He aha ʻo Cobimetinib: Nā Hoʻohana, Nā Kumu, Nā ʻaoʻao ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i manaʻo ʻia ʻo Cobimetinib e ālai ana i nā protein kikoʻī e kōkua ana i nā pūnaewele maʻi maʻi e ulu a laha. He lāʻau lapaʻau kauka ia e hoʻohana ai nā kauka me kekahi lāʻau lapaʻau i kapa ʻia ʻo vemurafenib e mālama i ka melanoma holomua, kahi ʻano maʻi ʻili koʻikoʻi.

ʻOi aku ka maikaʻi o kēia hui pū ʻana no ka poʻe nona ka melanoma i kahi loli genetic kikoʻī i kapa ʻia he BRAF V600E a i ʻole V600K mutation. E hoʻāʻo kāu kauka i kāu ʻiʻo maʻi maʻi e ʻike inā loaʻa iā ʻoe kēia mutation ma mua o ke kau ʻana iā cobimetinib.

No ke aha e hoʻohana ʻia ai ʻo Cobimetinib?

Hoʻomaʻamaʻa ʻo Cobimetinib i ka melanoma holomua i laha i nā ʻāpana ʻē aʻe o kou kino a ʻaʻole hiki ke wehe ʻia me ke ʻoki. Ua hoʻolālā ʻia no nā melanomas me nā BRAF gene mutations, e helu ana ma kahi o ka hapalua o nā hihia melanoma āpau.

E kauoha wale kāu oncologist iā cobimetinib inā hōʻoia nā hoʻokolohua lab i ka maʻi maʻi i nā hōʻailona genetic kūpono. Kōkua kēia ala i manaʻo ʻia e hōʻoia i ka maikaʻi o ka lāʻau lapaʻau no kāu ʻano melanoma.

Hoʻohana mau ʻia ka lāʻau lapaʻau me vemurafenib, ʻaʻole wale nō. Ua hōʻike kēia hui pū ʻana i nā hopena maikaʻi aʻe ma mua o ka hoʻohana ʻana i kekahi lāʻau lapaʻau ma kāna iho i nā haʻawina lapaʻau.

Pehea e hana ai ʻo Cobimetinib?

Ke ālai nei ʻo Cobimetinib i kahi protein i kapa ʻia ʻo MEK, he ʻāpana ia o kahi ala e haʻi ana i nā pūnaewele maʻi maʻi e ulu a hoʻonui. Ke loaʻa i ka melanoma nā BRAF mutations, lilo kēia ala ulu i mea hana nui, e hoʻoulu ana i ka laha ʻana o ka maʻi maʻi.

E noʻonoʻo e like me ka hoʻopau ʻana i kahi kuapo i paʻa i ke kūlana

He manaʻo ʻia he lapaʻau ikaika a kuhikuhi ʻia e hoʻouka kūikawā i nā loli molekala e hoʻokele ana i kāu maʻi kanesa. ʻOi aku ka pololei ma mua o ka chemotherapy kuʻuna no ka mea e kālele ana i nā protein kikoʻī e pono ai kāu maʻi kanesa e ola.

Pehea e lawe ai au i ka Cobimetinib?

E lawe i ka cobimetinib e like me ke kauoha a kāu kauka, maʻamau hoʻokahi manawa i ka lā me ka ʻole o ka meaʻai. E ale i nā papa holoʻokoʻa me ke aniani wai piha - mai ʻoki, nau, a wāwahi paha iā lākou.

E lawe maʻamau ʻoe i ka cobimetinib no 21 mau lā, a laila e loaʻa iā ʻoe kahi hoʻomaha 7 lā kahi āu e lawe ʻole ai. Kapa ʻia kēia ʻano 28 lā he pōʻaiapuni, a e hana hou ʻoe i ka wā e ʻōlelo ai kāu kauka.

E hoʻāʻo e lawe i kāu mahele i ka manawa like i kēlā me kēia lā e kōkua iā ʻoe e hoʻomanaʻo. Inā ʻoe e ʻai ma mua o ka lawe ʻana, e koho i kahi mea māmā ma mua o ka ʻai nui, no ka mea hiki i kēia ke kōkua i ka hōʻemi ʻana i ka ʻōpū.

E mālama i ka lāʻau lapaʻau i ka lumi wela mai ka makū a me ka wela. E mālama i loko o kāna pahu mua a mai hiki i nā keiki a me nā holoholona.

Pehea ka lōʻihi e lawe ai au i ka Cobimetinib?

E hoʻomau ʻoe i ka lawe ʻana i ka cobimetinib i ka wā e kōkua ana i ka mālama ʻana i kāu maʻi kanesa a ʻaʻole ʻoe e ʻike i nā hopena ʻaoʻao koʻikoʻi. Hiki i kēia ke mau mahina a ʻoi aku paha, ma muli o ka maikaʻi o kāu pane ʻana i ka lapaʻau.

E nānā pono kāu kauka iā ʻoe me nā hoʻokolohua koko maʻamau, nā scans, a me nā loiloi e ʻike pehea e hana nei ka lāʻau lapaʻau. E nānā pū lākou i nā hopena ʻaoʻao e koi ai i ka hoʻoponopono ʻana i kāu mahele a i ʻole ke kāpae ʻana i ka lapaʻau.

Lawe kekahi poʻe i ka cobimetinib no nā mahina he nui me nā hopena maikaʻi. Pono paha kekahi e hooki koke inā lilo nā hopena ʻaoʻao i mea paʻakikī loa e mālama a i ʻole e hoʻomaka hou ka maʻi kanesa.

He aha nā hopena ʻaoʻao o Cobimetinib?

E like me nā lāʻau lapaʻau maʻi kanesa a pau, hiki i ka cobimetinib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā mea a pau iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ka mālama olakino kūpono a me ka nānā ʻana.

Eia nā hopena ʻaoʻao maʻamau e ʻike ai ʻoe:

• Ka maʻi palahē, i kekahi manawa he koʻikoʻi
• Pāpaʻa ʻili a i ʻole ka ʻike ʻana i ka lā
• Luaʻi a me ka luaʻi
• Hiva a me ka luhi
• ʻEha ʻiʻo a i ʻole nā hui
• Nā loli i ka hana o ke ake (ʻike ʻia ma o nā hoʻokolohua koko)

E nānā pono kāu hui lapaʻau iā ʻoe a hiki ke hāʻawi i nā lāʻau lapaʻau a i ʻole nā hoʻolālā e kōkua i ka mālama ʻana i kēia mau hopena. Nui ka poʻe i ʻike e lilo nā hopena ʻaoʻao i mea hiki ke mālama ʻia i ka wā e hoʻoponopono ai ko lākou kino i ka lāʻau lapaʻau.

ʻO nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau e komo pū ana:

• Nā hopena ʻili koʻikoʻi a i ʻole ka ʻōpala
• Nā pilikia o ka maka, me ka ʻike pōpō a i ʻole ka ʻeha o ka maka
• Nā loli o ka puʻuwai
• Nā pilikia o ke kahe ʻana o ke koko
• Nā pilikia o ke ake koʻikoʻi

E hoʻokaʻaʻike koke i kāu hui mālama ola inā ʻoe e ʻike i ka ʻeha nui o ka ʻōpū, ka melemele o kou ʻili a i ʻole nā maka, ke kahe ʻana o ke koko ʻano ʻē, a i ʻole nā loli koke i kou ʻike a i ʻole ka puʻuwai.

ʻO wai ka mea pono ʻole e lawe iā Cobimetinib?

ʻAʻole kūpono ʻo Cobimetinib no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. ʻAʻole pono ʻoe e lawe i kēia lāʻau lapaʻau inā he maʻi ʻoe iā cobimetinib a i ʻole kekahi o kāna meaʻai.

ʻO ka poʻe me kekahi mau maʻi puʻuwai, nā pilikia o ke ake koʻikoʻi, a i ʻole nā maʻi kahe koko ʻaʻole paha he moho maikaʻi no cobimetinib. Pono kāu kauka e loiloi i kēia mau kūlana.

ʻAʻole pono nā wahine hāpai e lawe iā cobimetinib no ka mea hiki iā ia ke hōʻino i ka pēpē e ulu ana. Inā ʻoe e hoʻolālā nei e hāpai a i ʻole e hānai ana i ka waiū, e kūkākūkā i nā koho lapaʻau ʻē aʻe me kāu oncologist.

E haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau a pau āu e lawe nei, me nā lāʻau lapaʻau a me nā mea hoʻohui, no ka mea hiki i kekahi ke launa pū me cobimetinib a pili i ka maikaʻi o kāna hana.

Nā inoa inoa Cobimetinib

Kūʻai ʻia ʻo Cobimetinib ma lalo o ka inoa inoa ʻo Cotellic ma ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe. ʻO kēia ke ala maʻamau e ʻike ai ʻoe i ke kau ʻia a hāʻawi ʻia mai ka hale kūʻai lāʻau lapaʻau.

Hiki i kekahi mau ʻāina ke hoʻohana i nā inoa inoa like ʻole, akā, ʻo ka mea hana ikaika ka mea like. E nānā mau me kāu lāʻau lapaʻau inā he nīnau kāu e pili ana i ka inoa inoa kikoʻī āu e loaʻa nei.

Nā Koho ʻē aʻe o Cobimetinib

Nui nā lāʻau lapaʻau i manaʻo ʻia no ka melanoma holomua, e pili ana i kāu ʻano genetic kikoʻī a me ke kūlana olakino. Hiki ke noʻonoʻo ʻia kēia mau koho ʻē aʻe inā ʻaʻole kūpono ʻo cobimetinib iā ʻoe.

No ka melanoma i hoʻololi ʻia e BRAF, nā lāʻau lapaʻau hui pū ʻē aʻe e komo pū ana me dabrafenib me trametinib, e hana like ana me cobimetinib me vemurafenib. Hiki i kāu oncologist ke ʻōlelo aku i kēia hui inā ʻaʻole hiki iā ʻoe ke ʻae iā cobimetinib.

Inā ʻaʻole loaʻa nā loli BRAF i kāu melanoma, hiki i nā ala lapaʻau like ʻole e like me nā lāʻau lapaʻau immunotherapy (e like me pembrolizumab a i ʻole nivolumab) ke kūpono.

E noʻonoʻo kāu kauka i nā mea e like me ke ʻano genetic o kāu maʻi maʻi, ke olakino holoʻokoʻa, nā lāʻau lapaʻau i hala, a me nā makemake pilikino i ke koho ʻana i ke ala lapaʻau maikaʻi loa iā ʻoe.

Ua ʻoi aku ka maikaʻi o Cobimetinib ma mua o Vemurafenib wale nō?

ʻAe, hōʻike nā haʻawina i ka cobimetinib i hui pū ʻia me vemurafenib ʻoi aku ka maikaʻi ma mua o ka vemurafenib i hoʻohana ʻia e ia iho. Ua lilo kēia ala hui i ka maʻamau o ka mālama ʻana no ka poʻe me ka melanoma holomua i hoʻololi ʻia e BRAF.

Ua ʻike nā hoʻokolohua lapaʻau i ka poʻe e lawe ana i nā lāʻau lapaʻau ʻelua i noho lōʻihi me ka ʻole o ka holomua ʻana o kā lākou maʻi maʻi i hoʻohālikelike ʻia me ka poʻe e lawe ana iā vemurafenib wale nō. Ua hōʻike pū ka hui i nā helu ola holoʻokoʻa maikaʻi.

Eia naʻe, ʻo ka hoʻohana ʻana i nā lāʻau lapaʻau ʻelua i ka manawa like e hoʻonui ai i ka pilikia o nā hopena ʻaoʻao. E hana pū kāu hui lapaʻau me ʻoe e mālama i nā hopena ʻaoʻao i ka wā e loaʻa ai ka pōmaikaʻi nui mai kēia lāʻau lapaʻau hui.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Cobimetinib

He palekana anei ʻo Cobimetinib no ka poʻe me ka maʻi puʻuwai?

Hiki i ka cobimetinib ke hoʻopilikia i ka puʻuwai o kekahi poʻe, no laila e loiloi pono kāu kauka i ke olakino o kou puʻuwai ma mua o ke kau ʻana. Inā he maʻi puʻuwai kou, pono ʻoe e nānā mau me nā electrocardiograms (EKGs) i ka wā o ka mālama ʻana.

Hiki i ka nui o nā kānaka me nā maʻi puʻuwai maʻalahi ke lawe palekana i ka cobimetinib me ka nānā pono. E hana pū kāu cardiologist a me ka oncologist e hoʻoholo inā ʻoi aku ka maikaʻi ma mua o nā pilikia no kou kūlana.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o ka Cobimetinib?

E kelepona koke i kāu kauka a i ʻole nā lawelawe pilikia inā lawe ʻoe i ka nui o ka cobimetinib ma mua o ke kau ʻana. Mai kali e ʻike inā ʻoe e ʻike i nā hōʻailona, ​​no ka mea, hiki i ka overdose ke koʻikoʻi.

E lawe i ka hue lāʻau me ʻoe i ka haukapila i ʻike pono nā mea mālama ola i ke ʻano a me ka nui āu i lawe ai. Hiki iā lākou ke hāʻawi i ka lāʻau kūpono a me ka nānā ʻana e pili ana i ka nui o ka lāʻau i pili.

He aha kaʻu e hana ai inā hala au i kahi mahele o Cobimetinib?

Inā hala ʻoe i kahi mahele a ua hala ma lalo o 12 mau hola mai kou manawa i hoʻonohonoho ʻia, e lawe koke iā ia ke hoʻomanaʻo ʻoe. Inā ua hala ma mua o 12 mau hola, e lele i ka mahele i hala a lawe i kāu mahele aʻe i ka manawa maʻamau.

Mai lawe i ʻelua mahele i ka manawa hoʻokahi e hoʻopiha ai i kahi mahele i hala. Hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi me ka hāʻawi ʻole ʻana i kekahi pōmaikaʻi hou.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Cobimetinib?

E hooki wale i ka lawe ʻana i ka cobimetinib ke haʻi kāu kauka iā ʻoe. Hana maʻamau kēia inā hoʻomaka hou kāu maʻi maʻi i ka ulu ʻana me ka mālama ʻana, inā ʻoe e ʻike i nā hopena ʻaoʻao koʻikoʻi, a i ʻole inā hōʻike nā scans ua pane piha ka maʻi maʻi i ka mālama ʻana.

Mai hooki i ka lawe ʻana i ka cobimetinib iā ʻoe iho, ʻoiai inā ʻoe e ʻoi aku ka maikaʻi a i ʻole e ʻike i nā hopena ʻaoʻao. Hiki i kāu hui lapaʻau ke hoʻoponopono i kāu mahele a i ʻole e hāʻawi i ka mālama kākoʻo e kōkua iā ʻoe e hoʻomau i ka mālama ʻana me ka palekana.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Cobimetinib?

He mea maikaʻi e pale aku i ka waiʻona a i ʻole e kaupalena nui ʻia i ka wā e lawe ana i ka cobimetinib. Hiki i ka waiʻona ke hoʻonui i kekahi mau hopena ʻaoʻao e like me ka nausea a me nā pilikia o ke ake, a hiki ke hoʻopilikia i ke kino i ka hana ʻana i ka lāʻau lapaʻau.

Inā koho ʻoe e inu i kekahi manawa, e kūkākūkā mua me kāu kauka. Hiki iā lākou ke aʻo iā ʻoe i nā palena palekana e pili ana i kou olakino holoʻokoʻa a me ka maikaʻi o kou hoʻomanawanui ʻana i ka lāʻau lapaʻau.