He aha ʻo Bexarotene: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

ʻO Bexarotene kahi lāʻau lapaʻau maʻi i manaʻo ʻia e pili ana i kahi papa o nā lāʻau i kapa ʻia he retinoids, e pili ana i ka huaora A. Hana ia ma ka hoʻolohi ʻana i ka ulu ʻana o kekahi mau sela maʻi, ʻo ia hoʻi nā mea i loaʻa i ka cutaneous T-cell lymphoma (CTCL), kahi ʻano maʻi e pili ana i ka ʻili.

He koho lapaʻau nui kēia lāʻau lapaʻau no ka poʻe e hana nei me nā pae holomua o CTCL i ka wā i hana ʻole ai nā lāʻau lapaʻau ʻē aʻe. ʻOiai e koi ana i ka nānā pono ʻana, ua kōkua ʻo bexarotene i nā maʻi he nui e mālama i ko lākou maʻi a hoʻomaikaʻi i ko lākou ola.

No ke aha e hoʻohana ʻia ai ʻo Bexarotene?

Hoʻohana nui ʻia ʻo Bexarotene e mālama i ka cutaneous T-cell lymphoma, ʻo ia hoʻi no nā maʻi i holomua ai kā lākou maʻi maʻi me ka hoʻāʻo ʻana i hoʻokahi lāʻau lapaʻau ʻē aʻe. ʻO CTCL kahi ʻano o ka non-Hodgkin's lymphoma e hoʻomaka ana i nā sela immune i kapa ʻia ʻo T-cells a pili nui i ka ʻili.

Hiki i kāu kauka ke ʻōlelo aku iā bexarotene ke loaʻa iā ʻoe ka CTCL holomua e hōʻike ana i nā ʻeha ʻili mau, nā pā, a i ʻole nā ​​tumora. He mea kōkua nui ka lāʻau lapaʻau no nā maʻi i lilo i mea kūʻē i nā lāʻau lapaʻau ʻē aʻe e like me nā lāʻau lapaʻau topical, radiation, a i ʻole nā ​​lāʻau lapaʻau ʻōnaehana ʻē aʻe.

I kekahi mau hihia, hiki i nā kauka ke kuhikuhi i ka bexarotene no nā ʻano maʻi ʻē aʻe a i ʻole nā ​​maʻi ʻili, ʻoiai e manaʻo ʻia kēia he hoʻohana ʻole ʻia. E loiloi pono kāu mea mālama ola inā kūpono kēia lāʻau lapaʻau no kāu kūlana.

Pehea e hana ai ʻo Bexarotene?

Hana ʻo Bexarotene ma ka hoʻopaʻa ʻana i nā mea hoʻokipa kūikawā i nā sela maʻi i kapa ʻia he retinoid X receptors (RXRs). Ke pili ia i kēia mau mea hoʻokipa, hoʻomaka ia i nā loli e hiki ke hoʻolohi a hoʻōki paha i ka ulu ʻana o nā T-cells maʻi.

E manaʻo e like me ke kī e komo ana i loko o kahi laka kūikawā i loko o nā pūnaewele maʻi ʻaʻai. Ke huli ke kī i ka laka, hoʻouna ia i nā hōʻailona e hiki ke hoʻōki i ka hoʻonui ʻana o nā pūnaewele maʻamau a i ʻole e make maoli.

Ua manaʻo ʻia kēia lāʻau lapaʻau he ikaika ma waena o nā lāʻau lapaʻau maʻi ʻaʻai. ʻOiai ʻaʻole ikaika e like me ka chemotherapy, pono nō naʻe ka nānā pono ʻana no ka mea hiki iā ia ke hoʻopilikia i nā ʻōnaehana ʻē aʻe i loko o kou kino, ʻo ia hoʻi kou pae lipid a me ka hana thyroid.

Pehea e lawe ai au i ka Bexarotene?

E lawe i ka bexarotene e like me ke kauoha a kāu kauka, maʻamau hoʻokahi manawa i ka lā me ka ʻai a i ʻole ma hope koke o ka ʻai ʻana i ka mea momona. Kōkua ka momona i kāu ʻai i kou kino e komo i ka lāʻau lapaʻau me ka maikaʻi, e hana maikaʻi ai.

E ale i nā capsules holoʻokoʻa me ke aniani wai piha. Mai ʻoki, nau, a wehe paha i nā capsules, no ka mea, hiki i kēia ke hoʻopilikia i ke ʻano o ka hoʻokuʻu ʻia ʻana o ka lāʻau lapaʻau i loko o kou kino.

E hoʻāʻo e lawe i kāu lāʻau i ka manawa like i kēlā me kēia lā e kōkua iā ʻoe e hoʻomanaʻo a mālama i nā pae paʻa o ka lāʻau lapaʻau i loko o kāu ʻōnaehana. Inā pono ʻoe e ʻai i kekahi mea ma mua o ka lawe ʻana, e koho i nā meaʻai i loaʻa i kekahi momona, e like me nā nati, ka paʻakai, a i ʻole nā ​​meaʻai i kuke ʻia me ka ʻaila.

Pehea ka lōʻihi e lawe ai au i ka Bexarotene?

ʻO ka lōʻihi o ka mālama ʻana i ka bexarotene e ʻokoʻa loa mai kēlā kanaka i kēia kanaka, ma muli o ke ʻano o ka pane ʻana o kāu maʻi ʻaʻai a me ka maikaʻi o kou hoʻomanawanui ʻana i ka lāʻau lapaʻau. Hiki i kekahi poʻe maʻi ke lawe iā ia no nā mahina he nui, a pono paha kekahi poʻe i nā makahiki.

E loiloi mau kāu kauka i kāu pane ʻana i ka lāʻau lapaʻau ma o nā hoʻokolohua kino, nā hoʻokolohua koko, a me ka nānā ʻana i kou mau ʻeha ʻili. E ʻimi lākou i nā hōʻailona e pane ana ka maʻi ʻaʻai, e noho paʻa ana, a i ʻole e holomua ana.

He mea nui e hoʻomau i ka lawe ʻana i ka bexarotene inā ʻaʻole ʻoe e ʻike i nā hoʻomaikaʻi koke. Lawe pinepine nā lāʻau lapaʻau maʻi ʻaʻai i ka manawa e hōʻike i kā lākou hopena piha, a ʻo ka hoʻōki ʻana i ka wā mua e hiki ai i ka maʻi ʻaʻai ke ulu hou.

He aha nā hopena ʻaoʻao o ka Bexarotene?

E like me nā lāʻau lapaʻau a pau, hiki i ka bexarotene ke hana i nā hopena ʻē aʻe, ʻoiai ʻaʻole e ʻike nā mea a pau iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻē aʻe me ka nānā pono ʻana a me ke kākoʻo mai kāu hui mālama ola.

Eia nā hopena ʻē aʻe maʻamau e hiki iā ʻoe ke ʻike:

• Cholesterol kiʻekiʻe a me nā triglycerides (maʻamau loa)
• Nā pae hormone thyroid haʻahaʻa (hypothyroidism)
• Nā poʻo
• Nāwaliwali a i ʻole ka luhi
• Pāpaʻa ʻili a i ʻole ka ʻili maloʻo
• Nausea
• Maʻi
• ʻEha ʻōpū

E nānā kāu kauka i kāu mau pae lipid koko a me ka hana thyroid i nā manawa maʻamau, e kauoha pinepine ana i nā lāʻau lapaʻau hou e mālama i kēia mau hopena inā pono.

ʻO kekahi mau hopena ʻē aʻe akā ʻoi aku ka koʻikoʻi e hiki ke komo:

• Hoʻonui nui ʻia i nā momona koko e hiki ke alakaʻi i ka pancreatitis
• Hāʻule nui i nā helu keʻokeʻo koko
• Nā loli hana ate
• Cataracts (me ka hoʻohana lōʻihi)
• Kaumaha a i ʻole nā loli o ke ʻano

E kelepona koke i kāu kauka inā ʻike ʻoe i ka ʻeha nui o ka ʻōpū, ka luaʻi mau, nā hōʻailona o ka maʻi e like me ke kuni, a i ʻole nā loli koke i kou ʻike a i ʻole ke ʻano.

ʻO wai ka mea ʻaʻole pono e lawe i ka Bexarotene?

ʻAʻole kūpono ʻo Bexarotene no nā mea a pau, a ʻo kekahi mau kūlana e palekana ʻole ai ka hoʻohana ʻana i kēia lāʻau lapaʻau. E nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana.

ʻAʻole pono ʻoe e lawe i ka bexarotene inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, no ka mea, hiki iā ia ke hana i nā kīnā hānau koʻikoʻi. Pono nā wahine o ka makahiki hānau ke hoʻohana i ka contraception kūpono a loaʻa nā hoʻokolohua hāpai maikaʻi ʻole ma mua o ka hoʻomaka ʻana i ka mālama ʻana.

ʻAʻole hiki i nā poʻe me nā kūlana aʻe ke lawe palekana i ka bexarotene:

• Hāpai a i ʻole ka hānai ʻana
• Maʻi ate koʻikoʻi
• ʻAʻole i hoʻomalu ʻia ka cholesterol kiʻekiʻe a i ʻole nā triglycerides
• Mōʻaukala o ka pancreatitis
• Maʻi kīkī koʻikoʻi
• ʻIke ʻia ka maʻi i nā retinoids a i ʻole bexarotene

E makaʻala nō hoʻi kāu kauka i ka ʻōlelo ʻana i ka bexarotene inā he maʻi maʻi ʻoe, nā pilikia thyroid, a i ʻole ka mōʻaukala o ke kaumaha, no ka mea, hiki i ka lāʻau lapaʻau ke hoʻopilikia i kēia mau maʻi.

Nā inoa inoa inoa o Bexarotene

Loaʻa ka Bexarotene ma lalo o ka inoa inoa Targretin ma ʻAmelika Hui Pū ʻIa. ʻO kēia ke ʻano i kauoha pinepine ʻia o ka bexarotene waha.

Hele mai ka lāʻau lapaʻau i loko o nā capsules 75mg, a e hoʻoholo kāu kauka i ka mahele kūpono e pili ana i kou wahi kino a me ka pane ʻana i ka lāʻau. E hoʻohana mau i ka inoa inoa a i ʻole ka mana generic i kauoha kūikawā ʻia e kāu kauka.

Nā koho ʻē aʻe o Bexarotene

Inā ʻaʻole kūpono ka bexarotene iā ʻoe a i ʻole e pau ka hana ʻana, aia kekahi mau koho lapaʻau ʻē aʻe no ka lymphoma T-cell cutaneous. Hiki i kāu kauka ke noʻonoʻo i kēia mau koho ʻē aʻe e pili ana i kāu kūlana.

ʻO nā lāʻau lapaʻau ʻōnaehana ʻē aʻe no CTCL e komo pū ana:

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• Romidepsin (Istodax) - he mea hoʻopaʻa i ka histone deacetylase
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• Vorinostat (Zolinza) - he mea hoʻopaʻa i ka histone deacetylase
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• Mogamulizumab (Poteligeo) - he antibody monoclonal
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• Methotrexate - he lāʻau chemotherapy
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• Interferon alfa - he immunotherapy
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Hiki nō hoʻi nā lāʻau lapaʻau topical e like me ka mechlorethamine gel a i ʻole ka radiation therapy ma muli o ka nui a me kahi o kāu maʻi kanesa. E kōkua kāu oncologist iā ʻoe e hoʻomaopopo i nā koho ʻē aʻe e hana maikaʻi loa no kāu hihia.

ʻOi aku ka maikaʻi o ka Bexarotene ma mua o nā lāʻau lapaʻau CTCL ʻē aʻe?

Hāʻawi ka Bexarotene i nā pono kūikawā i hoʻohālikelike ʻia me nā lāʻau lapaʻau CTCL ʻē aʻe, akā inā he

Eia naʻe, ua hōʻike nā lāʻau lapaʻau hou e like me ka mogamulizumab i nā hopena maikaʻi i nā hoʻokolohua lapaʻau, a hiki i kekahi poʻe maʻi ke pane maikaʻi i nā lāʻau lapaʻau hui pū. E noʻonoʻo kāu kauka i nā mea e like me kou olakino holoʻokoʻa, nā lāʻau lapaʻau i hala, a me nā ʻano maʻi maʻi kikoʻī i ka wā e hoʻoholo ai i ke ala maikaʻi loa no ʻoe.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Bexarotene

He Palekana anei ʻo Bexarotene no ka poʻe me ka maʻi diabetes?

Hiki ke hoʻohana ʻia ʻo Bexarotene i ka poʻe me ka maʻi diabetes, akā pono ia i ka nānā ʻana no ka mea hiki i ka lāʻau lapaʻau ke hoʻopilikia i nā pae kōpaʻa koko a hiki ke hoʻonui i ka maikaʻi ʻole o ka maʻi diabetes. E hana pū kāu kauka me ʻoe e nānā pinepine i kou kōpaʻa koko.

Hiki i ka lāʻau lapaʻau ke hoʻonui i nā triglycerides, he mea e hopohopo nui ai no ka poʻe me ka maʻi diabetes i loaʻa mua i ka pilikia nui o ka maʻi puʻuwai. Pono paha kāu hui mālama ola kino e hoʻoponopono i kāu mau lāʻau lapaʻau diabetes a i ʻole e hoʻohui i nā lāʻau lapaʻau e mālama i kou pae lipid.

He aha kaʻu e hana ai inā ua lawe hewa au i ka nui o Bexarotene?

Inā ua lawe hewa ʻoe i ka nui o ka bexarotene ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka a i ʻole ke kikowaena mana ʻawa. Mai kali e ʻike inā e loaʻa iā ʻoe nā hōʻailona, ​​no ka mea, ʻaʻole paha e ʻike koke ʻia nā hopena o ka overdose.

Hiki i ka overdose o ka bexarotene ke alakaʻi i ka piʻi nui ʻana o ka cholesterol a me nā triglycerides, e hiki ai ke hoʻoulu i nā pilikia weliweli e like me ka pancreatitis. Makemake paha kāu kauka e nānā pono iā ʻoe a i ʻole e hana i nā hoʻokolohua koko e nānā i kou pae lipid.

He aha kaʻu e hana ai inā ua hala au i kahi mahele o Bexarotene?

Inā ua hala ʻoe i kahi mahele o ka bexarotene, e lawe iā ia i ka wā e hoʻomanaʻo ai ʻoe, inā he mau hola ma hope o kou manawa maʻamau. Eia naʻe, inā kokoke ka manawa no kāu mahele aʻe, e lele i ka mahele i hala a e hoʻomau me kāu papa manawa maʻamau.

Mai lawe i nā lāʻau ʻelua i ka manawa hoʻokahi e pani ai i ka lāʻau i hala, no ka mea, hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao. Inā poina pinepine ʻoe i nā lāʻau, e noʻonoʻo e hoʻonohonoho i kahi ʻōhua i kēlā me kēia lā a i ʻole e hoʻohana i kahi mea hoʻonohonoho pila e kōkua iā ʻoe e hoʻomanaʻo.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Bexarotene?

E hooki wale i ka lawe ʻana iā bexarotene ke haʻi aku kāu kauka iā ʻoe e hana pēlā. ʻOiai inā e hoʻomaikaʻi a nalo paha nā maʻi o kou ʻili, ʻo ka hooki ʻana i ka lāʻau i ka wā mua loa e hiki ai i ka maʻi kanesa ke hoʻi mai a i ʻole e holomua.

E loiloi mau kāu kauka i kāu pane ʻana i ka lāʻau a hiki ke hoʻoholo e hooki i ka bexarotene inā e holomua ana kāu maʻi kanesa me ka lāʻau, inā e loaʻa iā ʻoe nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia, a i ʻole inā e loaʻa iā ʻoe kahi hoʻōla mau. E alakaʻi lākou iā ʻoe ma nā loli i kāu hoʻolālā lapaʻau.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana iā Bexarotene?

ʻOi aku ka maikaʻi e kaupalena a pale paha i ka waiʻona i ka wā e lawe ana iā bexarotene, ʻoiai hiki i ka lāʻau ke hoʻonui i nā pae triglyceride a pili i ka hana o ke ake. Hiki i ka waiʻona ke hoʻonui i kēia mau hopena a hiki ke hoʻonui i kou pilikia o ka hoʻomohala ʻana i ka pancreatitis.

Inā koho ʻoe e inu i ka waiʻona i kekahi manawa, e kūkākūkā mua me kāu kauka. Hiki iā lākou ke ʻōlelo e pale loa i ka waiʻona a i ʻole e kaupalena iā ia i nā mea liʻiliʻi loa, ma muli o kou olakino holoʻokoʻa a me ke ʻano o kou pane ʻana i ka lāʻau.