He aha ʻo Daptomycin: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau antibiotic ikaika ʻo Daptomycin a nā kauka e hāʻawi ai ma o ka IV e hakakā i nā maʻi bacteria koʻikoʻi. No kahi papa kūikawā o nā lāʻau antibiotic i kapa ʻia ʻo lipopeptides, e hana ana i nā mea ʻē aʻe mai ka hapa nui o nā lāʻau antibiotic ʻē aʻe āu e ʻike ai.

Hoʻokaʻawale ʻia kēia lāʻau lapaʻau no nā maʻi i paʻakikī loa a i hana ʻia e nā bacteria ʻaʻole e pane i nā lāʻau lapaʻau ʻē aʻe. E kauoha wale kāu kauka iā daptomycin ke manaʻoʻiʻo lākou ʻo ia ke koho maikaʻi loa no kāu kūlana.

He aha ʻo Daptomycin?

ʻO Daptomycin kahi lāʻau antibiotic i kauoha ʻia e nā mea mālama ola e hāʻawi pololei i loko o kou kahe koko ma o ka laina intravenous (IV). ʻO ia ka mea a nā kauka e kapa ai he

• Nā maʻi ʻili a me nā ʻiʻo palupalu paʻakikī e pili ana i nā papa hohonu o ka ʻiʻo
• Nā maʻi i loko o ke kahe koko (bacteremia) kahi i komo ai ka bacteria i loko o kou koko
• Nā maʻi o ka puʻuwai ma ka ʻākau (endocarditis) e pili ana i ka uhi o loko o ka puʻuwai
• Nā maʻi iwi a me nā hui (osteomyelitis) i kekahi mau hihia
• Nā maʻi i hana ʻia e ka methicillin-resistant Staphylococcus aureus (MRSA)

He mea koʻikoʻi kēia mau maʻi akā hiki ke mālama ʻia me ka lāʻau lapaʻau kūpono. Ua koho kāu hui mālama ola kino i ka daptomycin no ka mea manaʻo lākou e hāʻawi iā ʻoe i ka manawa maikaʻi loa no ka hoʻōla piha.

Pehea e hana ai ka Daptomycin?

Hana ka Daptomycin ma ka hoʻouka ʻana i nā paia o nā cell bacteria ma ke ʻano kū hoʻokahi e hana ai i mea maikaʻi loa i ka bacteria kūpaʻa. Hoʻopilikia ia i ka hiki o ka bacteria ke mālama i ko lākou pūpū pale waho, a ma hope e pepehi iā lākou.

Ua manaʻo ʻia kēia antibiotic he mea ikaika loa, ʻo ia hoʻi, he ikaika nui ia e kūʻē i nā maʻi paʻakikī. Eia naʻe, ʻo kēia ikaika hoʻi ke ʻano e pono ai ka nānā pono ʻana e hōʻoia i ka hana palekana i loko o kou kino.

ʻO ka mea e hana ai ka daptomycin i mea kūikawā, ʻo ia ka hana ʻana inā ua ʻike ka bacteria i ke ʻano e kūʻē ai i nā antibiotics ʻē aʻe. He mea like ia me ka loaʻa ʻana o kahi kī nui e hana mau ana inā ua hoʻololi ka bacteria i kā lākou laka.

Pono ka lāʻau lapaʻau i ka calcium e hana pono, ʻo ia ke kumu e nānā ai kāu hui mālama ola kino i kāu pae calcium i ka wā o ka mālama ʻana. He mea nui kēia hui pū ʻana ma waena o ka daptomycin a me ka calcium no ka hana pono ʻana o ka lāʻau lapaʻau.

Pehea wau e lawe ai i ka Daptomycin?

Hāʻawi mau ʻia ka Daptomycin ma o ka laina IV e nā poʻe loea mālama ola kino i hoʻomaʻamaʻa ʻia i loko o kahi haukapila a i ʻole kahi hoʻonohonoho lapaʻau. ʻAʻole ʻoe e lawe i kēia lāʻau lapaʻau ma ka home a i ʻole ma ka waha.

Hāʻawi ʻia ka lāʻau lapaʻau i hoʻokahi manawa i ka lā, a lawe kēlā me kēia infusion ma kahi o 30 mau minuke e hoʻopau. E nānā kāu kahu hānai iā ʻoe i kēia manawa e hōʻoia e ʻoluʻolu ana ʻoe a e pane maikaʻi ana i ka lāʻau lapaʻau.

Ma mua o ka hoʻomaka ʻana o kāu lapaʻau, e hana paha kāu hui mālama ola i kekahi mau hoʻokolohua e hōʻoia i ka mākaukau o kou kino no ka lāʻau lapaʻau. E nānā lākou i kāu hana ʻāpana a me nā enzyme ʻiʻo e hoʻokumu i kahi kumu no ka nānā ʻana.

ʻAʻole pono ʻoe e hopohopo e pili ana i ka manawa o kēia lāʻau lapaʻau me nā meaʻai no ka mea e hele pololei ana i loko o kou kahe koko. Eia naʻe, ʻo ka noho ʻana i ka wai maikaʻi ma ka inu ʻana i ka wai nui (inā ʻaʻole ʻōlelo kāu kauka i nā mea ʻē aʻe) hiki ke kōkua i kou kino e hana i ka lāʻau lapaʻau me ka ʻoi aku ka maikaʻi.

Pehea ka lōʻihi e lawe ai au i ka Daptomycin?

ʻO ka lōʻihi o kāu lapaʻau daptomycin e pili ana i ke ʻano a me ke koʻikoʻi o kāu maʻi. Loaʻa ka lapaʻau ʻana i ka hapa nui o nā kānaka no 7 a 14 mau lā, akā pono paha kekahi mau maʻi i ka lapaʻau lōʻihi.

Na kāu kauka e hoʻoholo i ka lōʻihi pololei e pili ana i ka maikaʻi o kāu pane ʻana i ka lāʻau lapaʻau a me ka bacteria kikoʻī e hana ana i kāu maʻi. E nānā lākou i kāu holomua ma o nā hoʻokolohua koko maʻamau a me nā hoʻokolohua kino.

No nā maʻi kahe koko, pono paha ʻoe i ka lapaʻau no kekahi mau pule e hōʻoia i ka pau ʻana o nā bacteria a pau. Pono pinepine nā maʻi valve puʻuwai i nā manawa lapaʻau lōʻihi, i kekahi manawa a hiki i 6 pule a ʻoi aku paha.

He mea nui e hoʻopau i ka papa lapaʻau piha inā hoʻomaka ʻoe e maikaʻi. ʻO ka hooki ʻana i ka wā mua hiki ke ʻae i ka bacteria e hoʻi mai a lilo paha i mea kūʻē i ka lapaʻau.

He aha nā hopena ʻaoʻao o Daptomycin?

E like me nā lāʻau lapaʻau ikaika a pau, hiki i ka daptomycin ke hoʻoulu i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia. E nānā pono kāu hui mālama ola iā ʻoe e hopu i nā pilikia i ka wā mua a mālama pono iā lākou.

ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a hiki ke mālama ʻia. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a emi ka hopohopo e pili ana i kāu lapaʻau.

Eia nā hopena ʻaoʻao āu e ʻike ai, e hoʻomaka ana me nā mea maʻamau:

• Ka manaʻo ʻino a i ʻole ka ʻōpū e ʻeha ana
• ʻEha ke poʻo
• Pāpaʻa
• Paʻa ka ʻōpū
• Pōniuniu
• Nā hopena ma kahi i hoʻokomo ʻia ai ka lāʻau, e like me ka ʻulaʻula a i ʻole ka pehu
• Luhi a i ʻole ka manaʻo e luhi ana

He manawa pōkole nō kēia mau hopena maʻamau a pinepine lākou e hoʻomaikaʻi ana i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Loaʻa i kāu hui mālama ola ke akamai i ka mālama ʻana i kēia mau hopena a hiki ke kōkua iā ʻoe e ʻoluʻolu.

Aia kekahi mau hopena ʻaʻole maʻamau akā ʻoi aku ka koʻikoʻi e pono ai ka lāʻau lapaʻau koke. ʻOiai he mea maʻamau ʻole kēia, he mea nui e ʻike iā lākou:

• ʻEha ʻiʻo, nāwaliwali, a i ʻole ka ʻeha (nā hōʻailona o ka pōʻino ʻiʻo)
• Paʻakikī ka hanu a i ʻole ka pōkole o ka hanu
• Nā hopena maʻi maʻi koʻikoʻi me ka ʻōpala, ka pehu, a i ʻole ka paʻakikī i ka ʻai ʻana
• Ke kahe koko ʻano ʻē a i ʻole ka ʻeha
• Pāpaʻa koʻikoʻi e hōʻike ana i kahi maʻi ʻōpū koʻikoʻi
• ʻO ka neuropathy peripheral (ka ʻeha a i ʻole ka ʻeha ʻole i nā lima a i ʻole nā wāwae)

E nānā kāu hui lapaʻau iā ʻoe no kēia mau hopena koʻikoʻi ma o nā hoʻokolohua koko maʻamau a me nā nānā. Inā loaʻa iā ʻoe kekahi mau hōʻailona e pili ana, mai kānalua e hoʻomaopopo koke i kāu poʻe lawelawe mālama ola.

ʻO wai ka mea pono ʻole e lawe iā Daptomycin?

ʻAʻole kūpono ʻo Daptomycin no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. Hiki i kekahi mau maʻi a i ʻole nā lāʻau lapaʻau ke hoʻolilo iā daptomycin i mea palekana ʻole a i ʻole ka liʻiliʻi o ka pono.

ʻAʻole pono ka poʻe i ʻike ʻia he maʻi i ka daptomycin a i ʻole kekahi o kāna mau mea e loaʻa i kēia lāʻau. E nīnau kāu hui mālama ola e pili ana i kāu moʻolelo maʻi ma mua o ka hoʻomaka ʻana i ka lāʻau.

Eia nā kūlana i hiki ʻole ai iā daptomycin ke koho kūpono iā ʻoe:

• Pneumonia a i ʻole nā maʻi o ka māmā (ʻaʻole hana maikaʻi ka daptomycin i loko o ka ʻiʻo māmā)
• Maʻi kīkī koʻikoʻi a i ʻole ka hāʻule ʻana o ke kīkī
• Mōʻaukala o nā maʻi ʻiʻo a i ʻole ka ʻeha ʻiʻo i wehewehe ʻole ʻia
• Hoʻohana ʻia i kēia manawa i kekahi mau lāʻau lapaʻau hoʻohaʻahaʻa cholesterol (statins)
• Hāpai a i ʻole ka hānai ʻana i ka waiū (inā ʻaʻole ʻoi aku ka maikaʻi ma mua o nā pilikia)
• Nā keiki ma lalo o 12 mahina o ka makahiki

E loiloi kāu kauka i kēia mau mea i ka paʻakikī o kāu maʻi e hana i ka hoʻoholo maikaʻi loa no kou olakino. I kekahi manawa, ʻoi aku ka maikaʻi o ka mālama ʻana ma mua o nā pilikia, ʻoiai i nā kūlana paʻakikī.

Nā inoa inoa o Daptomycin

Loaʻa ka Daptomycin ma lalo o nā inoa inoa like ʻole, ʻo Cubicin ka inoa mua i ʻike nui ʻia. Hiki nō hoʻi iā ʻoe ke hālāwai me Cubicin RF, he ʻano hou i hoʻolālā ʻia e maʻalahi ke hoʻomākaukau.

Loaʻa nō hoʻi nā ʻano generic o daptomycin a hana like ka maikaʻi me nā ʻano inoa inoa. E hoʻohana kāu keʻena mālama ola i ka mea kūpono loa no kou kūlana.

ʻAʻole pili ka inoa inoa a i ʻole ka generic āu e loaʻa ai i ka maikaʻi o kāu mālama ʻana. Hoʻokō nā ʻano daptomycin i ʻae ʻia i nā kūlana palekana a me ka pono like.

Nā koho ʻē aʻe o Daptomycin

Hiki i kekahi mau lāʻau antibiotic ʻē aʻe ke mālama i nā maʻi like me ka daptomycin, akā ua koho kāu kauka iā daptomycin no nā kumu kikoʻī e pili ana i kou kūlana. ʻO nā koho maʻamau e pili ana i ka vancomycin, linezolid, a me ka tigecycline.

Manaʻo pinepine ʻia ʻo Vancomycin ka koho kokoke loa i ka daptomycin no ka mālama ʻana i nā maʻi bacteria gram-positive koʻikoʻi. Eia naʻe, hiki i kekahi mau bacteria e kūʻē i ka vancomycin ke pane i ka daptomycin.

Hiki ke lawe ʻia nā koho ʻē aʻe e like me ka linezolid ma ka waha, he mea maʻalahi paha. Eia naʻe, loaʻa i kēlā me kēia antibiotic kona mau ikaika a me nā palena, a ua koho kāu kauka iā daptomycin no ka mea ʻo ia ka mea kūpono loa no kāu maʻi kikoʻī.

Ke koho ʻana ma waena o kēia mau lāʻau lapaʻau e hilinaʻi ana i nā mea e like me ka bacteria kikoʻī e hana ana i kāu maʻi, ka hana o kou puʻupaʻa, nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, a me ke koʻikoʻi o kāu maʻi.

Ua ʻoi aku ka maikaʻi o Daptomycin ma mua o Vancomycin?

He mau lāʻau antibiotic maikaʻi loa ʻo Daptomycin a me vancomycin, akā hana lākou i nā ʻano like ʻole a loaʻa nā ikaika like ʻole. ʻAʻole kekahi i

E kāhea koke aku i kāu hui mālama ola inā loaʻa iā ʻoe ka ʻeha ʻiʻo, nāwaliwali, a i ʻole ka ʻū ʻana i ka wā e mālama ʻia ai me ka daptomycin. Hōʻike paha kēia mau hōʻailona i ka pōʻino o ka ʻiʻo e pono ai ka nānā koke.

Nānā kāu hui lapaʻau i nā pilikia ʻiʻo ma o nā hoʻokolohua koko maʻamau e nānā ana i nā enzyme ʻiʻo. Inā piʻi kēia mau pae, pono paha lākou e hooki i ka lāʻau a i ʻole e hoʻoponopono i kāu hoʻolālā lapaʻau.

Mai mālama ʻole i nā hōʻailona ʻiʻo a i ʻole e manaʻo he mai ka noho ʻana i ka haukapila. Hiki i ka ʻike mua a me ka mālama ʻana i nā hopena ʻaoʻao ʻiʻo ke pale i nā pilikia koʻikoʻi.

Hiki iaʻu ke lawe i nā lāʻau ʻē aʻe i ka wā e lawe ana i ka Daptomycin?

Hiki ke lawe palekana ʻia nā lāʻau he nui me ka daptomycin, akā hiki i kekahi ke launa pū a i ʻole e hoʻonui i ka pilikia o nā hopena ʻaoʻao. E nānā kāu hui mālama ola i kāu mau lāʻau a pau ma mua o ka hoʻomaka ʻana i ka lapaʻau.

Hiki i kekahi mau lāʻau cholesterol (statins) ke hoʻonui i ka pilikia o nā pilikia ʻiʻo ke hui pū ʻia me ka daptomycin. Hiki i kāu kauka ke hooki i kēia mau lāʻau i ka wā o kāu lapaʻau.

E hōʻike mau i kāu poʻe mālama ola e pili ana i nā lāʻau a pau, nā mea hoʻohui, a me nā huaora āu e lawe nei. Aia kēia i nā lāʻau lapaʻau ma luna o ka pā a me nā mea hoʻohui lāʻau i manaʻo ʻia he palekana.

Pehea wau e ʻike ai inā e hana ana ka Daptomycin?

E nānā kāu hui mālama ola i kāu pane ʻana i ka daptomycin ma o nā hoʻokolohua koko maʻamau, nā hoʻokolohua kino, a me ka nānā ʻana i nā hōʻailona. Pono ʻoe e hoʻomaka e maikaʻi i loko o kekahi mau lā ma hope o ka hoʻomaka ʻana i ka lapaʻau.

ʻO nā hōʻailona e hana ana ka lāʻau lapaʻau e komo pū ana me ka emi ʻana o ke kuni, ka liʻiliʻi o ka ʻeha a i ʻole ka pehu ʻana ma nā wahi maʻi, ka hoʻomaikaʻi ʻana i nā pae ikehu, a me ka manaʻo maikaʻi. E hōʻike pū ana kāu mau hoʻokolohua koko i ka emi ʻana o nā hōʻailona o ka maʻi.

Inā ʻaʻole ʻoe e ʻike i ka hoʻomaikaʻi ʻana ma hope o kekahi mau lā, mai hopohopo koke. Pono kekahi mau maʻi i ka manawa e pane ai, a e hoʻoponopono kāu kauka i ka hoʻolālā lapaʻau inā pono.

He aha ka mea e hana ai ma hope o ka pau ʻana o kaʻu lapaʻau Daptomycin?

Ma hope o ka pau ʻana o kāu papa daptomycin, e hoʻonohonoho paha kāu kauka i nā manawa e nānā ai e hōʻoia i ka pau loa ʻana o kāu maʻi. Pono paha ʻoe i nā hoʻokolohua koko hou e hōʻoia i ka pau ʻana o ka bacteria.

Hoʻi ka hapa nui o nā kānaka i kā lākou hana maʻamau ma hope o ka mālama ʻana, akā pili ka hoʻōla piha ʻana i ke koʻikoʻi o kāu maʻi a me kou olakino holoʻokoʻa. E alakaʻi kāu hui mālama ola iā ʻoe i ka wā e palekana ai ke hoʻomau i nā hana maʻamau.

Pono paha kekahi poʻe i nā lāʻau antibiotic hou ma ka waha e hoʻopau i kā lākou mālama ʻana, aʻo nā mea ʻē aʻe e pau loa paha i ka lāʻau antibiotic. E hana kāu kauka i kahi hoʻolālā hoʻōla i kūpona i kāu kūlana.