He aha ʻo Cladribine: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i kauoha ʻia ʻo Cladribine e kōkua i ka mālama ʻana i kekahi mau ʻano o ka sclerosis lehulehu ma ka hoʻemi ʻana i ka hana o nā pūnaewele immune e hoʻouka i kou ʻōnaehana nerve. He lāʻau lapaʻau i manaʻo ʻia e hana ʻokoʻa mai nā lāʻau lapaʻau MS ʻē aʻe, e hāʻawi ana i ka manaʻolana no ka poʻe me nā ʻano relapsing o kēia maʻi.

No kēia lāʻau lapaʻau i kahi papa o nā lāʻau i kapa ʻia ʻo antimetabolites, ʻo ia hoʻi, ke keakea nei i ke ʻano o ka ulu ʻana a me ka hoʻonui ʻana o kekahi mau pūnaewele. ʻOiai he mea hopohopo paha ia, ua hoʻolālā ʻia ʻo cladribine e kuhikuhi i nā pūnaewele immune kikoʻī e kōkua i nā hōʻailona MS me ka waiho ʻana i ka hapa nui o kāu mau pūnaewele olakino.

No ke aha e hoʻohana ʻia ai ʻo Cladribine?

Hoʻohana nui ʻia ʻo Cladribine e mālama i nā ʻano relapsing o ka sclerosis lehulehu i nā pākeke. Hiki i kāu kauka ke ʻōlelo aku i kēia lāʻau lapaʻau inā loaʻa iā ʻoe ka relapsing-remitting MS a i ʻole ka hana secondary progressive MS, kahi e hele mai ai kāu mau hōʻailona a hele i nā hanana.

Hiki mai ka sclerosis lehulehu ke hoʻouka hewa ʻia kou ʻōnaehana immune i ka uhi pale a puni kou mau aʻa nerve. Hoʻokumu kēia i ka mumū a me ka pōʻino e hiki ke hoʻoulu i nā hōʻailona e like me ka luhi, nā pilikia hele, ka ʻeha, a me nā pilikia me ka hoʻonohonoho. Kōkua ʻo Cladribine ma ka hoʻemi ʻana i ka helu o nā lymphocytes, ʻo ia nā pūnaewele immune kikoʻī e hana nei i kēia pōʻino.

Hoʻokaʻawale ʻia ka lāʻau lapaʻau no ka poʻe i loaʻa iā MS hana nui a i ʻole ʻaʻole i pane maikaʻi i nā lāʻau lapaʻau ʻē aʻe. E loiloi pono kāu mea mālama ola i kāu mōʻaukala olakino a me ke kūlana o kēia manawa e hoʻoholo ai inā ʻo cladribine ke koho kūpono iā ʻoe.

Pehea e hana ai ʻo Cladribine?

Hana ʻo Cladribine ma ka hoʻopaʻa ʻana a me ka hoʻemi ʻana i nā ʻano kikoʻī o nā keʻokeʻo koko i kapa ʻia ʻo lymphocytes, ʻo ia hoʻi nā pūnaewele B a me nā pūnaewele T e kōkua i ka mumū MS. E noʻonoʻo iā ia he mea hoʻoponopono koho e wehe i nā pūnaewele immune pilikia me ka waiho ʻana i ka hapa nui o kāu ʻōnaehana immune.

Ma hope o kou lawe ʻana i ka lāʻau lapaʻau, e hoʻololi ʻia ia i kahi ʻano hana i loko o kēia mau pūnaewele i manaʻo ʻia. A laila, keakea kēia ʻano hana i ka hiki o nā pūnaewele ke hoʻonui a ola, e alakaʻi ana i kahi hōʻemi nui akā manawa pōkole i nā pūnaewele immune e hoʻouka i kāu ʻōnaehana nerve.

Ua manaʻo ʻia he lāʻau lapaʻau ikaika i ka spectrum lapaʻau MS. ʻOi aku ka ikaika ma mua o kekahi mau lapaʻau laina mua akā ua hoʻolālā ʻia e hāʻawi i nā pōmaikaʻi lōʻihi me nā manawa lapaʻau pōkole. Hiki i nā hopena ke mau no nā mahina a i ʻole nā makahiki ma hope o ka pau ʻana o ka papa lapaʻau.

Pehea wau e lawe ai iā Cladribine?

Hele mai ʻo Cladribine ma ke ʻano he papa e lawe ai ʻoe ma ka waha, maʻamau e pili ana i kahi papa manawa kikoʻī ma luna o ʻelua makahiki. E hāʻawi kāu kauka i nā ʻōlelo kikoʻī, akā ʻo ke ʻano maʻamau e pili ana i ka lawe ʻana i ka lāʻau lapaʻau no kekahi mau lā i nā pule, me nā wā lōʻihi ma waena.

Pono ʻoe e lawe i nā papa cladribine ma ka ʻōpū ʻole, ma ka liʻiliʻi hoʻokahi hola ma mua o ka ʻai ʻana a i ʻole ʻelua hola ma hope o ka ʻai ʻana. E ale i nā papa holoʻokoʻa me ke aniani wai piha, a mai ʻoki, nau, a haki paha iā lākou. Kōkua kēia i ka hōʻoia ʻana ua komo pono ka lāʻau lapaʻau a hana e like me ka mea i manaʻo ʻia.

He mea nui e mālama pono i nā papa a holoi pono i kou mau lima ma mua a ma hope o ka lawe ʻana iā lākou. Inā haki a ʻānai paha kahi papa, mai hoʻopā pololei i nā ʻāpana. Akā, e hoʻohana i nā mīkina lima a i ʻole ka lole pulu e hoʻomaʻemaʻe, no ka mea, hiki ke komo ka lāʻau lapaʻau ma kou ʻili.

E hoʻonohonoho paha kāu mea mālama ola i nā hoʻokolohua koko maʻamau ma mua a i ka wā o ka mālama ʻana e nānā i kāu helu keʻokeʻo koko a me ke olakino holoʻokoʻa. He mea nui kēia mau manawa no ka hōʻoia ʻana e hana ana ka lāʻau lapaʻau me ka palekana a me ka pono.

Pehea ka lōʻihi e lawe ai au iā Cladribine?

He mau makahiki ʻelua ka lōʻihi o ka papa lāʻau cladribine maʻamau, akā ʻaʻole ʻoe e lawe mau i nā pila i kēia manawa. Akā, e loaʻa iā ʻoe nā manawa lapaʻau kūikawā a laila e hahai ʻia e nā wā lōʻihi me ka ʻole o ka lāʻau.

I ka maʻamau, e lawe ʻoe i ka cladribine no 4-5 mau lā i ka mahina mua, a laila hou no 4-5 mau lā i ka mahina ʻelua o ka makahiki mua. E like ana ka makahiki ʻelua, me nā manawa lapaʻau i nā mahina 13 a me 14. Ma hope o ka pau ʻana o kēia papa makahiki ʻelua, ʻaʻole pono ka nui o nā kānaka i ka lāʻau cladribine hou no nā makahiki he nui.

Hāʻawi nā āpau lōʻihi ma waena o nā manawa lapaʻau i kou ʻōnaehana pale e ola hou ana me ka mālama ʻana i nā hopena pale o ka lāʻau i nā hoʻihoʻi MS. E nānā kāu kauka i kou kūlana i kēia manawa a e hoʻoholo inā pono ʻoe i nā lāʻau hou i ka wā e hiki mai ana.

Pono paha kekahi poʻe e hoʻoponopono i kā lākou papa lapaʻau e pili ana i nā hopena o ka hoʻāʻo koko a i ʻole nā mea olakino ʻē aʻe. E hana pū kāu mea mālama ola me ʻoe e ʻimi i ka manawa kūpono a palekana a maikaʻi hoʻi no kou kūlana.

He aha nā hopena ʻaoʻao o Cladribine?

E like me nā lāʻau lapaʻau a pau, hiki i ka cladribine ke hana i nā hopena ʻaoʻao, ʻoiai ua ʻae ka nui o nā kānaka iā ia. ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a hiki ke mālama ʻia me ke kākoʻo olakino kūpono.

Eia nā hopena ʻaoʻao e ʻike nui ai ʻoe, me ka noʻonoʻo ʻana e nānā pono kāu hui mālama ola iā ʻoe i ka wā o ka lapaʻau:

• Nā maʻi o ka ʻōnaehana hanu luna e like me ke anu a i ʻole nā maʻi sinus
• Nā poʻo e hiki ke maʻalahi a i ʻole
• Hoʻemi ʻia nā helu keʻokeʻo koko, he ʻāpana maoli nō ia o ke ʻano o ka hana ʻana o ka lāʻau
• Nausea a i ʻole ka ʻoluʻolu o ka ʻōpū, ʻoiai ke hoʻomaka mua i ka lapaʻau
• Luhi a i ʻole ka manaʻo e luhi ma mua o ka maʻamau
• Hoʻopōkole a i ʻole ka nalowale o ka lauoho
• Pā a i ʻole nā hopena ʻili

ʻO ka hapa nui o kēia mau hopena he mea manawa wale nō a hoʻomaikaʻi ke hoʻoponopono kou kino i ka lāʻau lapaʻau a i ʻole ma hope o ka pau ʻana o ka papa lapaʻau.

Aia kekahi mau hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau e koi ai i ka lāʻau lapaʻau koke. ʻOiai he mea maʻamau kēia, he mea nui e ʻike iā lākou i hiki iā ʻoe ke ʻimi koke i ke kōkua inā pono:

• Nā maʻi koʻikoʻi ma muli o ka helu haʻahaʻa loa o nā keʻena koko keʻokeʻo
• Ke kahe koko a i ʻole ka ʻeha ʻokoʻa ʻaʻole e hoʻōla maʻamau
• Ke kuni mau a i ʻole nā ​​hōʻailona e like me ka maʻi flu
• Nā hopena maʻi koʻikoʻi me ka pilikia o ka hanu a i ʻole ka pehu
• Nā hōʻailona o nā pilikia o ke ake e like me ka ʻili melemele a i ʻole ka mimi ʻeleʻele
• Progressive multifocal leukoencephalopathy (PML), he maʻi lolo laha ʻole

E hana kāu kauka i nā hoʻokolohua koko maʻamau e hopu koke i nā loli e pili ana, a pono ʻoe e hoʻokaʻaʻike koke iā lākou inā loaʻa iā ʻoe kekahi mau hōʻailona e hopohopo nei.

ʻO wai ka mea ʻaʻole pono e lawe iā Cladribine?

ʻAʻole kūpono ʻo Cladribine no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. Pono ka lāʻau lapaʻau i kahi ʻōnaehana pale ikaika, hana e hoʻomaka ai, no laila e palekana kekahi mau kūlana.

ʻAʻole pono ʻoe e lawe iā cladribine inā loaʻa iā ʻoe kekahi mau maʻi ikaika, me nā maʻi maʻi e like me ka maʻi tuberculosis a i ʻole ka hepatitis. Pono e olakino kou ʻōnaehana pale ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau, no ka mea, e hōʻemi iki ka lāʻau lapaʻau i kou hiki ke pale aku i nā maʻi hou.

ʻAʻole hiki i ka poʻe me ka maʻi kīkī a i ʻole ke ake koʻikoʻi ke lawe palekana iā cladribine. Hoʻoponopono ʻia ka lāʻau lapaʻau ma o kēia mau ʻōpū, a hiki i ka hana ʻino ke alakaʻi i ka hōʻiliʻili ʻana o ka lāʻau i loko o kāu ʻōnaehana.

He mea nui nō hoʻi ka hāpai ʻana a me ka hānai ʻana i ka waiū. Hiki i ka Cladribine ke hōʻino i nā pēpē e ulu ana, no laila pono ʻoe e hoʻohana i nā mea pale hāpai pono i ka wā e mālama ʻia ai a no kekahi mau mahina ma hope. Inā ʻoe e hoʻolālā ana e hāpai, e kūkākūkā i nā lāʻau lapaʻau MS ʻē aʻe me kāu kauka.

Eia kekahi, inā he moʻolelo kou o kekahi mau maʻi ʻaʻai, ʻoi aku ka maʻi ʻaʻai koko, pono i kāu kauka e ana pono i nā pilikia a me nā pōmaikaʻi ma mua o ka ʻōlelo ʻana i ka cladribine.

Inoa Brand Cladribine

ʻO ka inoa brand no ka cladribine waha ʻo Mavenclad, i hana ʻia e EMD Serono. ʻO kēia ka formulation i ʻae ʻia no ka mālama ʻana i ka multiple sclerosis a hele mai i nā papa 10mg.

Hiki nō hoʻi iā ʻoe ke lohe e pili ana i ka cladribine i hoʻohana ʻia ma nā ʻano ʻē aʻe no nā kūlana like ʻole. No ka laʻana, aia kahi ʻano injectable i kapa ʻia ʻo Leustatin i hoʻohana ʻia e mālama i kekahi mau maʻi ʻaʻai koko, akā he lāʻau lapaʻau ʻokoʻa loa kēia me ka kaʻana like ʻana i ka mea hana like.

I ka wā e kūkākūkā ana i kāu lapaʻau me nā mea mālama ola a i ʻole nā ​​pharmacists, he mea kōkua ke kuhikuhi nei ʻoe e lawe ana ʻoe iā Mavenclad no ka mālama ʻana iā MS e pale aku i kekahi huikau me nā formulations cladribine ʻē aʻe.

Nā Koho Cladribine

Inā ʻaʻole kūpono ka cladribine iā ʻoe, aia kekahi mau lāʻau lapaʻau ʻē aʻe no ka relapsing MS e hiki i kāu kauka ke noʻonoʻo. Aia ke koho i kāu mau hōʻailona kikoʻī, ka mōʻaukala olakino, a me nā pahuhopu lapaʻau.

ʻO kekahi mau koho ʻē aʻe e pili ana i ka dimethyl fumarate (Tecfidera), i lawe ʻia i ʻelua manawa i ka lā a hana ma ka hōʻemi ʻana i ka mumū i loko o ke kikowaena o ke aʻalolo. ʻO Fingolimod (Gilenya) kekahi koho e pale ai i nā pūnaewele immune mai ka haʻalele ʻana i nā lymph nodes a me ka hoʻouka ʻana i ka lolo a me ke kuamoʻo.

No ka poʻe me ka MS hana nui, hiki ke noʻonoʻo ʻia nā lāʻau lapaʻau ikaika ʻē aʻe e like me ka natalizumab (Tysabri) a i ʻole ocrelizumab (Ocrevus). Hāʻawi ʻia kēia mau mea ma ke ʻano he infusions ma mua o nā pila i kēlā me kēia lā, kahi mea a kekahi poʻe e makemake ai.

He mau lāʻau lapaʻau e hoʻokomo ʻia e like me ka glatiramer acetate (Copaxone) a i ʻole nā hoʻomākaukau interferon beta he mau koho maikaʻi nō ia no nā kānaka he nui, ʻoiai no ka poʻe makemake i nā lāʻau lapaʻau me nā moʻolelo palekana lōʻihi.

E kōkua kāu mea mālama ola iā ʻoe e ana i nā pōmaikaʻi a me nā pilikia o kēlā me kēia koho e ʻike i ka lāʻau lapaʻau e kūpono i kou ola a me nā pono olakino.

Ua ʻoi aku ka maikaʻi o Cladribine ma mua o Ocrelizumab?

He mau lāʻau lapaʻau maikaʻi loa ʻo Cladribine a me ocrelizumab no ka MS e hoʻi hou ana, akā hana lākou ma nā ʻano like ʻole a loaʻa nā pōmaikaʻi like ʻole. ʻO ke koho

Hiki ke hoʻohana ʻia ʻo Cladribine i ka poʻe me ka maʻi puʻuwai, akā pono ka nānā pono ʻana a me ka noʻonoʻo ʻana i kou kūlana puʻuwai. ʻAʻole pili pololei ka lāʻau lapaʻau i ka hana o ka puʻuwai, akā hiki i nā maʻi a i ʻole nā pilikia ʻē aʻe ke hoʻopilikia i kou olakino cardiovascular.

Pono kāu cardiologist a me ka neurologist e hana pū e hōʻoia i ka palekana o ka mālama ʻana i ka cladribine iā ʻoe. E noʻonoʻo lākou i nā mea e like me kāu mau lāʻau lapaʻau puʻuwai i kēia manawa, ka paʻa o ka cardiovascular holoʻokoʻa, a me ka hiki ke pale aku i nā maʻi e pilikia ai kou puʻuwai.

Inā he moʻolelo kou o nā pilikia puʻuwai, e hōʻoia i ka ʻike ʻana o kāu loea MS a me ka cardiologist i kāu mau lāʻau lapaʻau a me nā kūlana olakino ma mua o ka hoʻomaka ʻana i ka mālama ʻana i ka cladribine.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o ka Cladribine?

Inā lawe hewa ʻoe i ka cladribine ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka a i ʻole ke kikowaena hoʻomalu i ka lāʻau make, ʻoiai inā maikaʻi ʻoe. ʻO ka lawe ʻana i ka nui hiki ke alakaʻi i nā hāʻule weliweli i kāu helu keʻokeʻo koko a i ʻole nā pilikia koʻikoʻi ʻē aʻe.

Mai ho'āʻo e hoʻopuka iā ʻoe iho a i ʻole e lawe i nā lāʻau lapaʻau ʻē aʻe ke ʻole i kuhikuhi ʻia e kahi loea mālama ola. E mālama i ka hue lāʻau me ʻoe i ka wā e ʻimi ai i ka mālama olakino i hiki i nā mea lawelawe ke ʻike pololei i ka mea a me ka nui āu i lawe ai.

Makemake paha kāu kauka e nānā i kāu helu koko a ʻoi aku ka pili a hiki ke ʻōlelo aku i ka mālama kākoʻo hou aʻe ma muli o ka nui o ka lāʻau lapaʻau hou āu i lawe ai a i ka wā i hana ʻia ai.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele o Cladribine?

Inā haʻalele ʻoe i kahi mahele o ka cladribine, e lawe koke iā ia ke hoʻomanaʻo ʻoe i ka lā hoʻokahi, inā aia nō ia i loko o ka manawa lapaʻau i koho ʻia. Eia naʻe, mai lawe i ʻelua mahele i ka lā hoʻokahi e hoʻoponopono ai i kahi mahele i haʻalele ʻia.

Inā hoʻomanaʻo ʻoe i ka lā aʻe a i ʻole ma hope, e lele i ka lāʻau i hala a hoʻomau me kāu papa manawa maʻamau. Mai ho'āʻo e hoʻolōʻihi i kāu manawa lapaʻau e uku ai i nā lāʻau i hala, no ka mea, hiki i kēia ke keakea i ka papa manawa lapaʻau i hoʻolālā ʻia.

E hoʻokaʻaʻike i kāu mea mālama ola e kūkākūkā i ka mea i hana ʻia a loaʻa nā ʻōlelo kikoʻī no kou kūlana. Hiki iā lākou ke hoʻololi i kāu papa manawa nānā a i ʻole e hāʻawi i nā ʻōlelo aʻo hou e pili ana i ka lāʻau i hala a me ka manawa.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Cladribine?

ʻAʻole pono ʻoe e hooki i ka lawe ʻana iā cladribine me ka ʻole e kūkākūkā mua i kāu kauka, ʻoiai inā ʻoe e ʻoi aku ka maikaʻi a i ʻole e ʻike i nā hopena ʻaoʻao. E hahai ana ka lāʻau lapaʻau i kahi hoʻolālā lapaʻau ʻelua makahiki i hoʻolālā ʻia e hāʻawi i nā pōmaikaʻi maikaʻi loa me ka hōʻemi ʻana i nā pilikia.

Hoʻopau ka hapa nui o nā kānaka i ka papa hana ʻelua makahiki e like me ke kau ʻia, ma hope o ka mea ʻaʻole lākou e pono i ka lāʻau cladribine hou no kekahi mau makahiki. E nānā kāu kauka i kou kūlana a e hoʻoholo inā pono ʻoe i kekahi lāʻau lapaʻau mālama a i ʻole nā ​​lapaʻau like ʻole i ka wā e hiki mai ana.

Inā loaʻa iā ʻoe nā hopena ʻaoʻao e pili ana a i ʻole nā ​​pilikia ʻē aʻe me ka lāʻau lapaʻau, e kūkākūkā me kāu mea mālama ola ma mua o ka hooki ʻana iā ʻoe iho. Hiki iā lākou ke kōkua i ka mālama ʻana i nā hopena ʻaoʻao a i ʻole e hoʻololi i kāu hoʻolālā lapaʻau inā pono.

Hiki iaʻu ke loaʻa nā lāʻau lapaʻau i ka wā e lawe ana iā Cladribine?

He mea nui ka manawa o ka lāʻau lapaʻau i ka wā e lawe ana iā cladribine, no ka mea, pili ka lāʻau lapaʻau i ka hiki o kāu ʻōnaehana pale e pane i nā lāʻau lapaʻau. Pono e pale loa ʻia nā lāʻau lapaʻau ola i ka wā o ka lapaʻau a no kekahi mau mahina ma hope.

E ʻōlelo maʻamau kāu kauka e kiʻi i nā lāʻau lapaʻau e pono ai ma mua o ka hoʻomaka ʻana i ka lapaʻau cladribine, i ka wā e ikaika ana kāu ʻōnaehana pale. Hiki i kēia ke komo i nā pana flu, nā lāʻau lapaʻau pneumonia, a i ʻole nā ​​lāʻau lapaʻau huakaʻi inā ʻoe e hoʻolālā ana i nā huakaʻi.

Inā pono nā lāʻau lapaʻau i ka wā e mālama ʻia ai, ʻoi aku ka palekana o nā lāʻau lapaʻau i hoʻopau ʻia ma mua o nā mea ola, akā pono ke kauka e loiloi i kēlā me kēia kūlana. E noʻonoʻo lākou i nā mea e like me kāu helu keʻokeʻo koko i kēia manawa a me ka wikiwiki o ka lāʻau lapaʻau.