke hōʻemi nui i nā kumukūʻai lapaʻau no nā maʻi a me nā ʻōnaehana mālama ola.

E hilinaʻi paha kāu koho ʻana ma waena o kēia mau lāʻau lapaʻau i nā mea e like me ka uhi ʻinikua, nā makemake formulary haukapila, a me ka loaʻa. Hiki iā ʻoe ke manaʻoʻiʻo e hāʻawi nā koho ʻelua i nā pōmaikaʻi hakakā maʻi ʻaʻai like.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Bevacizumab-tnjn

He palekana anei ʻo Bevacizumab-tnjn no ka poʻe me ka maʻi puʻuwai?

Pono e noʻonoʻo pono ʻia ka Bevacizumab-tnjn inā he maʻi puʻuwai kou, akā ʻaʻole ia e kāpae ʻia. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i ke koko a hiki ke hoʻoluhi i ka puʻuwai, no laila pono e hana pū kāu cardiologist a me ka oncologist e nānā pono iā ʻoe.

E nānā paha kāu hui mālama ola i kāu hana puʻuwai ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a nānā mau i ka wā o kāu lāʻau lapaʻau. Hiki iā lākou ke hoʻoponopono i kāu mau lāʻau puʻuwai a i ʻole e hoʻololi i kāu papa hana lapaʻau e mālama iā ʻoe i ka palekana e like me ka hiki i ka wā e hakakā ana i kāu maʻi maʻi.

He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o ka Bevacizumab-tnjn?

ʻAʻole paha e loaʻa ka overdose o ka bevacizumab-tnjn no ka mea e hāʻawi ʻia ka lāʻau lapaʻau e nā poʻe loea mālama ola i nā wahi i mālama ʻia. Eia naʻe, inā manaʻo ʻoe ua loaʻa iā ʻoe ka nui o ka lāʻau lapaʻau, e haʻi koke i kāu hui mālama ola.

E nānā pono kāu hui lapaʻau iā ʻoe no nā hopena ʻaoʻao a hiki ke hoʻoponopono i kāu papa hana lapaʻau. ʻAʻohe antidote kikoʻī no ka bevacizumab-tnjn, no laila e kālele ana ka lāʻau lapaʻau i ka mālama ʻana i nā hōʻailona e ulu ana a me ke kākoʻo ʻana i nā hana hoʻōla maoli o kou kino.

He aha kaʻu e hana ai inā hala iaʻu kahi mahele o Bevacizumab-tnjn?

Inā hala ʻoe i kahi infusion i hoʻonohonoho ʻia, e hoʻokaʻaʻike i kāu hui mālama ola i ka hiki wawe e hoʻonohonoho hou. Mai kali a hiki i kāu manawa i hoʻonohonoho mau ʻia, no ka mea, he mea nui ka mālama ʻana i ka manawa lapaʻau kūlike no ka pono o ka lāʻau lapaʻau.

Na kāu oncologist e hoʻoholo i ke ala maikaʻi loa e hoʻihoʻi ai i kāu lāʻau lapaʻau i ka papa. Hiki iā lākou ke hoʻoponopono i ka manawa o nā mahele e hiki mai ana a i ʻole e hoʻololi i kāu hoʻolālā lapaʻau e hōʻoia e hoʻomau ʻoe i ka loaʻa ʻana o ka pōmaikaʻi piha o ka lāʻau lapaʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Bevacizumab-tnjn?

Pono ʻoe e hoʻomau i ka lawe ʻana i ka bevacizumab-tnjn no ka lōʻihi e like me ka ʻōlelo a kāu kauka oncologist, ʻoiai inā e hoʻomaka ana ʻoe e maikaʻi. Hana ka lāʻau lapaʻau e kāohi i ka ulu ʻana o ka maʻi kanesa, a ʻo ka hooki ʻana i ka wā mua e hiki ai i ka maʻi kanesa ke holomua wikiwiki.

Na kāu kauka e hoʻoholo i ka manawa e hooki ai i ka lāʻau lapaʻau ma muli o ka maikaʻi o ka pane ʻana o kāu maʻi kanesa, inā e ʻike ana ʻoe i nā hopena ʻaoʻao nui, a me kou kūlana olakino holoʻokoʻa. E hoʻohana lākou i nā scans maʻamau, nā hoʻokolohua koko, a me nā hoʻokolohua kino e hana i kēia hoʻoholo.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Bevacizumab-tnjn?

ʻAe ʻia ka inu ʻana i ka waiʻona i ka wā e loaʻa ana ka bevacizumab-tnjn, akā he mea nui e kūkākūkā i kēia me kāu hui mālama ola. Hiki i ka waiʻona ke hoʻonui i kekahi mau hopena ʻaoʻao e like me ke koko kiʻekiʻe a hiki ke hoʻopilikia i ka hiki o kou kino ke hoʻōla.

Hiki i kāu kauka oncologist ke ʻōlelo e kaupalena i ka inu ʻana i ka waiʻona, ʻoiai inā e ʻike ana ʻoe i nā hopena ʻaoʻao e like me ke koko kiʻekiʻe a i ʻole inā e loaʻa ana ʻoe i nā lāʻau lapaʻau ʻē aʻe ʻaʻole i hui pū me ka waiʻona. Hiki iā lākou ke hāʻawi i ke alakaʻi pilikino e pili ana i kāu kūlana kikoʻī a me ka hoʻolālā lapaʻau holoʻokoʻa.