He aha ka Dalbavancin: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau antibiotic ikaika ka Dalbavancin a nā kauka e hāʻawi ai ma o ka IV e mālama i nā maʻi ʻili bacteria koʻikoʻi. No ka pūʻulu i kapa ʻia ʻo lipoglycopeptide antibiotics kēia lāʻau lapaʻau, e hana ana ma ka hoʻōki ʻana i nā bacteria ʻino mai ke kūkulu ʻana i ko lākou mau paia cell pale.

ʻO ka mea e hana ai ʻo dalbavancin he mea kūikawā, ʻo ia ka mea e noho ana i loko o kou kino no ka manawa lōʻihi. ʻO ia hoʻi, pono ʻoe i hoʻokahi a ʻelua paha mau lāʻau ma kahi o ka lawe ʻana i nā antibiotics i kēlā me kēia lā no nā pule. Ua hoʻolālā ʻia no nā mākua i loaʻa nā maʻi ʻili a me nā maʻi ʻiʻo palupalu i pane ʻole i nā lāʻau lapaʻau ʻē aʻe.

No ke aha e hoʻohana ʻia ai ka Dalbavancin?

Hoʻomaʻamaʻa ʻo Dalbavancin i nā maʻi ʻili a me nā maʻi ʻili (ABSSSI) i nā mākua. He mau maʻi koʻikoʻi kēia e hele hohonu ma mua o ka ʻili o kou ʻili a pili pinepine i nā papa ma lalo, me ka momona, ka ʻiʻo, a i ʻole ka ʻiʻo pili.

Hiki i kāu kauka ke kuhikuhi i ka dalbavancin ke loaʻa iā ʻoe nā maʻi e like me ka cellulitis, nā abscesses nui, a i ʻole nā maʻi ʻeha. He mea maikaʻi loa ia i nā bacteria gram-positive, me kekahi e kūʻē i nā antibiotics ʻē aʻe. Aia i loko o kēia mau bacteria ʻo Staphylococcus aureus (me MRSA), Streptococcus species, a me Enterococcus faecalis.

Mālama ʻia ka lāʻau lapaʻau no nā maʻi koʻikoʻi no ka mea he antibiotic ikaika loa ia. E koho maʻamau kāu mea mālama ola i ka dalbavancin ke hana ʻole nā antibiotics ʻē aʻe a i ʻole ke koʻikoʻi o ka maʻi e koi ai i ka haukapila.

Pehea e hana ai ka Dalbavancin?

He antibiotic ikaika loa ka Dalbavancin e hana ana ma ka hoʻouka ʻana i nā paia cell o nā bacteria. E noʻonoʻo i nā paia cell bacterial e like me ka pūpū pale a puni kahi hua - me ka ʻole, ʻaʻole hiki i ka bacteria ke ola.

Ke kālele pono nei ka lāʻau lapaʻau i kahi enzyme i kapa ʻia ʻo transglycosylase, pono i ka bacteria e kūkulu a mālama i ko lākou paia cell. Ke kāohi ʻo dalbavancin i kēia enzyme, hāʻule maoli ka bacteria a make. ʻO ia ka mea a nā kauka e kapa ai he antibiotic "bactericidal", ʻo ia hoʻi, pepehi ia i ka bacteria ma mua o ka hoʻōki ʻana iā lākou mai ka ulu ʻana.

He mea kupaianaha e pili ana iā dalbavancin kona ola hapalua lōʻihi, ʻo ia hoʻi, noho ia i loko o kou kino no kahi o 8-9 mau lā ma hope o ka hoʻokahi mahele. ʻO kēia noho lōʻihi e hiki ai iā ia ke hoʻomau i ka hakakā ʻana i ka maʻi ma hope o kou loaʻa ʻana o ka IV infusion.

Pehea wau e lawe ai iā Dalbavancin?

Hāʻawi ʻia ʻo Dalbavancin ma o ka IV infusion wale nō i loko o kahi haukapila a i ʻole ke keʻena lapaʻau. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka waha ma ka home. E hāʻawi mau kahi loea mālama ola iā ia e hōʻoia i ka hoʻohana kūpono a nānā iā ʻoe no nā hopena.

Lawe maʻamau ka infusion ma kahi o 30 mau minuke e hoʻopau. E hāʻawi mālie kāu kahu iā ʻoe ma o ke aʻa i kou lima. Ma mua o ka infusion, ʻaʻole pono ʻoe e hoʻokē ʻai a pale i ka ʻai ʻana i nā meaʻai kikoʻī, ʻoiai he mea maikaʻi mau ka noho ʻana i ka wai.

Loaʻa i ka hapa nui o nā kānaka hoʻokahi mahele o 1500 mg a i ʻole ʻelua mau mahele i hāʻawi ʻia i hoʻokahi pule kaʻawale (1000 mg i ka wā mua, a laila 500 mg ʻehiku mau lā ma hope). E hoʻoholo kāu kauka i ka papa hana e hana maikaʻi loa no kāu maʻi kikoʻī a me ke olakino holoʻokoʻa.

Pehea ka lōʻihi e lawe ai au iā Dalbavancin?

ʻO ka nani o dalbavancin ʻo ia ka mea e pono ai ʻoe i hoʻokahi a ʻelua mau mahele. ʻAʻole like me nā antibiotics kuʻuna e koi ai i nā pila i kēlā me kēia lā no 7-14 mau lā, ʻo ka hopena lōʻihi o dalbavancin ʻo ia ka pau ʻana o ka mālama ʻana ma hope o hoʻokahi a ʻelua mau kipa haukapila.

Inā loaʻa iā ʻoe ka lāʻau hoʻokahi, e loaʻa iā ʻoe he 1500 mg i hoʻokahi manawa a ʻo ia nō. Me ka lāʻau ʻelua, e loaʻa iā ʻoe ka lua o ka lāʻau i nā lā ʻehiku ma hope o ka mea mua. E koho kāu kauka i ke ala e pili ana i nā mea e like me ka paʻakikī o kou maʻi a me ke ʻano o kou pane ʻana i ka lāʻau.

ʻOiai ʻaʻole ʻoe e lawe i ka lāʻau i kēlā me kēia lā, e hana mau ana ka antibiotic i loko o kou kino no nā pule ma hope o ka hoʻokomo ʻana. ʻO kēia hana lōʻihi ka mea e hana ai ka papa hana pōkole i mea maikaʻi loa no nā maʻi ʻili koʻikoʻi.

He aha nā hopena ʻaoʻao o Dalbavancin?

E like me nā lāʻau lapaʻau a pau, hiki i ka dalbavancin ke hana i nā hopena ʻaoʻao, ʻoiai e ʻae ka hapa nui o nā kānaka iā ia. ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a he manawa pōkole.

Eia nā hopena ʻaoʻao āu e ʻike ai, e hoʻomaka ana me nā mea maʻamau:

• Nausea a me ka luaʻi
• Pāpaʻa
• Poʻo
• ʻAmi
• Pāpaʻa a i ʻole ka ʻū
• ʻEha, ʻulaʻula, a i ʻole ka pehu ʻana ma ke kahua IV

Hoʻomaikaʻi maʻamau kēia mau hōʻailona i loko o hoʻokahi a ʻelua paha lā a ʻaʻole pono e hoʻōki i ka lāʻau. Eia naʻe, pono ʻoe e haʻi mau i kāu hui mālama ola inā ʻoe e ʻike i kekahi ʻoluʻolu.

ʻAʻole maʻamau nā hopena ʻaoʻao koʻikoʻi akā hiki ke komo i nā hopena maʻi maʻi koʻikoʻi, ka puʻuwai puʻuwai ʻole, a i ʻole kahi maʻi weliweli i kapa ʻia ʻo C. diff colitis (ka mumū ʻōpū koʻikoʻi). Inā ʻoe e ʻike i ka pilikia o ka hanu ʻana, ka ʻeha nui o ka ʻōpū, a i ʻole ka maʻi maʻi wai mau, e ʻimi koke i ka lāʻau lapaʻau.

ʻO wai ka mea pono ʻole e lawe iā Dalbavancin?

ʻAʻole kūpono ʻo Dalbavancin no nā mea a pau, a e nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana. ʻAʻole pono ʻoe e loaʻa i kēia lāʻau inā ua loaʻa iā ʻoe kahi hopena maʻi i ka dalbavancin a i ʻole nā ​​antibiotics like i ka wā i hala.

Pono ka poʻe me kekahi mau maʻi puʻuwai i ka mālama keu no ka mea hiki i ka dalbavancin ke hoʻopilikia i ka puʻuwai. E nānā paha kāu kauka i kahi EKG ma mua o ka mālama ʻana inā he moʻolelo kou o nā pilikia puʻuwai a i ʻole e lawe i nā lāʻau e pili ana i ka helu o kou puʻuwai.

ʻAʻole i ʻae ʻia kēia lāʻau no nā keiki ma lalo o 18 mau makahiki, no ka mea, ʻaʻole i hoʻokumu ʻia ka palekana a me ka pono i nā maʻi pediatric. Eia kekahi, inā hāpai ʻoe a i ʻole e hānai ana i ka waiū, e kaupaona kāu kauka i nā pōmaikaʻi e kūʻē i nā pilikia hiki ke loaʻa ma mua o ka ʻōlelo ʻana i ka dalbavancin.

Inoa Brand Dalbavancin

Kūʻai ʻia ʻo Dalbavancin ma lalo o ka inoa brand Dalvance ma ʻAmelika Hui Pū ʻIa. ʻO kēia ka inoa maʻamau āu e ʻike ai ma nā moʻolelo haukapila a me nā lepili lāʻau.

Hana ʻia ka lāʻau e Allergan (i kēia manawa he ʻāpana o AbbVie) a ua loaʻa mai ka makahiki 2014. Ke kūkākūkā ʻana i kāu mālama ʻana me nā mea mālama ola, hiki iā lākou ke kuhikuhi iā ia ma kekahi inoa - dalbavancin a i ʻole Dalvance.

Nā Koho ʻē aʻe o Dalbavancin

Nui nā lāʻau antibiotic ʻē aʻe e hiki ke mālama i nā maʻi ʻili koʻikoʻi, ʻoiai he mau pono like ʻole a me nā papa hana. Hiki i kāu kauka ke noʻonoʻo i nā koho ʻē aʻe e pili ana i kāu bacteria kikoʻī, ka mōʻaukala olakino, a me nā makemake lapaʻau.

ʻO nā koho maʻamau e pili ana i ka vancomycin, e koi ana i nā infusions IV i kēlā me kēia lā no 7-10 mau lā, a i ʻole linezolid, e hele mai ana i nā ʻano IV a me ka waha. ʻO Telavancin kekahi koho lōʻihi, ʻoiai e koi ana i nā infusions i kēlā me kēia lā no 7-10 mau lā ma mua o ka dalbavancin hoʻokahi a ʻelua paha.

ʻO nā koho hou aku e pili ana i ka oritavancin, he lāʻau lapaʻau hoʻokahi, a me ka tedizolid, hiki ke hāʻawi ʻia no 6 mau lā ma IV a i ʻole ma ka waha. E koho kāu mea mālama ola i ke koho maikaʻi loa e pili ana i nā ʻano o kāu maʻi a me kou kūlana olakino holoʻokoʻa.

Ua ʻoi aku ka maikaʻi o Dalbavancin ma mua o Vancomycin?

He lāʻau lapaʻau maikaʻi ʻo Dalbavancin a me vancomycin no nā maʻi ʻili koʻikoʻi, akā hana lākou ma nā ʻano like ʻole a loaʻa nā pono like ʻole. ʻO ka pōmaikaʻi nui o dalbavancin he maʻalahi - pono ʻoe i hoʻokahi a ʻelua paha lāʻau ma kahi o nā lāʻau IV i kēlā me kēia lā no hoʻokahi pule.

ʻO Vancomycin ka maʻamau gula no nā makahiki he nui a loaʻa iā ia ka noiʻi nui e kākoʻo ana i kona pono. Eia naʻe, pono ia i ka nānā ʻana i kēlā me kēia lā i nā pae koko a hiki ke hoʻoulu i nā pilikia o ka puʻupaʻa me ka hoʻohana lōʻihi. ʻAʻole pono ʻo Dalbavancin i kēia nānā nui.

Ma ke ʻano o ka pono, hōʻike nā haʻawina e hana like nā lāʻau lapaʻau ʻelua no ka mālama ʻana i nā maʻi ʻili paʻakikī. E koho kāu kauka ma muli o nā mea e like me ka hana o kou puʻupaʻa, ka bacteria kikoʻī e hoʻoulu ai i kou maʻi, a inā makemake ʻoe i nā kipa liʻiliʻi i ka haukapila.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Dalbavancin

He Palekana ʻo Dalbavancin no ka maʻi puʻupaʻa?

Hiki ke hoʻohana ʻia ʻo Dalbavancin i ka poʻe me ka maʻi puʻupaʻa, akā e hoʻoponopono kāu kauka i ka lāʻau ma muli o ka maikaʻi o ka hana ʻana o kou puʻupaʻa. Inā loaʻa iā ʻoe nā pilikia puʻupaʻa koʻikoʻi, hiki iā ʻoe ke loaʻa i kahi lāʻau liʻiliʻi a i ʻole ka nānā ʻana i ka wā o ka mālama ʻana.

Hoʻopau mua ʻia ka lāʻau lapaʻau ma o kou puʻupaʻa, no laila ʻo ka hana puʻupaʻa i hōʻemi ʻia, ʻo ia hoʻi, e noho ka lāʻau i loko o kou kino no ka lōʻihi. ʻAʻole pono kēia he mea weliweli, akā pono ia i ka mālama olakino e hōʻoia i ka loaʻa ʻana o ka nui kūpono.

He aha kaʻu e hana ai inā loaʻa iaʻu kahi hopena maʻi i ka Dalbavancin?

Inā loaʻa iā ʻoe nā hōʻailona o kahi hopena maʻi i ka wā a i ʻole ma hope o kāu infusion, e hoʻomaopopo koke i kāu hui mālama ola. Hiki i nā hōʻailona ke komo i ka pilikia o ka hanu ʻana, ka pehu ʻana o kou maka a i ʻole ka ʻāʻī, ka ʻeha nui, a i ʻole ka manaʻo nāwaliwali.

Mai ka mea e hāʻawi ʻia ana ʻo dalbavancin ma kahi olakino, hiki i nā limahana i aʻo ʻia ke pane koke i nā hopena maʻi. Loaʻa iā lākou nā lāʻau lapaʻau a me nā lako i mākaukau e mālama i nā hopena koʻikoʻi. ʻO ka hapa nui o nā hopena maʻi i ka dalbavancin he maʻalahi, akā ʻoi aku ka maikaʻi o ka makaʻala a kamaʻilio inā ʻaʻole maikaʻi kekahi mea.

He aha kaʻu e hana ai inā ua hala wau i kahi mahele o Dalbavancin?

Inā ua hoʻonohonoho ʻia ʻoe no ka regimen ʻelua-mahele a ua hala ʻoe i kāu manawa lua, e hoʻokaʻaʻike i kāu mea mālama ola kino i ka hiki wawe. Pono e hāʻawi ʻia ka mahele lua i ʻehiku mau lā ma hope o ka mea mua, akā aia ka maʻalahi i ka manawa.

Hiki i kāu kauka ke hoʻonohonoho hou iā ʻoe no ka manawa i loaʻa aʻe a i ʻole e hoʻoponopono i kāu hoʻolālā lapaʻau e pili ana i ke ʻano o kāu pane ʻana i ka mahele mua. Mai hoʻāʻo e helu a hoʻonohonoho hou iā ʻoe iho - e hoʻopili mau me kāu hui mālama ola kino.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Dalbavancin?

ʻAʻole like me nā lāʻau antibiotic kuʻuna, ʻaʻole ʻoe e