He aha ʻo Cabazitaxel: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau chemotherapy ikaika ʻo Cabazitaxel i hoʻohana ʻia e mālama i ka maʻi maʻi prostate holomua i hohola i nā wahi ʻē aʻe o ke kino. No ka papa o nā lāʻau lapaʻau i kapa ʻia ʻo taxanes kēia lāʻau intravenous, e hana ana ma ka hoʻōki ʻana i nā cell cancer mai ka mahele a me ka ulu ʻana.

Inā ua kau ʻia ʻo cabazitaxel iā ʻoe a i ʻole kekahi āu e mālama ai, nui paha kāu mau nīnau e pili ana i kēia lapaʻau. ʻO ka hoʻomaopopo ʻana i ka hana ʻana o kēia lāʻau, ka mea e manaʻo ai, a pehea e mālama ai i nā hopena ʻaoʻao hiki ke kōkua iā ʻoe e mākaukau a hilinaʻi i kāu huakaʻi maʻi maʻi.

He aha ʻo Cabazitaxel?

He lāʻau chemotherapy ʻo Cabazitaxel i hoʻolālā ʻia e hakakā i nā cell cancer prostate i kūpaʻa i nā lāʻau lapaʻau ʻē aʻe. He mea i hana ʻia mai kahi mea maoli i loaʻa i ka ʻili lāʻau yew, i hoʻololi ʻia i loko o nā laboratories e hana i mea ʻoi aku ka maikaʻi i nā cell cancer paʻakikī.

Ua manaʻo ʻia kēia lāʻau he lāʻau lapaʻau laina ʻelua, ʻo ia hoʻi, ua kauoha nā kauka iā ia ma hope o ka pau ʻana o nā lāʻau hormone ʻē aʻe. He mea waiwai nui ʻo Cabazitaxel no ka mea hiki iā ia ke hoʻouka i nā cell cancer ʻoiai ua kūpaʻa lākou i ka docetaxel, kahi lāʻau chemotherapy maʻamau.

Hāʻawi mau ʻia ka lāʻau ma o ka infusion IV i loko o kahi haukapila a i ʻole ke kikowaena lapaʻau maʻi maʻi kūikawā. ʻAʻole ʻoe e lawe i kēia lāʻau ma ka home, no ka mea, pono ia i ka nānā pono ʻana a me ka hoʻokele ʻoihana e hōʻoia i kou palekana.

No ke aha i hoʻohana ʻia ai ʻo Cabazitaxel?

Hoʻohana nui ʻia ʻo Cabazitaxel e mālama i ka maʻi maʻi prostate metastatic castration-resistant (mCRPC). ʻO ia hoʻi, ua hohola ka maʻi maʻi ma mua o ka prostate gland a ʻaʻole e pane hou i nā lāʻau lapaʻau e ālai ana i ka hormone e hoʻohaʻahaʻa i nā pae testosterone.

E ʻōlelo maʻamau kāu kauka iā cabazitaxel ke holomua kāu maʻi maʻi prostate me ka nānā ʻole i nā lāʻau lapaʻau mua me ka chemotherapy i hoʻokumu ʻia e docetaxel. Ua ʻae ʻia ia no nā kāne nona ka maʻi maʻi i ʻoi aku ka maikaʻi ma hope o ka loaʻa ʻana o ka hormone therapy a me ka lāʻau docetaxel.

I kekahi mau hihia, hiki i nā kauka ke noʻonoʻo iā cabazitaxel ma ke ʻano he koho chemotherapy mua, ʻoiai no nā mea maʻi i hiki ʻole ke ʻae iā docetaxel a i ʻole nā ​​mea hōʻailona genetic kikoʻī e hōʻike ana e ʻoi aku ka maikaʻi o cabazitaxel. E loiloi kāu oncologist i kou kūlana pilikino e hoʻoholo ai inā kūpono kēia lāʻau lapaʻau iā ʻoe.

Pehea e hana ai ʻo Cabazitaxel?

Hana ʻo Cabazitaxel ma ka ʻimi ʻana i ka hale i loko o nā cell maʻi maʻi, e hoʻopilikia ana i nā paipu liʻiliʻi i kapa ʻia ʻo microtubules e kōkua i nā cell e māhele. E noʻonoʻo i kēia mau microtubules ma ke ʻano he scaffolding e pono ai nā cell e māhele i ʻelua cell hou i ka wā o ka hana hou ʻana.

Ke komo ʻo cabazitaxel i loko o nā cell maʻi maʻi, pili ia i kēia mau microtubules a pale iā lākou mai ka wāwahi pono ʻana. Hoʻopaʻa maoli kēia i nā cell maʻi maʻi ma kahi, e kāohi ana iā lākou mai ka māhele ʻana a i ka hopena e make ai lākou.

ʻO ka mea e hana ai ʻo cabazitaxel i mea maikaʻi loa, ʻo ia kona hiki ke hele i ka pale koko-lolo a komo i loko o nā cell maʻi maʻi i loaʻa ka pale ʻana i nā lāʻau chemotherapy ʻē aʻe. Manaʻo ʻia he lāʻau chemotherapy ikaika, ʻoi aku ka ikaika ma mua o nā lāʻau hormone akā ua hoʻolālā ʻia e hiki ke mālama ʻia me ke kākoʻo olakino kūpono.

Pehea wau e lawe ai iā Cabazitaxel?

Hāʻawi mau ʻia ʻo Cabazitaxel ma ke ʻano he infusion intravenous ma kahi o hoʻokahi hola, maʻamau i kēlā me kēia ʻekolu pule. E loaʻa iā ʻoe kēia lāʻau lapaʻau i loko o kahi haukapila, kikowaena maʻi maʻi, a i ʻole kahi keʻena infusion kūikawā kahi e hiki ai i nā poʻe loea mālama ola i aʻo ʻia ke nānā pono iā ʻoe.

Ma mua o kēlā me kēia hoʻokomo ʻana, e loaʻa iā ʻoe nā lāʻau lapaʻau ma mua e kōkua ai i ka pale ʻana i nā hopena maʻi a me ka hōʻemi ʻana i ka nausea. ʻO kēia mau mea maʻamau e komo pū me nā antihistamines, corticosteroids, a me nā lāʻau anti-nausea i hāʻawi ʻia ma kahi o 30 mau minuke ma mua o ka hoʻomaka ʻana o kāu lapaʻau cabazitaxel.

ʻAʻole pono ʻoe e ʻai wikiwiki ma mua o ka lapaʻau ʻana, akā ʻo ka ʻai ʻana i ka meaʻai māmā ma mua hiki ke kōkua i ka hōʻemi ʻana i ka nausea. E noho maikaʻi i ka wai ma ka inu ʻana i ka wai nui i nā lā e alakaʻi ana i kāu hoʻokomo ʻana. E hāʻawi kāu hui mālama ola i nā ʻōlelo kikoʻī e pili ana i nā lāʻau lapaʻau āu e pale ai ma mua o ka lapaʻau.

I ka wā o ka hoʻokomo ʻana, e nānā nā kahu hānai i kāu mau hōʻailona ola i nā manawa maʻamau a nānā i nā hōʻailona o nā hopena maʻi. E nānā pono ʻia ka pūnaewele IV e hōʻoia i ka kahe pono ʻana o ka lāʻau a ʻaʻole e hoʻonāukiuki i kou vein.

Pehea ka lōʻihi e lawe ai au i ka Cabazitaxel?

ʻO ka lōʻihi o ka lapaʻau cabazitaxel e ʻokoʻa nui mai kēlā me kēia kanaka, ma muli o ka maikaʻi o ka pane ʻana o ka maʻi kanesa a me ka maikaʻi o kou ʻae ʻana i ka lāʻau. Loaʻa ka hapa nui o nā kānaka i ka lapaʻau no kekahi mau mahina, maʻamau mai 6 a 10 mau pōʻai.

E loiloi kāu oncologist i kāu pane ma hope o kēlā me kēia 2-3 pōʻai me ka hoʻohana ʻana i nā hoʻokolohua koko, nā kiʻi kiʻi, a me nā loiloi o kāu mau hōʻailona. Inā e hana ana ka lapaʻau a ke mālama maikaʻi nei ʻoe i nā hopena ʻaoʻao, hiki iā ʻoe ke hoʻomau no nā pōʻai hou.

Hoʻomau ka lapaʻau a hiki i kekahi o nā mea he nui e hana: ua pau ka maʻi kanesa i ka pane ʻana i ka lāʻau, ua paʻakikī loa nā hopena ʻaoʻao e mālama ai, a i ʻole ʻoe a me kāu kauka e hoʻoholo ʻaʻole i ʻoi aku nā pōmaikaʻi ma mua o nā pilikia. Hiki i kekahi poʻe maʻi ke loaʻa i ka cabazitaxel no hoʻokahi makahiki a ʻoi aku paha inā e hoʻomau ana ia e kāohi i kā lākou maʻi kanesa.

He aha nā hopena ʻaoʻao o Cabazitaxel?

E like me nā lāʻau chemotherapy a pau, hiki i ka cabazitaxel ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole i ʻike nā mea a pau iā lākou a pau. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e hoʻomākaukau a ʻike i ka manawa e hoʻopili ai i kāu hui mālama ola.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia ka luhi, ka maʻi, ka maʻi palahē, a me ka nalowale o ka lauoho no ka manawa pōkole. Nui nā maʻi e ʻike pū i nā loli i ko lākou ʻai a hiki ke ʻike i kekahi ʻano ʻeha a i ʻole ke kani ʻana i ko lākou mau lima a me nā wāwae.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia e pili ana i nā maʻi he nui:

• Ka luhi a me ka nāwaliwali e mau ana no nā lā ma hope o ka lapaʻau
• Ka maʻi a me ka luaʻi, hiki ke mālama ʻia me nā lāʻau anti-nausea
• Ka maʻi palahē, i kekahi manawa hiki ke koʻikoʻi a koi i ka lāʻau lapaʻau
• Ka nalowale o ka lauoho, e hoʻomaka ana ma hope o nā lapaʻau mua
• Hoʻemi ʻia ka ʻai a me nā loli i ka ʻono
• Haʻahaʻa nā helu koko, e hoʻonui ana i ka pilikia o ka maʻi
• Ka ʻeha a i ʻole ke kani ʻana i nā lima a me nā wāwae (peripheral neuropathy)
• ʻEha ʻiʻo a me ka ʻeha hui

He manawa pōkole kēia mau hopena ʻaoʻao a hoʻomaikaʻi i waena o nā pōʻai lapaʻau. E hāʻawi kāu hui mālama ola i nā lāʻau lapaʻau a me nā hoʻolālā e kōkua i ka mālama ʻana i kēia mau hōʻailona.

ʻAʻole maʻamau, hiki i kekahi mau maʻi ke ʻike i nā hopena ʻaoʻao koʻikoʻi e koi ana i ka lāʻau lapaʻau koke. ʻOiai e hana ana kēia i ka liʻiliʻi o nā kānaka, he mea nui e ʻike iā lākou.

Eia nā hopena ʻaoʻao kakaʻikahi akā koʻikoʻi e nānā ai:

• Nā hopena maʻi koʻikoʻi i ka wā a i ʻole ma hope koke o ka hoʻokomo ʻana
• Nā maʻi koʻikoʻi ma muli o nā helu keʻokeʻo koko haʻahaʻa loa
• Nā pilikia o ka puʻupaʻa, me nā loli i ka mimi a i ʻole ka pehu
• Ka maʻi palahē koʻikoʻi e alakaʻi ana i ka dehydration
• Nā pilikia hanu a i ʻole ka ʻū mau
• Ke kahe koko ʻano ʻē a i ʻole ka ʻeha
• ʻEha ʻōpū koʻikoʻi a i ʻole ka luaʻi mau

Inā ʻike ʻoe i kekahi o kēia mau hōʻailona koʻikoʻi, e hoʻokaʻaʻike koke i kāu oncologist a i ʻole e ʻimi i ka lāʻau lapaʻau pilikia. E nānā pono kāu hui mālama ola iā ʻoe me nā hoʻokolohua koko maʻamau e hopu i nā pilikia i ka wā mua.

ʻO wai ka mea pono ʻole e lawe iā Cabazitaxel?

ʻAʻole kūpono ʻo Cabazitaxel no nā mea a pau, a e loiloi pono kāu kauka inā palekana kēia lapaʻau iā ʻoe. Hiki i kekahi mau maʻi olakino a i ʻole nā kūlana ke hoʻoweliweli a i ʻole ka liʻiliʻi o ka cabazitaxel.

ʻAʻole pono ʻoe e loaʻa iā cabazitaxel inā he maʻi koʻikoʻi ʻoe i kēia lāʻau a i ʻole kekahi o kāna mau meaʻai, me ka polysorbate 80. Pono paha ka poʻe me nā ʻōnaehana pale maʻi i hoʻopilikia nui ʻia a i ʻole nā helu keʻokeʻo koko haʻahaʻa loa e pale i kēia lapaʻau.

E makaʻala loa kāu kauka i ka kuhikuhi ʻana i ka cabazitaxel inā loaʻa iā ʻoe kekahi o kēia mau maʻi:

• Nā pilikia ate koʻikoʻi a i ʻole nā enzyme ate kiʻekiʻe
• Nā maʻi ikaika, ʻaʻole i mālama ʻia
• ʻO ka ʻoki nui hou a i ʻole nā ʻeha lohi
• Maʻi kīkī koʻikoʻi
• Nā pilikia o ka naʻau a i ʻole ka puʻuwai i kēia manawa
• Mōʻaukala o nā hopena maʻi koʻikoʻi i nā lāʻau taxane
• ʻAʻole maikaʻi ke olakino holoʻokoʻa

ʻAʻole hoʻokaʻawale wale ka makahiki iā ʻoe mai ka loaʻa ʻana o ka cabazitaxel, akā e nānā pono ʻia nā mākua ʻelemakule no nā hopena ʻaoʻao. E kaupaona kāu oncologist i nā pōmaikaʻi kūpono e kūʻē i nā pilikia e pili ana i kāu ʻikepili olakino.

Nā inoa inoa o Cabazitaxel

Loaʻa ʻo Cabazitaxel ma lalo o ka inoa inoa ʻo Jevtana, i hana ʻia e Sanofi. ʻO kēia ke ʻano kumu a me ka mea i kuhikuhi pinepine ʻia o ka cabazitaxel i loaʻa ma ka hapa nui o nā ʻāina.

Hiki ke loaʻa nā mana generic o cabazitaxel ma kekahi mau wahi, ʻoiai aia nā mea hana like a hana like me ka mana inoa inoa. E kōkua kāu hale kūʻai lāʻau lapaʻau a me ka ʻoihana ʻinikua e hoʻoholo i ka mana āu e loaʻa ai.

Me ka nānā ʻole i ka brand āu e loaʻa ai, ua like ka lāʻau lapaʻau i ka pono a me nā hopena ʻaoʻao. ʻO nā ʻokoʻa nui paha i ka ʻeke, ke ʻano, a i ʻole ke kumukūʻai, akā ua like nā pōmaikaʻi therapeutic.

Nā koho ʻē aʻe o Cabazitaxel

Inā ʻaʻole kūpono ʻo cabazitaxel iā ʻoe a i ʻole e pau ka hana pono ʻana, aia kekahi mau koho lapaʻau ʻē aʻe no ka maʻi maʻi prostate holomua. E kōkua kāu oncologist iā ʻoe e ʻimi i kēia mau koho ʻē aʻe e pili ana i kou kūlana kikoʻī.

ʻO nā koho chemotherapy ʻē aʻe e komo pū ana me docetaxel, ka mea i hoʻāʻo pinepine ʻia ma mua o cabazitaxel, a me mitoxantrone, ka mea e noʻonoʻo ʻia no ka mālama ʻana i nā hōʻailona. Hāʻawi nā lāʻau lapaʻau i manaʻo ʻia e like me enzalutamide, abiraterone, a me darolutamide i nā ʻano hana like ʻole.

ʻO nā koho ʻē aʻe e noʻonoʻo ai kāu kauka:

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• Radium-223, he lapaʻau radioactive no nā metastases iwi
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• Sipuleucel-T, he lapaʻau immunotherapy
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• Olaparib a i ʻole rucaparib no nā maʻi me nā loli genetic kikoʻī
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• Lutetium-177 PSMA no kekahi mau ʻano maʻi maʻi prostate holomua
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• Nā hoʻokolohua lapaʻau e hoʻāʻo ana i nā lapaʻau hoʻokolohua hou
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ʻO ke koho maikaʻi loa e pili ana i kāu mau lapaʻau mua, nā hopena hoʻāʻo genetic, ke olakino holoʻokoʻa, a me nā makemake pilikino. E hana pū kāu hui mālama ola me ʻoe e ʻimi i ka hana kūpono e hiki mai ana.

Ua ʻoi aku ka maikaʻi o Cabazitaxel ma mua o Docetaxel?

He mau lāʻau chemotherapy maikaʻi ʻo Cabazitaxel a me docetaxel no ka maʻi maʻi prostate, akā hoʻohana ʻia lākou i nā pae like ʻole o ka lapaʻau. ʻO Docetaxel ka koho chemotherapy mua, ʻoiai ua mālama ʻia ʻo cabazitaxel no ka wā e pau ai ka hana ʻana o docetaxel.

Hōʻike ka noiʻi e hiki ke maikaʻi ʻo cabazitaxel ma hope o ka ulu ʻana o ke kūʻē ʻana o docetaxel, e lilo ia i koho laina lua waiwai. Eia naʻe, ʻaʻole pono kēia e manaʻo ʻo cabazitaxel

Nīnau pinepine ʻia e pili ana iā Cabazitaxel

He palekana anei ʻo Cabazitaxel no ka poʻe me ka maʻi diabetes?

Hiki ke hoʻohana palekana ʻia ʻo Cabazitaxel i ka poʻe me ka maʻi diabetes, akā pono paha e nānā pono ʻia nā pae kōpaʻa koko i ka wā o ka mālama ʻana. Hiki i nā lāʻau lapaʻau mua āu e loaʻa ai, ʻo ia hoʻi nā corticosteroids, ke hoʻonui i nā pae kōpaʻa koko no ka manawa.

E hana paʻa me kāu oncologist a me ka hui mālama diabetes e hoʻoponopono i kāu mau lāʻau diabetes inā pono. E nānā i kou kōpaʻa koko i nā manawa pinepine ma mua o ka maʻamau, ʻoiai i nā lā lapaʻau a me nā lā ma hope.

He aha kaʻu e hana ai inā ua hala au i kahi lāʻau Cabazitaxel?

No ka mea, hāʻawi ʻia ʻo cabazitaxel i loko o kahi keʻena lapaʻau, ʻaʻole ʻoe e hala i kahi lāʻau ma ka home. Inā pono ʻoe e hoʻopaneʻe i kahi lapaʻau i hoʻonohonoho ʻia ma muli o ka maʻi, nā helu koko haʻahaʻa, a i ʻole nā pilikia olakino ʻē aʻe, e hoʻokaʻaʻike i kāu oncologist i ka hiki wawe.

Na kāu hui mālama ola e hoʻoholo i ka wā e palekana ai ke hoʻonohonoho hou i kāu lapaʻau. I kekahi manawa he mea pono ka lohi e hiki ai i kou kino ke ola, a ʻaʻole pono kēia e hōʻino i nā hopena o kāu lapaʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Cabazitaxel?

ʻO ka hoʻoholo e hooki i ka cabazitaxel e hilinaʻi ana i nā mea he nui, me ka maikaʻi o ka mālama ʻana i ka maʻi kanesa a me ke ʻano o kou mālama ʻana i nā hopena ʻaoʻao. E loiloi mau kāu oncologist i kāu pane me ka hoʻohana ʻana i nā hoʻokolohua koko a me nā haʻawina kiʻi.

Hiki iā ʻoe ke hooki i ka lapaʻau inā holomua ka maʻi kanesa me ka ʻole o ka lāʻau lapaʻau, inā lilo nā hopena ʻaoʻao i mea paʻakikī loa ke mālama ʻia, a i ʻole inā hoʻoholo ʻoe a me kāu kauka ʻaʻole i ʻoi aku nā pōmaikaʻi ma mua o nā pilikia. Mai hooki i ka lapaʻau me ka ʻole e kūkākūkā mua me kāu hui mālama ola.

Hiki iaʻu ke hana i ka wā e loaʻa ana iaʻu ka lapaʻau Cabazitaxel?

Hiki i ka nui o nā kānaka ke hoʻomau i ka hana i ka wā e loaʻa ana iā cabazitaxel, akā pono paha ʻoe e hoʻololi i kāu papa manawa a i ʻole nā ​​kuleana. He mea maʻamau ka luhi a hiki ke mau i kekahi mau lā ma hope o kēlā me kēia pōʻai lapaʻau.

E noʻonoʻo e hoʻolālā i nā lā hana māmā ma hope koke o kāu mau infusions, a e mākaukau e hoʻomaha inā loaʻa iā ʻoe nā maʻi a i ʻole nā pilikia ʻē aʻe. E kūkākūkā i kāu kūlana hana me kāu hui mālama ola e hoʻomohala i kahi hoʻolālā maoli.

E Hoʻopilikia ʻo Cabazitaxel i koʻu hiki ke loaʻa nā keiki?

Hiki i ka Cabazitaxel ke hoʻopilikia i ka momona i nā kāne a hiki ke hōʻino i nā genes i ka sperm. Inā ʻoe e hoʻolālā nei e loaʻa nā keiki i ka wā e hiki mai ana, e kūkākūkā i nā koho mālama momona me kāu oncologist ma mua o ka hoʻomaka ʻana i ka lāʻau.

E hoʻohana i ka contraception maikaʻi i ka wā o ka lāʻau a no kekahi mau mahina ma hope, e like me ka mea i ʻōlelo ʻia e kāu hui mālama ola. Hiki ke noho ka lāʻau i loko o kāu ʻōnaehana no kekahi manawa ma hope o kāu mahele hope loa.