He aha ʻo Ceritinib: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i manaʻo ʻia ʻo Ceritinib e ālai ana i nā protein kikoʻī e kōkua ana i kekahi mau maʻi maʻi maʻi māmā e ulu. Ua hoʻolālā ʻia no nā kānaka me kahi ʻano maʻi maʻi māmā non-small cell i loaʻa kahi loli genetic i kapa ʻia ʻo ALK rearrangement.

Hōʻike kēia lāʻau lapaʻau i kahi holomua nui i ka mālama ʻana i ka maʻi maʻi pilikino. Ma mua o ka hoʻouka ʻana i nā cell e mahele wikiwiki ana e like me ka chemotherapy kuʻuna, hana ʻo ceritinib me ka pololei ma ka manaʻo ʻana i ka protein abnormal e hoʻokele i ka ulu ʻana o ka maʻi maʻi i kāu ʻano maʻi kikoʻī.

He aha ʻo Ceritinib?

No ka papa o nā lāʻau lapaʻau i kapa ʻia ʻo tyrosine kinase inhibitors ʻo Ceritinib. E noʻonoʻo iā ia he kī kikoʻī loa e kūpono i loko o kahi laka kikoʻī ma nā cell maʻi maʻi, e hoʻōki ana iā lākou mai ka loaʻa ʻana o nā hōʻailona e pono ai lākou e ulu a hoʻonui.

Hele mai ka lāʻau lapaʻau ma ke ʻano o nā capsules āu e lawe ai ma ka waha. ʻO ia ka mea a nā kauka e kapa ai he

Hoʻohana ʻia ka lāʻau lapaʻau i ka wā i pau ai nā mea pale ALK ʻē aʻe i ka hana pono. Hiki i nā pūnaewele maʻi ʻaʻai ke kūʻē i kekahi lāʻau lapaʻau, akā hiki nō ke hana ʻo ceritinib no ka mea he hana ʻokoʻa iki ia ma mua o nā lāʻau like ʻē aʻe.

Pehea e Hana ai ʻo Ceritinib?

Hana ʻo Ceritinib ma ka pale ʻana i ka protein ALK e hoʻouna mau ana i nā hōʻailona

E hoʻāʻo e lawe i kāu lāʻau i ka manawa like i kēlā me kēia lā e mālama i nā pae kūlike i loko o kou kahe koko. Nui ka poʻe i ʻike he mea kōkua ke hoʻopili ʻana i ka lawe ʻana i kā lākou lāʻau me kahi hana maʻamau i kēlā me kēia lā, e like me ka ʻaina kakahiaka a i ʻole ka ʻaina awakea.

Pehea ka lōʻihi e lawe ai au i ka Ceritinib?

E hoʻomau ʻoe i ka lawe ʻana i ka ceritinib no ka lōʻihi e kāohi ana i kāu maʻi maʻi a ke ʻae maikaʻi nei ʻoe iā ia. Hiki paha kēia i nā mahina a i ʻole nā makahiki, ma muli o ke ʻano o ka pane ʻana o kāu maʻi maʻi i ka lāʻau lapaʻau.

E nānā kāu kauka i kāu holomua me nā scans maʻamau a me nā hoʻokolohua koko. Inā pau ka hana ʻana o ka lāʻau lapaʻau a i ʻole inā paʻakikī loa nā hopena ʻaoʻao e mālama ai, e kūkākūkā kāu kauka i nā koho lapaʻau ʻē aʻe me ʻoe.

Mai hooki i ka lawe ʻana i ka ceritinib me ka ʻole e kamaʻilio mua me kāu kauka. ʻOiai inā maikaʻi ʻoe, ke hana nei paha ka lāʻau lapaʻau e kāohi i kāu maʻi maʻi. ʻO ka hooki ʻana i ka hikiwawe hiki ke ʻae i ka maʻi maʻi e hoʻomaka e ulu hou.

He aha nā hopena ʻaoʻao o Ceritinib?

E like me nā lāʻau lapaʻau maʻi maʻi a pau, hiki i ka ceritinib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā mea a pau iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao, a e hana pū kāu hui mālama ola me ʻoe e hōʻemi i nā pilikia.

Eia nā hopena ʻaoʻao maʻamau e ʻike ai ʻoe, ma ke ʻano mai ka mea maʻamau a i ka liʻiliʻi:

• Pāpaʻa a me ka ʻōpū
• Nausea a me ka luaʻi
• Luhi a me ka luhi
• Hoʻemi ʻia ka ʻai
• ʻEha ʻōpū
• ʻO ka ʻili a i ʻole nā ​​hoʻololi ʻili
• Nā loli i nā hoʻokolohua hana ate

E nānā pono kāu kauka i kēia mau hopena ʻaoʻao a hiki ke hoʻoponopono i kāu mahele a i ʻole e hāʻawi i nā lāʻau lapaʻau e kōkua i ka mālama ʻana iā lākou. ʻIke ka hapa nui o ka poʻe e lilo nā hopena ʻaoʻao i mea hiki ke mālama ʻia i ka wā e hoʻoponopono ai ko lākou kino i ka lāʻau lapaʻau.

Pono kekahi mau hopena ʻaoʻao laha akā koʻikoʻi i ka lāʻau lapaʻau koke. Pākuʻi ʻia kēia mau pilikia hanu nui, nā loli o ka puʻuwai, nā pilikia ate nui, a i ʻole nā ​​hōʻailona o ka mumū māmā koʻikoʻi.

• He hanu pōkole loa a i ʻole nā pilikia hanu hou
• Ka puʻuwai ʻole a i ʻole ka ʻeha o ka umauma
• Ka ʻeha nui o ka ʻōpū a i ʻole ka melemele o ka ʻili/nā maka
• Ka ʻūlū mau me ke kuni
• Ka nausea nui a mau e pale ana i ka ʻai a i ʻole ka inu

Inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona koʻikoʻi, e hoʻokaʻaʻike koke i kāu mea mālama ola a i ʻole e ʻimi i ka lāʻau lapaʻau pilikia. ʻAʻole maʻamau kēia mau pilikia akā pono e mālama koke ʻia ke loaʻa.

ʻO wai ka mea pono ʻole e lawe iā Ceritinib?

ʻAʻole kūpono ʻo Ceritinib no nā mea a pau. E nānā pono kāu kauka i kāu moʻolelo olakino a me ke kūlana olakino i kēia manawa ma mua o ke kau ʻana i kēia lāʻau.

ʻAʻole pono ʻoe e lawe iā ceritinib inā he maʻi ʻoe iā ia a i ʻole kekahi o kāna mau mea. E akahele nō hoʻi kāu kauka i ke kau ʻana inā loaʻa iā ʻoe kekahi mau maʻi puʻuwai, nā pilikia ate nui, a i ʻole nā maʻi māmā ʻē aʻe ma mua o ka maʻi kanesa.

ʻAʻole pono nā wahine hāpai e lawe iā ceritinib no ka mea hiki iā ia ke hōʻino i ka pēpē e ulu ana. Inā he makahiki hānau keiki kāu, pono ʻoe e hoʻohana i ka contraception kūpono i ka wā o ka mālama ʻana a no kekahi mau mahina ma hope o ka hoʻōki ʻana i ka lāʻau.

Pono paha ka poʻe me ka maʻi kīkī nui i nā hoʻoponopono ʻana i ka lāʻau a i ʻole nā lāʻau lapaʻau ʻē aʻe. E nānā kāu kauka i kāu hana kīkī ma mua o ka hoʻomaka ʻana i ka mālama ʻana a nānā mau i ka wā o kāu therapy.

Nā inoa inoa Ceritinib

Kūʻai ʻia ʻo Ceritinib ma lalo o ka inoa inoa Zykadia. ʻO kēia ka inoa maʻamau āu e ʻike ai ma nā ʻōmole kauoha a me nā palapala lapaʻau.

Hiki ke hilinaʻi ʻia inā loaʻa iā ʻoe ka inoa inoa a i ʻole kahi mana generic ma kāu ʻinikua a me ka hale kūʻai lāʻau lapaʻau. Loaʻa i nā mana ʻelua ka mea hana like a hana like i loko o kou kino.

Nā koho ʻē aʻe o Ceritinib

Loaʻa kekahi mau mea pale ALK ʻē aʻe inā ʻaʻole ʻo ceritinib ke koho kūpono iā ʻoe. Aia kēia mau mea i ka crizotinib (Xalkori), alectinib (Alecensa), a me brigatinib (Alunbrig).

Na kāu kauka e koho i ka mea pale ALK maikaʻi loa e pili ana i kou kūlana kikoʻī. ʻO nā mea e pili ana, inā ua loaʻa iā ʻoe ka lāʻau i hala, ka nui o kāu maʻi ʻaʻai, a me kou olakino holoʻokoʻa.

Inā ʻaʻole kūpono nā mea pale ALK, hiki i nā koho lapaʻau ʻē aʻe ke komo i ka immunotherapy, ka chemotherapy kuʻuna, a i ʻole ke komo ʻana i nā hoʻokolohua lapaʻau e hoʻāʻo ana i nā lāʻau lapaʻau hou.

Ua ʻoi aku ka maikaʻi o Ceritinib ma mua o Crizotinib?

He mea maikaʻi ʻo Ceritinib a me crizotinib i nā mea pale ALK, akā he mau ʻokoʻa nui ko lākou. ʻOi aku ka maikaʻi o Ceritinib no nā maʻi ʻaʻai i kūʻē i ka crizotinib, a hiki ke hana maikaʻi i ka maʻi ʻaʻai i laha i ka lolo.

Eia naʻe, hiki i ka ceritinib ke hana i nā hopena ʻaoʻao e pili ana i ka ʻōpū ma mua o ka crizotinib. ʻO ke koho

Inā ua lawe hewa ʻoe i ka ceritinib ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka a i ʻole ke kikowaena mana ʻawa. ʻO ka lawe ʻana i ka nui loa e hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi, e pili ana i kou puʻuwai, ate, a i ʻole ʻōpū.

Mai hoʻāʻo e hoʻoponopono i ka overdose ma ka haʻalele ʻana i kāu mahele aʻe. Akā, e hahai i nā ʻōlelo a kāu kauka e pili ana i ka hana ʻana me kāu papa hana maʻamau.

He aha kaʻu e hana ai inā ua hala au i kahi mahele o Ceritinib?

Inā ua hala ʻoe i kahi mahele a ua hala ma lalo o 12 hola mai kou manawa i hoʻonohonoho ʻia, e lawe koke i ka wā e hoʻomanaʻo ai ʻoe. Inā ua hala ma mua o 12 hola, e haʻalele i ka mahele i hala a e lawe i kāu mahele aʻe i ka manawa maʻamau.

Mai lawe ʻelua mahele i ka manawa hoʻokahi e hoʻoponopono ai i kahi mahele i hala. Hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao me ka ʻole e hāʻawi i ka pōmaikaʻi hou.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Ceritinib?

Pono ʻoe e hooki i ka lawe ʻana i ka ceritinib ma lalo o ke alakaʻi a kāu kauka. ʻOiai inā maikaʻi kou manaʻo, ke hana nei ka lāʻau lapaʻau e kāohi i kāu maʻi kanesa, a ʻo ka hooki ʻana e hiki ai ke hoʻomaka hou.

E loiloi mau kāu kauka i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau ma o nā scans a me nā hoʻokolohua koko. Inā pau ka hana ʻana a i ʻole inā lilo nā hopena ʻaoʻao i mea koʻikoʻi loa, e kūkākūkā lākou i nā koho lapaʻau ʻē aʻe me ʻoe.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Ceritinib?

ʻOi aku ka maikaʻi e pale a i ʻole e kaupalena i ka waiʻona i ka wā e lawe ana i ka ceritinib. Hiki i ka waiʻona ke hoʻonui i ka pilikia o nā pilikia o ke ake a hiki ke hoʻonui i kekahi mau hopena ʻaoʻao e like me ka nausea a me ka ʻōpū.

Inā koho ʻoe e inu i kekahi manawa, e kūkākūkā mua me kāu kauka. Hiki iā lākou ke aʻo iā ʻoe e pili ana i kou olakino holoʻokoʻa a me ka maikaʻi o ka hana ʻana o kou ate i ka wā o ka mālama ʻana.