He aha ʻo Brigatinib: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i hoʻolālā ʻia ʻo Brigatinib e mālama i kahi ʻano maʻi maʻi maʻi maʻi maʻi i kapa ʻia ʻo ALK-positive non-small cell lung cancer. Hana kēia lāʻau lapaʻau ma ka pale ʻana i nā protein kikoʻī e kōkua i nā pūnaewele maʻi maʻi e ulu a laha i loko o kou kino.

Inā ua kauoha ʻia ʻo brigatinib iā ʻoe a i ʻole kekahi āu e mālama nei, ke ʻimi nei ʻoe i ka ʻike maopopo a hilinaʻi e pili ana i ka mea e manaʻo ai. E hele kākou i nā mea a pau āu e pono ai e ʻike e pili ana i kēia lāʻau lapaʻau ma ke ʻano e hiki ai ke mālama a hōʻoluʻolu.

He aha ʻo Brigatinib?

No ka papa o nā lāʻau lapaʻau i kapa ʻia ʻo kinase inhibitors ʻo Brigatinib, ʻo ia hoʻi nā lāʻau lapaʻau i manaʻo ʻia no ka maʻi maʻi. E noʻonoʻo iā ia he mea hana pololei ma mua o ka lāʻau lapaʻau ākea—e kālele ana i nā pūnaewele maʻi maʻi i loaʻa kahi loli genetic i kapa ʻia ʻo ALK rearrangement.

Hele mai kēia lāʻau lapaʻau ma ke ʻano o nā papa waha āu e lawe ai ma ka waha, e maʻalahi ai ma mua o nā lāʻau lapaʻau maʻi maʻi maʻamau e koi ai i nā kipa i ka haukapila no ka hoʻokomo ʻana. Ua hoʻomohala ʻia ka lāʻau lapaʻau e kūʻē i nā pūnaewele maʻi maʻi maʻi e kūʻē i nā mea pale ALK ʻē aʻe.

E kauoha maʻamau kāu oncologist i ka brigatinib ma hope o ka hōʻoia ʻana ma o ka hoʻāʻo genetic i loaʻa i kāu maʻi maʻi ka hoʻoponopono hou ʻana o ka gene ALK. Kōkua kēia ala pilikino e hōʻoiaʻiʻo nei e loaʻa ana iā ʻoe ka lāʻau lapaʻau kūpono loa no kāu ʻano maʻi maʻi.

No ke aha e hoʻohana ʻia ai ʻo Brigatinib?

Hoʻohana nui ʻia ʻo Brigatinib e mālama i ka ALK-positive metastatic non-small cell lung cancer (NSCLC). ʻO ia hoʻi, ua kauoha ʻia no ka maʻi maʻi maʻi e laha ana i nā ʻāpana ʻē aʻe o ke kino a loaʻa nā loli genetic kikoʻī.

Hiki i kāu kauka ke kuhikuhi iā brigatinib ma ke ʻano he lapaʻau laina mua inā ua ʻike ʻia ʻoe me ka maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi ALK-positive. ʻOkoʻa, hiki ke ʻōlelo ʻia inā ua holomua kāu maʻi maʻi a i ʻole ua pau ka pane ʻana i nā mea pale ALK ʻē aʻe e like me crizotinib a i ʻole ceritinib.

Ke aʻo ʻia nei ka lāʻau lapaʻau no nā ʻano maʻi maʻi ʻē aʻe i loaʻa nā loli gene ALK, ʻoiai e manaʻo ʻia ana kēia mau hoʻohana ʻana he mea hoʻokolohua. E hoʻoholo kāu oncologist inā kūpono ʻo brigatinib e pili ana i kāu ʻano maʻi maʻi a me nā hopena hoʻāʻo genetic.

Pehea e hana ai ʻo Brigatinib?

Hana ʻo Brigatinib ma ka pale ʻana i ka protein ALK, e hana ana e like me ka hoʻololi hewa e haʻi ana i nā cell cancer e ulu a hoʻonui ʻole. Ma ka pale ʻana i kēia protein, hoʻopau ka lāʻau lapaʻau i ka hōʻailona e hoʻokele ana i ka ulu ʻana o ka maʻi maʻi.

Ua manaʻo ʻia he lāʻau lapaʻau ikaika, i manaʻo ʻia no ka mea e hoʻouka pololei ana i ke ala molecular e hoʻokele ana i kāu maʻi maʻi. ʻAʻole like me ka chemotherapy kuʻuna e pili ana i nā cell olakino a me nā cell cancerous, ua hoʻolālā ʻia ʻo brigatinib e koho hou i kāna hana.

Loaʻa nō hoʻi ka hana ʻana o ka lāʻau lapaʻau i kekahi mau loli e hiki ke ulu i ka wā e lilo ai ka maʻi maʻi i mea pale i nā mea pale ALK ʻē aʻe. ʻO kēia ka mea e waiwai nui ai no ka mālama ʻana i nā maʻi maʻi i ulu e pale i nā lāʻau lapaʻau i manaʻo ʻia.

Hoʻomaka ka hapa nui o nā maʻi e ʻike i nā hopena i loko o nā pule mua o ka mālama ʻana, ʻoiai e hiki ke lawe i nā mahina e ʻike ʻia ai ka pōmaikaʻi piha ma nā haʻawina kiʻi.

Pehea wau e lawe ai iā Brigatinib?

E lawe iā brigatinib e like me ke kauoha a kāu oncologist, maʻamau i hoʻokahi manawa i ka lā me ka ʻole o ka meaʻai. Hiki iā ʻoe ke lawe me ke aniani wai, a ʻaʻohe koi kūikawā e lawe me ka waiū a i ʻole e pale i kekahi mau meaʻai.

E ʻai i nā papa i ka holoʻokoʻa me ka ʻole o ka ʻoki ʻana, ka nau ʻana, a i ʻole ka wāwahi ʻana iā lākou. Inā pilikia ʻoe i ka ʻai ʻana i nā pila, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua ai, akā mai hoʻololi i nā papa ma kāu iho.

E hoʻāʻo e lawe i ka brigatinib i ka manawa like i kēlā me kēia lā e mālama i nā pae kūlike i loko o kou kino. Nui nā maʻi i ʻike he mea kōkua ka hoʻopili ʻana i ka lawe ʻana i kā lākou lāʻau i kahi hana maʻamau i kēlā me kēia lā, e like me ka ʻaina kakahiaka a i ʻole ka palaki ʻana i ko lākou niho.

ʻAʻole pono ʻoe e ʻai i nā meaʻai kikoʻī ma mua o ka lawe ʻana i ka brigatinib, akā ʻo ka mālama ʻana i ka meaʻai maikaʻi i ka wā o kāu mālama ʻana hiki ke kōkua i ke kākoʻo ʻana i kou olakino holoʻokoʻa a me nā pae ikehu.

Pehea ka lōʻihi e lawe ai au i ka Brigatinib?

E hoʻomau ʻoe i ka lawe ʻana i ka brigatinib no ka lōʻihi e kāohi pono ana i kāu maʻi ʻaʻai a ke ʻae maikaʻi nei ʻoe iā ia. Hiki i kēia ke lilo i mau mahina a i ʻole mau makahiki, ma muli o ke ʻano o ka pane ʻana o kāu maʻi ʻaʻai i ka lāʻau.

E nānā kāu oncologist i kāu holomua ma o nā scans maʻamau a me nā hoʻokolohua koko e hoʻoholo ai inā e hana pono ana ka lāʻau. Hana pinepine ʻia kēia mau nānā ʻana i kēlā me kēia mau mahina, ʻoiai paha e ʻokoʻa ka papa manawa ma muli o kou kūlana pilikino.

Hoʻomau kekahi poʻe maʻi i ka brigatinib no nā manawa lōʻihi me ka mālama maikaʻi ʻana i ka maʻi ʻaʻai a me nā hopena ʻaoʻao hiki ke mālama ʻia. Pono paha nā mea ʻē aʻe e hoʻoponopono i kā lākou hoʻolālā lapaʻau inā e hoʻomohala ka maʻi ʻaʻai i ke kūpaʻa a i ʻole inā pilikia nā hopena ʻaoʻao.

Mai hooki i ka lawe ʻana i ka brigatinib me ka ʻole e kūkākūkā mua me kāu hui mālama ola. ʻOiai inā maikaʻi kou manaʻo, ʻo ka hoʻōki koke ʻana hiki ke ʻae i kāu maʻi ʻaʻai e ulu wikiwiki.

He aha nā hopena ʻaoʻao o Brigatinib?

E like me nā lāʻau lapaʻau maʻi ʻaʻai a pau, hiki i ka brigatinib ke hana i nā hopena ʻaoʻao, ʻoiai he nui nā maʻi i ʻike he hiki ke mālama ʻia me ke kākoʻo kūpono a me ka nānā ʻana. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a hilinaʻi i kāu lapaʻau.

Eia nā hopena ʻaoʻao maʻamau i ʻike ʻia e nā maʻi, e pili ana i ka 20% o ka poʻe e lawe ana i ka brigatinib:

• Ka maʻi palahē, hiki ke mālama ʻia me nā loli ʻai a me nā lāʻau lapaʻau
• Luhi, a i ʻole ka manaʻo luhi ma mua o ka maʻamau
• ʻO ka luaʻi, hiki ke mālama ʻia me nā lāʻau anti-nausea
• ʻEha ke poʻo, maʻamau ka maʻalahi a i ʻole ka waena
• ʻUho, pili paha i kou maʻi māmā a i ʻole ka lāʻau lapaʻau
• ʻEha ʻiʻo a me nā ami
• Pehu i kou mau wāwae, nā kuʻekuʻe wāwae, a i ʻole nā wāwae
• Pōkole o ka hanu

Hiki ke mālama ʻia kēia mau hopena ʻaoʻao maʻamau, a hiki i kāu hui mālama ola ke hāʻawi i nā hoʻolālā e kōkua i ka hōʻemi ʻana i ko lākou hopena i kou ola i kēlā me kēia lā.

Aia kekahi mau hopena ʻaoʻao maʻamau ʻole akā ʻoi aku ka koʻikoʻi e koi ai i ka lāʻau lapaʻau koke. ʻOiai e pili ana kēia i ka liʻiliʻi o nā maʻi, he mea nui e ʻike iā lākou:

• Nā pilikia o ka māmā, me ka mumū o nā māmā (pneumonitis)
• Ke koko kiʻekiʻe e ulu koke ana
• Ka puʻuwai lohi a i ʻole nā pilikia o ka puʻuwai
• ʻEha ʻiʻo nui a i ʻole nāwaliwali
• Nā loli ʻike, me ka ʻike pōpō a i ʻole ka ʻike māmā
• ʻEha ʻōpū nui a mau paha
• Nā hōʻailona o ka pancreatitis, e like me ka ʻeha o ka ʻōpū nui e hiki ke pāhola i kou kua

E hoʻokaʻaʻike koke i kāu mea mālama ola inā ʻike ʻoe i kekahi o kēia mau hōʻailona koʻikoʻi. Hiki i ka hana mua ke pale i nā pilikia a mālama iā ʻoe me ka palekana i ka lāʻau lapaʻau.

ʻO kekahi mau hopena ʻaoʻao laha akā koʻikoʻi e pili ana i nā hopena ʻili nui a me nā pilikia o ke ake. E nānā mau kāu kauka iā ʻoe ma o nā hoʻokolohua koko e hopu i nā pilikia i ka wā mua.

ʻO wai ka mea pono ʻole e lawe iā Brigatinib?

ʻAʻole kūpono ʻo Brigatinib no nā mea a pau, a e loiloi pono kāu oncologist inā palekana ia iā ʻoe e pili ana i kou olakino holoʻokoʻa a me ka mōʻaukala olakino. Kōkua kēia loiloi e hōʻoia e loaʻa iā ʻoe ka pōmaikaʻi nui me ka pilikia haʻahaʻa.

ʻAʻole pono ʻoe e lawe i ka brigatinib inā he maʻi ʻoe i ka lāʻau a i ʻole kekahi o kāna mau mea. E nānā kāu kauka i kāu mōʻaukala maʻi ma mua o ke kau ʻana i kēia lapaʻau.

Pono paha ka poʻe me kekahi mau maʻi puʻuwai i ka nānā kūikawā a i ʻole ʻaʻole paha he moho no ka brigatinib. Pākuʻi ʻia kēia i ka poʻe me nā pilikia o ka puʻuwai nui a i ʻole ka hana puʻuwai i hōʻemi nui ʻia.

Inā he pilikia nui kou ate a i ʻole nā pilikia kīkī, pono paha kāu kauka e hoʻoponopono i kāu mahele a i ʻole e noʻonoʻo i nā lapaʻau ʻē aʻe. He mea nui ka nānā mau ʻana i kēia mau kūlana.

ʻAʻole pono nā wahine hāpai e lawe i ka brigatinib no ka mea hiki iā ia ke hōʻeha i ka pēpē e ulu ana. Inā ʻoe i ka makahiki hānau keiki, pono ʻoe e hoʻohana i ka mana hānau maikaʻi i ka wā o ka lapaʻau a no kekahi manawa ma hope o ka pau ʻana o ka lāʻau.

Inoa Brand Brigatinib

Kūʻai ʻia ʻo Brigatinib ma lalo o ka inoa brand Alunbrig ma ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe. Hiki iā ʻoe ke ʻike i kekahi inoa ma kāu ʻōmole kauoha a i ʻole nā pepa ʻinikua.

Hana ʻia ka lāʻau e Takeda Pharmaceuticals, a ʻo ia ka mea hana like ʻole inā ʻōlelo kāu kauoha

ʻO Ceritinib (Zykadia) kekahi koho ʻē aʻe i hiki ke kūpono i nā maʻi maʻi i lilo i mea kūʻē i ka crizotinib. He ʻano ʻokoʻa kona o nā hopena ʻaoʻao, i hiki ke makemake ʻia e kekahi poʻe maʻi.

Ua manaʻo ʻia ʻo Alectinib (Alecensa) he mea maikaʻi loa no ka maʻi maʻi maʻi maʻi ALK-positive a he liʻiliʻi paha nā hopena ʻaoʻao ma mua o kekahi mau koho ʻē aʻe. He mea maikaʻi loa ia i ka mālama ʻana i ka maʻi maʻi i hohola i ka lolo.

Ua hoʻolālā ʻia ʻo Lorlatinib (Lorbrena) e lanakila i ke kūʻē ʻana i nā mea pale ALK ʻē aʻe a hiki ke mālama pono i nā metastases lolo. He mea ia o kekahi o nā koho hou loa i kēia papa o nā lāʻau lapaʻau.

Ua ʻoi aku ka maikaʻi o Brigatinib ma mua o Crizotinib?

Hōʻike nā haʻawina lapaʻau e ʻoi aku ka maikaʻi o ka brigatinib ma mua o ka crizotinib, ʻoiai no nā maʻi i hohola ʻia kā lākou maʻi maʻi i ka lolo a i ʻole i hoʻomohala i ke kūʻē ʻana i nā lāʻau lapaʻau ʻē aʻe. Eia naʻe,

Hiki i ka lāʻau lapaʻau ke hoʻoulu i ke koko kiʻekiʻe a me ka puʻuwai lohi i kekahi poʻe maʻi. Inā he maʻi puʻuwai kou, e nānā pono kāu mau kauka i kēia mau hopena a hiki ke hoʻololi i kāu hoʻolālā lapaʻau.

Hiki i nā maʻi he nui me nā pilikia puʻuwai maʻalahi a i ʻole kaulike ke lawe palekana i ka brigatinib me ka nānā pono. E ana kāu hui mālama ola i nā pōmaikaʻi o ka mālama ʻana i ka maʻi maʻi e kūʻē i nā pilikia puʻuwai.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o Brigatinib?

Inā lawe hewa ʻoe i ka nui o ka brigatinib ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu mea mālama ola a i ʻole ke kikowaena mana ʻawa. Mai kali e ʻike inā e ulu nā hōʻailona, ​​no ka mea, ʻoi aku ka maikaʻi o ka hana mua.

ʻO ka lawe ʻana i ka nui o ka brigatinib hiki ke hoʻonui i nā hopena ʻaoʻao e like me ka nausea, ka maʻi maʻi, a i ʻole nā ​​hoʻololi ʻana i ke koko. ʻO ka loaʻa ʻana o ka hue lāʻau lapaʻau me ʻoe i ka wā e kelepona ai hiki ke kōkua i nā mea mālama ola e hāʻawi iā ʻoe i ka ʻōlelo aʻoaʻo kūpono loa.

No ka pale ʻana i ka overdose ulia pōpilikia, e noʻonoʻo e hoʻohana i kahi mea hoʻonohonoho pila a i ʻole e hoʻonohonoho i nā hoʻomanaʻo kelepona e kōkua iā ʻoe e mālama i kāu mahele lāʻau i kēlā me kēia lā.

He aha kaʻu e hana ai inā e poina iaʻu kahi mahele lāʻau o Brigatinib?

Inā poina iā ʻoe kahi mahele lāʻau a ua hala ma mua o 12 mau hola mai kou manawa maʻamau, e lawe i ka mahele lāʻau i poina iā ʻoe i ka wā e hoʻomanaʻo ai. Inā ua hala ma mua o 12 mau hola, e lele i ka mahele lāʻau i poina a lawe i kāu mahele lāʻau aʻe i ka manawa maʻamau.

Mai lawe i ʻelua mahele lāʻau i ka manawa hoʻokahi e hoʻopiha ai i kahi mahele lāʻau i poina, no ka mea, hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao. ʻOi aku ka maikaʻi o ka mālama ʻana i kāu papa manawa maʻamau e hele nei.

Inā poina pinepine ʻoe i nā mahele lāʻau, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua iā ʻoe e hoʻomanaʻo. ʻO ka hoʻopaʻa ʻana i ka mahele lāʻau e kōkua i ka mālama ʻana i nā pae paʻa o ka lāʻau lapaʻau i loko o kou kino.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Brigatinib?

Pono ʻoe e hooki i ka lawe ʻana iā brigatinib ma lalo o ke alakaʻi a kāu oncologist. Hoʻokumu ʻia kēia hoʻoholo ma ke ʻano o ka mālama ʻana o ka lāʻau lapaʻau i kāu maʻi maʻi a me ka maikaʻi o kou ʻae ʻana i nā hopena ʻaoʻao.

E hoʻohana kāu kauka i nā scans maʻamau a me nā hoʻokolohua koko e nānā inā he pono ka lāʻau lapaʻau. Inā hoʻomaka hou kāu maʻi 'aʻai e ulu a i ʻole e loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, hiki iā lākou ke ʻōlelo e hooki a hoʻololi paha i kahi lapaʻau ʻē aʻe.

ʻOiai inā maikaʻi kou manaʻo, ʻo ka hooki ʻana i ka brigatinib me ka ʻole o ka mālama ʻana i ka lāʻau lapaʻau hiki ke ʻae i kāu maʻi 'aʻai e ulu wikiwiki. E kūkākūkā mau i nā hopohopo e pili ana i kāu lapaʻau me kāu hui mālama ola mua.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Brigatinib?

ʻOiai ʻaʻohe pilina kikoʻī ma waena o ka brigatinib a me ka waiʻona, ua ʻōlelo ʻia e kaupalena i ka inu ʻana i ka waiʻona i ka wā o ka lapaʻau maʻi 'aʻai. Hiki i ka waiʻona ke hoʻonui i kekahi mau hopena ʻaoʻao a hiki ke hoʻopilikia i ka hiki o kou kino ke hana i ka lāʻau lapaʻau.

Inā koho ʻoe e inu i ka waiʻona i kekahi manawa, e kūkākūkā mua me kāu hui mālama ola. Hiki iā lākou ke aʻo iā ʻoe i ka nui, inā he, e palekana paha ma muli o kou olakino holoʻokoʻa a me ka hoʻolālā lapaʻau.

E hoʻomanaʻo hiki i ka waiʻona ke hoʻopilikia i kāu hana ate, a pono ka brigatinib i ka nānā ʻana i ke ake. ʻO ka mālama ʻana i ka inu ʻana i ka waiʻona e kōkua i ka hōʻoia ʻana i nā hopena nānā pono.