He aha ka Dacarbazine: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau chemotherapy ʻo Dacarbazine i hoʻohana ʻia e mālama i kekahi mau ʻano maʻi maʻi, me ka melanoma a me ka lymphoma o Hodgkin. Hana kēia lāʻau lapaʻau anti-cancer ikaika ma ka hōʻino ʻana i ka DNA o nā sela maʻi maʻi, e pale ana iā lākou mai ka ulu ʻana a me ka hoʻonui ʻana. ʻOiai ua manaʻo ʻia he lāʻau lapaʻau ikaika e hiki ke hakakā pono i ka maʻi maʻi, hele pū mai nō hoʻi me nā hopena ʻaoʻao nui e pono ai ka nānā pono ʻana e kāu hui mālama ola.

He aha ka Dacarbazine?

He ʻākena alkylating ʻo Dacarbazine, ʻo ia hoʻi, no ka papa o nā lāʻau chemotherapy e hoʻouka pololei i nā sela maʻi maʻi. Hāʻawi ʻia ia ma o ka IV (intravenous) injection i loko o kahi haukapila a i ʻole ke keʻena lapaʻau. Ua hoʻohana ʻia kēia lāʻau lapaʻau no nā makahiki he nui e mālama i ka maʻi maʻi a ua manaʻo ʻia ʻo ia kekahi o nā lāʻau lapaʻau maʻamau no ka melanoma holomua a me kekahi mau lymphomas.

He synthetic ka lāʻau, ʻo ia hoʻi, ua hana ʻia i loko o kahi hale hana ma mua o ka loaʻa ʻana mai nā kumu kūlohelohe. E hoʻoholo kāu oncologist inā kūpono ka dacarbazine no kāu ʻano a me ke kahua o ka maʻi maʻi e pili ana i nā mea like ʻole me kou olakino holoʻokoʻa a me ke ʻano o ka pane ʻana o kāu maʻi maʻi i nā lāʻau lapaʻau ʻē aʻe.

No ke aha i hoʻohana ʻia ai ka Dacarbazine?

Hoʻohana nui ʻia ʻo Dacarbazine e mālama i ka melanoma holomua a me ka lymphoma o Hodgkin. No nā maʻi melanoma, ua kauoha pinepine ʻia ke maʻi maʻi i nā ʻāpana ʻē aʻe o ke kino (metastatic melanoma). I nā hihia lymphoma o Hodgkin, hoʻohana pinepine ʻia ia ma ke ʻano he ʻāpana o kahi lāʻau lapaʻau i hui pū ʻia i kapa ʻia ʻo ABVD.

Hiki i kāu kauka ke noʻonoʻo i ka dacarbazine no nā maʻi maʻi laha ʻē aʻe e like me nā sarcomas ʻiʻo palupalu. Aia ka hoʻoholo e hoʻohana i kēia lāʻau lapaʻau i ke kahua o kāu maʻi maʻi, kahi, a me ke ʻano o ka pane ʻana i nā lāʻau lapaʻau ʻē aʻe. I kekahi manawa hoʻohana ʻia ia wale nō, akā ʻoi aku ka pinepine i hui pū ʻia me nā lāʻau chemotherapy ʻē aʻe e hoʻonui i ka pono.

Pehea ka hana ʻana o Dacarbazine?

Hana ʻo Dacarbazine ma ka hoʻopilikia ʻana i ka hiki o nā pūnaewele maʻi ʻaʻai e hoʻoponopono a kope i ko lākou DNA. E noʻonoʻo e like me ka hoʻopilikia ʻana i ka manual aʻo o ka pūnaewele maʻi ʻaʻai, e hana ana i mea hiki ʻole i ka pūnaewele ke hana pono a i ʻole e hana i nā pūnaewele maʻi ʻaʻai hou. ʻO kēia kaʻina hana e alakaʻi i ka make ʻana o ka pūnaewele maʻi ʻaʻai.

He lāʻau lapaʻau ikaika kēia i ʻole e hoʻokaʻawale ma waena o nā pūnaewele maʻi ʻaʻai a me kekahi mau pūnaewele olakino. ʻO ia ke kumu e ʻike ai ʻoe i nā hopena ʻaoʻao ma nā wahi o kou kino kahi e mahele wikiwiki ai nā pūnaewele, e like me kāu ʻōnaehana digestive, nā follicles lauoho, a me ka iwi iwi. ʻO ka lono maikaʻi, ʻoi aku ka maikaʻi o nā pūnaewele olakino i ka hoʻōla ʻana mai kēia pōʻino ma mua o nā pūnaewele maʻi ʻaʻai.

Pehea e lawe ai au i ka Dacarbazine?

Hāʻawi mau ʻia ʻo Dacarbazine ma o ka IV i loko o kahi keʻena lapaʻau e nā poʻe loea mālama ola i hoʻomaʻamaʻa ʻia. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka home a i ʻole ma ka waha. Lawe maʻamau ka infusion i 30 mau minuke a i hoʻokahi hola, a e nānā ʻia ʻoe i ke kaʻina hana.

Ma mua o kāu lapaʻau, e ʻai i ka meaʻai māmā ke ʻole e ʻōlelo ʻia e kāu kauka. Manaʻo kekahi poʻe maʻi i ka loaʻa ʻana o kekahi mea i loko o ko lākou ʻōpū e kōkua i ka hōʻemi ʻana i ka nausea. E hāʻawi kāu hui mālama ola iā ʻoe i nā lāʻau anti-nausea ma mua o ka infusion e kōkua i ka pale ʻana i ka ʻōpū.

Pono ʻoe e hōʻea i kāu manawa me ka wai maikaʻi, no laila e inu i ka wai nui i ka lā ma mua a me ke kakahiaka o kāu lapaʻau. E pale i ka waiʻona no ka liʻiliʻi o 24 mau hola ma mua a ma hope o kāu infusion, no ka mea, hiki i kēia ke hoʻonui i nā hopena ʻaoʻao a keakea i ke ʻano o ka hana ʻana o kou kino i ka lāʻau.

Pehea ka lōʻihi e lawe ai au i ka Dacarbazine?

He ʻokoʻa nui ka lōʻihi o ka lapaʻau dacarbazine ma muli o kāu ʻano maʻi ʻaʻai a me ka maikaʻi o kāu pane ʻana i ka lāʻau. Loaʻa i ka hapa nui o nā maʻi ka lapaʻau i nā pōʻai, me kēlā me kēia pōʻai e mau ana ma kahi o 3-4 mau pule. Pono paha ʻoe i nā pōʻai mai 3 a 8, ʻoiai pono kekahi poʻe maʻi i ka lapaʻau lōʻihi.

E nānā mau kāu kauka maʻi maʻi i kou holomua ma o nā hoʻokolohua koko, nā scans, a me nā hoʻokolohua kino. Inā pane maikaʻi kāu maʻi 'aʻai a hiki ke mālama ʻia nā hopena ʻaoʻao, hiki ke hoʻomau ʻia ka lapaʻau. Eia naʻe, inā ʻaʻole pane ka maʻi 'aʻai a i ʻole e lilo nā hopena ʻaoʻao i mea koʻikoʻi loa, e kūkākūkā kāu kauka i nā koho lapaʻau ʻē aʻe.

He mea nui e hoʻopau i kāu papa lapaʻau piha ʻoiai inā hoʻomaka ʻoe e maikaʻi. Hiki ke loaʻa nā sela maʻi 'aʻai ʻoiai ke maikaʻi ʻoe, a ʻo ka hoʻōki ʻana i ka lapaʻau ma mua o ka manawa e hiki ai i ka maʻi 'aʻai ke hoʻi mai me ka ikaika ma mua.

He aha nā hopena ʻaoʻao o Dacarbazine?

E like me nā lāʻau chemotherapy a pau, hiki i ka dacarbazine ke hana i nā hopena ʻaoʻao mai ka maʻalahi a i ke koʻikoʻi. ʻIke ka hapa nui o nā kānaka i kekahi mau hopena ʻaoʻao, akā e hoʻomanaʻo e mākaukau ana kāu hui mālama ola e kōkua i ka mālama pono ʻana iā lākou.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike:

• Nausea a me ka luaʻi (hoʻopilikia i ka hapa nui o nā maʻi)
• Ka nalowale o ka ʻai
• Luhi a me ka nāwaliwali
• Nā helu koko haʻahaʻa
• Ka nalowale o ka lauoho
• Nā ʻeha waha
• Nā hōʻailona e like me ka maʻi flu me ke kuni a me nā ʻeha ʻiʻo

Hiki ke mālama ʻia kēia mau hopena ʻaoʻao maʻamau me ka mālama kākoʻo a me nā lāʻau lapaʻau. E hāʻawi kāu hui mālama ola iā ʻoe i nā lāʻau anti-nausea a me nā lāʻau lapaʻau kākoʻo ʻē aʻe e kōkua iā ʻoe e ʻoluʻolu.

ʻOiai ʻaʻole maʻamau, hiki i kekahi mau maʻi ke ʻike i nā hopena ʻaoʻao koʻikoʻi e koi ai i ka lāʻau lapaʻau koke:

• Maʻi koʻikoʻi ma muli o ka helu haʻahaʻa o ke keʻena koko keʻokeʻo
• Ke kahe ʻana a i ʻole ka ʻeha ʻana
• Nā pilikia ate koʻikoʻi
• Nā hopena maʻi maʻi i ka wā o ka infusion
• Nā hopena ʻili koʻikoʻi
• Nā pilikia o ka puʻuwai (ʻaʻole maʻamau)

E kāhea koke aku i kāu mea mālama ola inā loaʻa iā ʻoe ke kuni, ke kahe koko ʻano ʻē, ka luaʻi nui e pale ai iā ʻoe mai ka mālama ʻana i nā wai, a i ʻole kekahi mau hōʻailona e hopohopo ai iā ʻoe. Hiki i ka hana mua ke pale i nā pilikia a mālama iā ʻoe i ka ʻoluʻolu.

ʻO wai ka mea ʻaʻole pono e lawe iā Dacarbazine?

ʻAʻole kūpono ʻo Dacarbazine no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia nāu. ʻAʻole pono e loaʻa i ka poʻe me nā ʻōnaehana pale maʻi i hoʻopilikia nui ʻia a i ʻole ka poʻe i loaʻa i nā hopena maʻi koʻikoʻi i ka dacarbazine i kēia lāʻau.

E mālama nui kāu kauka inā loaʻa iā ʻoe nā pilikia o ke ake, ka maʻi kīkī, a i ʻole ka mōʻaukala o nā maʻi puʻuwai. ʻAʻole pono e loaʻa i nā wahine hāpai i ka dacarbazine no ka mea hiki iā ia ke hōʻino i ka pēpē e ulu ana. Inā ʻoe e hānai ana i ka waiū, pono ʻoe e hooki ma mua o ka hoʻomaka ʻana i ka lāʻau.

Ma mua o ka hoʻomaka ʻana i ka dacarbazine, e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau a pau āu e lawe nei, me nā lāʻau lapaʻau a me nā mea hoʻohui. Hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka dacarbazine a hoʻonui i nā hopena ʻaoʻao a i ʻole e hōʻemi i kona pono.

Nā inoa inoa o Dacarbazine

Loaʻa ʻo Dacarbazine ma lalo o ka inoa inoa DTIC-Dome ma nā ʻāina he nui. Eia naʻe, ua ʻōlelo pinepine ʻia ʻo dacarbazine a i ʻole DTIC i nā wahi lapaʻau. Loaʻa nā mana generic a hana like me ka lāʻau inoa inoa.

E hoʻohana kāu haukapila a i ʻole ke keʻena lapaʻau i ka mana i loaʻa, a ʻaʻole pono ʻoe e hopohopo e noi i kahi inoa inoa kikoʻī. Hoʻokō nā mana a pau o ka dacarbazine i nā kūlana palekana a me ka pono.

Nā koho ʻē aʻe o Dacarbazine

Nui nā koho ʻē aʻe i ka dacarbazine, ʻoiai ʻo ke koho maikaʻi loa e pili ana i kāu ʻano maʻi maʻi. No ka melanoma, nā koho hou aku e pili ana i nā lāʻau immunotherapy e like me ka pembrolizumab (Keytruda) a me ka nivolumab (Opdivo), e kōkua ana i kāu ʻōnaehana pale e hakakā i ka maʻi maʻi.

ʻO nā koho ʻē aʻe no ka chemotherapy e komo pū ana me temozolomide, i lawe ʻia ma ka waha a hana like me dacarbazine. No ka lymphoma o Hodgkin, hiki ke noʻonoʻo ʻia nā therapies hui ʻē aʻe e like me BEACOPP a i ʻole ICE inā ʻaʻole kūpono ʻo ABVD (aia i loko o dacarbazine).

E noʻonoʻo kāu oncologist i nā mea e like me nā ʻano o kāu maʻi maʻi, kou olakino holoʻokoʻa, a me nā lāʻau lapaʻau i hala i ka wā e ʻōlelo ai i nā koho ʻē aʻe. Mai hooki i ka dacarbazine a i ʻole e hoʻololi i nā lāʻau lapaʻau me ka ʻole e kūkākūkā mua me kāu hui mālama ola.

Ua ʻoi aku ka maikaʻi o Dacarbazine ma mua o Temozolomide?

Hana like ʻo Dacarbazine a me temozolomide, akā he mau mea maikaʻi ʻokoʻa ko lākou. Hiki ke lawe ʻia ʻo Temozolomide ma ke ʻano he pila ma ka home, a ʻike ka nui o nā maʻi he mea maʻalahi ma mua o nā infusions IV. Eia naʻe, ua hoʻohana ʻia ʻo dacarbazine no ka lōʻihi a ʻoi aku ka nui o ka noiʻi i hoʻokumu ʻia ma hope ona.

No nā metastases lolo, makemake ʻia ʻo temozolomide no ka mea e hele maʻalahi i loko o ka lolo. No nā ʻano maʻi maʻi ʻē aʻe, hiki ke koho ʻia ʻo dacarbazine ma ke ʻano he ʻāpana o nā therapies hui i hōʻoia ʻia. E noʻonoʻo kāu kauka i kāu kūlana kikoʻī i ke koho ʻana ma waena o kēia mau lāʻau.

Aia ka koho

Inā he pilikia koʻikoʻi kou ate, hiki i kāu kauka ke hoʻololi i kāu mahele lāʻau a i ʻole e nānā pono iā ʻoe. Akā naʻe, ʻaʻole kūpono paha ka poʻe me ka maʻi ate koʻikoʻi no ka dacarbazine. E ʻoiaʻiʻo me kāu hui mālama ola e pili ana i kekahi mōʻaukala o nā pilikia ate, me ka hepatitis a i ʻole ka hoʻohana ʻana i ka waiʻona nui.

He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o ka Dacarbazine?

No ka mea, hāʻawi ʻia ka dacarbazine e nā poʻe loea mālama ola i aʻo ʻia ma nā keʻena lapaʻau, he mea maʻamau loa ka nui o nā mahele lāʻau. Hoʻohālikelike pono kāu hui mālama ola i kāu mahele lāʻau e pili ana i ka nui o kou kino a nānā pono i ka hoʻokomo ʻana.

Inā hopohopo ʻoe e pili ana i kāu mahele lāʻau a i ʻole e ʻike i nā hopena ʻaoʻao koʻikoʻi ma hope o ka mālama ʻana, e hoʻokaʻaʻike koke aku i kāu mea mālama ola. Hiki iā lākou ke hāʻawi i ka mālama kākoʻo a nānā iā ʻoe no nā pilikia. Mai hoʻāʻo e mālama i nā hōʻailona o ka nui o ka mahele lāʻau iā ʻoe iho.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele lāʻau o Dacarbazine?

Inā haʻalele ʻoe i kahi manawa dacarbazine i hoʻonohonoho ʻia, e hoʻokaʻaʻike i ke keʻena o kāu oncologist i ka hiki wawe e hoʻonohonoho hou. Mai hoʻāʻo e hoʻoponopono i nā mahele lāʻau i haʻalele ʻia a i ʻole e pāpālua i nā lāʻau lapaʻau. E hoʻoponopono kāu hui mālama ola i kāu papa hana lapaʻau me ka palekana.

ʻAʻole e hōʻino ka haʻalele ʻana i hoʻokahi mahele lāʻau i kāu lapaʻau, akā he mea nui ka kūlike no nā hopena maikaʻi loa. Inā pilikia ʻoe i ka mālama ʻana i nā manawa ma muli o nā hopena ʻaoʻao a i ʻole nā pilikia ʻē aʻe, e kūkākūkā i kēia me kāu hui mālama ola. Hiki iā lākou ke kōkua iā ʻoe e mālama i nā hopena ʻaoʻao a i ʻole e hoʻoponopono i kāu papa hana inā pono.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Dacarbazine?

Pono ʻoe e hooki i ka dacarbazine ke hoʻoholo kāu oncologist he kūpono. Hoʻokumu ʻia kēia hoʻoholo i ka maikaʻi o ka pane ʻana o kāu maʻi maʻi i ka lapaʻau, pehea ke koʻikoʻi o kāu mau hopena ʻaoʻao, a me kou kūlana olakino holoʻokoʻa.

Hoʻopau kekahi poʻe maʻi i kā lākou papa hana lapaʻau i hoʻolālā ʻia me ka holomua, aʻo nā mea ʻē aʻe e pono paha e hooki mua ma muli o nā hopena ʻaoʻao a i ʻole ka nele o ka pane. E hoʻohana kāu kauka i nā scans maʻamau a me nā hoʻokolohua koko e nānā i kou holomua a e hana i kēia hoʻoholo me ʻoe.

Hiki iaʻu ke kalaiwa ma hope o ka lapaʻau ʻana me Dacarbazine?

He nui nā maʻi e ʻike i ka luhi a i ʻole ka maikaʻi ʻole ma hope o nā infusions dacarbazine, no laila, ʻoi aku ka maikaʻi e hoʻonohonoho i kekahi e kalaiwa iā ʻoe i ka home ma hope o ka lapaʻau. Hiki i ka luhi, ka nausea, a me nā hōʻailona e like me ka maʻi flu ke hoʻopilikia i kou hiki ke kalaiwa palekana.

E hoʻolālā e hoʻomaha no ke koena o ka lā ma hope o kāu lapaʻau. ʻOi aku ka maikaʻi o ka hapa nui o nā maʻi i loko o hoʻokahi a ʻelua paha lā, akā e hoʻolohe i kou kino a mai kalaiwa inā ʻaʻole ʻoe e maikaʻi a i ʻole ka wili. ʻO kou palekana a me ka palekana o nā poʻe ʻē aʻe ma ke alanui ka mea nui loa.