He aha ʻo Binimetinib: Nā Hoʻohana, Ka Laʻau, Nā ʻAoʻao ʻino a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i hoʻopaʻa ʻia ʻo Binimetinib e ālai ana i nā protein kikoʻī e kōkua ana i nā pūnaewele maʻi maʻi e ulu a laha. He ʻāpana ia o kahi papa lāʻau lapaʻau hou i kapa ʻia ʻo MEK inhibitors, i hoʻolālā ʻia e hoʻopau i nā hōʻailona e hoʻoulu ai i kekahi mau ʻano maʻi maʻi.

Hōʻike kēia lāʻau lapaʻau i kahi holomua nui i ka mālama ʻana i ka maʻi maʻi pilikino. Ma mua o ka hoʻouka ʻana i nā pūnaewele e māhele wikiwiki ana e like me ka chemotherapy kuʻuna, ua hoʻopaʻa ʻo binimetinib i nā pūnaewele maʻi maʻi me nā loli genetic kūikawā, e hana ana i kahi ala pololei e hakakā ai i ka maʻi.

No ke aha e hoʻohana ʻia ai ʻo Binimetinib?

Hoʻohana nui ʻia ʻo Binimetinib e mālama i ka melanoma, kahi ʻano maʻi ʻili koʻikoʻi i laha i nā ʻāpana ʻē aʻe o ke kino. Ua kauoha ʻia no nā maʻi nona nā pūnaewele maʻi maʻi i kahi loli genetic i kapa ʻia ʻo BRAF V600E a i ʻole V600K mutation.

Hāʻawi ʻia kēia lāʻau lapaʻau me kekahi lāʻau i hoʻopaʻa ʻia i kapa ʻia ʻo encorafenib. ʻOi aku ka maikaʻi o ka hui ʻana ma mua o kekahi lāʻau hoʻokahi no ka mea e ālai ana i nā hōʻailona ulu maʻi maʻi ma nā wahi ʻelua like ʻole i ke ala like.

E hoʻāʻo kāu kauka i kāu ʻiʻo tumora e hōʻoia ua loaʻa iā ʻoe ka loli genetic kūpono ma mua o ke kau ʻana iā binimetinib. Hōʻoia kēia hoʻāʻo ʻana e pono ka lāʻau lapaʻau no kāu ʻano maʻi maʻi.

Pehea e hana ai ʻo Binimetinib?

Hana ʻo Binimetinib ma ka ālai ʻana i kahi protein i kapa ʻia ʻo MEK1 a me MEK2, he ʻāpana o ke ala kamaʻilio kelepona e haʻi ana i nā pūnaewele maʻi maʻi e ulu a hoʻonui. E noʻonoʻo e like me ka hoʻopau ʻana i kahi kamaʻilio kelepona ma waena o nā ʻāpana like ʻole o ka pūnaewele maʻi maʻi.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau maʻi maʻi ikaika. ʻOiai ua hoʻopaʻa ʻia ma mua o ka chemotherapy kuʻuna, loaʻa nō nā hopena koʻikoʻi i kou kino a pono e nānā pono ʻia e kāu hui mālama ola.

Ke kālele pono nei ka lāʻau i ke ala MAPK, he mea hana nui i nā maʻi maʻi he nui me nā loli BRAF. Ma ka pale ʻana i kēia ala ma ka pae MEK, kōkua ʻo binimetinib i ka hoʻolohi a i ʻole ka hoʻōki ʻana i ka ulu ʻana a me ka mahele ʻana o nā sela maʻi.

Pehea e lawe ai au i ka Binimetinib?

E lawe i ka binimetinib e like me ke kauoha a kāu kauka, ʻelua manawa i ka lā ma kahi o 12 hola kaawale. Hiki iā ʻoe ke lawe me ka ʻai a i ʻole me ka ʻole o ka ʻai, akā e hoʻāʻo e kūlike me kāu hana maʻamau e mālama i nā pae paʻa i kou kino.

E ale i nā capsules holoʻokoʻa me ke aniani wai. Mai ʻoki, nau, a wehe paha iā lākou, no ka mea, hiki i kēia ke hoʻopilikia i ke ʻano o ka lawe ʻana i ka lāʻau a hiki ke hoʻonui i nā hopena ʻaoʻao.

Inā ʻoe e luaʻi i loko o hoʻokahi hola o ka lawe ʻana i kāu mahele, mai lawe i kahi mahele ʻē aʻe a hiki i kou manawa i hoʻonohonoho ʻia. ʻAʻole e hoʻoponopono ka lawe ʻana i ka lāʻau hou i ka mea i nalowale a hiki ke pilikia.

E hoʻomaka paha kāu kauka iā ʻoe ma kahi mahele maʻamau a hiki ke hoʻoponopono iā ia e pili ana i ke ʻano o kāu pane ʻana a me nā hopena ʻaoʻao āu e ʻike ai. E kōkua nā hoʻokolohua koko maʻamau a me nā loiloi e hoʻoholo inā pono e hoʻololi i ka mahele.

Pehea ka lōʻihi e lawe ai au i ka Binimetinib?

E hoʻomau ʻoe i ka lawe ʻana i ka binimetinib i ka wā e hana ana e kāohi i kāu maʻi maʻi a ke ʻae nei ʻoe i nā hopena ʻaoʻao me ka maikaʻi. Hiki i kēia ke lilo i mau mahina a i ʻole mau makahiki, ma muli o kou kūlana pilikino.

E nānā mau kāu kauka i kāu pane ma o nā scans, nā hoʻokolohua koko, a me nā hoʻokolohua kino. Inā pau ka pane ʻana o ka maʻi maʻi i ka lāʻau a i ʻole inā lilo nā hopena ʻaoʻao i mea koʻikoʻi, hiki iā lākou ke ʻōlelo e hoʻōki a hoʻololi paha i kahi lāʻau lapaʻau ʻē aʻe.

Mai hoʻōki i ka lawe ʻana i ka binimetinib me ka ʻole e kamaʻilio mua me kāu kauka. ʻOiai inā ʻoe e manaʻo maikaʻi ana, hiki nō ke hana nei ka lāʻau e mālama i kāu maʻi maʻi.

He aha nā hopena ʻaoʻao o Binimetinib?

E like me nā lāʻau lapaʻau maʻi 'aʻai a pau, hiki i ka binimetinib ke hana i nā hopena ʻē aʻe, ʻoiai ʻaʻole e loaʻa iā lākou a pau. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hoʻokaʻaʻike aku ai i kāu hui mālama ola.

Eia nā hopena ʻē aʻe maʻamau e hiki iā ʻoe ke ʻike:

• Luhi a me ka nāwaliwali e hiki ke hoʻopilikia i nā hana o kēlā me kēia lā
• ʻO ka nausea a me ka luaʻi, hiki ke mālama pinepine ʻia me nā lāʻau anti-nausea
• ʻO ka maʻi maʻi, i kekahi manawa lawa ka pinepine e koi ai i ka lāʻau lapaʻau
• ʻO ka ʻili ʻili a i ʻole ka ʻili maloʻo, ʻoi aku ma kou mau lima a me nā wāwae
• ʻO ka ʻeha ʻiʻo a me nā hui e hiki ke hele mai a hele
• ʻO ke kuni, pono e hōʻike mau ʻia i kāu kauka
• Nā loli ʻike, me ka ʻike ʻole a i ʻole ka ʻike ʻana i nā kiko

Hiki ke mālama ʻia kēia mau hopena ʻē aʻe maʻamau me ka mālama kākoʻo a i kekahi manawa nā hoʻoponopono ʻana i ka mahele. He ʻike ko kāu hui mālama ola i ke kōkua ʻana i nā maʻi e hoʻokele i kēia mau pilikia.

ʻO kekahi mau hopena ʻē aʻe ʻaʻole maʻamau akā ʻoi aku ka koʻikoʻi e koi i ka lāʻau lapaʻau koke. ʻOiai ʻaʻole e loaʻa kēia mau mea i ka hapa nui o nā kānaka, he mea nui e ʻike iā lākou:

• Nā pilikia o ka naʻau, me nā loli i ka puʻuwai a i ʻole ka hana
• Nā pilikia maka nui e hiki ke hoʻopilikia i kou ʻike mau
• Nā pilikia o ke ake, e hōʻike ana i nā hoʻokolohua koko ma mua o kou manaʻo i nā hōʻailona
• Nā hopena ʻili nui, me nā ʻili ʻeha a i ʻole ka ʻōpū
• Nā koko koko, hiki ke hoʻoulu i ka pehu, ka ʻeha, a i ʻole ka pōkole o ka hanu

E nānā pono kāu kauka iā ʻoe no kēia mau hopena ʻē aʻe ma o nā koho maʻamau a me nā hoʻokolohua koko. Hiki ke hopu ʻia ka nui o kēia mau pilikia i ka wā mua a mālama pono ʻia.

ʻO wai ka mea pono ʻole e lawe iā Binimetinib?

ʻAʻole kūpono ʻo Binimetinib no nā mea a pau, a e noʻonoʻo pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana. ʻAʻole pono ʻoe e lawe i kēia lāʻau lapaʻau inā he maʻi ʻoe iā binimetinib a i ʻole kekahi o kāna meaʻai.

Hiki i kekahi mau maʻi ke hana i ka binimetinib i palekana ʻole a i ʻole e koi i ka nānā kūikawā. E mālama nui kāu kauka inā loaʻa iā ʻoe:

• Maʻi puʻuwai a i ʻole nā ​​puʻuwai puʻuwai ʻole
• Nā pilikia o ka maka, ʻoi aku ka maʻi retinal
• Maʻi ate a i ʻole nā ​​enzyme ate kiʻekiʻe
• Mōʻaukala o nā koko koko
• Nā pilikia kīkī koʻikoʻi

Pono ka hāpai ʻana a me ka hānai ʻana i ka umauma i ka noʻonoʻo kūikawā. Hiki i ka Binimetinib ke hōʻeha i kahi pēpē i hānau ʻole ʻia, no laila he mea nui ka mana hānau pono i ka wā o ka mālama ʻana a no kekahi manawa ma hope o ka hoʻōki ʻana i ka lāʻau.

E nānā pū kāu kauka i kāu mau lāʻau lapaʻau ʻē aʻe a pau, no ka mea, hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka binimetinib a pili i ka maikaʻi o kāna hana a i ʻole e hoʻonui i kou pilikia o nā hopena ʻaoʻao.

Nā inoa inoa inoa Binimetinib

Kūʻai ʻia ʻo Binimetinib ma lalo o ka inoa inoa Mektovi ma ka hapa nui o nā ʻāina, me ʻAmelika Hui Pū ʻIa a me ʻEulopa. ʻO kēia ka inoa maʻamau āu e ʻike ai ma kāu mau ʻōmole kuhikuhi a me nā moʻolelo olakino.

Hana ʻia ka lāʻau lapaʻau e Array BioPharma a loaʻa wale nō ma ke kau ʻana. ʻAʻole ʻoe e ʻike i nā mana generic o ka binimetinib, no ka mea he lāʻau lapaʻau hou ia i pale ʻia e nā palapala.

Hiki i kekahi mau hoʻolālā ʻinikua ke kuhikuhi iā ia ma kona inoa generic (binimetinib) ʻoiai nā mea ʻē aʻe e hoʻohana i ka inoa inoa (Mektovi). E pili ana nā mea ʻelua i ka lāʻau lapaʻau like, no laila mai hopohopo inā ʻoe e ʻike i nā inoa like ʻole ma nā palapala like ʻole.

Nā koho ʻē aʻe o Binimetinib

Inā ʻaʻole kūpono ka binimetinib iā ʻoe a i ʻole e pau ka hana ʻana, he nui nā lāʻau lapaʻau ʻē aʻe e noʻonoʻo ai kāu kauka. Aia ke koho i kāu ʻano maʻi maʻi, nā hoʻololi genetic, a me ke olakino holoʻokoʻa.

ʻO nā mea pale MEK ʻē aʻe e pili ana i ka trametinib a me ka cobimetinib, e hana like me ka binimetinib akā loaʻa nā ʻano hopena ʻaoʻao like ʻole. Hoʻohana pinepine ʻia kēia mau mea me nā mea pale BRAF, e like me ka binimetinib.

No nā maʻi melanoma, hiki i nā koho ʻē aʻe ke komo i nā lāʻau immunotherapy e like me pembrolizumab a i ʻole nivolumab, e kōkua ana i kāu ʻōnaehana pale e hakakā i ka maʻi kanesa. Hiki nō hoʻi i ka chemotherapy kuʻuna a i ʻole nā lāʻau lapaʻau i manaʻo ʻia he mau koho e pili ana i kou kūlana.

E noʻonoʻo kāu oncologist i nā mea e like me ke ʻano genetic o kāu maʻi kanesa, nā lāʻau lapaʻau i hala, a me kou olakino holoʻokoʻa i ka wā e ʻōlelo ai i nā koho ʻē aʻe. ʻO ka pahuhopu ka loaʻa ʻana o ka lāʻau lapaʻau maikaʻi loa me nā hopena ʻaoʻao hiki ke mālama ʻia.

Ua ʻoi aku ka maikaʻi o Binimetinib ma mua o Trametinib?

ʻO Binimetinib a me trametinib nā mea pale MEK e hana ana ma nā ʻano like, akā ʻaʻole hiki ke hoʻohālikelike pololei ʻia no ka mea e hoʻohana pinepine ʻia lākou i nā lāʻau lapaʻau like ʻole. Hoʻohui pinepine ʻia ʻo Binimetinib me encorafenib, aʻo trametinib e hui pinepine ʻia me dabrafenib.

Aia ka pono o kēlā me kēia hui ʻana i nā ʻano maʻi kanesa o kēlā me kēia kanaka a me ke ʻano o ka pane ʻana o kou kino i ka lāʻau lapaʻau. Hōʻike nā haʻawina lapaʻau e hiki i nā hui ʻelua ke maikaʻi no ka mālama ʻana i ka melanoma BRAF-mutated.

E koho kāu kauka ma waena o kēia mau koho e pili ana i nā mea e like me kāu mōʻaukala olakino, nā hopena ʻaoʻao hiki ke loaʻa, a me nā pilina lāʻau. ʻO ka mea nui ka loaʻa ʻana o ka hui e hana maikaʻi loa no kou kūlana.

Hiki i kekahi poʻe maʻi ke ʻae i kekahi hui ʻana ma mua o kekahi, a hiki i kāu kauka ke hoʻololi i nā lāʻau lapaʻau inā pono. ʻO ka mea nui ka loaʻa ʻana o nā koho maikaʻi he nui.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Binimetinib

He palekana anei ʻo Binimetinib no ka poʻe me ka maʻi puʻuwai?

Hiki i ka Binimetinib ke hoʻopilikia i ka hana o ka puʻuwai, no laila pono e mālama nui inā he pilikia kou puʻuwai. E kauoha paha kāu kauka i nā hoʻokolohua puʻuwai ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a nānā mau i ka hana o kou puʻuwai i ka wā o ka lāʻau lapaʻau.

Hiki i ka nui o nā kānaka me nā maʻi puʻuwai maʻalahi ke lawe palekana i ka binimetinib me ka nānā pono. E hana pū kāu cardiologist a me ka oncologist e hōʻoia i ka olakino o kou puʻuwai i ka wā o ka mālama ʻana i ka maʻi kanesa.

Inā loaʻa iā ʻoe nā pilikia puʻuwai i ka wā e lawe ana i ka binimetinib, pono paha i kāu kauka ke hoʻōki i ka mālama ʻana, e hōʻemi i kāu mahele, a i ʻole e hoʻololi i kahi lāʻau lapaʻau ʻē aʻe. ʻO ka pahuhopu ka mālama ʻana i kāu maʻi kanesa me ka mālama ʻana i kou puʻuwai.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o ka Binimetinib?

Inā lawe hewa ʻoe i ka nui o ka binimetinib ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena mana ʻawaʻawa kūloko. Mai kali e ʻike inā maʻi ʻoe, no ka mea, ʻaʻole ʻike koke ʻia kekahi mau hopena o ka overdose.

E hele i ka lumi pilikia inā loaʻa iā ʻoe nā hōʻailona koʻikoʻi e like me ka pilikia o ka hanu ʻana, ka nausea a me ka luaʻi ʻana, a i ʻole ka ʻeha o ka umauma. E lawe mai i kāu hue lāʻau me ʻoe i ʻike pono nā mea mālama ola i kāu mea i lawe.

No ka pale ʻana i ka overdose ulia, e mālama i kāu lāʻau lapaʻau i loko o kāna pahu kumu a e hoʻohana i kahi mea hoʻonohonoho pila inā pono. E hoʻonohonoho i nā mea hoʻomanaʻo kelepona e kōkua iā ʻoe e hoʻomanaʻo i ka wā i lawe mua ai ʻoe i kāu mahele.

He aha kaʻu e hana ai inā hala au i kahi mahele o Binimetinib?

Inā hala ʻoe i kahi mahele a ua hala ma mua o 6 mau hola mai kou manawa i hoʻonohonoho ʻia, e lawe koke iā ia ke hoʻomanaʻo ʻoe. Inā ua hala ma mua o 6 mau hola, e lele i ka mahele i hala a e lawe i kāu mahele aʻe i ka manawa maʻamau.

Mai lawe i ʻelua mahele kokoke i kekahi i kekahi e hana i kahi mahele i hala. Hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi me ka hāʻawi ʻole ʻana i kekahi pōmaikaʻi hou no kāu mālama ʻana i ka maʻi kanesa.

E ho'āʻo e hoʻokumu i kahi hana maʻamau e kōkua iā ʻoe e hoʻomanaʻo i kāu mau manawa lāʻau. ʻO ka lawe ʻana i nā mahele i nā manawa like i kēlā me kēia lā, e like me ka ʻaina kakahiaka a me ka ʻaina ahiahi, hiki ke kōkua i ka pale ʻana i nā mahele i hala.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Binimetinib?

Pono ʻoe e hooki i ka lawe ʻana i ka binimetinib ke haʻi aku kāu kauka iā ʻoe he palekana ke hana pēlā. Hana maʻamau kēia inā holomua ka maʻi maʻi me ka mālama ʻana, inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, a i ʻole inā pono ʻoe e hoʻololi i kahi lapaʻau ʻē aʻe.

Hiki i kekahi poʻe maʻi ke lawe i nā wā hoʻomaha lapaʻau inā loaʻa iā lākou nā hopena ʻaoʻao paʻakikī, akā pono e hana mau ʻia kēia ma lalo o ka mālama olakino. E loiloi kāu kauka i nā pilikia a me nā pōmaikaʻi o ka hooki ʻana i ka lapaʻau.

Mai hooki i ka lawe ʻana i ka binimetinib no ka mea e ʻoi aku ana kou maikaʻi. Hiki i ka lāʻau lapaʻau ke hana e mālama i kāu maʻi maʻi ma lalo o ka mana inā maikaʻi ʻoe. Kōkua nā scans maʻamau a me nā hoʻokolohua koko i kāu kauka e hoʻoholo inā ke hana nei ka lapaʻau.

Hiki iaʻu ke lawe i ka Binimetinib me nā lāʻau lapaʻau ʻē aʻe?

Hiki i ka Binimetinib ke launa pū me nā lāʻau lapaʻau ʻē aʻe, no laila he mea nui e haʻi aku i kāu kauka i nā mea a pau āu e lawe nei, me nā lāʻau lapaʻau i kauoha ʻia, nā lāʻau lapaʻau ma luna o ka pāʻani, a me nā mea hoʻohui.

Hiki i kekahi mau lāʻau lapaʻau ke hoʻemi i ka hopena o ka binimetinib a i ʻole e hoʻonui i kou pilikia o nā hopena ʻaoʻao. E nānā kāu kauka a i ʻole ka lāʻau lapaʻau i nā lāʻau lapaʻau a pau a pono paha e hoʻoponopono i nā dosages a i ʻole ka manawa e pale ai i nā pilina pōʻino.

E nānā mau me kāu hui mālama ola ma mua o ka hoʻomaka ʻana i nā lāʻau lapaʻau hou i ka wā e lawe ana i ka binimetinib. Aia kēia me nā antibiotics, nā lāʻau lapaʻau ʻeha, a me nā mea hoʻohui maʻamau e like me St. John's wort, hiki ke hoʻopilikia i ka hana ʻana o nā lāʻau lapaʻau maʻi.