He aha ʻo Bezlotoxumab: Nā Hoʻohana, Nā Kumu, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

He lāʻau lapaʻau antibody kūikawā ʻo Bezlotoxumab i hoʻolālā ʻia e pale i ka hoʻi ʻana mai o kahi maʻi ʻōpū weliweli. Inā ʻoe e hana nei me nā maʻi Clostridioides difficile (C. diff), hiki i kāu kauka ke ʻōlelo i kēia lapaʻau e kōkua iā ʻoe e pale aku i nā hanana e hiki mai ana.

Hana ʻokoʻa kēia lāʻau lapaʻau mai nā lāʻau antibiotic maʻamau. Ma kahi o ka pepehi pololei ʻana i ka bacteria, kōkua ia i kāu ʻōnaehana pale e ʻike a hakakā i nā mea ʻawaʻawa e hana ai i nā maʻi C. diff i mea pōʻino. E noʻonoʻo e like me ka hāʻawi ʻana i nā pale kūlohelohe o kou kino i kahi hoʻoikaika kōkua ke pono lākou.

He aha ʻo Bezlotoxumab?

ʻO Bezlotoxumab kahi monoclonal antibody e kuhikuhi ana i ka toxin B i hana ʻia e ka bacteria Clostridioides difficile. Hele mai kēia lāʻau lapaʻau ma ke ʻano he infusion intravenous, ʻo ia hoʻi, hāʻawi pololei ʻia i loko o kou kahe koko ma o ka vein.

No kahi papa lāʻau i kapa ʻia ʻo monoclonal antibodies ka lāʻau lapaʻau. ʻO kēia nā protein i hana ʻia i ka hale hana e hoʻohālike i ka hiki o kāu ʻōnaehana pale e hakakā i nā mea pōʻino. Hoʻopaʻa kūikawā ʻo Bezlotoxumab a hoʻopau i ka toxin e hana ai i nā hōʻailona koʻikoʻi loa o nā maʻi C. diff.

ʻAʻole like me nā antibiotics e pepehi i ka bacteria, hana ʻo bezlotoxumab ma ka pale ʻana i nā hopena pōʻino o nā toxins bacterial. Kōkua kēia ala e hōʻemi i ka pilikia o ka hoʻi ʻana mai o nā maʻi i ka wā e ʻae ai i kāu bacteria ʻōpū maʻamau e ola hou.

No ke aha e hoʻohana ʻia ai ʻo Bezlotoxumab?

Hoʻohana ʻia ʻo Bezlotoxumab e hōʻemi i ka hiki ʻana mai o ka maʻi Clostridioides difficile i nā pākeke i pilikia nui i ka hoʻi ʻana mai. E ʻōlelo maʻamau kāu kauka i kēia lāʻau lapaʻau inā e loaʻa ana iā ʻoe ka lapaʻau antibiotic no C. diff a loaʻa kekahi mau mea pilikia.

He mea kōkua nui kēia lāʻau lapaʻau no ka poʻe i loaʻa i nā maʻi C. diff he nui ma mua. Hōʻike nā haʻawina ma kahi o 20-30% o ka poʻe e ola ana mai hoʻokahi maʻi C. diff e loaʻa hou kekahi i loko o kekahi mau mahina. Hiki i ka Bezlotoxumab ke hoʻemi nui i kēia pilikia.

Ua manaʻo ʻia ka lāʻau lapaʻau no nā maʻi ma luna o 65 mau makahiki, loaʻa nā ʻōnaehana pale i hoʻopilikia ʻia, a i ʻole nā ​​maʻi olakino koʻikoʻi. ʻO kēia mau mea e hiki ai i nā maʻi C. diff ke hoʻi mai a lilo paha i mea koʻikoʻi.

Pehea e hana ai ʻo Bezlotoxumab?

Hana ʻo Bezlotoxumab ma ka ʻimi ʻana a me ka hoʻopau ʻana i ka toxin B, kekahi o nā mea ʻino nui i hana ʻia e ka bacteria C. diff. ʻO kēia toxin ke kuleana no ka mumū a me ka pōʻino e hana ʻia i loko o kou ʻōpū i ka wā o ka maʻi.

Ke loaʻa iā ʻoe ka bezlotoxumab, e hele ana kēia mau antibodies kūikawā i loko o kou kahe koko a paʻa i nā molekala toxin B. Ma ka hoʻopili ʻana i ka toxin, pale nā ​​antibodies iā ia mai ka hōʻino ʻana i kāu mau cell intestinal a me ke kumu o nā hōʻailona e pili ana me nā maʻi C. diff.

Ua manaʻo ʻia he lāʻau lapaʻau pale ikaika. ʻOiai ʻaʻole ia e pepehi pololei i ka bacteria, hāʻawi ia i ka pale nui mai nā toxins e hana ai i ka pōʻino nui. Hiki ke mau nā hopena no kekahi mau mahina, e hāʻawi ana i kou kino i ka manawa e hoʻihoʻi ai i ke kaulike bacteria gut olakino.

Pehea e lawe ai au i ka Bezlotoxumab?

Hāʻawi ʻia ʻo Bezlotoxumab ma ke ʻano he infusion intravenous hoʻokahi i loko o kahi hoʻonohonoho mālama ola e like me ka haukapila a i ʻole ke kikowaena infusion. Hoʻohui ʻia ka lāʻau lapaʻau me ka hopena saline a hāʻawi mālie ʻia ma kahi o 60 mau minuke ma o ka laina IV i kou lima.

ʻAʻole pono ʻoe e hoʻokē ʻai ma mua o ka loaʻa ʻana o ka bezlotoxumab, a ʻaʻohe kapu meaʻai kikoʻī. Eia naʻe, he mea kōkua ke ʻai i ka meaʻai māmā ma mua e pale aku i ka nausea i ka wā o ka infusion. Manaʻo ʻia hoʻi e noho maikaʻi i ka wai ma ka inu ʻana i ka wai nui.

E hāʻawi ʻia ka hoʻokomo ʻana i ka wā e lawe ana ʻoe i nā lāʻau antibiotic no kāu maʻi C. diff i kēia manawa. E nānā pono kāu hui mālama ola iā ʻoe i ka wā a ma hope o ka mālama ʻana e nānā i nā hopena. Hiki i ka hapa nui o nā kānaka ke hele i ka home i ka lā hoʻokahi ma hope o kahi manawa nānā pōkole.

Pehea ka lōʻihi e lawe ai au i ka Bezlotoxumab?

Hāʻawi ʻia ʻo Bezlotoxumab ma ke ʻano he lāʻau lapaʻau hoʻokahi, ʻaʻole ma ke ʻano he lāʻau lapaʻau e hoʻomau nei. E loaʻa iā ʻoe kahi hoʻokomo hoʻokahi e hāʻawi ana i ka pale no kekahi mau mahina ma hope o kāu mālama ʻana i ka maʻi C. diff i kēia manawa.

ʻO ka hopena pale e mau ana no kahi o 12 pule ma hope o ka hoʻokomo ʻana. I kēia manawa, e mau ana nā antibodies i loko o kāu ʻōnaehana, e kōkua ana e pale i ka toxin B mai ka hana ʻana i kahi maʻi ʻē aʻe inā ʻoe e hōʻike hou ʻia i ka bacteria C. diff.

E nānā kāu kauka i kāu hoʻōla a hiki ke ʻōlelo aku i nā hana pale hou aʻe ma mua o ka manawa 12-pule. Eia naʻe, ʻaʻole pono ka hapa nui o nā kānaka i nā mahele hou o bezlotoxumab ke ʻole lākou e hoʻomohala i kahi maʻi C. diff i ka wā e hiki mai ana.

He aha nā hopena ʻaoʻao o Bezlotoxumab?

Hoʻomanawanui ka hapa nui o nā kānaka i ka bezlotoxumab, akā e like me nā lāʻau lapaʻau, hiki iā ia ke hana i nā hopena ʻaoʻao. ʻO nā hopena maʻamau ka maʻamau a hana i ka wā a i ʻole ma hope koke o ka hoʻokomo ʻana.

Eia nā hopena ʻaoʻao āu e ʻike ai, me ka noʻonoʻo ʻana ʻaʻole pilikia ka nui o nā kānaka:

• Nausea a me ka luhi - ʻO kēia nā hopena ʻaoʻao i hōʻike pinepine ʻia, e pili ana i ka 7-8% o nā maʻi
• Fiva a me ke poʻo - Hiki ke hana i ka wā a i ʻole i loko o kekahi mau hola o ka hoʻokomo ʻana
• Dizziness - Maʻamau ka maʻalahi a me ka manawa
• Nā hopena pūnaewele injection - ʻO ka ʻulaʻula, ka pehu, a i ʻole ka ʻoluʻolu kahi i waiho ʻia ai ka IV

Hiki i nā hopena ʻaoʻao koʻikoʻi akā kakaʻikahi ke komo i nā pilikia o ka naʻau, ʻoi aku hoʻi inā he maʻi puʻuwai kou. E nānā kāu hui mālama ola i kou helu puʻuwai a me ke koko i ka wā o ka hoʻokomo ʻana e ʻike koke i nā loli e pili ana.

ʻAʻole maʻamau nā hopena maʻi i ka bezlotoxumab akā hiki nō. Hiki i nā hōʻailona ke komo i ka pilikia o ka hanu ʻana, ka pehu ʻana o ka maka a i ʻole ka ʻāʻī, a i ʻole nā hopena ʻili koʻikoʻi. ʻO ia ke kumu e nānā pono ʻia ai ʻoe i ka wā a ma hope o kāu lapaʻau.

ʻO wai ka mea ʻaʻole pono e lawe iā Bezlotoxumab?

ʻAʻole kūpono ʻo Bezlotoxumab no nā mea a pau, a e nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ka ʻōlelo ʻana i kēia lapaʻau. ʻAʻole i ʻae ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana i nā keiki ma lalo o 18 mau makahiki.

Pono paha ka poʻe me kekahi mau maʻi puʻuwai i ka noʻonoʻo kūikawā a i ʻole ʻaʻole paha he moho no kēia lapaʻau. Inā he puʻuwai puʻuwai congestive a i ʻole ka mōʻaukala o nā pilikia o ka puʻuwai koʻikoʻi, e kaupaona kāu kauka i nā pōmaikaʻi e kūʻē i nā pilikia hiki ke hana.

Pono ʻoe e haʻi i kāu kauka e pili ana i nā hopena maʻi i nā lāʻau lapaʻau, ʻoi aku hoʻi i nā antibodies monoclonal ʻē aʻe. ʻOiai he kakaʻikahi, hiki i kekahi poʻe ke maʻi i nā mea i loko o bezlotoxumab, e hoʻolilo ana i ka lapaʻau i palekana ʻole.

Pono nā wahine hāpai a i ʻole e hānai ana i ka waiū e kūkākūkā i nā pilikia a me nā pōmaikaʻi me kā lākou mea mālama ola. ʻOiai he palena ka ʻikepili e pili ana i ka hoʻohana ʻana i ka bezlotoxumab i ka wā hāpai, hiki i kāu kauka ke kōkua i ka hoʻoholo inā ʻoi aku ka maikaʻi ma mua o nā pilikia e hiki mai ana no ʻoe a me kāu pēpē.

ʻO ka inoa inoa o Bezlotoxumab

Loaʻa ʻo Bezlotoxumab ma lalo o ka inoa inoa ʻo Zinplava. ʻO kēia wale nō ka inoa inoa i loaʻa i kēia manawa no kēia lāʻau lapaʻau ma ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe.

Hana ʻia ʻo Zinplava e Merck a ua ʻae ʻia e ka FDA i ka makahiki 2016. ʻAʻohe mana generic o bezlotoxumab i loaʻa i kēia manawa, no laila ʻo Zinplava wale nō ke koho inā kuhikuhi kāu kauka i kēia lapaʻau.

Hiki ke ʻokoʻa kāu ʻinikua no nā lāʻau lapaʻau inoa inoa e like me Zinplava. He mea pono ke nānā me kāu mea hoʻolako ʻinikua e pili ana i ka uhi a me nā koi ʻae mua ma mua o ka hoʻonohonoho ʻana i kāu lapaʻau.

Nā Koho ʻē aʻe iā Bezlotoxumab

ʻOiai he mea kū hoʻokahi ʻo bezlotoxumab i kāna ala e pale ai i ka hoʻi hou ʻana o C. diff, aia nā hoʻolālā ʻē aʻe e noʻonoʻo ai kāu kauka. Hana ʻokoʻa kēia mau koho ʻē aʻe akā hiki nō ke kōkua i ka hōʻemi ʻana i ka pilikia o nā maʻi e hoʻi hou ana.

ʻO ka hoʻololi ʻana i ka microbiota fecal (FMT) kekahi koho ʻē aʻe no ka pale ʻana i ka hoʻi hou ʻana o C. diff. Hoʻokomo kēia kaʻina hana i nā bacteria ʻōpū olakino mai kahi mea hāʻawi e kōkua i ka hoʻihoʻi ʻana i kāu kaulike ʻōpū maoli. Hiki ke maikaʻi loa ʻo FMT akā pono nā hale kūikawā a me ka nānā pono.

Hiki ke ʻōlelo ʻia nā papa antibiotic i hoʻolōʻihi ʻia a i ʻole i hoʻopaʻa ʻia ma kahi o bezlotoxumab a i ʻole ma ka ʻaoʻao. Ua kauoha kekahi mau kauka i ka vancomycin a i ʻole fidaxomicin no nā manawa lōʻihi a i ʻole i nā ʻano hoʻemi mālie e pale ai i ka hoʻi hou ʻana.

Hiki i nā probiotics a me nā hoʻololi ʻana i ka meaʻai ke pāʻani i kahi hana kākoʻo, ʻoiai ua hoʻohana ʻia lākou me nā lāʻau lapaʻau ʻē aʻe ma mua o nā koho ʻē aʻe. E kōkua kāu kauka e hoʻoholo i ke ala maikaʻi loa e pili ana i kāu kūlana kikoʻī a me nā mea pilikia.

Ua ʻoi aku ka maikaʻi o Bezlotoxumab ma mua o Vancomycin?

Hana ʻo Bezlotoxumab a me vancomycin ma nā ʻano like ʻole, no laila ʻaʻole like ka hoʻohālikelike ʻana iā lākou me ka hoʻohālikelike ʻana i nā ʻāpala i nā ʻāpala. He antibiotic ʻo Vancomycin e mālama i nā maʻi C. diff ikaika, ʻoiai ʻo bezlotoxumab e pale i nā maʻi e hiki mai ana mai ka hoʻi hou ʻana.

ʻO ka hapa nui o ka poʻe e loaʻa ana iā bezlotoxumab e lawe pū ana i ka vancomycin a i ʻole kekahi antibiotic ʻē aʻe e mālama i kā lākou maʻi i kēia manawa. Hana pū nā lāʻau lapaʻau ʻelua ma mua o ka hoʻokūkū ʻana i kekahi i kekahi. Hoʻopau ʻo Vancomycin i ka bacteria C. diff e hana nei i kāu mau hōʻailona i kēia manawa, ʻoiai ʻo bezlotoxumab e kōkua i ka pale ʻana i nā hanana e hiki mai ana.

Hōʻike nā haʻawina i ka poʻe i loaʻa iā bezlotoxumab me ka lāʻau antibiotic maʻamau he 10% ka haʻahaʻa o ka pilikia o ka maʻi C. diff hou i hoʻohālikelike ʻia me ka poʻe i loaʻa i nā antibiotics wale nō. ʻO kēia ka mea e lilo ai ʻo bezlotoxumab i mea waiwai i ka mālama ʻana ma mua o ka pani ʻana i nā antibiotics.

E noʻonoʻo kāu kauka i nā mea e like me kou makahiki, nā maʻi C. diff i hala, a me ke olakino holoʻokoʻa i ka wā e hoʻoholo ai inā e ʻōlelo ʻo bezlotoxumab me kāu lāʻau antibiotic. Hāʻawi pinepine ke ala hui i ka pale maikaʻi loa i nā maʻi o kēia manawa a me ka wā e hiki mai ana.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Bezlotoxumab

Q1. Palekana anei ʻo Bezlotoxumab no ka poʻe me ka maʻi puʻuwai?

Pono ʻo Bezlotoxumab i ka noʻonoʻo pono i ka poʻe me ka maʻi puʻuwai, ʻo ia hoʻi ka poʻe me ka puʻuwai. Ua hōʻike nā haʻawina lapaʻau i kahi pilikia liʻiliʻi o nā hopena ʻaoʻao e pili ana i ka puʻuwai i nā maʻi me nā maʻi puʻuwai.

E loiloi kāu kauka i kou maʻi puʻuwai kikoʻī a me ke kūlana olakino o kēia manawa ma mua o ka ʻōlelo ʻana iā bezlotoxumab. Makemake paha lākou e nānā pono i kāu hana puʻuwai i ka wā o ka infusion a i ʻole e hoʻoholo paha nā pilikia i nā pōmaikaʻi i kāu hihia.

Inā loaʻa iā ʻoe ka bezlotoxumab me ka maʻi puʻuwai, e loaʻa paha iā ʻoe ka nānā pinepine ʻana i ka wā a ma hope o ka mālama ʻana. Kōkua kēia ʻano hou i ka hopu ʻana i nā pilikia i ka wā mua a hōʻoia i kou palekana i ke kaʻina hana.

Q2. He aha kaʻu e hana ai inā loaʻa iaʻu kahi hopena i ka wā o ka Bezlotoxumab Infusion?

Inā ʻike ʻoe i nā hōʻailona e pili ana i ka wā o kāu bezlotoxumab infusion, e haʻi koke i kāu hui mālama ola. Hiki ke mālama pinepine ʻia nā hopena maʻamau e like me ka nausea māmā a i ʻole ka luhi ma ka hoʻolohi ʻana i ka helu infusion a i ʻole ka hāʻawi ʻana i ka mālama kākoʻo.

Pono nā hopena koʻikoʻi e like me ka pilikia o ka hanu ʻana, ka ʻeha o ka umauma, a i ʻole ka wili nui i ka nānā ʻana i ka lāʻau lapaʻau koke. Ua aʻo ʻia kāu hui mālama ola e ʻike a mālama koke i kēia mau hopena, ʻo ia ke kumu e hāʻawi mau ʻia ai ka hoʻokomo ʻana i kahi hoʻonohonoho lāʻau lapaʻau.

Hiki ke loaʻa ka hapa nui o nā hopena i ka wā o ka hoʻokomo ʻana a i ʻole i loko o kekahi mau hola ma hope. ʻO kēia ke kumu e nānā pono ʻia ai ʻoe i ka wā o ka mālama ʻana a no kekahi manawa ma hope o ka pau ʻana o ka hoʻokomo ʻana. Mai kānalua e ʻōlelo inā ʻaʻole maikaʻi kou manaʻo.

Q3. He aha kaʻu e hana ai inā e hala wau i kaʻu manawa Bezlotoxumab i hoʻonohonoho ʻia?

Inā e hala ʻoe i kāu hoʻokomo bezlotoxumab i hoʻonohonoho ʻia, e hoʻokaʻaʻike i kāu mea mālama ola i ka hiki wawe e hoʻonohonoho hou. No ka mea he lāʻau lapaʻau hoʻokahi wale nō i hāʻawi ʻia i ka wā o kāu papa antibiotic no C. diff, hiki ke koʻikoʻi ka manawa no ka pono nui.

Hiki i kāu kauka ke makemake e hoʻonohonoho hou i ka hoʻokomo ʻana i ka hiki wawe, ʻoiai inā e lawe ana ʻoe i nā antibiotics no kāu maʻi C. diff i kēia manawa. ʻO ka pahuhopu e hāʻawi iā ʻoe i nā antibodies pale ma mua o ka pau ʻana o kāu lāʻau antibiotic.

Mai hopohopo inā pono ʻoe e hoʻonohonoho hou - maopopo i kāu hui mālama ola e hiki mai ana nā paio hoʻonohonoho. E hana pū lākou me ʻoe e ʻimi i ka manawa maikaʻi loa e hāʻawi mau ana i ka pale maikaʻi loa i ka hoʻi hou ʻana o C. diff.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka hopohopo e pili ana i ka hoʻi hou ʻana o C. diff ma hope o Bezlotoxumab?

Hāʻawi ʻo Bezlotoxumab i ka pale ikaika loa i nā pule 12 mua ma hope o kāu hoʻokomo ʻana. I kēia manawa, noho mau nā antibodies i ko lākou pae kiʻekiʻe loa i kāu ʻōnaehana, e hāʻawi ana i ka pale nui loa i nā toxins C. diff.

Ma hope o 12 mau pule, e emi mālie nā hopena pale, akā nui ka poʻe e hoʻomau i ka loaʻa ʻana o kekahi pale no kekahi mau mahina. Aia kou pilikia pilikino o ka hoʻi hou ʻana i nā mea e like me kou makahiki, ka ʻōnaehana pale, a inā pono ʻoe e lawe i nā antibiotics no nā kūlana ʻē aʻe.

He mea nui e hoʻomau i ka hahai ʻana i nā hana maʻemaʻe maikaʻi a e hōʻike i kāu mau mea mālama ola e pili ana i kāu moʻolelo C. diff inā pono ʻoe i nā lāʻau antibiotic i ka wā e hiki mai ana. ʻOiai e hōʻemi nui ana ka bezlotoxumab i kou pilikia, he mea nui ka noho makaʻala e pili ana i ka pale ʻana i ka wā lōʻihi.

Q5. Hiki iaʻu ke loaʻa iā Bezlotoxumab ma mua o hoʻokahi manawa?

ʻAe, hiki iā ʻoe ke loaʻa hou iā bezlotoxumab inā loaʻa iā ʻoe kahi maʻi C. diff ʻē aʻe i ka wā e hiki mai ana. Pono paha kekahi poʻe i nā lāʻau lapaʻau hou, ʻoiai inā he mau mea pilikia mau a i ʻole nā ʻōnaehana pale maʻi i hoʻopilikia ʻia.

E loiloi kāu kauka inā kūpono kekahi mahele o bezlotoxumab e pili ana i kāu mau kūlana pilikino. ʻO nā mea e like me ka lōʻihi o ka hala ʻana mai kāu infusion mua a me kāu mau mea pilikia i kēia manawa e hoʻopili i kēia hoʻoholo.

ʻAʻohe palena kikoʻī i ka nui o nā manawa hiki iā ʻoe ke loaʻa iā bezlotoxumab, akā pono e hana ʻia kēlā me kēia hoʻoholo lapaʻau me ka mālama ʻana me kāu mea mālama ola. E noʻonoʻo lākou i nā pōmaikaʻi a me nā pilikia no kāu kūlana kikoʻī i kēlā me kēia manawa.