He aha ʻo Dacomitinib: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i manaʻo ʻia ʻo Dacomitinib e kōkua ana i ka mālamaʻana i kahi ʻano maʻi maʻi maʻi maʻi maʻi maʻi liʻiliʻi ʻole. Hana kēia lāʻau lapaʻau waha ma ka pale ʻana i kekahi mau protein e hoʻoulu ai i ka ulu ʻana o nā sela maʻi, e hāʻawi ana i ka manaʻolana no nā maʻi nona nā maʻi tumora i nā loli genetic. ʻO ka hoʻomaopopo ʻana i ka hana ʻana o kēia lāʻau lapaʻau a me ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a hilinaʻi i kāu huakaʻi lapaʻau.

He aha ʻo Dacomitinib?

He lāʻau lapaʻau i kauoha ʻia ʻo Dacomitinib e pili ana i kahi papa o nā lāʻau i kapa ʻia ʻo tyrosine kinase inhibitors. Ua hoʻolālā ʻia e mālama i ka maʻi maʻi maʻi maʻi liʻiliʻi ʻole (NSCLC) i laha i nā ʻāpana ʻē aʻe o ke kino a i ʻole ʻaʻole hiki ke wehe ʻia e ke ʻoki. Hoʻopili kēia lāʻau lapaʻau i nā sela maʻi i loaʻa nā loli genetic kikoʻī, e hana ana i kahi ala lapaʻau pilikino.

Hana ka lāʻau ma ka pale ʻana i nā protein i kapa ʻia ʻo EGFR (epidermal growth factor receptor) e hoʻouna ana i nā hōʻailona e haʻi ana i nā sela maʻi e ulu a hoʻonui. Ma ka hoʻopau ʻana i kēia mau hōʻailona, ​​kōkua ʻo dacomitinib e hoʻolohi a hoʻōki paha i ka laha ʻana o ka maʻi. ʻO kēia ala i manaʻo ʻia e pili ana i nā sela maʻi i ka wā e pili ana i nā sela maʻamau ma mua o ka chemotherapy kuʻuna.

No ke aha e hoʻohana ʻia ai ʻo Dacomitinib?

Hoʻohana nui ʻia ʻo Dacomitinib e mālama i ka maʻi maʻi maʻi maʻi liʻiliʻi ʻole i nā maʻi nona nā maʻi tumora i nā loli gene EGFR kikoʻī. E hoʻāʻo kāu kauka i kāu ʻiʻo tumora e hōʻoia ua loaʻa iā ʻoe kēia mau loli ma mua o ke kau ʻana i kēia lāʻau lapaʻau. ʻO kēia hoʻāʻo genetic e hōʻoia i ka maikaʻi o ka lapaʻau no kāu ʻano maʻi kikoʻī.

Hoʻohana pinepine ʻia ka lāʻau lapaʻau ke laha ka maʻi ʻaʻai o ka māmā ma waho o nā māmā i nā wahi ʻē aʻe o kou kino. Manaʻo ʻia he lapaʻau laina mua, ʻo ia hoʻi, ʻo ia kekahi o nā lāʻau lapaʻau mua loa e ʻōlelo ai kāu kauka inā ua ʻike ʻia ʻoe me kēia ʻano maʻi ʻaʻai. E hoʻoholo kāu oncologist inā kūpono ka dacomitinib no kou kūlana kikoʻī e pili ana i nā hopena o kāu hoʻokolohua a me ke olakino holoʻokoʻa.

Pehea e Hana ai ʻo Dacomitinib?

Manaʻo ʻia ʻo Dacomitinib he lāʻau lapaʻau i manaʻo ʻia a maikaʻi no ka maʻi ʻaʻai o ka māmā me nā loli EGFR. Hana ia ma ka hoʻopaʻa mau ʻana i ka protein EGFR ma nā sela maʻi ʻaʻai, he ʻokoʻa kēia mai kekahi mau lāʻau lapaʻau like ʻē aʻe e hoʻopaʻa manawa wale nō. Hiki i kēia hoʻopaʻa mau ʻana ke ʻoi aku ka maikaʻi i ka hoʻōki ʻana i ka ulu ʻana o nā sela maʻi ʻaʻai i ka wā.

E noʻonoʻo i nā protein EGFR e like me nā kuapo e hoʻā i ka ulu ʻana o nā sela maʻi ʻaʻai. Hana ʻo Dacomitinib e like me ka laka e hoʻopau mau i kēia mau kuapo, e pale ana i nā sela maʻi ʻaʻai mai ka loaʻa ʻana o nā hōʻailona e pono ai lākou e hoʻonui. Kōkua kēia ala i manaʻo ʻia e mālama i ka nui o kāu mau sela olakino i hoʻohālikelike ʻia me ka chemotherapy kuʻuna, ʻoiai paha e ʻike ʻoe i nā hopena ʻaoʻao.

Pale pū ka lāʻau lapaʻau i nā protein pili ʻē aʻe i ka ʻohana like, hiki ke kōkua i ka pale ʻana i nā sela maʻi ʻaʻai mai ka loaʻa ʻana o nā ala ʻē aʻe e ulu ai. Hiki i kēia hana pale ākea ke kōkua i ka mālama ʻana i ka lapaʻau i ka maikaʻi no ka lōʻihi ma mua o kekahi mau lāʻau lapaʻau i manaʻo ʻia.

Pehea e Lawe ai au i ka Dacomitinib?

E lawe i ka dacomitinib e like me ke kau ʻana a kāu kauka, maʻamau hoʻokahi manawa i ka lā ma ka ʻōpū ʻole. ʻO ka mea nui e lawe iā ia i ka manawa like i kēlā me kēia lā, hoʻokahi hola ma mua o ka ʻai ʻana a i ʻole ʻelua hola ma hope o ka ʻai ʻana. Kōkua kēia manawa kūlike i kou kino e komo pono i ka lāʻau lapaʻau a mālama i nā pae paʻa i loko o kāu ʻōnaehana.

E ale i ka papa holoʻokoʻa me ke aniani wai piha. Mai ʻoki, nau, a wāwahi paha i ka papa, no ka mea, hiki i kēia ke hoʻopilikia i ke ʻano o ka hana ʻana o ka lāʻau lapaʻau i loko o kou kino. Inā pilikia ʻoe i ka ale ʻana i nā pila, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua ai, akā ʻaʻole loa e hoʻololi i ka papa ponoʻī.

Pono ʻoe e pale i kekahi mau meaʻai a me nā lāʻau lapaʻau e hiki ke hoʻopilikia i ka dacomitinib. Hiki i ka hua waina a me ka wai hua waina ke hoʻonui i nā pae o ka lāʻau lapaʻau i loko o kou koko, e hiki ai ke hana i nā hopena ʻaoʻao hou aʻe. E nānā pū kāu kauka i kāu mau lāʻau lapaʻau ʻē aʻe a pau e hōʻoia ʻaʻohe pilina weliweli.

Pono nā hoʻokolohua koko maʻamau e nānā i ke ʻano o ka pane ʻana o kou kino i ka lāʻau lapaʻau. Kōkua kēia mau hoʻokolohua i kāu kauka e hoʻoponopono i kāu mahele inā pono a nānā i nā loli e pili ana i kāu helu koko a i ʻole ka hana o nā ʻōkana.

Pehea ka lōʻihi e lawe ai au i ka Dacomitinib?

E hoʻomau ʻoe i ka lawe ʻana i ka dacomitinib i ka wā e kōkua ana i ka mālama ʻana i kāu maʻi kanesa a ke ʻae maikaʻi nei ʻoe i nā hopena ʻaoʻao. He mau mahina paha a i ʻole he mau makahiki paha kēia, ma muli o ke ʻano o ka pane ʻana o kāu maʻi kanesa i ka lāʻau lapaʻau. E nānā kāu oncologist i kāu holomua ma o nā scans maʻamau a me nā hoʻokolohua koko e hoʻoholo ai inā e hana pono ana ka lāʻau lapaʻau.

He ʻokoʻa nui ka lōʻihi o ka lāʻau lapaʻau mai kēlā kanaka i kēia kanaka. Lawe kekahi poʻe i ka dacomitinib no nā mahina he nui me ka mālama maikaʻi ʻana i ka maʻi kanesa, a ʻo nā mea ʻē aʻe e pono e hoʻololi i nā lāʻau lapaʻau ʻē aʻe i ka wā ma mua. E hana pū kāu kauka me ʻoe e ʻimi i ke kaulike kūpono ma waena o ka mālama ʻana i kāu maʻi kanesa a me ka mālama ʻana i nā hopena ʻaoʻao āu e ʻike ai.

Mai hooki koke i ka lawe ʻana i ka dacomitinib a i ʻole e hoʻololi i kāu mahele me ka ʻole e kamaʻilio mua me kāu hui mālama ola. ʻOiai inā ʻoe e ʻoi aku ka maikaʻi, e hana ana paha ka lāʻau lapaʻau i ka mālama ʻana i nā pūnaewele maʻi kanesa ʻaʻole hiki iā ʻoe ke ʻike a manaʻo paha. E alakaʻi kāu kauka iā ʻoe ma o nā hoʻoponopono ʻana i ka mahele a i ʻole nā hoʻololi lāʻau lapaʻau e pili ana i kāu pane pilikino a me nā hopena hoʻokolohua.

He aha nā hopena ʻaoʻao o Dacomitinib?

E like me nā lāʻau lapaʻau maʻi āpau, hiki i ka dacomitinib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole nā mea a pau e ʻike like iā lākou. Hiki ke mālama ʻia nā hopena ʻaoʻao maʻamau me ka mālama kūpono a me ka nānā ʻana mai kāu hui mālama ola. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hōʻea ai no ke kākoʻo.

Eia nā hopena ʻaoʻao maʻamau e ʻike ai ʻoe:

• Ka maʻi maʻi, hiki ke ʻano mai ka maʻalahi a i ka koʻikoʻi
• Nā loli ʻili a me nā kui, me ka ʻōpala, ka ʻili maloʻo, a me nā pilikia kui
• Nā ʻeha waha a i ʻole ka mumū
• Ka nalowale o ka ʻai a me ka pohō kaumaha
• ʻO ka luhi a me ka nāwaliwali maʻamau
• ʻO ka nausea a me ka luaʻi

Hiki ke mālama ʻia kēia mau hopena ʻaoʻao maʻamau me nā lāʻau lapaʻau a me nā hoʻoponopono ola. E hāʻawi kāu hui mālama ola i ke alakaʻi kikoʻī e pili ana i ka mālama ʻana i kēlā me kēia hōʻailona āu e ʻike ai.

Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau e koi ana i ka lāʻau lapaʻau koke:

• Nā pilikia māmā koʻikoʻi, me ka mumū a i ʻole ka ʻōpala
• Nā hopena ʻili koʻikoʻi e uhi ana i nā wahi nui o kou kino
• Nā pilikia maka, me ka mumū corneal a i ʻole ka perforation
• Nā pilikia ate koʻikoʻi
• Nā loli puʻuwai puʻuwai

ʻOiai he kakaikahi kēia mau hopena ʻaoʻao koʻikoʻi, he mea nui e ʻike i nā hōʻailona hōʻailona a e hoʻokaʻaʻike koke i kāu kauka inā ʻoe e ʻike i nā pilikia hanu koʻikoʻi, nā hopena ʻili ākea, ka ʻeha o ka maka a i ʻole nā loli ʻike, a i ʻole nā puʻuwai puʻuwai maʻamau.

ʻO wai ka mea ʻaʻole pono e lawe iā Dacomitinib?

ʻAʻole kūpono ʻo Dacomitinib no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia iā ʻoe. Pono paha ka poʻe me kekahi mau maʻi olakino a i ʻole nā kūlana e pale i kēia lāʻau lapaʻau a i ʻole e koi i ka nānā kūikawā. E nānā kāu hui mālama ola i kāu mōʻaukala olakino piha ma mua o ke kau ʻana iā dacomitinib.

ʻAʻole pono ʻoe e lawe i ka dacomitinib inā he maʻi ʻoe iā ia a i ʻole kekahi o kāna mau mea. E haʻi i kāu kauka e pili ana i nā hopena maʻi ma mua i nā lāʻau lapaʻau, ʻoiai nā lāʻau lapaʻau maʻi ʻaʻai ʻē aʻe. Pono nō hoʻi kāu kauka e ʻike e pili ana i nā maʻi olakino a me nā lāʻau lapaʻau i kēia manawa e hōʻoia i ka palekana o ka dacomitinib iā ʻoe.

ʻAʻole pono nā wahine hāpai a hānai ʻana i ka waiū e lawe i ka dacomitinib, no ka mea, hiki iā ia ke hōʻeha i kahi pēpē e ulu ana. Inā hiki iā ʻoe ke hāpai, pono ʻoe e hoʻohana i ka mana hānau kūpono i ka wā o ka mālama ʻana a no ka liʻiliʻi he 17 mau lā ma hope o kāu lāʻau hope loa. Pono nō hoʻi nā kāne e lawe ana i ka dacomitinib e hoʻohana i ka contraception inā hiki i kā lākou hoa ke hāpai.

Hiki i nā poʻe me nā pilikia kīkī a i ʻole ke akepaʻa ke koi i nā hoʻoponopono ʻana i ka lāʻau a i ʻole ʻaʻole hiki ke lawe palekana i ka dacomitinib. E hana kāu kauka i nā hoʻokolohua koko e nānā i kāu hana ʻōkana ma mua o ka hoʻomaka ʻana i ka mālama ʻana a e hoʻomau i ka nānā ʻana i kāu therapy.

Inoa Brand Dacomitinib

Kūʻai ʻia ka Dacomitinib ma lalo o ka inoa brand Vizimpro. ʻO kēia wale nō ka inoa brand i loaʻa i kēia manawa no kēia lāʻau lapaʻau ma ʻAmelika Hui Pū ʻIa. Ke kiʻi ʻoe i kāu kauoha, e ʻike ʻoe iā "Vizimpro" ma ka lepili o ka hue, ʻo ia ka lāʻau lapaʻau like me ka dacomitinib.

E hōʻoia mau e loaʻa ana iā ʻoe ka lāʻau lapaʻau kūpono ma ka nānā ʻana i ka inoa generic (dacomitinib) a me ka inoa brand (Vizimpro) me kāu lāʻau lapaʻau. Kōkua kēia i ka pale ʻana i ka huikau a i ʻole nā ​​hewa lāʻau lapaʻau, ʻoiai inā ʻoe e lawe ana i nā lāʻau lapaʻau maʻi ʻaʻai he nui.

Nā Koho ʻē aʻe o Dacomitinib

Nui nā lāʻau lapaʻau ʻē aʻe e hana like me ka dacomitinib no ka mālama ʻana i ka maʻi ʻaʻai māmā EGFR-positive. Aia kēia mau koho ʻē aʻe i ka erlotinib (Tarceva), gefitinib (Iressa), afatinib (Gilotrif), a me osimertinib (Tagrisso). Hoʻopā kēlā me kēia lāʻau lapaʻau i nā protein EGFR akā hiki ke hana iki i nā ʻano like ʻole a i ʻole kūpono no nā kūlana like ʻole.

Koho kāu kauka i ka lāʻau lapaʻau maikaʻi loa e pili ana i nā hopena o kāu hoʻokolohua genetic, nā lāʻau lapaʻau i hala, a me ke olakino holoʻokoʻa. He ʻoi aku ka maikaʻi o kekahi mau koho ʻē aʻe inā e kūʻē ʻoe i ka dacomitinib, a ʻoi aku paha ka maikaʻi o nā mea ʻē aʻe ma ke ʻano he lāʻau lapaʻau mua e pili ana i nā ʻano o kāu maʻi maʻi.

Inā pau ka hana ʻana o ka dacomitinib a i ʻole e hana i nā hopena ʻaoʻao he nui loa, hiki i kāu oncologist ke kūkākūkā i ka hoʻololi ʻana i kekahi o kēia mau koho ʻē aʻe. He ʻokoʻa ko kēlā me kēia lāʻau lapaʻau i nā hopena ʻaoʻao a me ka pono, no laila aia pinepine nā koho maikaʻi inā pono ʻoe e hoʻololi i nā lāʻau lapaʻau.

Ua ʻoi aku ka maikaʻi o ka Dacomitinib ma mua o Erlotinib?

Hōʻike nā haʻawina lapaʻau i ka dacomitinib ʻoi aku ka maikaʻi ma mua o ka erlotinib no kekahi poʻe maʻi me ka maʻi maʻi maʻi maʻi maʻi EGFR-positive. Hōʻike ka noiʻi i ka poʻe e lawe ana i ka dacomitinib i nā manawa lōʻihi ma mua o ka holomua ʻana o kā lākou maʻi maʻi i ka poʻe e lawe ana i ka erlotinib. Eia naʻe, ʻoi aku ka nui o nā hopena ʻaoʻao o ka dacomitinib ma mua o ka erlotinib.

Aia ke koho ma waena o kēia mau lāʻau lapaʻau i kāu kūlana pilikino, me kāu mau hoʻololi genetic kikoʻī, ke olakino holoʻokoʻa, a me ka hiki ke ʻae i nā hopena ʻaoʻao. ʻOi aku ka maikaʻi o kekahi poʻe maʻi me ka erlotinib no ka mea ʻike lākou i nā hopena ʻaoʻao liʻiliʻi, aʻo nā mea ʻē aʻe e pōmaikaʻi hou mai nā hopena hakakā maʻi maʻi ikaika o ka dacomitinib.

E noʻonoʻo kāu oncologist i kēia mau mea a pau i ka wā e ʻōlelo ai i ka lāʻau lapaʻau maikaʻi loa nāu. He mau koho maikaʻi nā lāʻau lapaʻau ʻelua, a ʻo ke koho

Pono ka nānā pono ʻana iā Dacomitinib i ka poʻe me ka maʻi puʻuwai, no ka mea, hiki i kekahi manawa ke hoʻopilikia i ka puʻuwai. E loiloi kāu kauka i ke olakino o kou puʻuwai ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a hiki ke ʻōlelo aku i ka nānā mau ʻana i ka puʻuwai i ka wā o ka lāʻau lapaʻau. Inā he moʻolelo kou o nā pilikia puʻuwai, e hana pū kāu cardiologist a me ka oncologist e hōʻoia i ka palekana o kāu lāʻau lapaʻau.

Hiki i ka hapa nui o ka poʻe me nā maʻi puʻuwai paʻa ke lawe iā dacomitinib me ka nānā pono. E nānā kāu hui mālama ola no nā loli i ka puʻuwai o kou puʻuwai a hoʻoponopono i kāu lāʻau lapaʻau inā pono. E haʻi mau i kāu kauka e pili ana i kekahi ʻeha o ka umauma, ka puʻuwai ʻole, a i ʻole ka hanu ʻana i ka wā e lawe ana i kēia lāʻau.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o Dacomitinib?

Inā lawe hewa ʻoe i ka nui o dacomitinib ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu mea mālama ola a i ʻole ke kikowaena mana. ʻO ka lawe ʻana i ka nui hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi, me ka maʻi maʻi koʻikoʻi, nā hopena ʻili, a me nā pilikia ʻē aʻe. Mai kali e ʻike inā maikaʻi ʻoe, no ka mea, ʻaʻole paha e ʻike koke kekahi mau hopena.

E mālama i ka hue lāʻau me ʻoe i ka wā e kāhea ai i hiki iā ʻoe ke hāʻawi i ka ʻike pololei e pili ana i ka nui āu i lawe ai a me ka manawa. Inā ʻoe e ʻike nei i nā hōʻailona koʻikoʻi, e hele koke i ka lumi pilikia. Mai hoʻāʻo e

E hoʻāʻo e hoʻokumu i kahi hana maʻamau e kōkua iā ʻoe e hoʻomanaʻo i kāu lāʻau i kēlā me kēia lā, e like me ka lawe ʻana i ka manawa like i kēlā me kēia lā a i ʻole ke hoʻonohonoho ʻana i kahi ʻōlelo hoʻomanaʻo kelepona. Inā poina pinepine ʻoe i nā lāʻau, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua iā ʻoe e noho ma ke ala me kāu papa lāʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Dacomitinib?

Pono ʻoe e hooki i ka lawe ʻana iā dacomitinib ke haʻi aku kāu kauka iā ʻoe he palekana ke hana pēlā. Hoʻokumu ʻia kēia hoʻoholo i ka maikaʻi o ka lāʻau e kāohi ana i kāu maʻi kanesa, nā hopena ʻaoʻao āu e ʻike nei, a me kou kūlana olakino holoʻokoʻa. E hoʻohana kāu oncologist i nā scans maʻamau a me nā hoʻokolohua koko e nānā i kāu holomua a e hoʻoholo i ka manawa maikaʻi loa e hoʻomau a hoʻololi paha i kāu lapaʻau.

Pono paha kekahi poʻe e hooki no ka manawa pōkole inā loaʻa iā lākou nā hopena ʻaoʻao koʻikoʻi, a laila e hoʻomaka hou i kahi lāʻau haʻahaʻa ke ola hou lākou. Hiki i nā mea ʻē aʻe ke hoʻololi i kahi lāʻau lapaʻau ʻē aʻe inā pau ka hana ʻana o dacomitinib. E alakaʻi kāu kauka iā ʻoe ma nā loli lapaʻau a giải thích i nā kumu ma hope o kā lākou ʻōlelo.

Hiki iaʻu ke lawe iā Dacomitinib me nā lapaʻau maʻi kanesa ʻē aʻe?

Hoʻohana pinepine ʻia ʻo Dacomitinib ma ke ʻano he lapaʻau hoʻokahi ma mua o ka hui pū ʻana me nā lāʻau lapaʻau maʻi kanesa ʻē aʻe. E hoʻoholo kāu oncologist i ke ala lapaʻau maikaʻi loa e pili ana i kāu kūlana kikoʻī, akā lawe ka hapa nui o nā kānaka iā dacomitinib wale nō ma mua o ka chemotherapy a i ʻole nā ​​lāʻau lapaʻau i manaʻo ʻia.

Eia naʻe, hiki iā ʻoe ke loaʻa nā lāʻau lapaʻau kākoʻo me dacomitinib e kōkua i ka mālama ʻana i nā hopena ʻaoʻao. E haʻi mau i kāu hui mālama ola e pili ana i nā lāʻau lapaʻau, nā mea hoʻohui, a i ʻole nā ​​lapaʻau ʻē aʻe āu e noʻonoʻo nei, no ka mea, hiki i kekahi ke launa pū me dacomitinib a i ʻole e pili i ka maikaʻi o kāna hana.