He aha ka Conjugated Estrogens a me Bazedoxifene: Nā Hoʻohana, Dosage, Nā ʻaoʻao ʻaoʻao a me nā mea hou aku

ʻO ka conjugated estrogens a me ka bazedoxifene he lāʻau lapaʻau hui pū ʻia e kōkua ana i ka mālama ʻana i nā hōʻailona menopause i ka wā e pale ana i kou mau iwi. Hoʻohui kēia hui kūʻokoʻa i nā hormones estrogen me kahi mea hoʻololi receptor estrogen koho (SERM) e hāʻawi iā ʻoe i ke kōkua mai nā uila wela a me nā sweats pō me ka hoʻonui ʻole ʻana i kou pilikia o ka maʻi kanesa endometrial.

E noʻonoʻo i kēia lāʻau lapaʻau ma ke ʻano he ala kaulike i ka hormone therapy. Hoʻoponopono ka mea estrogen i kēlā mau hōʻailona menopause ʻoluʻolu ʻole, ʻoiai ʻo ka bazedoxifene e hana e like me ka pale pale no kou laina uterine, e hoʻopau ana i ka pono no kahi lāʻau progestin kaʻawale.

He aha ka Conjugated Estrogens a me Bazedoxifene?

Hoʻohui kēia lāʻau lapaʻau i ʻelua mau mea hana e hana pū ana e mālama i nā hōʻailona menopause me ka palekana. ʻO nā estrogens conjugated he hui pū ʻia o nā hormones estrogen i loaʻa mai nā kumu kūlohelohe, ʻoiai ʻo bazedoxifene he ʻano hou o ka hormone modulator e koho ana i nā mea hoʻokipa estrogen.

Ua hoʻolālā kūikawā ʻia ka hui ʻana no nā wahine i loaʻa nō ko lākou ʻōpū a pono i ka hormone therapy. ʻAʻole like me ka hormone replacement therapy kuʻuna e koi ana i ka hoʻohui ʻana i ka progestin e pale i ka laina uterine, aia kēia lāʻau lapaʻau i ka bazedoxifene e hāʻawi i kēlā pale maoli.

Hiki iā ʻoe ke ʻike i kēia lāʻau lapaʻau ma kona inoa inoa Duavee. Hele mai ia ma ke ʻano he papa waha āu e lawe ai i hoʻokahi manawa i ka lā, e lilo ia i koho kūpono no ka mālama ʻana i nā hōʻailona menopause i ka wā e mālama ana i ke olakino iwi.

No ke aha e hoʻohana ʻia ai ka Conjugated Estrogens a me Bazedoxifene?

Hoʻomaʻamaʻa mua kēia lāʻau lapaʻau i nā uila wela a me nā sweats pō e pili ana i ka menopause. Inā ʻoe e ʻike nei i kēia mau hōʻailona vasomotor e hoʻopilikia i kou ola i kēlā me kēia lā a i ʻole ka hiamoe, hiki i kēia hui pū ʻana ke hāʻawi i ke kōkua nui.

Kōkua pū ka lāʻau lapaʻau i ka pale ʻana i ka osteoporosis i nā wāhine ma hope o ka menopause i pilikia i ka haki ʻana o ka iwi. I ka emi ʻana o nā pae estrogen i ka wā menopause, hiki i kou mau iwi ke nāwaliwali a maʻalahi hoʻi i ka haki. Kōkua kēia lapaʻau i ka mālama ʻana i ka paʻa a me ka ikaika o ka iwi.

Hiki i kāu kauka ke ʻōlelo aku i kēia lāʻau lapaʻau inā he mau hōʻailona menopause hoʻonāukiuki kāu a makemake ʻoe e pale i ka lawe ʻana i nā lāʻau lapaʻau ʻokoʻa no ka hoʻomaha ʻana i nā hōʻailona a me ka pale ʻana i ka iwi. He mea kōkua nui ia no nā wāhine i loaʻa nā hopena ʻaoʻao mai nā hui lapaʻau hormone kuʻuna.

Pehea e hana ai nā Estrogens Conjugated a me Bazedoxifene?

Hana kēia lāʻau lapaʻau ma o kahi mīkini hana pālua sophisticated e pili ana i nā hōʻailona menopause i ka wā e pale ana i kou mau ʻiʻo hānau. Hoʻololi ka mea estrogen i kekahi o nā hormones e hoʻōki ai kou kino i ka hana ʻana i ka wā menopause, e kōkua ana i ka hoʻoponopono ʻana i ka ʻōnaehana hoʻomalu wela o kou kino.

Hana ʻo Bazedoxifene ma ke ʻano he mea hoʻoponopono receptor estrogen koho, ʻo ia hoʻi, hana ia e like me ka estrogen ma kekahi mau wahi o kou kino (e like me nā iwi) i ka wā e ālai ana i nā hopena estrogen i nā mea ʻē aʻe (e like me ka ʻōpū). Kōkua kēia hana koho i ka pale ʻana i ka mānoanoa o kou laina uterine e hiki ke alakaʻi i ka pilikia o ka maʻi kanesa.

Manaʻo ʻia ka hui ʻana he koho lapaʻau hormone ikaika. Ua lawa ka ikaika e hāʻawi ai i ka hoʻomaha ʻana i nā hōʻailona a me ka pale ʻana i ka iwi, akā ua hana ʻia e hōʻemi i ka nui o nā pilikia e pili ana i ka lapaʻau hormone kuʻuna.

Pehea e lawe ai au i nā Estrogens Conjugated a me Bazedoxifene?

E lawe i kēia lāʻau lapaʻau e like me ke kauoha a kāu kauka, maʻamau hoʻokahi papa ma ka waha i hoʻokahi manawa i ka lā. Hiki iā ʻoe ke lawe me ka ʻole o ka meaʻai, akā ʻo ka lawe ʻana me ka ʻai e kōkua paha i ka hōʻemi ʻana i nā pilikia o ka ʻōpū āu e ʻike ai i ka wā mua.

E hoʻāʻo e lawe i kāu papa i ka manawa like i kēlā me kēia lā e mālama i nā pae hormone kūlike i loko o kou kino. Nui nā wāhine i ʻike he mea kōkua ke lawe pū me ka ʻaina kakahiaka a i ʻole ka ʻaina awakea ma ke ʻano he ʻāpana o kā lākou hana maʻamau i kēlā me kēia lā. Kōkua kēia kūlike i kou kino e hoʻoponopono i ka lāʻau lapaʻau me ka ʻoi aku ka maikaʻi.

E ale i ka papa holoʻokoʻa me ke aniani wai piha. Mai ʻoki, nau, a wāwahi paha i ka papa, no ka mea, hiki i kēia ke hoʻopilikia i ke ʻano o ka lawe ʻana a me ka hoʻokuʻu ʻia ʻana o ka lāʻau lapaʻau i loko o kou kino. Inā pilikia ʻoe i ka ale ʻana i nā pila, e kamaʻilio me kāu kauka e pili ana i nā koho ʻē aʻe.

Pehea ka lōʻihi e lawe ai au i nā Estrogens Conjugated a me Bazedoxifene?

He ʻokoʻa ka lōʻihi o ka mālama ʻana ma muli o kāu mau hōʻailona pilikino a me nā pahuhopu olakino. Nui nā wāhine e lawe i kēia lāʻau lapaʻau no kekahi mau makahiki e mālama i nā hōʻailona menopause, ʻoiai ʻo nā mea ʻē aʻe e hoʻohana ia mea no ka pale ʻana i ka iwi a hoʻomau i ka hoʻohana ʻana i ka wā lōʻihi.

E loiloi mau kāu kauka inā pono ʻoe i kēia lāʻau lapaʻau, maʻamau i kēlā me kēia 6 a 12 mahina. Kōkua kēia mau loiloi e hōʻoia i ka hoʻomau ʻana o nā pōmaikaʻi i nā pilikia hiki ke loaʻa. ʻIke kekahi mau wahine hiki iā lākou ke hōʻemi i kā lākou mahele a i ʻole e hooki i ka lāʻau lapaʻau i ka wā e hoʻomaikaʻi maoli ai kā lākou mau hōʻailona menopause i ka manawa.

No ka pale ʻana i ka iwi, pono paha ka hoʻohana ʻana i ka wā lōʻihi, ʻoiai inā he mau mea pilikia hou aʻe kāu no ka osteoporosis. E noʻonoʻo kāu kauka i kāu mau hoʻokolohua density iwi, ka mōʻaukala ʻohana, a me ke olakino holoʻokoʻa i ka wā e hoʻoholo ai i ka lōʻihi kūpono o ka mālama ʻana.

He aha nā hopena ʻaoʻao o nā Estrogens Conjugated a me Bazedoxifene?

E like me nā lāʻau lapaʻau a pau, hiki i kēia hui pū ʻana ke hana i nā hopena ʻaoʻao, ʻoiai ua ʻae maikaʻi nā wahine he nui. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hoʻopili ai i kāu mea mālama ola.

ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a hoʻomaikaʻi pinepine i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau i nā pule mua o ka mālama ʻana.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai:

• Ka manaʻo ʻino a i ʻole ka ʻoluʻolu o ka ʻōpū, ʻoi loa i ka hoʻomaka ʻana i ka lāʻau
• Ka palupalu a i ʻole ka pehu ʻana o ka umauma
• Ke poʻo, he maʻalahi a he manawa pōkole
• Ke kahe ʻana o ka ʻōpū a i ʻole ka ʻike ʻana, ʻoi loa i nā mahina mua
• Nā ʻeha wāwae a i ʻole nā ʻiʻo
• Ka wili a i ʻole ka māmā

E emi ana kēia mau hopena maʻamau i ka wā e hoʻoponopono ai kou kino i nā loli hormone. Hiki i ka lawe ʻana i ka lāʻau me ka meaʻai ke kōkua i ka hōʻemi ʻana i ka nausea a me ka ʻōpū.

ʻAʻole maʻamau akā ʻoi aku ka nui o nā hopena ʻaoʻao e koi ai i ka lāʻau lapaʻau koke, ʻoiai e hana pinepine ʻia i ka hapanui o nā wahine.

E kelepona koke i kāu kauka inā ʻoe e ʻike:

• ʻEha nui o ka ʻōpū a i ʻole ka nausea mau a me ka luaʻi
• Ke kahe ʻana o ka ʻōpū maʻamau ʻole a i ʻole e hoʻomau ana ma mua o nā mahina mua
• Nā poʻo nui ʻaʻole e pane i nā lāʻau lapaʻau maʻamau
• Nā loli ʻike a i ʻole ka nalo koke ʻana o ka ʻike
• ʻEha o ka umauma a i ʻole ka pilikia o ka hanu
• ʻEha nui o ka wāwae a i ʻole ka pehu ʻana e hōʻike ana i ka ʻōpū koko
• Ka melemele ʻana o kou ʻili a i ʻole nā maka, hiki ke hōʻailona i nā pilikia o ke ake

ʻOiai ʻaʻole maʻamau nā hopena ʻaoʻao koʻikoʻi, ʻo ka ʻike ʻana i kēia mau hōʻailona hōʻailona e kōkua i ka hōʻoia ʻana e loaʻa iā ʻoe ka mālama olakino wikiwiki inā pono.

ʻO wai ka mea pono ʻole e lawe i nā Estrogens Conjugated a me Bazedoxifene?

ʻAʻole kūpono kēia lāʻau lapaʻau no nā mea a pau, a ʻo kekahi mau maʻi olakino e palekana ʻole ai ka hoʻohana ʻana. E nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana i kēia lāʻau lapaʻau e hōʻoia i ka kūpono iā ʻoe.

ʻAʻole pono ʻoe e lawe i kēia lāʻau lapaʻau inā he mōʻaukala kou o nā ʻōpū koko, ka hahau, a i ʻole ka puʻuwai. Hiki i ka mea estrogen ke hoʻonui i kou pilikia o ka hoʻomohala ʻana i kēia mau hanana cardiovascular koʻikoʻi, ʻoi loa inā loaʻa iā ʻoe nā mea pilikia.

Pono nā wāhine me ka mōʻaukala o ka maʻi ʻaʻai umauma, ka maʻi ʻaʻai endometrial, a i ʻole nā maʻi ʻaʻai ʻē aʻe e pili ana i ka hormone e pale i kēia lāʻau. Hiki i ka mea estrogen ke hoʻoulu i ka ulu ʻana o nā ʻōpū e pili ana i ka hormone, e hoʻolilo ana i mea palekana ʻole no nā wāhine me kēia mau maʻi.

ʻO nā mea kūʻē nui ʻē aʻe e komo pū ana:

• Maʻi ate hana a i ʻole nā enzyme ate kiʻekiʻe loa
• Ke kahe ʻana o ke koko ʻaʻole i wehewehe ʻia ʻaʻole i loiloi ʻia e ke kauka
• Hāpai i ʻike ʻia a i manaʻo ʻia paha
• Maʻi kīkī koʻikoʻi
• Nā maʻi hoʻopaʻa koko i hoʻoilina ʻia
• Nā ʻeha poʻo migraine koʻikoʻi me ka aura

Inā loaʻa iā ʻoe ka maʻi diabetes, ke koko kiʻekiʻe, a i ʻole nā maʻi maʻi ʻē aʻe, e loiloi kāu kauka i nā pōmaikaʻi a me nā pilikia ma mua o ke kau ʻana i kēia lāʻau.

ʻO nā Estrogens Conjugated a me Bazedoxifene Brand Name

Loaʻa kēia lāʻau hui ma lalo o ka inoa brand Duavee ma ʻAmelika Hui Pū ʻIa. Aia i loko o Duavee he 0.45 mg o nā estrogens conjugated a me 20 mg o bazedoxifene i kēlā me kēia papa.

Hana ʻia ka lāʻau e Pfizer a ua ʻae ʻia e ka FDA i ka makahiki 2013. ʻO ia wale nō ka hui pū ʻana o nā estrogens conjugated a me bazedoxifene ma ka mākeke, no laila ʻaʻole i loaʻa nā mana generic.

Hiki i kāu hale kūʻai lāʻau lapaʻau ke kuhikuhi iā ia ma kona inoa generic, akā ke kiʻi ʻoe i kāu kauoha, e loaʻa iā ʻoe nā papa brand Duavee. He ʻano oval a ʻulaʻula nā papa, e maʻalahi ai lākou e ʻike.

Nā Koho ʻē aʻe o nā Estrogens Conjugated a me Bazedoxifene

Inā ʻaʻole kūpono kēia lāʻau iā ʻoe, aia kekahi mau koho ʻē aʻe e hiki ke kōkua i ka mālama ʻana i nā hōʻailona menopause a me ka pale ʻana i ke olakino o ka iwi. Hiki i kāu kauka ke kōkua iā ʻoe e ʻimi i kēia mau koho ʻē aʻe e pili ana i kāu mau pono a me ke olakino.

ʻO nā hui lapaʻau hormone kuʻuna e komo pū ana me nā lāʻau estrogen me progestin e like me Prempro a i ʻole Premphase. He kūpono paha kēia mau koho inā ʻaʻole hiki iā ʻoe ke lawe i ka bazedoxifene akā pono nō e hoʻololi i ka hormone.

ʻO nā koho ʻē aʻe ʻaʻole hormone no ka mālama ʻana i nā hōʻailona menopause e komo pū ana:

• Nā mea hoʻopaʻa hou ʻana i ka serotonin koho (SSRIs) e like me paroxetine (Brisdelle) no nā wela
• Gabapentin no ka hōʻemi ʻana i nā wela a me ka hoʻomaikaʻi ʻana i ka hiamoe
• Clonidine no ka mālama ʻana i nā hōʻailona vasomotor
• Nā hoʻololi ʻana i ke ola e komo pū ana me ka hoʻoikaika kino maʻamau a me nā loli meaʻai

No ka pale ʻana i ka iwi, e ʻōlelo paha kāu kauka i nā bisphosphonates e like me alendronate (Fosamax) a i ʻole risedronate (Actonel), a i ʻole nā lāʻau ʻē aʻe e like me denosumab (Prolia).

Ua ʻoi aku ka maikaʻi o Conjugated Estrogens a me Bazedoxifene ma mua o ka Hormone Therapy kuʻuna?

Hāʻawi kēia hui i kekahi mau mea maikaʻi ma luna o ka hormone replacement therapy kuʻuna, ʻoiai no nā wahine e makemake e pale i nā hopena ʻaoʻao e pili ana i ka progestin. ʻO ka hoʻokomo ʻana i ka bazedoxifene ma kahi o ka progestin hiki ke hōʻemi i ka bloating, nā loli o ke ʻano, a me ka palupalu o ka umauma i loaʻa i kekahi mau wahine me ka hormone therapy maʻamau.

Hiki nō hoʻi i ka lāʻau lapaʻau ke loaʻa ka hopena maikaʻi i kāu ʻikepili lipid i hoʻohālikelike ʻia me kekahi mau hui hormone kuʻuna. Hōʻike kekahi mau haʻawina e hiki ke kōkua i ka mālama ʻana a i ʻole ka hoʻomaikaʻi ʻana i nā pae cholesterol i ka wā e hāʻawi ana i ka hōʻoluʻolu hōʻailona menopause.

Eia naʻe, ʻoi aku paha ka kūpono o ka hormone therapy kuʻuna no kekahi mau wahine, ʻoiai ka poʻe e pono ai i nā lāʻau estrogen kiʻekiʻe a i ʻole nā manaʻo olakino kikoʻī. Hiki i kāu kauka ke kōkua i ka hoʻoholo ʻana i ke ala e kūpono i kāu mau pono pilikino a me nā pahuhopu olakino.

Nā nīnau i nīnau pinepine ʻia e pili ana i ka Conjugated Estrogens a me Bazedoxifene

Ua palekana ʻo Conjugated Estrogens a me Bazedoxifene no nā wahine me ka osteoporosis?

ʻAe, ua ʻae ʻia kēia lāʻau lapaʻau no ka pale ʻana i ka osteoporosis i nā wahine ma hope o ka menopause a he koho maikaʻi loa ia inā pilikia ʻoe i nā haʻi iwi. Kōkua ka mea estrogen i ka mālama ʻana i ka nui o ka iwi, ʻoiai ʻo bazedoxifene e hāʻawi i nā hopena pale iwi hou.

E nānā kāu kauka i kou nui o ka iwi ma o nā scans DEXA maʻamau e hōʻoia i ka pale pono ʻana o ka lāʻau lapaʻau i kou mau iwi. Nui nā wahine e ʻike i ka hoʻomaikaʻi ʻana i kā lākou mau hōʻailona nui o ka iwi i loko o ka makahiki mua o ka mālama ʻana.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o nā Estrogens Conjugated a me Bazedoxifene?

Inā lawe hewa ʻoe i ka nui ma mua o kāu kau ʻana, e kelepona koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make. ʻO ka lawe ʻana i ka nui hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi e like me nā koko koko, ka nausea nui, a i ʻole ke kahe ʻana o ke koko.

Mai ho'āʻo e

Hiki i kāu kauka ke hoʻemi mālie i kāu mahele ma mua o ka hoʻōki ʻana loa, ʻoiai inā ua lawe ʻoe i ka lāʻau no ka manawa lōʻihi. Hiki i kēia ala e hoʻemi i ka hoʻi ʻana mai o nā hōʻailona a e ʻoluʻolu ke kaʻina.

Hiki iaʻu ke lawe i nā Conjugated Estrogens a me Bazedoxifene me nā lāʻau ʻē aʻe?

Hiki i kēia lāʻau ke launa pū me nā lāʻau ʻē aʻe, no laila he mea nui e haʻi aku i kāu kauka e pili ana i nā lāʻau lapaʻau a pau, nā mea hoʻohui, a me nā huahana lāʻau lapaʻau āu e lawe nei. Hiki i kekahi mau lāʻau lapaʻau ke hoʻonui a hoʻemi paha i ka pono o ka hormone therapy.

Hiki i kekahi mau antibiotics, antifungal medications, a me nā lāʻau lapaʻau hopu ke hoʻopilikia i ke ʻano o kou kino e hana ai i kēia lāʻau. Pono paha kāu kauka e hoʻoponopono i kāu mahele a i ʻole e nānā pono iā ʻoe inā ʻoe e lawe nei i kēia mau ʻano lāʻau lapaʻau.