He aha ʻo Dasatinib: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi ʻaʻai ʻo Dasatinib e ālai ana i nā protein kikoʻī e kuleana ana i ka ulu ʻana o nā cell maʻi ʻaʻai. Ua kauoha mua ʻia no kekahi mau ʻano leukemia a hana ma ka hoʻopilikia ʻana i nā hōʻailona e haʻi ana i nā cell maʻi ʻaʻai e hoʻonui a ola.

No ka papa o nā lāʻau i kapa ʻia ʻo tyrosine kinase inhibitors kēia lāʻau lapaʻau, i hoʻolālā ʻia e ʻoi aku ka pololei ma mua o ka chemotherapy kuʻuna. E noʻonoʻo iā ia he ala i manaʻo ʻia e kālele ana i nā ala kikoʻī e hoʻohana ai nā cell maʻi ʻaʻai e ulu, ma mua o ka hoʻopilikia ʻana i nā cell e mahele wikiwiki ana i kou kino.

No ke aha e hoʻohana ʻia ai ʻo Dasatinib?

Ua ʻae ʻia ʻo Dasatinib e mālama i kekahi mau ʻano maʻi ʻaʻai koko, ʻo ia hoʻi ka chronic myeloid leukemia (CML) a me ka acute lymphoblastic leukemia (ALL). ʻO kēia mau maʻi ʻaʻai e pili ana i kāu mau cell e hana ana i ke koko i loko o ka iwi iwi.

Hiki i kāu kauka ke kauoha iā dasatinib inā loaʻa iā ʻoe ka CML i ka maʻi maʻi, wikiwiki, a i ʻole ka pahū. Hoʻohana ʻia nō hoʻi no ka Philadelphia chromosome-positive ALL, e pili ana i kahi loli genetic kikoʻī i loaʻa i nā cell maʻi ʻaʻai. Manaʻo pinepine ʻia kēia lāʻau lapaʻau ke hana ʻole nā lāʻau lapaʻau ʻē aʻe e like me imatinib a i ʻole i hana i nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia.

I kekahi mau hihia, hiki ke hoʻohana ʻia ʻo dasatinib ma ke ʻano he lapaʻau laina mua, ʻo ia hoʻi ʻo ia ka lāʻau lapaʻau mua a kāu kauka e ʻōlelo ai. Aia ka hoʻoholo i nā mea like ʻole me kāu ʻano leukemia kikoʻī, ke olakino holoʻokoʻa, a me ke ʻano o ka pane ʻana o kāu maʻi ʻaʻai i ka lāʻau lapaʻau.

Pehea e hana ai ʻo Dasatinib?

Hana ʻo Dasatinib ma ka ālai ʻana i kekahi mau protein i kapa ʻia ʻo tyrosine kinases e pono ai nā cell maʻi ʻaʻai e ulu a ola. Hana kēia mau protein e like me nā kuapo e haʻi ana i nā cell maʻi ʻaʻai e hoʻonui, a hoʻopau ʻo dasatinib i kēia mau kuapo.

He mana kēia lāʻau lapaʻau a me ka mea pale kinase ākea, 'o ia ho'i, ke kāohi nei ia i nā ala he nui e ho'ohana ai nā pūnaewele ma'i 'a'ai. 'A'ole like me kekahi mau lā'au lapa'au i mana'o 'ia e kālele ana i ho'okahi protein, ho'opilikia 'o dasatinib i nā hō'ailona like 'ole i ka manawa ho'okahi, 'o ia ho'i, hiki ke 'oi aku ka maika'i e kū'ē i nā pūnaewele ma'i 'a'ai kū'ē.

He mea maika'i loa ka lā'au lapa'au e kū'ē i ka protein BCR-ABL, 'o ia ka mea nui e ho'okele ai i ka CML a me ka Philadelphia chromosome-positive ALL. Ma ka kāohi 'ana i kēia protein, kōkua 'o dasatinib i ka ho'olohi a i 'ole ke kāohi 'ana i ka hana 'ana o nā pūnaewele koko ke'oke'o 'oko'a e hō'ike ana i kēia mau ma'i 'a'ai.

Pehea e lawe ai au i ka Dasatinib?

E lawe i ka dasatinib e like me ke kauoha a kāu kauka, ma'amau ho'okahi manawa i ka lā i ka manawa like i kēlā me kēia lā. Hiki iā 'oe ke lawe me ka 'ai a i 'ole me ka 'ole o ka 'ai, akā e ho'ā'o e kūlike me kāu koho e mālama i nā pae pa'a i loko o kou kino.

E ale i nā papa holo'oko'a me ke aniani wai - mai wāwahi, uhaki, a nau paha iā lākou. Inā pilikia 'oe i ka ale 'ana i nā papa, e kama'ilio me kāu kauka e pili ana i nā koho 'ē a'e. He mea nui e lawe i ka dasatinib ma ka 'ōpū 'ole a i 'ole me ka 'ai māmā, no ka mea, hiki i kekahi mau mea 'ai ke ho'opilikia i ka maika'i o kou kino e komo ai i ka lā'au lapa'au.

E pale i ka hua waina a me ka wai hua waina i ka wā e lawe ana i ka dasatinib, no ka mea, hiki iā lākou ke ho'onui i ka nui o ka lā'au lapa'au i loko o kou koko i nā pae weliweli. Eia kekahi, e maka'ala me nā antacids - inā pono 'oe iā lākou, e lawe iā lākou ma ka li'ili'i he 2 hola ma mua a i 'ole ma hope o kāu lā'au dasatinib.

Pehea ka lō'ihi e lawe ai au i ka Dasatinib?

He nui ka lō'ihi o ka mālama 'ana i ka dasatinib mai kēlā kanaka i kēia kanaka a pili i ka maika'i o ka pane 'ana o kāu ma'i 'a'ai i ka lā'au lapa'au. Nui ka po'e e lawe i ka dasatinib no nā makahiki, a pono paha kekahi e ho'omau ia mea no ka manawa pau 'ole ma ke 'ano he lā'au lapa'au mālama lō'ihi.

E nānā kāu kauka i kou pane ʻana ma o nā hoʻokolohua koko maʻamau a me nā hoʻokolohua iwi iwi. Inā hiki i kāu maʻi ʻaʻai i kekahi mau pae pane, hiki i kāu kauka ke kūkākūkā i ka hiki ke hōʻemi i ka mahele, a i kekahi mau hihia, e hoʻomaha mai ka lapaʻau.

Ua hōʻike nā noiʻi hou i kekahi poʻe maʻi i loaʻa nā pane hohonu a mau loa e hiki ke hooki i ka dasatinib ma lalo o ka mālama olakino akahele. Eia naʻe, pono e hana ʻia kēia hoʻoholo me ke alakaʻi ʻana o kāu oncologist, no ka mea, ʻo ka hooki ʻana i ka wā mua hiki ke alakaʻi i ka hoʻi ʻana mai o ka maʻi ʻaʻai.

He aha nā hopena ʻaoʻao o Dasatinib?

E like me nā lāʻau lapaʻau maʻi ʻaʻai a pau, hiki i ka dasatinib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole i loaʻa i nā mea a pau. ʻO nā hopena ʻaoʻao maʻamau ka mea hiki ke mālama ʻia me ka mālama olakino kūpono a me ka nānā ʻana.

Eia nā hopena ʻaoʻao āu e ʻike ai, mai ka mea maʻamau a hiki i ka mea liʻiliʻi:

• Ka paʻa wai a me ka pehu ʻana, ʻoi loa a puni nā maka, nā lima, a me nā wāwae
• Luhi a me ka nāwaliwali e pili ana i kāu mau hana i kēlā me kēia lā
• Pāpaʻa, nausea, a i ʻole nā pilikia ʻē aʻe
• Nā ʻeha poʻo a me nā ʻeha ʻiʻo a i ʻole nā iwi
• Pāpaʻa ʻili a i ʻole nā loli i ke ʻano o ka ʻili
• Ka pōkole o ka hanu a i ʻole ka pilikia o ka hanu
• Nā helu koko haʻahaʻa, hiki ke hoʻonui i ka pilikia o ka maʻi

Hoʻomaikaʻi pinepine kēia mau hopena ʻaoʻao maʻamau i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau, a hiki i kāu hui mālama ola ke hāʻawi i nā hoʻolālā e mālama pono iā lākou.

Pono kekahi mau hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi i ka nānā olakino koke. Aia kēia mau mea i ka hōʻiliʻili wai nui a puni nā māmā a i ʻole ka puʻuwai, ke kahe nui ʻana, nā maʻi koʻikoʻi ma muli o nā helu keʻokeʻo koko haʻahaʻa, a i ʻole nā hōʻailona o nā pilikia o ka puʻuwai e like me ka ʻeha o ka umauma a i ʻole ka puʻuwai ʻole.

Hiki i nā hopena ʻaoʻao laha ʻole akā koʻikoʻi ke komo pū me ka maʻi hypertension arterial pulmonary (ke koko kiʻekiʻe i loko o nā māmā), nā pilikia ate koʻikoʻi, a i ʻole ka maʻi lysis tumor (ke wāwahi wikiwiki ʻia nā pūnaewele maʻi maʻi). ʻOiai ʻaʻole maʻamau kēia mau mea, e nānā mau kāu kauka iā ʻoe e ʻike i nā loli e pili ana i ka wā mua.

ʻO wai ka mea pono ʻole e lawe iā Dasatinib?

ʻAʻole kūpono ʻo Dasatinib no nā mea a pau, a hiki i kekahi mau maʻi olakino a i ʻole nā kūlana ke palekana ʻole iā ʻoe e lawe i kēia lāʻau. E loiloi pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana.

ʻAʻole pono ʻoe e lawe iā dasatinib inā he maʻi ʻoe i ka lāʻau a i ʻole kekahi o kāna meaʻai. ʻAʻole kūpono paha ka poʻe me ka maʻi ate koʻikoʻi, nā maʻi koko ikaika, a i ʻole kekahi mau maʻi puʻuwai no kēia lapaʻau.

ʻAʻole pono nā wahine hāpai a me nā wahine e hānai ana i ka waiū i ka dasatinib, no ka mea, hiki iā ia ke hōʻeha i ka pēpē e ulu ana. Inā he makahiki hānau keiki kāu, e kūkākūkā kāu kauka i nā ʻano hana contraception kūpono e hoʻohana ʻia i ka wā lapaʻau a no kekahi manawa ma hope o ka hoʻōki ʻana i ka lāʻau.

Pono ka poʻe me kekahi mau maʻi i loaʻa mua i ka noʻonoʻo kūikawā. Pākuʻi ʻia kēia mau mea me ka poʻe me nā pilikia puʻuwai, ka maʻi māmā, nā maʻi koko, a i ʻole ka mōʻaukala o ka pancreatitis. E kaupaona kāu kauka i nā pōmaikaʻi e kūʻē i nā pilikia i kēia mau kūlana.

Nā inoa inoa Dasatinib

Loaʻa ʻo Dasatinib ma lalo o ka inoa inoa Sprycel, i hana ʻia e Bristol Myers Squibb. ʻO kēia ka brand i kauoha pinepine ʻia ma ka hapa nui o nā ʻāina kahi i loaʻa ai ka lāʻau.

Ua loaʻa nā mana generic o dasatinib ma kekahi mau wahi, hiki ke ʻoi aku ka maʻalahi o ke kumukūʻai me ka hāʻawi ʻana i nā pōmaikaʻi therapeutic like. Hiki i kāu kauka a i ʻole ka lāʻau lapaʻau ke kōkua iā ʻoe e hoʻomaopopo i ka mana maikaʻi loa no kou kūlana a me ka uhi ʻinikua.

ʻAʻole pili inā loaʻa iā ʻoe ka inoa inoa a i ʻole ka mana generic, ua like ka mea hana a me ka pono. ʻO ka mea nui e lawe i ka lāʻau lapaʻau e like me ke kau ʻia e kāu mea mālama ola.

Nā Koho ʻē aʻe o Dasatinib

Nui nā lāʻau lapaʻau i manaʻo ʻia e loaʻa ana no ka mālama ʻana i nā ʻano leukemia like me dasatinib. ʻO ke koho ma waena o kēia mau lāʻau lapaʻau e pili ana i nā mea e like me kāu ʻano maʻi maʻi, nā lāʻau lapaʻau i hala, a me ka maikaʻi o kou hoʻomanawanui ʻana i nā hopena ʻaoʻao.

ʻO nā koho maʻamau e komo pū ana me imatinib (Gleevec), ʻo ia ka mea i hoʻohana pinepine ʻia i ka mālama mua ʻana no CML, a me nilotinib (Tasigna), kekahi mea hoʻopaʻa tyrosine kinase hanauna lua. ʻO Bosutinib (Bosulif) a me ponatinib (Iclusig) nā koho hou aʻe no kekahi mau kūlana.

Loaʻa i kēlā me kēia o kēia mau lāʻau lapaʻau kāna ʻano hopena ʻaoʻao a me nā hiʻohiʻona pono. Hiki i kekahi poʻe ke hana maikaʻi me kekahi lāʻau lapaʻau ma mua o kekahi, a pono paha i kāu kauka e hoʻāʻo i nā koho like ʻole e ʻike i ka mea e hana maikaʻi ai iā ʻoe. ʻO ka pahuhopu ka loaʻa ʻana o ka lāʻau lapaʻau maikaʻi loa me nā hopena ʻaoʻao hiki ke mālama ʻia.

Ua ʻoi aku ka maikaʻi o Dasatinib ma mua o Imatinib?

He mau lāʻau lapaʻau maikaʻi ʻo Dasatinib a me imatinib no CML, akā hana lākou i nā mea like ʻole a loaʻa nā pōmaikaʻi like ʻole. Manaʻo pinepine ʻia ʻo Dasatinib he mea ikaika a hana wikiwiki ma mua o imatinib i nā maʻi he nui.

Ua hōʻike nā haʻawina lapaʻau hiki iā dasatinib ke hoʻokō i nā pane hohonu a me ka wikiwiki i kekahi poʻe, ʻo ia hoʻi ka poʻe me ka maʻi holomua a i ʻole ka poʻe i pane ʻole i ka imatinib. Eia naʻe, ua lōʻihi ka imatinib a loaʻa iā ia kahi moʻolelo lōʻihi o ka palekana a me ka pono.

ʻO ke koho ma waena o kēia mau lāʻau lapaʻau e pili pinepine ana i nā mea pilikino. ʻOi aku ka maikaʻi o kekahi poʻe i ka imatinib, aʻo nā mea ʻē aʻe he liʻiliʻi nā hopena ʻaoʻao me dasatinib. E noʻonoʻo kāu kauka i kou kūlana kikoʻī, me nā ʻano maʻi maʻi ʻaʻai, ke olakino holoʻokoʻa, a me nā makemake pilikino i ka wā e hana ai i kēia hoʻoholo.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Dasatinib

He Palekana ʻo Dasatinib no ka poʻe me ka maʻi puʻuwai?

Pono ʻo Dasatinib i ka nānā pono ʻana i ka poʻe me nā maʻi puʻuwai. Hiki i ka lāʻau lapaʻau ke hana i ka paʻa wai a puni ka puʻuwai a i ʻole e pili i ka puʻuwai, no laila pono kāu kauka e loiloi i ke olakino o kou puʻuwai ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau.

Inā loaʻa iā ʻoe ka maʻi puʻuwai, e kauoha paha kāu kauka i nā hoʻokolohua puʻuwai kumu a nānā pono iā ʻoe i ka wā o ka lāʻau lapaʻau. Nui ka poʻe me nā maʻi puʻuwai e hiki nō ke lawe palekana iā dasatinib, akā pono ia i ka mālama pono a me nā hoʻoponopono ʻana i ka mahele.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o Dasatinib?

Inā lawe hewa ʻoe i ka nui o dasatinib ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu kauka a i ʻole nā lawelawe pilikia. Mai kali e ʻike inā e loaʻa iā ʻoe nā hōʻailona, ​​no ka mea, hiki i ka overdose ke hana i nā pilikia koʻikoʻi.

ʻOiai e kali ana i ke kōkua olakino, mai hoʻāʻo e hoʻopuka iā ʻoe iho a i ʻole e lawe i nā lāʻau lapaʻau ʻē aʻe ke ʻole i kuhikuhi ʻia e kekahi mea mālama ola. E mālama i ka hue lāʻau me ʻoe i hiki i nā poʻe loea lapaʻau ke ʻike pololei i ka mea a me ka nui āu i lawe ai.

He aha kaʻu e hana ai inā hala au i kahi mahele o Dasatinib?

Inā hala ʻoe i kahi mahele o dasatinib, e lawe koke iā ia ke hoʻomanaʻo ʻoe, ke ʻole kokoke ka manawa no kāu mahele i hoʻonohonoho ʻia. I kēlā hihia, e lele i ka mahele i hala a hoʻomau me kāu papa maʻamau - mai lawe i ʻelua mahele i ka manawa hoʻokahi.

Inā poina pinepine ʻoe i nā lāʻau, e noʻonoʻo e hoʻonohonoho i nā mea hoʻomanaʻo kelepona a i ʻole e hoʻohana i kahi mea hoʻonohonoho pila. He mea nui ka lawe ʻana i nā lāʻau i kēlā me kēia lā no ka mālama ʻana i nā pae kūpono o ka lāʻau i loko o kou kino.

Iāhea Hiki iaʻu ke Hooki i ka Lawe ʻana i ka Dasatinib?

Pono e hana ʻia ka hoʻoholo e hooki i ka dasatinib me ke alakaʻi ʻana o kāu oncologist, ʻoiai inā maikaʻi ʻoe. Hiki i kekahi poʻe maʻi i loaʻa nā pane hohonu a mau loa ke lilo i mau moho no ka hoʻokuʻu ʻana me ka ʻole o ka lāʻau, akā pono kēia i ka nānā pono ʻana.

E loiloi kāu kauka i nā mea e like me ka lōʻihi o kou noho ʻana i ke kala ʻana, ka hohonu o kāu pane, a me kāu mau mea pilikia pilikino. Inā hooki ʻoe, pono ʻoe i ka nānā pinepine ʻana e hōʻoia ʻaʻole e hoʻi mai ka maʻi kanesa.

Hiki iaʻu ke Lawe i nā Lāʻau ʻē aʻe i ka wā e lawe ana i ka Dasatinib?

Hiki i nā lāʻau he nui ke launa pū me ka dasatinib, no laila he mea nui e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau i kauoha ʻia, nā lāʻau lapaʻau ma luna o ka pāʻani, a me nā mea hoʻohui āu e lawe ai. Hiki i kekahi mau pilina ke hoʻemi i ka pono o ka dasatinib a i ʻole e hoʻonui i ka pilikia o nā hopena ʻaoʻao.

ʻO nā pilina pilikia maʻamau e pili ana i kekahi mau antacids, nā mea hoʻoheheʻe koko, a me nā lāʻau e pili ana i ka waikawa ʻōpū. Hiki i kāu kauka a me ka lāʻau lapaʻau ke kōkua iā ʻoe e mālama i kēia mau pilina me ka palekana, pinepine ma ka hoʻoponopono ʻana i ka manawa a i ʻole nā ​​lāʻau o kāu mau lāʻau.