He aha ʻo Crizotinib: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i manaʻo ʻia ʻo Crizotinib e kōkua ana i ka hoʻolohi ʻana i ka ulu ʻana o kekahi mau ʻano maʻi maʻi maʻi māmā. Hana ia ma ka pale ʻana i nā protein kikoʻī e pono ai nā sela maʻi maʻi e ulu a laha i loko o kou kino.

Hōʻike kēia lāʻau lapaʻau i kahi holomua nui i ka mālama ʻana i ka maʻi maʻi pilikino. E kauoha maʻamau kāu kauka i ka hoʻāʻo genetic o kāu maʻi ma mua o ke kau ʻana iā crizotinib e hōʻoia i ka kūpono no kāu ʻano maʻi maʻi.

He aha ʻo Crizotinib?

ʻO Crizotinib kahi lāʻau lapaʻau maʻi maʻi waha e pili ana i kahi papa o nā lāʻau i kapa ʻia ʻo tyrosine kinase inhibitors. Hoʻopili pono ia i nā sela maʻi maʻi i ka wā e hōʻeha ai i nā sela olakino ma mua o ka chemotherapy kuʻuna.

Hele mai ka lāʻau lapaʻau i ke ʻano capsule a lawe ʻia e ka waha ʻelua i ka lā. Ua ʻae mua ʻia e ka FDA i ka makahiki 2011 a mai ia manawa ua kōkua i nā tausani o nā maʻi me nā ʻano maʻi maʻi māmā e ola lōʻihi a olakino.

E noʻonoʻo iā crizotinib ma ke ʻano he mea hana pololei loa e hiki ke ʻike a ālai i nā hōʻailona kikoʻī e haʻi ana i kekahi mau sela maʻi maʻi e ulu. ʻO kēia ala i manaʻo ʻia he liʻiliʻi nā hopena ʻaoʻao ma mua o nā lāʻau lapaʻau maʻi maʻi ākea.

No ke aha e hoʻohana ʻia ai ʻo Crizotinib?

Hoʻohana nui ʻia ʻo Crizotinib e mālama i ka maʻi maʻi māmā non-small cell (NSCLC) i loaʻa nā loli genetic kikoʻī. Pono e hoʻāʻo maikaʻi kāu maʻi maʻi no ALK gene rearrangements a i ʻole ROS1 gene rearrangements i mea e pono ai kēia lāʻau lapaʻau.

Hoʻonohonoho maʻamau ʻia ka lāʻau lapaʻau i ka wā i laha ai ka maʻi maʻi i nā ʻāpana ʻē aʻe o kou kino a i ʻole ke ʻoki ʻana ʻaʻole ia he koho. Manaʻo ʻia he lapaʻau laina mua, ʻo ia hoʻi, ʻo ia ka lāʻau mua e hoʻāʻo ai kāu kauka no kēia mau ʻano maʻi maʻi.

I kekahi mau hihia, hiki ke hoʻohana ʻia ʻo crizotinib no kekahi mau maʻi maʻi laha ʻole i loaʻa nā loli gene ALK, e like me nā maʻi myofibroblastic inflammatory. E hoʻoholo kāu oncologist inā kūpono kāu ʻano maʻi maʻi a me ka genetic makeup iā ʻoe no kēia lapaʻau.

Pehea e Hana ai ʻo Crizotinib?

Hana ʻo Crizotinib ma ka pale ʻana i nā protein abnormal e hoʻohana ai nā sela maʻi e ulu a hoʻonui. ʻO ka mea kikoʻī, ua manaʻo ʻia ʻo ALK a me ROS1 proteins i lilo i mea hana nui ma muli o nā loli genetic i loko o kāu mau sela maʻi.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau maʻi ikaika, i ʻoi aku ka pahuhopu ma mua o ka chemotherapy kuʻuna. Hoʻopilikia ia i ka hiki o ke kelepona maʻi e loaʻa ai nā hōʻailona ulu, e hōʻole ana i nā kelepona maʻi i ka mea e pono ai lākou e ola a laha.

ʻO ka nani o crizotinib aia i kāna pololei. ʻOiai e pili ana ka chemotherapy kuʻuna i nā kelepona olakino a me nā kelepona maʻi, ʻo crizotinib ka mea nui e kālele ana i nā kelepona me nā abnormalities genetic kikoʻī. ʻO kēia ala i manaʻo ʻia e alakaʻi pinepine i nā hopena maikaʻi me nā hopena ʻaoʻao liʻiliʻi.

Pehea wau e lawe ai iā Crizotinib?

E lawe iā crizotinib e like me ke kauoha a kāu kauka, maʻamau ʻelua i ka lā me ka ʻole o ka meaʻai. E ale i nā capsules holoʻokoʻa me ke aniani wai piha, a mai ʻoki, nau, a wehe paha iā lākou.

Hiki iā ʻoe ke lawe iā crizotinib me nā meaʻai inā e hoʻopilikia ana i kou ʻōpū, ʻoiai ʻaʻole pono ka meaʻai no ka absorption. Nui nā maʻi e ʻike nei i ka lawe ʻana me kahi meaʻai māmā e kōkua i ka hōʻemi ʻana i ka nausea, he hopena ʻaoʻao maʻamau.

E hoʻāʻo e lawe i kāu mau lāʻau i nā manawa like i kēlā me kēia lā, ma kahi o 12 mau hola. Kōkua kēia i ka mālama ʻana i nā pae paʻa o ka lāʻau lapaʻau i loko o kou kahe koko. Inā ʻoe e lawe ana i nā lāʻau ʻē aʻe, e kūkākūkā i ka manawa me kāu kauka e pale aku i nā pilina hiki.

E pale i ka hua waina a me ka wai hua waina i ka wā e lawe ana iā crizotinib, no ka mea, hiki iā lākou ke hoʻonui i ka nui o ka lāʻau lapaʻau i loko o kou koko a hiki ke hana i nā hopena ʻaoʻao.

Pehea ka lōʻihi e lawe ai au i ka Crizotinib?

Hoʻomau ka hapa nui o nā maʻi i ka lawe ʻana i ka crizotinib no ka lōʻihi e mālama ana i kā lākou maʻi ʻaʻai a hiki ke mālama ʻia nā hopena ʻaoʻao. Hiki i kēia ke mau mahina a i ʻole mau makahiki, ma muli o ka maikaʻi o ka pane ʻana o kāu maʻi ʻaʻai i ka lāʻau lapaʻau.

E nānā kāu kauka i kou holomua ma o nā scans maʻamau a me nā hoʻokolohua koko, maʻamau i kēlā me kēia 2-3 mahina i ka wā mua. Kōkua kēia mau hoʻokolohua e hoʻoholo inā e hana pono ana ka lāʻau a inā paha e hoʻomau ʻoe i ka lāʻau.

Pono paha kekahi poʻe maʻi e hoʻomaha mai ka crizotinib inā lilo nā hopena ʻaoʻao i mea koʻikoʻi loa, a ʻo nā mea ʻē aʻe paha e hoʻololi i nā lāʻau lapaʻau like ʻole inā e kūkulu ana kā lākou maʻi ʻaʻai i ke kūpaʻa. E hoʻopilikino ʻia kāu hoʻolālā lapaʻau e pili ana i kāu pane a me ke olakino holoʻokoʻa.

He aha nā hopena ʻaoʻao o Crizotinib?

E like me nā lāʻau lapaʻau maʻi ʻaʻai a pau, hiki i ka crizotinib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole e ʻike nā mea a pau iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau.

Eia nā hopena ʻaoʻao maʻamau e ʻike ai ʻoe:

• Ka maʻi a me ka luaʻi
• Ka maʻi maʻi a i ʻole ka paʻa ʻana
• Luhi a me ka nāwaliwali
• Ka pehu ʻana i nā wāwae, nā kuʻekuʻe wāwae, a i ʻole a puni nā maka
• Nā loli ʻike, me ka ʻike ʻana a i ʻole ka ʻike ʻana i nā kukuna o ke kukui
• ʻO ka ʻūlū a i ʻole ka māmā
• Hoʻemi ʻia ka ʻai
• Pākuʻi ʻili

ʻO kēia mau hopena ʻaoʻao maʻamau he maʻalahi a maʻalahi paha a hiki ke mālama ʻia me ka mālama kākoʻo a i ʻole nā hoʻololi lāʻau.

Hiki ke loaʻa nā hopena ʻaoʻao koʻikoʻi, ʻoiai ʻaʻole maʻamau lākou. He mea nui e ʻike i kēia mau mea i hiki iā ʻoe ke ʻimi i ka lāʻau lapaʻau inā pono:

• Nā pilikia o ke ake (melemele o ka ʻili a i ʻole nā maka, mimi ʻeleʻele, luhi nui)
• Hū o ka māmā (ʻū hou a i ʻole e ʻino nei, pōkole o ka hanu, ʻeha o ka umauma)
• Nā pilikia o ka puʻuwai (puʻuwai ʻole, ʻeha o ka umauma, nāwaliwali)
• Nā pilikia nui o ka puʻupaʻa (nā loli i ka mimi, pehu)
• Nā hopena maʻi maʻi nui (paʻakikī o ka hanu, ʻōpala nui, pehu o ka maka a i ʻole ka ʻāʻī)

E kelepona koke i kāu hui mālama ola inā loaʻa iā ʻoe kekahi o kēia mau hopena ʻaoʻao koʻikoʻi. Hiki iā lākou ke hāʻawi i ke alakaʻi a hoʻoponopono i kāu lapaʻau inā pono.

ʻO wai ka mea pono ʻole e lawe iā Crizotinib?

ʻAʻole kūpono ʻo Crizotinib no nā mea a pau, a hiki i kekahi mau maʻi olakino a i ʻole nā kūlana ke palekana ʻole iā ʻoe. E loiloi pono kāu kauka i kou olakino holoʻokoʻa ma mua o ke kau ʻana i kēia lāʻau.

ʻAʻole pono ʻoe e lawe iā crizotinib inā he maʻi ʻoe i ka lāʻau a i ʻole kekahi o kāna meaʻai. Eia kekahi, pono nā wahine hāpai e pale i ka crizotinib no ka mea hiki iā ia ke hōʻino i ka pēpē e ulu ana.

Pono ka poʻe me kekahi mau maʻi olakino i ka mālama hou aʻe a i ʻole ʻaʻole paha he moho no ka lāʻau crizotinib:

• Maʻi ate koʻikoʻi a i ʻole ka pōʻino o ke ake
• Maʻi puʻupaʻa koʻikoʻi
• Nā maʻi puʻuwai a i ʻole nā maʻi puʻuwai nui
• Maʻi māmā ikaika a i ʻole nā pilikia hanu
• Hāpai a i ʻole ka hānai ʻana i ka waiū

E noʻonoʻo pū kāu kauka i kāu mau lāʻau lapaʻau ʻē aʻe, no ka mea, hiki i ka crizotinib ke launa pū me nā lāʻau he nui. E hāʻawi mau i kahi papa inoa piha o nā lāʻau lapaʻau a pau, nā mea hoʻohui, a me nā huahana lāʻau lapaʻau āu e lawe nei.

Nā inoa inoa Crizotinib

Kūʻai ʻia ʻo Crizotinib ma lalo o ka inoa inoa Xalkori ma ʻAmelika Hui Pū ʻIa a me ka hapa nui o nā ʻāina ʻē aʻe. ʻO kēia ka inoa inoa mua i hoʻomohala ʻia e Pfizer, ka hui lāʻau lapaʻau i hana i ka lāʻau.

Hiki nō iā ʻoe ke ʻike i ka crizotinib i kapa ʻia e kona inoa maʻamau i loko o nā palapala lapaʻau a i ʻole ke kūkākūkā ʻana i nā koho lapaʻau me kāu hui mālama ola. Hoʻopili nā inoa ʻelua i ka lāʻau lapaʻau hoʻokahi me nā mea hana like.

Hiki ke loaʻa nā mana maʻamau o ka crizotinib i ka wā e hiki mai ana, akā i kēia manawa, ʻo Xalkori ka inoa nui i loaʻa ma ka hapa nui o nā mākeke.

Nā Koho ʻē aʻe o Crizotinib

Loaʻa kekahi mau lāʻau lapaʻau ʻē aʻe no ka mālama ʻana i nā maʻi maʻi maʻi maʻi maʻi ALK-positive a me ROS1-positive. Hiki i kāu kauka ke noʻonoʻo i kēia mau mea inā ʻaʻole kūpono ka crizotinib iā ʻoe a i ʻole inā e kūkulu ʻia ka pale ʻana o kāu maʻi maʻi.

No ka maʻi maʻi maʻi maʻi ALK-positive, nā koho ʻē aʻe e komo pū ana me alectinib (Alecensa), ceritinib (Zykadia), a me brigatinib (Alunbrig). Hoʻohana ʻia kēia mau lāʻau lapaʻau hou i kekahi manawa ma ke ʻano he lapaʻau laina mua a i ʻole ke pau ka hana ʻana o ka crizotinib.

Ke waiho nei ka chemotherapy kuʻuna i kahi koho, ʻoiai ʻo nā lāʻau lapaʻau i manaʻo ʻia e like me ka crizotinib e hāʻawi pinepine i nā hopena maikaʻi aʻe me ka liʻiliʻi o nā hopena ʻaoʻao no nā maʻi me nā hōʻailona genetic kūpono. E kōkua kāu oncologist e hoʻoholo i ke ala lapaʻau maikaʻi loa no kāu kūlana kikoʻī.

ʻOi aku ka maikaʻi o Crizotinib ma mua o Alectinib?

He mau lapaʻau maikaʻi ʻo Crizotinib a me alectinib no ka maʻi maʻi maʻi maʻi ALK-positive, akā hōʻike nā haʻawina hou e loaʻa paha i ka alectinib kekahi mau pono ma ke ʻano he lapaʻau laina mua. Aia ke koho ma waena o lākou i kāu kūlana kikoʻī a me ka mōʻaukala olakino.

Me he mea lā ʻoi aku ka maikaʻi o ka Alectinib i ka pale ʻana i ka maʻi maʻi mai ka laha ʻana i ka lolo a hiki ke hana i nā hopena ʻaoʻao liʻiliʻi no kekahi mau maʻi. Eia naʻe, ua hoʻohana ʻia ka crizotinib no ka lōʻihi a loaʻa ka ʻike maoli e kākoʻo ana i kona pono.

E noʻonoʻo kāu oncologist i nā mea e like me kou olakino holoʻokoʻa, nā maʻi olakino ʻē aʻe, nā hopena ʻaoʻao hiki ke loaʻa, a me kāu mau makemake pilikino i ke koho ʻana ma waena o kēia mau lāʻau lapaʻau. He mau koho maikaʻi loa nā mea ʻelua no ka mālama ʻana i ka maʻi maʻi maʻi ALK-positive.

Nā Nīnau i Nīnau pinepine ʻia e pili ana iā Crizotinib

He Palekana anei ʻo Crizotinib no nā kānaka me ka maʻi puʻuwai?

Hiki i ka Crizotinib ke hoʻopilikia i ka puʻuwai, no laila pono e nānā pono ʻia nā kānaka me nā maʻi puʻuwai. E kauoha paha kāu kauka i ka electrocardiogram (EKG) ma mua o ka hoʻomaka ʻana i ka lāʻau a me ka wā o ka lāʻau.

Inā loaʻa iā ʻoe ka maʻi puʻuwai, e hana pū kāu cardiologist a me ka oncologist e hoʻoholo inā palekana ʻo crizotinib iā ʻoe. Hiki iā lākou ke hoʻoponopono i kāu mau lāʻau puʻuwai a i ʻole e nānā pono iā ʻoe, akā hiki i nā maʻi he nui me nā maʻi puʻuwai ke lawe palekana i ka crizotinib.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o Crizotinib?

Inā lawe hewa ʻoe i ka nui o crizotinib ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make. Mai kali a hiki i ka hōʻike ʻana o nā hōʻailona, ​​no ka mea, he mea nui ka mālama olakino wikiwiki.

Hiki i nā hōʻailona o ka overdose ke komo i ka nausea koʻikoʻi, ka luaʻi, ka maʻi maʻi, a i ʻole ka ʻūlū. E mālama i ka hue lāʻau me ʻoe i ka wā e ʻimi ai i ka mālama olakino i ʻike pono nā mea mālama ola i ke ʻano a me ka nui āu i lawe ai.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele o Crizotinib?

Inā haʻalele ʻoe i kahi mahele a ʻoi aku ma mua o 6 mau hola a hiki i kāu mahele i hoʻonohonoho ʻia, e lawe i ka mahele i haʻalele ʻia i ka wā e hoʻomanaʻo ai ʻoe. Inā ʻoi aku ka liʻiliʻi ma mua o 6 mau hola a hiki i kāu mahele e hiki mai ana, e lele i ka mahele i haʻalele ʻia a hoʻomau me kāu papa manawa maʻamau.

Mai lawe i ʻelua mahele i ka manawa hoʻokahi e hoʻoponopono ai i kahi mahele i haʻalele ʻia. Hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao me ka ʻole o ka pono hou. Inā poina pinepine ʻoe i nā mahele, e noʻonoʻo e hoʻohana i kahi mea hoʻonohonoho pila a i ʻole e hoʻonohonoho i nā mea hoʻomanaʻo kelepona.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Crizotinib?

E hooki wale i ka lawe ʻana iā crizotinib ke haʻi mai kāu kauka iā ʻoe he palekana ke hana pēlā. ʻOiai inā ʻoe e ʻoi aku ka maikaʻi, hiki nō i ka lāʻau ke hana nei e kāohi i kāu maʻi maʻi, a ʻo ka hooki ʻana i ka hiki ke ʻae i ka maʻi maʻi e ulu hou.

E hoʻohana kāu kauka i nā scans maʻamau a me nā hoʻokolohua koko e nānā i kāu pane ʻana i ka lāʻau. Inā holomua ka maʻi 'aʻai a i ʻole nā hopena ʻaoʻao i hiki ʻole ke mālama ʻia, e hana kāu kauka me ʻoe e hoʻololi i kahi ala lapaʻau ʻē aʻe me ka palekana.

Hiki iaʻu ke hele i ka wā e lawe ana i ka Crizotinib?

ʻAe, hiki iā ʻoe ke hele maʻamau i ka wā e lawe ana i ka crizotinib, akā pono ia i kekahi hoʻolālā. E lawe mai i ka lāʻau lapaʻau keu inā loaʻa nā lohi, a e mālama i kāu lāʻau lapaʻau i loko o kāu ʻeke lawe inā e lele ana e pale i ka nalowale.

E hōʻike i kāu hui mālama ola e pili ana i nā hoʻolālā huakaʻi, ʻoi aku hoʻi inā e hele ana ʻoe i nā ʻāina ʻē kahi e paʻakikī ai ke kiʻi koke i ka mālama olakino. Hiki iā lākou ke hāʻawi i ke alakaʻi ʻana i ka mālama ʻana i nā hopena ʻaoʻao i ka wā e hele ana a e hōʻoia i ka loaʻa ʻana o nā lako lāʻau lapaʻau kūpono.