He aha ʻo Difelikefalin: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Difelikefalin i hāʻawi ʻia ma o ka IV e kōkua i ka poʻe ma ka dialysis e loaʻa ana i ka pruritus e pili ana i ka maʻi maʻi maʻi maʻi (CKD-aP). ʻO kēia ka huaʻōlelo lapaʻau no ka ʻūlū mau, pinepine hiki ʻole ke ʻae ʻia e hiki mai ana ke hana ʻole kāu mau puʻupaʻa. Hiki paha iā ʻoe ke ʻike i kēia lāʻau lapaʻau ma kona inoa inoa ʻo Korsuva, a hana ʻokoʻa ia mai nā lāʻau lapaʻau maʻamau ma ka hoʻopaʻa ʻana i nā mea loaʻa i loko o kou kino e hoʻomalu i ka manaʻo ʻūlū.

He aha ʻo Difelikefalin?

He lāʻau lapaʻau synthetic ʻo Difelikefalin e hoʻohālike i kekahi mau mea kūlohelohe i loko o kou kino i kapa ʻia he peptides. No ka papa o nā lāʻau lapaʻau i ʻike ʻia he kappa opioid receptor agonists, ʻo ia hoʻi, hoʻāla ia i nā mea loaʻa i loko o kāu ʻōnaehana nerve me ka ʻole o ka hopena maʻamau āu e manaʻo ai mai nā opioids e like me ka morphine a i ʻole codeine.

Ua hoʻolālā kūikawā ʻia ka lāʻau lapaʻau e kōkua i ka poʻe ʻaʻole e kānana pono ana ko lākou mau puʻupaʻa i ka ʻōpala, e alakaʻi ana i ka hōʻiliʻili ʻana o nā toxins e hiki ke hoʻoulu i ka ʻūlū nui. ʻAʻole like me nā ʻaila topical a i ʻole nā antihistamines e hana ana ma ka ʻili o kou ʻili, hana ʻo difelikefalin mai loko mai ma ka hoʻopaʻa ʻana i nā ala nerve e hoʻouna ana i nā hōʻailona ʻūlū i kou lolo.

No ke aha i hoʻohana ʻia ai ʻo Difelikefalin?

Hoʻomaʻamaʻa ʻo Difelikefalin i ka pruritus e pili ana i ka maʻi maʻi maʻi maʻi i nā pākeke e loaʻa ana i ka hemodialysis. Hoʻopilikia kēia maʻi i ka nui o ka poʻe me ka maʻi puʻupaʻa a hiki ke hoʻopilikia nui i kou maikaʻi o ke ola, e paʻakikī ai ka hiamoe, ka hana, a i ʻole ka leʻaleʻa i nā hana i kēlā me kēia lā.

ʻAʻole like ka ʻūlū ʻana mai ka maʻi puʻupaʻa me ka ʻūlū maʻamau āu e loaʻa ai mai ka ʻili maloʻo a i ʻole ka nahu ʻana o ka makika. Ua wehewehe pinepine ʻia he manaʻo hohonu, ʻā e hiki ke hana ma nā wahi a pau o kou kino akā pili pinepine i kou kua, nā lima, a me nā wāwae. ʻAʻole hāʻawi pinepine nā lāʻau lapaʻau kuʻuna e like me nā antihistamines a i ʻole nā ʻaila topical i ka hoʻomaha kūpono no kēia ʻano ʻūlū.

Hiki i kāu kauka ke noʻonoʻo i ka difelikefalin inā ua hoʻāʻo ʻoe i nā lāʻau lapaʻau ʻē aʻe me ka holomua ʻole a ke keakea nei kāu ʻūlū i kou ola i kēlā me kēia lā. Ua ʻae ʻia ka lāʻau lapaʻau no ka poʻe e loaʻa ana i ka dialysis, no ka mea, hāʻawi ʻia ia i ka wā o kāu mau kau dialysis.

Pehea e Hana ai ʻo Difelikefalin?

Hana ʻo Difelikefalin ma ka hoʻāla ʻana i nā mea hoʻokipa opioid kappa i loko o kāu ʻōnaehana nerve peripheral, ʻo ia nā aʻalolo ma waho o kou lolo a me ke kuamoʻo. Ke hoʻāla ʻia kēia mau mea hoʻokipa, kōkua lākou i ka hōʻemi ʻana i ka hoʻouna ʻana i nā hōʻailona ʻūlū mai kou ʻili i kou lolo, e hāʻawi ana i ke kōkua mai ka makemake mau e ʻānai.

ʻO ka mea e kū hoʻokahi ai kēia lāʻau lapaʻau, ua hoʻolālā ʻia ia e noho i loko o kāu ʻōnaehana nerve peripheral ma mua o ka hele ʻana i kou lolo. ʻO kēia ala i manaʻo ʻia, ʻo ia hoʻi, loaʻa iā ʻoe nā pōmaikaʻi anti-itch me ka ʻole o ka ʻike ʻana i ka sedation, euphoria, a i ʻole ka hiki ke hoʻohui ʻia e hele mai me nā lāʻau opioid kuʻuna.

Manaʻo ʻia ka lāʻau lapaʻau he mea maikaʻi no kēia ʻano ʻūlū. ʻOiai ʻaʻole paha e hoʻopau loa i kāu mau hōʻailona, ​​hōʻike nā haʻawina lapaʻau hiki iā ia ke hōʻemi nui i ka ikaika o ka ʻūlū a hoʻomaikaʻi i kou maikaʻi o ke ola holoʻokoʻa ke hoʻohana mau ʻia.

Pehea e Lawe ai au i ka Difelikefalin?

Hāʻawi ʻia ʻo Difelikefalin ma ke ʻano he injection intravenous pololei i loko o kāu laina dialysis i ka wā o kēlā me kēia kau hemodialysis. Na kāu hui mālama ola e lawelawe i ka lāʻau lapaʻau, no laila ʻaʻole pono ʻoe e hopohopo e hāʻawi iā ʻoe iho a i ʻole e hoʻomanaʻo e lawe iā ia ma ka home.

Hāʻawi ʻia ka injection ma ka hopena o kāu kau dialysis, ma hope o ka pau ʻana o ka mālama dialysis akā ma mua o ka wehe ʻia ʻana o kāu laina komo. Hāʻawi ʻia ka lāʻau lapaʻau i ka lohi ma kahi o hoʻokahi minuke, a e noho ʻoe i ke kikowaena dialysis no ka nānā ʻana ma hope o ka loaʻa ʻana.

ʻAʻole pono ʻoe e hana i nā loli meaʻai kūikawā a i ʻole nā hoʻomākaukau ʻana ma mua o ka loaʻa ʻana o ka difelikefalin. Ma muli o ka hāʻawi ʻia ʻana i ka wā o kāu mau manawa dialysis maʻamau, lilo ia i ʻāpana o kāu hana lapaʻau e kū nei me ka ʻole e koi ana i nā kipa hou i ka hale mālama ola.

Pehea ka lōʻihi e lawe ai au i ka Difelikefalin?

Aia ka lōʻihi o ka lapaʻau difelikefalin i kāu pane pilikino a me ka maikaʻi o kou ʻae ʻana i ka lāʻau. Nui ka poʻe e hoʻomau i ka loaʻa ʻana o ia mea i ka wā e loaʻa ana iā lākou ka dialysis a me ka ʻike ʻana i ka pōmaikaʻi mai ka lapaʻau.

E loiloi mau kāu kauka i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau iā ʻoe a inā paha e ʻike ana ʻoe i nā hopena ʻaoʻao. E nānā paha lākou me ʻoe e pili ana i kāu mau pae ʻōpala a me ka maikaʻi o ke ola holoʻokoʻa e hoʻoholo ai inā he mea kūpono ka hoʻomau ʻana i ka lapaʻau.

ʻIke kekahi poʻe i ka hoʻomaikaʻi ʻana i kā lākou ʻōpala i nā pule mua o ka lapaʻau, ʻoiai e pono paha nā poʻe ʻē aʻe i kekahi mau mahina e ʻike i nā pōmaikaʻi piha. He mea nui e hoʻomanawanui a kūlike me kāu lapaʻau, no ka mea, e kūkulu ana nā hopena anti-itch i ka manawa.

He aha nā hopena ʻaoʻao o Difelikefalin?

E like me nā lāʻau lapaʻau a pau, hiki i ka difelikefalin ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā kānaka a pau iā lākou. He maʻalahi a hiki ke mālama ʻia nā hopena ʻaoʻao maʻamau, akā he mea nui e ʻike i ka mea e nānā ai.

ʻO nā hopena ʻaoʻao i hōʻike pinepine ʻia, ʻo ia ka maʻi maʻi, ka ʻūlū, ka nausea, a me ka hāʻule ʻana o ke koko no ka manawa. He maʻalahi kēia mau hōʻailona a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau i nā pule mua o ka lapaʻau.

Eia nā hopena ʻaoʻao maʻamau āu e ʻike ai:

• Ka maʻi palahē, hiki ke hana i loko o nā hola ma hope o ka loaʻa ʻana o ka pahu
• Ka wili, a i ʻole ka māmā ʻana, ʻoi loa ke kū i luna
• Ka maʻi ʻōpū, a i ʻole ka ʻōpū māmā
• Ka luaʻi ʻana, ʻoiai ʻaʻole maʻamau kēia ma mua o ka maʻi ʻōpū
• Ka emi ʻana o ke koko no ka manawa
• Ka luhi a i ʻole ka manaʻo e luhi ana ma mua o ka maʻamau

ʻO ka hapa nui o kēia mau hopena ʻaoʻao he manawa wale nō a e emi ana i ka wā e maʻa ai kou kino i ka lāʻau. E nānā pono kāu hui dialysis iā ʻoe, ʻoi loa i kāu mau lapaʻau mua.

ʻOiai he mea maʻamau ʻole, hiki i kekahi poʻe ke loaʻa nā hopena ʻaoʻao koʻikoʻi e pono ai ka lāʻau lapaʻau koke. Aia kēia mau mea i nā hopena maʻi koʻikoʻi, nā loli nui o ke koko, a i ʻole ka luaʻi mau e pale ai iā ʻoe mai ka mālama ʻana i nā wai.

ʻAʻole maʻamau nā hopena maʻi i ka difelikefalin akā hiki ke komo i nā hōʻailona e like me ka pilikia o ka hanu ʻana, ka pehu ʻana o kou maka a i ʻole ka ʻāʻī, a i ʻole ka ʻōpala ākea. Inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona, ​​e hoʻōki koke kāu hui lapaʻau i ka lāʻau a hāʻawi i ka lāʻau kūpono.

ʻO wai ka mea pono ʻole e lawe iā Difelikefalin?

ʻAʻole kūpono ʻo Difelikefalin no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. Ua ʻae ʻia ka lāʻau lapaʻau no nā pākeke e loaʻa ana i ka hemodialysis, no laila ʻaʻole hoʻohana ʻia i nā poʻe me ka hana maʻamau o ka puʻupaʻa a i ʻole nā ​​mea ma nā ʻano dialysis ʻē aʻe.

ʻAʻole pono ʻoe e loaʻa iā difelikefalin inā loaʻa iā ʻoe kahi maʻi i ka lāʻau a i ʻole kekahi o kāna mau mea. E hoʻohana pū kāu kauka i ka akahele inā loaʻa iā ʻoe kekahi mau maʻi puʻuwai, ka maʻi ate koʻikoʻi, a i ʻole ka moʻolelo o nā pilikia koko nui.

Eia nā kūlana kahi i kūpono ʻole ai ʻo difelikefalin:

• Ka maʻi puʻuwai nui a i ʻole nā puʻuwai puʻuwai paʻa ʻole
• Ka maʻi ate nui e pili ana i ke ʻano o ka hana ʻana o kou kino i nā lāʻau lapaʻau
• He moʻolelo o nā hopena maʻi maʻi nui i nā lāʻau lapaʻau like
• Hāpai a i ʻole ka hānai ʻana i ka waiū, no ka mea, ʻaʻole i hoʻokumu ʻia ka palekana
• Ka paʻa ʻole o ke koko nui
• Ka hoʻohana ʻana i nā mea ʻino e pili ana i nā opioids

E loiloi kāu kauka i nā pōmaikaʻi e hiki mai ana i nā pilikia e pili ana i kou olakino. E noʻonoʻo pū lākou i ke ʻano o nā lāʻau lapaʻau ʻē aʻe āu e lawe nei e pili ana me ka difelikefalin.

Inoa Brand Difelikefalin

Hoʻolaha ʻia ka Difelikefalin ma lalo o ka inoa brand Korsuva e Cara Therapeutics. ʻO kēia wale nō ka inoa brand i loaʻa no kēia lāʻau lapaʻau, no ka mea, he lāʻau lapaʻau hou ia i loaʻa i ka ʻae ʻia e ka FDA i ka makahiki 2021.

Ke kamaʻilio ʻana me kāu hui mālama ola a i ʻole ka hui ʻinikua, hiki iā lākou ke kuhikuhi i ka lāʻau lapaʻau ma kekahi inoa. ʻO Korsuva a me difelikefalin e pili ana i ka lāʻau lapaʻau hoʻokahi, no laila, mai huikau inā lohe ʻoe i nā huaʻōlelo ʻelua e hoʻohana ʻia.

Nā Koho ʻē aʻe o Difelikefalin

Inā ʻaʻole hana maikaʻi ka difelikefalin iā ʻoe a i ʻole e hana i nā hopena ʻaoʻao pilikia, aia kekahi mau lāʻau lapaʻau ʻē aʻe no ka ʻūlū e pili ana i ka maʻi kīkī. Hiki i kāu kauka ke kōkua iā ʻoe e ʻimi i kēia mau koho e pili ana i kou kūlana a me ka mōʻaukala olakino.

ʻO nā lāʻau lapaʻau kuʻuna e pili ana i nā antihistamines e like me hydroxyzine a i ʻole cetirizine, akā ʻaʻole pinepine kēia mau mea i ka maikaʻi no ka ʻūlū e pili ana i ka kīkī. Hiki i nā lāʻau lapaʻau topical e like me nā ʻaila i hoʻokumu ʻia i ka menthol a i ʻole ka lotion calamine ke hāʻawi i kekahi mea hōʻoluʻolu, ʻoiai ke hoʻohana ʻia me nā lāʻau lapaʻau ʻē aʻe.

ʻO nā koho ʻē aʻe e pili ana i ka gabapentin, e pili ana i nā hōʻailona nerve i nā ʻano like ʻole ma mua o ka difelikefalin, a i ʻole pregabalin, kekahi lāʻau lapaʻau e hiki ke kōkua i nā hōʻailona e pili ana i ka nerve. Loaʻa i kekahi poʻe ka hōʻoluʻolu me ka lāʻau lapaʻau kukui ultraviolet, akā pono kēia i nā lako kūikawā a me ka nānā ʻana.

I kekahi mau hihia, ʻo ka hoʻomaikaʻi ʻana i kāu mālama dialysis ponoʻī hiki ke kōkua i ka hōʻemi ʻana i ka ʻūlū. Hiki i kēia ke komo i ka hoʻoponopono ʻana i kāu papa dialysis, ka hoʻololi ʻana i ke ʻano o ka dialyzer i hoʻohana ʻia, a i ʻole ka hoʻololi ʻana i kāu mau helu wehe wai.

Ua ʻoi aku ka maikaʻi o Difelikefalin ma mua o nā lāʻau lapaʻau ʻē aʻe?

Hāʻawi ʻo Difelikefalin i kekahi mau mea maikaʻi ʻole ma mua o nā lāʻau lapaʻau kuʻuna no ka ʻūlū e pili ana i ka maʻi kīkī, akā inā he

E loiloi kāu kauka i ke olakino o kou puʻuwai ma mua o ka hoʻomaka ʻana i ka difelikefalin a makemake paha e nānā pono i kou koko a me ka puʻuwai i ka wā o ka mālama ʻana. Inā he maʻi puʻuwai koʻikoʻi a i ʻole nā puʻuwai ʻole, hiki i kāu kauka ke ʻōlelo i nā lāʻau lapaʻau ʻē aʻe a i ʻole nā hana mālama hou.

He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o ka Difelikefalin?

No ka mea, hāʻawi ʻia ka difelikefalin e nā poʻe loea mālama ola i ka wā dialysis, he kakaikahi loa nā overdoses. Ana ʻia a hāʻawi ʻia ka lāʻau lapaʻau e nā limahana i hoʻomaʻamaʻa ʻia e hahai ana i nā protocols kikoʻī e hōʻoia ai e loaʻa iā ʻoe ka mahele kūpono.

Inā manaʻo ʻoe ua loaʻa iā ʻoe ka nui o ka lāʻau lapaʻau a i ʻole e ʻike i nā hopena ʻaoʻao koʻikoʻi e like me ka pilikia o ka hanu ʻana, ka ʻūlū nui, a i ʻole ka nalowale o ka ʻike, e hoʻomaopopo koke i kāu hui dialysis. Ua aʻo ʻia lākou e ʻike a mālama i nā pilikia e pili ana i ka lāʻau lapaʻau a e hana lākou i nā hana kūpono e hōʻoia i kou palekana.

He aha kaʻu e hana ai inā hala iaʻu kahi mahele o Difelikefalin?

Inā hala ʻoe i kahi kau dialysis a no laila e hala i kāu mahele difelikefalin, e hoʻomau wale i kāu papa hana lapaʻau maʻamau me kāu manawa dialysis e hiki mai ana. Mai ho'āʻo e hana i ka mahele i hala ma ka lawe ʻana i ka lāʻau lapaʻau hou a i ʻole ka hoʻololi ʻana i kāu papa hana lapaʻau.

ʻAʻole e hōʻeha nui ka hala ʻana i nā mahele i kekahi manawa, akā e hoʻāʻo e mālama i kāu papa hana dialysis maʻamau e like me ka hiki no nā hopena maikaʻi loa. Inā hala pinepine ʻoe i nā manawa, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua iā ʻoe e hoʻomau me kāu lapaʻau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Difelikefalin?

Hiki iā ʻoe ke hooki i ka lawe ʻana i ka difelikefalin i kēlā me kēia manawa ma ke kūkākūkā ʻana me kāu kauka. ʻAʻole pono e hoʻemi mālie i ka mahele, no ka mea, ʻaʻole i hana ka lāʻau lapaʻau i ka hilinaʻi kino a i ʻole nā hōʻailona haʻalele ke hooki koke ʻia.

Hiki i kāu kauka ke ʻōlelo e hooki i ka lāʻau lapaʻau inā loaʻa iā ʻoe nā hopena ʻaoʻao nui, inā e hoʻomaikaʻi ana kāu ʻūlū ʻana i ka nui ʻaʻole pono hou ka lāʻau lapaʻau, a i ʻole inā ʻaʻole ʻoe e loaʻa hou ana i ka hemodialysis. Pono e hana mau ʻia ka hoʻoholo e hoʻomau a hooki paha me kāu hui mālama ola ma muli o kou kūlana pilikino.

Hiki iaʻu ke lawe i nā lāʻau lapaʻau ʻē aʻe i ka wā e hoʻohana ana i ka Difelikefalin?

Hiki ke lawe palekana ʻia ka hapa nui o nā lāʻau lapaʻau me ka difelikefalin, akā he mea nui e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau i kauoha ʻia, nā lāʻau lapaʻau ma luna o ka pāʻālua, a me nā mea hoʻohui āu e hoʻohana nei. Hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka difelikefalin a i ʻole e hoʻonui i kou pilikia o nā hopena ʻaoʻao.

E mālama nui i nā lāʻau lapaʻau e hiki ke hoʻohaʻahaʻa i ke koko a i ʻole ke hiamoe, no ka mea, hiki ke hoʻonui ʻia kēia mau hopena ke hui pū ʻia me ka difelikefalin. E nānā kāu kauka a me ka hui dialysis i kāu papa inoa lāʻau lapaʻau piha e ʻike ai i nā pilina kūpono a hana i nā hoʻoponopono kūpono inā pono.