He aha ʻo Brodalumab: Nā Hoʻohana, Ka Leka, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

He lāʻau lapaʻau i kauoha ʻia ʻo Brodalumab e kōkua i ka mālama ʻana i ka psoriasis plaque maʻalahi a koʻikoʻi i nā pākeke. He lāʻau olaola ia e hana ana ma ka pale ʻana i nā protein kikoʻī i loko o kou ʻōnaehana pale e hoʻoulu ai i ka mumū a me ka ulu wikiwiki ʻana o nā cell ʻili i ʻike ʻia i ka psoriasis.

Hele mai kēia lāʻau lapaʻau ma ke ʻano he injection i hoʻopiha mua ʻia āu e hāʻawi ai iā ʻoe iho ma lalo o ka ʻili, maʻamau i hoʻokahi manawa i kēlā me kēia 12 pule ma hope o ka manawa hoʻouka mua. E loiloi pono kāu kauka inā kūpono ʻo brodalumab iā ʻoe, no ka mea, pono ia i ka nānā kūikawā ma muli o kekahi mau hopena ʻaoʻao koʻikoʻi akā kakaʻikahi.

He aha ʻo Brodalumab?

No ka papa o nā lāʻau lapaʻau i kapa ʻia ʻo interleukin-17 receptor antagonists ʻo Brodalumab. He lāʻau lapaʻau olaola i manaʻo ʻia e ālai pono i ka hana o interleukin-17, kahi protein e pāʻani nui i ka hana ʻana i nā hōʻailona psoriasis.

E noʻonoʻo i ka interleukin-17 ma ke ʻano he ʻelele e haʻi ana i kou ʻōnaehana pale e hana i ka mumū a me ka wikiwiki ʻana i ka hana ʻana o nā cell ʻili. Hoʻopau maoli ʻo Brodalumab i kēia leka, e kōkua ana i ka hoʻomaha ʻana i ka pane pale nui e hana ai i nā plaques psoriasis.

Hana ʻia ka lāʻau lapaʻau ma ke ʻano he hopena sterile a hele mai i nā syringes i hoʻopiha mua ʻia a i ʻole nā ​​auto-injectors. ʻOi aku ka maʻalahi o kēia iā ʻoe e hoʻokele iā ʻoe iho i ka injection ma ka home ke aʻo pono ʻia ʻoe e kāu mea mālama ola.

No ke aha e hoʻohana ʻia ai ʻo Brodalumab?

Ua ʻae ʻia ʻo Brodalumab no ka mālama ʻana i ka psoriasis plaque maʻalahi a koʻikoʻi i nā pākeke i kūpono no ka lāʻau lapaʻau systemic a i ʻole phototherapy. E noʻonoʻo kāu kauka i kēia lāʻau lapaʻau ke hāʻawi ʻole nā ​​lāʻau lapaʻau topical i ka hōʻoluʻolu.

ʻO ka psoriasis plaque ke ʻano maʻamau o ka psoriasis, i hōʻike ʻia e nā ʻāpana ʻulaʻula, ʻulaʻula, a me ka ʻili ma ka ʻili. Hiki i kēia mau plaques ke ʻā, ʻeha, a hoʻopilikia nui i kou ola. Kōkua ʻo Brodalumab i ka hōʻemi ʻana i ka nui, ka mānoanoa, a me ka ʻulaʻula o kēia mau plaques.

Hiki i kāu mea mālama ola ke ʻōlelo aku iā brodalumab inā he psoriasis kāu e uhi ana i kahi ʻāpana nui o kou kino, a i ʻole inā e hoʻopilikia nui ana ke kūlana i kāu mau hana i kēlā me kēia lā, ka hana, a i ʻole ka maikaʻi o ka naʻau. Mālama ʻia ka lāʻau lapaʻau no nā hihia kahi e ʻoi aku ai nā pōmaikaʻi ma mua o nā pilikia hiki.

Pehea e hana ai ʻo Brodalumab?

Ua manaʻo ʻia ʻo Brodalumab he lāʻau lapaʻau ikaika a i manaʻo ʻia e hana ana ma ka pale ʻana i ka mea hoʻokipa interleukin-17. Ke ālai ʻia kēia mea hoʻokipa, pale ia i ka cascade inflammatory e alakaʻi ai i nā hōʻailona psoriasis.

I ka psoriasis, hoʻouka hewa kāu ʻōnaehana pale i nā cell ʻili olakino, e hana ana iā lākou e hoʻonui wikiwiki ma mua o ka maʻamau. Ma kahi o ka pōʻai 28-lā maʻamau, hiki i nā cell ʻili ke hana hou i nā lā 3-4 wale nō, e alakaʻi ana i ka hōʻiliʻili ʻana o nā plaques mānoanoa a me ka ʻili.

Ma ka ālai ʻana i ka hōʻailona interleukin-17, kōkua ʻo brodalumab i ka hoʻolohi ʻana i kēia hana cell ʻili wikiwiki. Hoʻemi pū ia i ka mumū e hana ai i ka ʻulaʻula, ka pehu, a me ka hōʻoluʻolu ʻole e pili ana me nā plaques psoriasis. Hoʻomaka ka hapa nui o nā kānaka e ʻike i nā hoʻomaikaʻi i loko o 4-6 pule o ka hoʻomaka ʻana i ka lāʻau lapaʻau.

Pehea wau e lawe ai iā Brodalumab?

Hāʻawi ʻia ʻo Brodalumab ma ke ʻano he injection subcutaneous, ʻo ia hoʻi, ua hoʻokomo ʻia i loko o ka ʻiʻo momona ma lalo pono o kou ʻili. E aʻo aku kāu mea mālama ola iā ʻoe pehea e hoʻomākaukau pono ai a hāʻawi iā ʻoe iho i ka injection.

Hoʻomaka ka papa hana maʻamau me ʻekolu mau kau hoʻouka o 210 mg kēlā me kēia, i hāʻawi ʻia i nā pule 0, 1, a me 2. Ma hope o kēia manawa mua, e loaʻa iā ʻoe nā kau mālama o 210 mg i kēlā me kēia 12 pule. Hiki i kāu kauka ke hoʻololi i kēia papa hana ma muli o kāu pane ʻana i ka lāʻau lapaʻau.

Hiki iā ʻoe ke hoʻokomo i ka brodalumab i loko o kou ʻūhā, lima luna, a i ʻole ka ʻōpū, e hoʻololi ana i nā wahi injection e pale ai i ka huhū. Pono e mālama ʻia ka lāʻau lapaʻau i loko o ka pahu hau a lawe ʻia i ka mahana o ka lumi ma mua o ka injection. Mai lulu i ka lāʻau lapaʻau, no ka mea, hiki i kēia ke hōʻino i ka protein.

ʻOi aku ka maikaʻi o ka lawe ʻana i ka brodalumab i ka manawa like o ka lā no kēlā me kēia mahele i hoʻonohonoho ʻia. ʻAʻole pono ʻoe e lawe me ka meaʻai, akā ʻo ka mālama ʻana i kahi papa manawa kūlike e kōkua i ka hōʻoia ʻana i ka maikaʻi.

Pehea ka lōʻihi e lawe ai au i ka Brodalumab?

ʻO ka lōʻihi o ka mālama ʻana i ka brodalumab e ʻokoʻa mai kēlā me kēia kanaka a hilinaʻi i ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau. Pono ka hapa nui o nā kānaka e hoʻomau i ka mālama ʻana i ka wā lōʻihi e mālama i ka ʻili maʻemaʻe, no ka mea, he maʻi maʻi ka psoriasis.

E loiloi kāu kauka i kāu holomua i kēlā me kēia 3-6 mahina e hoʻoholo ai inā ʻo brodalumab ke ʻano kūpono iā ʻoe. Inā loaʻa iā ʻoe ka hoʻomaikaʻi nui, hiki i kāu mea mālama ola ke kūkākūkā inā e hoʻomau, hoʻoponopono i ka papa manawa dosing, a i ʻole e noʻonoʻo i nā koho lapaʻau ʻē aʻe.

Hiki i kekahi poʻe ke hoʻolōʻihi i ka manawa ma waena o nā injections inā maikaʻi ka psoriasis. Eia naʻe, ʻo ka hoʻōki ʻana i ka brodalumab holoʻokoʻa e alakaʻi pinepine i ka hoʻihoʻi ʻana o nā hōʻailona psoriasis i loko o kekahi mau mahina.

He aha nā hopena ʻaoʻao o Brodalumab?

E like me nā lāʻau lapaʻau a pau, hiki i ka brodalumab ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole i loaʻa i nā mea a pau. ʻO ka hoʻomaopopo ʻana i ka mea e nānā ai e kōkua iā ʻoe e manaʻo ʻoi aku ka mākaukau a me ka hilinaʻi e pili ana i kāu mālama ʻana.

ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a hiki ke mālama ʻia. Aia kēia mau mea i ka ʻeha hui, ke poʻo, ka luhi, ka maʻi maʻi, ka ʻeha ʻāʻī, ka nausea, ka ʻeha ʻiʻo, nā hopena ma ka wahi injection, a me nā maʻi tinea (nā maʻi ʻili fungal e like me ka wāwae o ka mea pāʻani).

Hiki ke loaʻa nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau, a he mea nui e ʻike i kēia mau mea hiki:

• Hoʻonui ʻia ka pilikia o nā maʻi, me nā maʻi bacteria, viral, a me fungal
• Maʻi ʻōpū mumū, me ka hoʻomaka ʻana a i ʻole ka ʻino ʻana o ka maʻi Crohn a i ʻole ulcerative colitis
• Nā manaʻo a i ʻole nā hana pepehi kanaka (he mea kakaikahi kēia akā pono ka lāʻau lapaʻau koke)
• Nā hopena maʻi, mai nā hopena ʻili maʻalahi a hiki i ka anaphylaxis koʻikoʻi

E nānā pono kāu kauka iā ʻoe no kēia mau pilikia hiki ke loaʻa. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ka mālama olakino kūpono, a ʻoi aku ka maikaʻi o ka mālama ʻana ma mua o nā pilikia no ka poʻe me ka psoriasis koʻikoʻi.

ʻO wai ka mea pono ʻole e lawe iā Brodalumab?

ʻAʻole kūpono ʻo Brodalumab no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia iā ʻoe. ʻO kekahi mau maʻi olakino a me nā kūlana e hana i kēia lāʻau lapaʻau kūpono ʻole a i ʻole e koi i nā hana kūikawā.

ʻAʻole pono ʻoe e lawe iā brodalumab inā loaʻa iā ʻoe kahi maʻi maʻi, me nā maʻi bacteria, viral, a i ʻole fungal. Hoʻopau ka lāʻau lapaʻau i kāu ʻōnaehana pale, hiki ke hoʻolilo i nā maʻi i ʻoi aku ka koʻikoʻi a i ʻole paʻakikī ke mālama.

Pono ka poʻe me ka moʻolelo o ka maʻi ʻōpū mumū e hoʻohana iā brodalumab me ka akahele nui, no ka mea, hiki iā ia ke hoʻonui i kēia mau kūlana. Pēlā nō, inā he moʻolelo kou o nā manaʻo pepehi kanaka a i ʻole ke kaumaha, pono kāu kauka e kaupaona pono i nā pilikia a me nā pōmaikaʻi.

ʻO nā mea ʻē aʻe e noʻonoʻo ai, ʻo ia nā lāʻau lapaʻau ola hou, ka hāpai ʻana a i ʻole ka hānai ʻana i ka umauma, a me nā maʻi maʻi i ʻike ʻia i brodalumab a i ʻole kāna mau meaʻai. E nānā kāu mea mālama ola i kāu mōʻaukala olakino piha ma mua o ke kau ʻana i kēia lāʻau lapaʻau.

Brodalumab Brand Name

Loaʻa ʻo Brodalumab ma lalo o ka inoa brand Siliq ma ʻAmelika Hui Pū ʻIa. ʻO kēia wale nō ke ʻano kūʻai aku o brodalumab i ʻae ʻia e ka FDA.

Hana ʻia ʻo Siliq e Bausch Health a hele mai i loko o nā syringes i hoʻopiha mua ʻia me 210 mg o brodalumab i 1.5 mL o ka wai. Pono ka lāʻau lapaʻau i kahi palapala kauoha a loaʻa maʻamau ma o nā hale kūʻai lāʻau lapaʻau kūikawā.

No ka mea he lāʻau lapaʻau olaola ʻo brodalumab, ʻaʻohe mana generic i loaʻa i kēia manawa. ʻO ka pale ʻana i ka patent a me ke kaʻina hana paʻakikī e manaʻo ʻia ʻo Siliq ka koho wale nō no ka lāʻau brodalumab.

Nā koho ʻē aʻe o Brodalumab

Nui nā lāʻau lapaʻau olaola ʻē aʻe i loaʻa no ka mālama ʻana i ka psoriasis maʻamau a koʻikoʻi, me kēlā me kēia me kāna mau pōmaikaʻi a me nā mea e noʻonoʻo ai. Hiki i kāu kauka ke kōkua iā ʻoe e hoʻomaopopo i ke koho e hana maikaʻi loa no kāu kūlana kikoʻī.

ʻO nā mea pale interleukin-17 ʻē aʻe e pili ana iā secukinumab (Cosentyx) a me ixekizumab (Taltz), e hana like me brodalumab akā he mau papa hana ʻokoʻa a me nā ʻaoʻao hopena. Hiki ke noʻonoʻo ʻia kēia mau lāʻau lapaʻau inā ʻaʻole kūpono ʻo brodalumab iā ʻoe.

ʻO nā mea pale TNF e like me adalimumab (Humira), etanercept (Enbrel), a me infliximab (Remicade) e hōʻike ana i kahi papa ʻē aʻe o nā biologics no ka psoriasis. Hana kēia mau lāʻau lapaʻau ma ka pale ʻana i ka factor necrosis tumor, kahi protein mumū ʻokoʻa i pili i ka psoriasis.

ʻO nā koho hou aku e pili ana i nā mea pale interleukin-23 e like me guselkumab (Tremfya), tildrakizumab (Ilumya), a me risankizumab (Skyrizi). Pono pinepine kēia mau lāʻau lapaʻau i ka liʻiliʻi o ka dosing a loaʻa paha nā ʻano hopena ʻokoʻa i hoʻohālikelike ʻia me brodalumab.

ʻOi aku ka maikaʻi o Brodalumab ma mua o Adalimumab?

He mau lāʻau lapaʻau maikaʻi ʻo Brodalumab a me adalimumab no ka psoriasis, akā hana lākou ma o nā mīkini like ʻole a loaʻa nā pōmaikaʻi a me nā hemahema. ʻO ke koho

Hiki paha i ka Brodalumab ke hāʻawi i ka hoʻomaikaʻi wikiwiki i ka wā mua, me kekahi poʻe e ʻike ana i nā hopena i loko o 2-4 pule. Hoʻohana ʻia hoʻi ia i ka liʻiliʻi pinepine ma hope o ka wā hoʻomaka, e koi ana i nā injections i kēlā me kēia 12 pule no ka mālama ʻana.

Ua loaʻa ʻo Adalimumab no ka manawa lōʻihi a he nui nā ʻikepili palekana lōʻihi. Ua ʻae ʻia no nā maʻi he nui ma waho o ka psoriasis, me ka rheumatoid arthritis a me ka maʻi ʻōpū inflammatory. Eia naʻe, pono ia i nā injections pinepine, maʻamau i kēlā me kēia pule ʻē aʻe.

ʻO ke koho ma waena o kēia mau lāʻau lapaʻau e hilinaʻi pinepine ʻia i nā mea e like me kou pilikia o nā maʻi, ka mōʻaukala o ka maʻi ʻōpū inflammatory, ka makemake injection, a me ke ʻano o kou pane ʻana i nā lāʻau lapaʻau ma mua. E kōkua kāu dermatologist iā ʻoe e noʻonoʻo i kēia mau mea e hana i ka hoʻoholo maikaʻi loa no kou kūlana.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Brodalumab

He Palekana ʻo Brodalumab no ka poʻe me ka maʻi diabetes?

Hiki ke hoʻohana palekana ʻia ʻo Brodalumab i ka poʻe me ka maʻi diabetes, akā pono paha ka nānā ʻana. Hiki i ka maʻi diabetes ke hoʻonui i kou pilikia o nā maʻi, a pili pū ʻo brodalumab i ka hiki o kou ʻōnaehana pale e hakakā i nā maʻi.

E nānā nui kāu kauka i kāu kaohi kōpaʻa koko a e nānā i nā hōʻailona o nā maʻi, ʻoiai nā maʻi fungal i ʻoi aku ka maʻamau i ka poʻe me ka maʻi diabetes. He mea nui e mālama i ka mana kōpaʻa koko maikaʻi a e hahai i ka mālama pono ʻana i ka pūnaewele injection e hōʻemi i ka pilikia o ka maʻi.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o Brodalumab?

Inā hoʻokomo hewa ʻoe i ka brodalumab ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu mea mālama ola. ʻOiai ua kaupalena ʻia ka ʻike overdose, he mea nui e kiʻi i ka ʻōlelo aʻo lapaʻau e pili ana i ka nānā ʻana i nā hopena ʻaoʻao i hoʻonui ʻia.

Mai hoʻāʻo e "kaulike" i ka lāʻau ʻoi loa ma ka haʻalele ʻana i kāu lāʻau i hoʻonohonoho ʻia e hiki mai ana. Akā, e hahai i ke alakaʻi a kāu kauka e pili ana i ka manawa e hoʻomaka hou ai i kāu papa hana lāʻau maʻamau. E mālama i ka mea i hana ʻia a me ka manawa e kōkua ai i kāu mea mālama ola e loiloi i ke kūlana.

He aha kaʻu e hana ai inā ua hala wau i kahi lāʻau o Brodalumab?

Inā ua hala ʻoe i kahi injection brodalumab i hoʻonohonoho ʻia, e hāʻawi iā ʻoe iho i ka injection i ka wā e hoʻomanaʻo ai ʻoe, a laila e hoʻomau me kāu papa hana lāʻau maʻamau. Mai hoʻāʻo e hopu ma ka lawe ʻana i ʻelua lāʻau kokoke.

Inā ua lohi loa ʻoe me kahi lāʻau (ʻoi aku ma mua o kekahi mau pule), e hoʻokaʻaʻike i kāu mea mālama ola no ke alakaʻi. Pono paha lākou e hoʻoponopono i kāu papa hana lapaʻau a i ʻole e nānā pono iā ʻoe no ka hoʻi ʻana mai o nā hōʻailona psoriasis.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Brodalumab?

Pono ʻoe e hooki i ka lawe ʻana iā brodalumab ma lalo o ke alakaʻi a kāu mea mālama ola. He maʻi maʻi ʻo Psoriasis, a ʻo ka hooki ʻana i ka lapaʻau e alakaʻi pinepine i ka hoʻi ʻana mai o nā hōʻailona i loko o kekahi mau mahina.

Hiki i kāu kauka ke noʻonoʻo e hooki i ka brodalumab inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, inā ʻaʻole hana pono ka lāʻau, a i ʻole inā e ulu ana ʻoe i nā kūlana e palekana ʻole ai ka lapaʻau mau. Mai hooki i ka lawe ʻana iā brodalumab me ka ʻole o ka nānā ʻana i ka lāʻau.

Hiki iaʻu ke hele i ka wā e lawe ana iā Brodalumab?

Hiki iā ʻoe ke hele i ka wā e lawe ana iā brodalumab, akā pono ʻoe e hoʻolālā i mua e mālama pono i kāu lāʻau a mālama i kāu papa hana injection. Pono e hoʻomaʻalili ʻia ʻo Brodalumab, no laila pono ʻoe i kahi mea hoʻoluʻu no ka lawe ʻana.

E lawe mai i kahi leka mai kāu kauka e wehewehe ana i kou pono no ka lāʻau a me nā lako injection i ka wā e hele ai ma ka lewa. E noʻonoʻo i ka manawa o kāu huakaʻi a puni kāu papa hana injection, a i ʻole e kūkākūkā me kāu mea mālama ola e pili ana i ka hoʻoponopono ʻana i nā lāʻau no nā huakaʻi lōʻihi.