He aha ʻo Darunavir a me Cobicistat: Nā Hoʻohana, Dosage, Nā ʻaoʻao ʻaoʻao a me nā mea hou aku

ʻO Darunavir a me cobicistat he lāʻau lapaʻau hui pū ʻia e mālama ai i ka maʻi HIV i nā pākeke a me nā keiki. Hana pū kēia hui ikaika e kōkua i ka mālama ʻana i ka maʻi a mālama i kou ʻōnaehana pale ikaika.

Ua hele lōʻihi ka mālama ʻana i ka HIV, a ʻo kēia lāʻau lapaʻau e hōʻike ana i kekahi o nā koho maikaʻi loa i loaʻa i kēia lā. Ke lawe ʻia ma ke ʻano he ʻāpana o kahi hoʻolālā lapaʻau HIV piha, hiki iā ia ke kōkua iā ʻoe e ola i ke ola olakino a piha i ka wā e mālama ana i kou maʻi.

He aha ʻo Darunavir a me Cobicistat?

Hoʻohui ʻo Darunavir a me cobicistat i ʻelua mau lāʻau lapaʻau like ʻole e hana pū ana e kūʻē i ka HIV. No ka hui ʻana o nā lāʻau lapaʻau i kapa ʻia he protease inhibitors ʻo Darunavir, ʻoiai ʻo cobicistat e hana ma ke ʻano he mea hoʻoikaika e kōkua iā darunavir e hana maikaʻi i kou kino.

E noʻonoʻo iā cobicistat ma ke ʻano he mea kōkua e hōʻoia i ka noho ʻana o darunavir i ka hana lōʻihi i kāu ʻōnaehana. Me ka ʻole o cobicistat, e wāwahi kou kino iā darunavir i ka wikiwiki, e hoʻemi ana i ka maikaʻi o ka maʻi.

Hoʻohana mau ʻia kēia hui pū ʻana me nā lāʻau lapaʻau HIV ʻē aʻe, ʻaʻole wale nō. E kuhikuhi kāu kauka iā ia ma ke ʻano he ʻāpana o ka mea i kapa ʻia he therapy antiretroviral hui pū ʻia, e hoʻohana ana i nā lāʻau he nui e hoʻouka i ka HIV mai nā kihi like ʻole.

No ke aha e hoʻohana ʻia ai ʻo Darunavir a me Cobicistat?

Mālama kēia lāʻau lapaʻau i ka maʻi HIV-1 i nā pākeke a me nā keiki e kaupaona ana ma kahi o 40 kilokani (ma kahi o 88 paona). Hoʻolālā ʻia ia no ka poʻe e hoʻomaka ana i ka mālama ʻana i ka HIV no ka manawa mua a i ʻole e hoʻololi ana mai nā lāʻau lapaʻau HIV ʻē aʻe.

ʻO ka pahuhopu nui e hōʻemi i ka nui o ka HIV i kou koko i nā pae hiki ʻole ke ʻike ʻia. Ke lilo ka HIV i mea hiki ʻole ke ʻike ʻia, ʻo ia hoʻi ʻaʻole hiki ke hoʻouna ʻia ka maʻi i nā poʻe ʻē aʻe ma o ka pilina pili kino, a hiki i kou ʻōnaehana pale ke noho ikaika a olakino.

Hiki i kāu kauka ke kuhikuhi i kēia lāʻau lapaʻau inā ua kūʻē ʻoe i nā lāʻau HIV ʻē aʻe. He mea maikaʻi loa ʻo Darunavir i nā ʻano HIV he nui i kūʻē i nā lāʻau lapaʻau kahiko.

Pehea e hana ai ʻo Darunavir a me Cobicistat?

Pale ʻo Darunavir i kahi enzyme i kapa ʻia ʻo protease e pono ai ka HIV e hana i nā kope o ia iho. Me ka ʻole o kēia enzyme, ʻaʻole hiki i ka maʻi ke hana hou a laha i loko o kou kino.

ʻAʻole hakakā pololei ʻo Cobicistat i ka HIV. Akā, pale ia i kekahi mau enzyme ate e wāwahi maʻamau i ka darunavir, e ʻae ana i ka lāʻau lapaʻau nui e noho lōʻihi i loko o kou ʻōnaehana a hana ʻoi aku ka maikaʻi.

Ua manaʻo ʻia he lāʻau lapaʻau HIV ikaika e hana maikaʻi loa ke hoʻohana pono ʻia. ʻO ka hapa nui o ka poʻe e lawe ana e like me ke kauoha e ʻike i kā lākou mau ukana viral e hāʻule i nā pae hiki ʻole ke ʻike ʻia i loko o kekahi mau mahina o ka hoʻomaka ʻana i ka lāʻau lapaʻau.

Pehea wau e lawe ai iā Darunavir a me Cobicistat?

E lawe i kēia lāʻau lapaʻau e like me ke kauoha a kāu kauka, maʻamau hoʻokahi manawa i ka lā me ka meaʻai. Kōkua ka meaʻai i kou kino e komo pono i ka lāʻau lapaʻau a hoʻemi i ka pilikia o ka ʻōpū.

Hiki iā ʻoe ke lawe me kekahi ʻano meaʻai a i ʻole ka ʻai nui. Mai lawe ia mea ma ka ʻōpū ʻole, no ka mea, hiki i kēia ke hoʻemi nui i ka maikaʻi o kou kino e komo i ka lāʻau lapaʻau.

E ale i nā papa holoʻokoʻa me ka wai a i ʻole kekahi wai ʻē aʻe. Mai ʻoki, nau, a haki paha i nā papa, no ka mea, hiki i kēia ke hoʻopilikia i ke ʻano o ka hoʻokuʻu ʻia ʻana o ka lāʻau lapaʻau i loko o kou kino.

E hoʻāʻo e lawe i kāu mahele i ka manawa like i kēlā me kēia lā e mālama i nā pae paʻa o ka lāʻau lapaʻau i loko o kāu ʻōnaehana. Hiki i ka hoʻonohonoho ʻana i ka alarm kelepona ke kōkua iā ʻoe e hoʻomanaʻo i kāu mahele i kēlā me kēia lā.

Pehea ka lōʻihi e lawe ai au iā Darunavir a me Cobicistat?

Pono ʻoe e lawe i kēia lāʻau lapaʻau no ke ola ma ke ʻano he ʻāpana o kāu lāʻau lapaʻau HIV e hoʻomau nei. He maʻi maʻi ʻo HIV e koi ana i ka lāʻau lapaʻau mau e mālama i ka maʻi i kāohi ʻia.

Mai hooki i ka lawe ʻana i kēia lāʻau lapaʻau me ka ʻole e kamaʻilio mua me kāu kauka, ʻoiai inā ʻoe e manaʻo maikaʻi loa. ʻO ka hooki ʻana i ka lapaʻau HIV hiki ke hoʻoulu i ka maʻi e pāpālua wikiwiki a hiki ke hoʻomohala i ke kūʻē i kāu mau lāʻau lapaʻau.

E nānā kāu kauka i kāu holomua me nā hoʻokolohua koko maʻamau e nānā i kāu ukana viral a me ka helu CD4. Kōkua kēia mau hoʻokolohua e hōʻoia i ka hana pono ʻana o ka lāʻau lapaʻau a ke noho nei ʻoe i ke olakino.

He aha nā hopena ʻaoʻao o Darunavir a me Cobicistat?

Hoʻomanawanui ka hapa nui o nā kānaka i kēia lāʻau lapaʻau, akā e like me nā lāʻau lapaʻau a pau, hiki iā ia ke hana i nā hopena ʻaoʻao. ʻO ka lono maikaʻi, ʻaʻole maʻamau nā hopena ʻaoʻao koʻikoʻi, a nui nā hopena ʻaoʻao maʻalahi e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau.

Eia nā hopena ʻaoʻao maʻamau loa e ʻike ai ʻoe i nā pule mua o ka lapaʻau:

• Nausea a i ʻole ka ʻōpū
• Pāpaʻa
• Pōpō
• Luhi a i ʻole ka luhi
• Pāpaʻa ʻili
• Nā loli i ka ʻono

ʻO kēia mau hopena ʻaoʻao maʻamau e lilo pinepine i mea ʻike ʻole i ka wā e maʻa ai kou kino i ka lāʻau lapaʻau. Inā mau lākou a lilo paha i mea hoʻonāukiuki, e kamaʻilio me kāu mea mālama ola e pili ana i nā ala e mālama ai iā lākou.

Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi e koi ai i ka lāʻau lapaʻau koke. ʻOiai ʻaʻole maʻamau kēia mau mea, he mea nui e ʻike i ka mea e nānā ai:

• Nā hopena ʻili koʻikoʻi me ke kuni, ka ʻōpala, a i ʻole ka ʻili
• Nā hōʻailona o nā pilikia o ke ake e like me ka melemele o ka ʻili a i ʻole nā maka, ka mimi ʻeleʻele, a i ʻole ka ʻeha nui o ka ʻōpū
• Ke kahe ʻana a i ʻole ka ʻeha maʻamau
• Nausea mau, ka luaʻi ʻana, a i ʻole ka nalowale o ka ʻai
• ʻO ka ʻūlū nui a i ʻole ka hāʻule

E kelepona koke i kāu kauka inā ʻike ʻoe i kekahi o kēia mau hōʻailona koʻikoʻi. Hiki i ka ʻike mua a me ka mālama ʻana i kēia mau hopena ʻaoʻao kakaʻikahi akā koʻikoʻi ke pale i nā pilikia.

Hiki i kekahi poʻe ke ʻike i nā loli i ka hāʻawi ʻana o ka momona o ke kino i ka wā, me ka piʻi ʻana o ka momona a puni ka ʻōpū, ka ʻāʻī, a i ʻole ke kua luna. ʻOi aku ka maʻamau o kēia me ka mālama lōʻihi ʻana i ka HIV a hiki ke mālama ʻia me nā loli o ke ola a me ke alakaʻi olakino.

ʻO wai ka mea pono ʻole e lawe iā Darunavir a me Cobicistat?

ʻAʻole kūpono kēia lāʻau lapaʻau no nā mea a pau. E nānā pono kāu kauka i kāu mōʻaukala olakino a me nā lāʻau lapaʻau i kēia manawa ma mua o ke kau ʻana e hōʻoia i ka palekana iā ʻoe.

ʻAʻole pono ʻoe e lawe i kēia lāʻau lapaʻau inā he maʻi ʻoe iā darunavir, cobicistat, a i ʻole kekahi o nā mea hana ʻole i loko o nā papa. ʻO nā hōʻailona o ka hopena maʻi e komo pū ana me ka ʻulaʻula nui, ka pilikia o ka hanu ʻana, a i ʻole ka pehu ʻana o kou maka, nā lehelehe, ke alelo, a i ʻole ka ʻāʻī.

Pono nā poʻe me nā pilikia ate koʻikoʻi e pale i kēia lāʻau lapaʻau, no ka mea, hiki i ka darunavir a me ka cobicistat ke hoʻopilikia i ka hana ate. E nānā kāu kauka i kāu mau enzyme ate ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau.

Hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka darunavir a me ka cobicistat. Hiki ke koʻikoʻi kēia mau pilina a hiki ke hoʻoweliweli i ke ola:

• ʻO kekahi mau lāʻau lapaʻau puʻuwai e like me amiodarone a i ʻole quinidine
• ʻO kekahi mau lāʻau lapaʻau hopu e like me carbamazepine a i ʻole phenytoin
• ʻO kekahi mau lāʻau antibiotic e like me rifampin
• Nā mea hoʻohui lāʻau lapaʻau e like me St. John's wort
• ʻO kekahi mau lāʻau lapaʻau cholesterol

E haʻi mau i kāu kauka e pili ana i nā lāʻau lapaʻau a pau, nā mea hoʻohui, a me nā huahana lāʻau lapaʻau āu e lawe nei. Aia kēia me nā lāʻau lapaʻau a me nā huaora i kūʻai ʻia ma luna o ka pāʻani, no ka mea, hiki i kēia mau mea ke launa pū me nā lāʻau lapaʻau HIV.

Pono nā wāhine hāpai e kūkākūkā i nā pilikia a me nā pōmaikaʻi me kā lākou mea mālama ola. ʻOiai he mea nui ka mālama ʻana i ka HIV i ka wā hāpai, pono paha kāu kauka e hoʻoponopono i kāu ʻano lāʻau lapaʻau e hōʻoia i nā hopena maikaʻi loa no ʻoe a me kāu pēpē.

Nā inoa inoa o Darunavir a me Cobicistat

ʻO ka inoa inoa maʻamau no kēia lāʻau lapaʻau hui pū ʻo Prezcobix, i hana ʻia e Janssen Pharmaceuticals. ʻO kēia ka inoa inoa āu e ʻike nui ai ma kāu hale kūʻai lāʻau.

Hiki i kekahi mau hale kūʻai lāʻau ke lawe pū i nā mana generic o kēia hui pū. Loaʻa i nā lāʻau lapaʻau generic nā mea hana like me nā lāʻau inoa inoa a he mea maikaʻi nō hoʻi, pinepine i ke kumu kūʻai haʻahaʻa.

Hiki i kāu hoʻolālā ʻinikua ke makemake i kekahi mau inoa inoa a i ʻole generics. E hana pū me kāu mea mālama ola a me ka lāʻau lapaʻau e ʻimi i ke koho kūpono loa e hana ana no kou kūlana.

Nā Koho ʻē aʻe no Darunavir a me Cobicistat

Hiki ke hoʻohana ʻia kekahi mau hui pū ʻana o nā lāʻau lapaʻau HIV ma kahi o darunavir a me cobicistat, ma muli o kāu mau pono kikoʻī a me ka mōʻaukala olakino. E kōkua kāu kauka iā ʻoe e koho i ke koho maikaʻi loa no kou kūlana.

ʻO nā hui pū ʻana o nā mea pale protease ʻē aʻe e komo pū ana me darunavir me ritonavir (he mea hoʻoikaika ʻē aʻe), a i ʻole atazanavir me cobicistat. Hana like kēia mau mea akā loaʻa paha nā ʻaoʻao ʻokoʻa a i ʻole nā papa hana dosing.

ʻO nā papa hana e pili ana i ka integrase inhibitor, e like me nā mea i loaʻa i ka dolutegravir a i ʻole bictegravir, he mau koho ʻē aʻe maikaʻi loa. Hana kēia mau lāʻau lapaʻau ma ka pale ʻana i kahi enzyme ʻokoʻa e pono ai ka HIV e hana hou.

Loaʻa nā papa hana papa hoʻokahi e hui pū ana i nā lāʻau HIV he nui i hoʻokahi pila no ka poʻe makemake i nā pila liʻiliʻi i kēlā me kēia lā. ʻO nā laʻana e komo pū ana me Biktarvy, Genvoya, a me Stribild.

ʻO ke koho o ke koho ʻē aʻe e pili ana i nā mea e like me kāu ʻano kūʻē viral, nā kūlana olakino ʻē aʻe, nā pilina lāʻau lapaʻau, a me nā makemake pilikino. E kōkua kāu loea HIV iā ʻoe e kaupaona i kēia mau mea e ʻimi i ke ala lapaʻau maikaʻi loa.

ʻOi aku ka maikaʻi o Darunavir a me Cobicistat ma mua o Atazanavir a me Cobicistat?

He maikaʻi nā lāʻau lapaʻau HIV ʻo darunavir/cobicistat a me atazanavir/cobicistat, akā he mau ikaika a me nā ʻano like ʻole. ʻO ke koho "maikaʻi" e hilinaʻi ana i kou kūlana pilikino a me ka mōʻaukala olakino.

He pale kiʻekiʻe ko Darunavir i ke kūʻē ʻana, ʻo ia hoʻi e pono ana i nā loli hou aku no ka HIV e kūʻē iā ia. He koho maikaʻi kēia no ka poʻe i kūʻē i nā lāʻau lapaʻau HIV ʻē aʻe.

Hiki i ka Atazanavir ke hana i nā hopena ʻaoʻao gastrointestinal liʻiliʻi e like me ka nausea a me ka maʻi maʻi i hoʻohālikelike ʻia me darunavir. Eia naʻe, hiki iā ia ke hana i ka melemele o ka ʻili a me nā maka (jaundice) i kekahi poʻe, akā ʻaʻole pilikia kēia.

Hōʻike nā haʻawina he maikaʻi loa nā lāʻau lapaʻau ʻelua i ka hoʻopaʻa ʻana i ka HIV ke lawe ʻia e like me ke kauoha. ʻO ke koho pinepine e pili ana i kāu ʻano kūʻē, nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, a me ka maikaʻi o kou ʻae ʻana i kēlā me kēia koho.

E noʻonoʻo kāu loea HIV i kāu ukana viral, helu CD4, nā hopena hoʻāʻo kūʻē, a me nā mea olakino ʻē aʻe i ka wā e ʻōlelo ai i ka lāʻau lapaʻau maikaʻi loa nāu. ʻO ka mea e hana maikaʻi loa e ʻokoʻa mai kēlā me kēia kanaka.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Darunavir a me Cobicistat

He Palekana ʻo Darunavir a me Cobicistat no ka poʻe me ka maʻi diabetes?

ʻAe, hiki ke hoʻohana palekana ʻia kēia lāʻau lapaʻau i ka poʻe me ka maʻi diabetes, akā pono e nānā pono. Hiki i nā mea pale protease HIV e like me darunavir ke hoʻopilikia i nā pae kō koko, no laila e makemake kāu kauka e nānā pono i kāu kaohi diabetes.

Pono paha ʻoe e nānā pinepine i kou kō koko i ka wā e hoʻomaka ai i kēia lāʻau lapaʻau. Loaʻa i kekahi poʻe ka piʻi iki ʻana o nā pae kō koko, hiki ke mālama ʻia ma ka hoʻoponopono ʻana i nā lāʻau lapaʻau diabetes a i ʻole ka hana ʻana i nā loli meaʻai.

E hana pili me kāu loea HIV a me kāu hui mālama diabetes e hōʻoia i ka mālama maikaʻi ʻana i nā kūlana ʻelua. E kōkua nā hoʻāʻo koko maʻamau i ka nānā ʻana i ka hopena o ka lāʻau lapaʻau i kou kō koko i ka manawa.

He aha kaʻu e hana ai inā ua hoʻohana au i ka nui o Darunavir a me Cobicistat?

Inā ua lawe ʻoe i ka nui ma mua o kāu kauoha, e kelepona koke i kāu kauka a i ʻole ke kikowaena mana ʻawa. ʻO ka lawe ʻana i ka nui o kēia lāʻau lapaʻau hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi.

Mai hoʻāʻo e hoʻokomo iā ʻoe iho e luaʻi ke ʻole i kuhikuhi ʻia e kahi loea mālama ola. Akā, e inu i ka wai nui a e ʻimi koke i ka lāʻau lapaʻau.

E lawe mai i ka hue lāʻau lapaʻau me ʻoe i ka lumi pilikia a i ʻole ke keʻena o ke kauka i ʻike pono ai nā mea mālama ola i ka mea āu i lawe ai a me ka nui. He mea nui ka manawa i ka mālama ʻana i nā lāʻau lapaʻau i ka nui.

He aha kaʻu e hana ai inā ua hala au i kahi mahele o Darunavir a me Cobicistat?

Inā ua hala ʻoe i kahi mahele a ua hala ma lalo o 12 mau hola mai kou manawa maʻamau, e lawe i ka mahele i hala me ka meaʻai i ka wā e hoʻomanaʻo ai ʻoe. Inā ua hala ma mua o 12 mau hola, e lele i ka mahele i hala a e lawe i kāu mahele aʻe i ka manawa maʻamau.

Mai lawe i ʻelua mahele i ka manawa hoʻokahi e hoʻoponopono ai i kahi mahele i hala. Hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao me ka ʻole o ka hāʻawi ʻana i ka pōmaikaʻi hou.

ʻO ka hala ʻana i nā mahele i kekahi manawa ʻaʻole ia e hoʻopilikia koke, akā e hoʻāʻo e mālama i ka lawe ʻana i kēlā me kēia lā no nā hopena maikaʻi loa. E noʻonoʻo e hoʻonohonoho i nā ʻōhua kelepona a i ʻole e hoʻohana i kahi mea hoʻonohonoho pila e kōkua iā ʻoe e hoʻomanaʻo i kāu lāʻau lapaʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Darunavir a me Cobicistat?

ʻAʻole pono ʻoe e hooki i ka lawe ʻana i kēia lāʻau lapaʻau me ka ʻole e kūkākūkā mua me kāu loea HIV. He ola lōʻihi ka mālama ʻana i ka HIV, a ʻo ka hooki ʻana hiki ke hoʻonui i ka maʻi a hiki ke hoʻomohala i ke kūpaʻa.

ʻOiai inā lilo kāu ukana viral i mea hiki ʻole ke ʻike ʻia a noho pēlā no nā makahiki, pono nō ʻoe e hoʻomau i ka lawe ʻana i kāu mau lāʻau HIV. ʻO ka ukana viral hiki ʻole ke ʻike ʻia ka hopena o ka mālama ʻana i ka holomua, ʻaʻole ia he hōʻailona ua ola ʻoe.

Inā e ʻike ana ʻoe i nā hopena ʻaoʻao e hoʻopilikia ana, e kamaʻilio me kāu kauka e pili ana i ka hoʻoponopono ʻana i kāu ʻōnaehana lapaʻau ma mua o ka hoʻōki ʻana. Nui nā koho lāʻau HIV i loaʻa, a hiki i kāu kauka ke kōkua iā ʻoe e loaʻa i kahi mea e hana maikaʻi ai iā ʻoe.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Darunavir a me Cobicistat?

ʻO ka inu ʻana i ka waiʻona me ka maʻalahi, ua ʻae ʻia i ka wā e lawe ana i kēia lāʻau, akā he mea nui e kūkākūkā i kāu hoʻohana ʻana i ka waiʻona me kāu kauka. Hoʻoponopono ʻia ka lāʻau a me ka waiʻona e kou ate, no laila ʻo ka inu nui ʻana hiki ke hoʻonui i ka pilikia o nā pilikia o ke ake.

Inā he pilikia o ke ake kou, a i ʻole e lawe ana i nā lāʻau ʻē aʻe e pili ana i ke ake, hiki i kāu kauka ke ʻōlelo e pale loa i ka waiʻona. Pono ka poʻe me ka hepatitis B a i ʻole C e makaʻala loa i ka hoʻohana ʻana i ka waiʻona.

E hoʻomanaʻo e hiki i ka waiʻona ke keakea i kou hiki ke lawe mau i nā lāʻau a hana i nā koho ola olakino. Inā koho ʻoe e inu, e hana me ka maʻalahi a mai ʻae loa ia e keakea i ka lawe ʻana i kāu mau lāʻau HIV e like me ke kauoha.