He aha ʻo Doxorubicin: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau chemotherapy ikaika ʻo Doxorubicin i hoʻohana ʻia e mālama i nā ʻano maʻi maʻi like ʻole. No ka papa o nā lāʻau i kapa ʻia ʻo anthracyclines, e hana ana ma ka hoʻopilikia ʻana i ka hiki o nā sela maʻi maʻi ke ulu a hoʻonui.

Ua lilo kēia lāʻau lapaʻau i mea nui o ka mālama ʻana i ka maʻi maʻi no nā makahiki he nui, e kōkua ana i nā maʻi he nui e hakakā i ko lākou maʻi. ʻOiai he lāʻau ikaika ia e pono ai ka nānā pono ʻana, hiki i ka hoʻomaopopo ʻana i ke ʻano o ka hana ʻana e kōkua iā ʻoe e mākaukau no kāu huakaʻi lapaʻau.

He aha ʻo Doxorubicin?

He lāʻau anti-cancer ʻo Doxorubicin i hāʻawi pololei ʻia i loko o kou kahe koko ma o ka IV. Ua kapa pinepine ʻia ʻo Adriamycin, a he ʻāpana ia o kahi ʻohana o nā lāʻau i loaʻa mai kahi ʻano bacteria i kapa ʻia ʻo Streptomyces.

Hoʻokaʻawale ʻia kēia lāʻau lapaʻau ma ke ʻano he lāʻau cytotoxic, ʻo ia hoʻi ua hoʻolālā ʻia e hōʻino a luku paha i nā sela. ʻO ka pahuhopu ka hoʻopaʻa ʻana i nā sela maʻi maʻi e mahele wikiwiki ana ʻoiai ʻoi aku ka maikaʻi o kāu mau sela olakino e ola hou ma waena o nā lāʻau lapaʻau.

E hāʻawi maʻamau kāu oncologist iā doxorubicin ma ke ʻano he ʻāpana o kahi hoʻolālā lapaʻau hui. Hoʻohana ʻia ia wale nō no ka mea ʻo ka hui ʻana me nā lāʻau ʻē aʻe e hana pinepine i nā hopena maikaʻi aʻe e kūʻē i ka maʻi maʻi.

No ke aha e hoʻohana ʻia ai ʻo Doxorubicin?

Hoʻomaʻamaʻa ʻo Doxorubicin i nā ʻano maʻi maʻi like ʻole, e lilo ia i hoʻokahi o nā lāʻau chemotherapy maʻalahi loa i loaʻa. Hiki i kāu kauka ke kuhikuhi iā ia no ka maʻi maʻi umauma, lymphomas, leukemias, a i ʻole nā ​​tumora paʻa like ʻole.

Eia nā kūlana nui kahi e hōʻoia ai ʻo doxorubicin i ka maikaʻi loa:

• Ka maʻi ʻaʻai umauma (hui pinepine ʻia me nā lāʻau chemotherapy ʻē aʻe)
• Lymphoma o Hodgkin a me ka lymphoma ʻaʻole o Hodgkin
• Leukemia lymphoblastic acute a me ka leukemia myeloid acute
• Sarcomas ʻiʻo palupalu a me nā sarcomas iwi
• Ka maʻi ʻaʻai ovarian a me ka maʻi ʻaʻai endometrial
• Ka maʻi ʻaʻai ʻōpū a me ka maʻi ʻaʻai ʻōpū
• Ka maʻi ʻaʻai māmā (nā ʻano like ʻole)
• Ka maʻi ʻaʻai thyroid i nā kūlana kikoʻī

ʻAʻole maʻamau, hiki i nā kauka ke hoʻohana i ka doxorubicin no nā maʻi ʻaʻai laha ʻole e like me ka maʻi ʻo Wilms i nā keiki a i ʻole kekahi mau ʻano maʻi ʻaʻai ate. E hoʻoholo kāu oncologist inā kūpono ka doxorubicin no kou kūlana kikoʻī e pili ana i ke ʻano o kāu maʻi ʻaʻai, ke kahua, a me ke olakino holoʻokoʻa.

Pehea e hana ai ka Doxorubicin?

Hana ka Doxorubicin ma ka komo ʻana i loko o nā pūnaewele maʻi ʻaʻai a hōʻino i ko lākou DNA. E noʻonoʻo i ka DNA ma ke ʻano he manual aʻo e haʻi ana i nā pūnaewele pehea e ulu ai a māhele – ke hoʻopilikia ka doxorubicin i kēia mau ʻōlelo aʻo, ʻaʻole hiki i nā pūnaewele maʻi ʻaʻai ke hana hou.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau chemotherapy ikaika loa. Palaka ia i kahi enzyme i kapa ʻia ʻo topoisomerase II, pono nā pūnaewele maʻi ʻaʻai e kope i kā lākou DNA. Me ka hana pono ʻole o kēia enzyme, huikau nā pūnaewele maʻi ʻaʻai a make hope.

Hana pū ka lāʻau i nā molekala ʻino i kapa ʻia he mau radical manuahi i loko o nā pūnaewele. Hoʻopilikia kēia mau radical manuahi i nā hale i loko o nā pūnaewele maʻi ʻaʻai, e paʻakikī ai iā lākou ke ola a hoʻonui.

No ka mea he ikaika loa ka doxorubicin, e nānā pono kāu hui lapaʻau iā ʻoe i ka wā o ka mālama ʻana. ʻO ka ikaika e hana ai i ka maikaʻi e kūʻē i ka maʻi ʻaʻai, ʻo ia hoʻi ka mālama pono ʻana a me ka hoʻopaʻa ʻana.

Pehea wau e lawe ai i ka Doxorubicin?

Hāʻawi mau ʻia ka Doxorubicin intravenously (ma o ka IV) i loko o kahi haukapila a i ʻole ke kikowaena lapaʻau maʻi ʻaʻai. ʻAʻole ʻoe e lawe i kēia lāʻau lapaʻau ma ka home a i ʻole ma ka waha – pono e lawelawe ʻia e nā poʻe loea mālama ola i aʻo ʻia.

E hoʻokomo kāu kahu maʻi i kahi paipu liʻiliʻi i loko o ke aʻa i kou lima a i ʻole e komo i kāu awa inā loaʻa iā ʻoe kekahi. E kahe mālie ka lāʻau lapaʻau i loko o kou kahe koko ma luna o 15 a 30 mau minuke, ʻoiai i kekahi manawa e lōʻihi paha ia ma muli o kāu hoʻolālā lapaʻau.

Ma mua o kāu hoʻokomo ʻana, e hāʻawi kāu hui lapaʻau iā ʻoe i nā lāʻau anti-nausea e kōkua i ka pale ʻana i nā hopena ʻaoʻao. Hiki nō hoʻi iā ʻoe ke loaʻa nā wai e kōkua i ka pale ʻana i kou mau puʻupaʻa a e mālama iā ʻoe i ka wai i ka wā o ka lapaʻau.

ʻAʻole pono ʻoe e ʻai i kekahi mea kūikawā ma mua o ka lapaʻau, akā ʻo ka ʻai ʻana i ka meaʻai māmā ma mua hiki ke kōkua iā ʻoe e ʻoluʻolu. E pale i ka waiʻona no ka liʻiliʻi o 24 mau hola ma mua a ma hope o kāu lapaʻau, no ka mea, hiki iā ia ke keakea i ke ʻano o ka hana ʻana o kou kino i ka lāʻau lapaʻau.

Pehea ka lōʻihi e lawe ai au i ka Doxorubicin?

ʻO ka lōʻihi o kāu lapaʻau doxorubicin e pili ana i kāu ʻano maʻi maʻi a me ka maikaʻi o kāu pane ʻana i ka lāʻau lapaʻau. Loaʻa ka hapa nui o nā kānaka i nā lapaʻau i kēlā me kēia 2 a 3 pule no kekahi mau mahina.

E helu pono kāu oncologist i ka nui o ka doxorubicin hiki iā ʻoe ke loaʻa palekana i kou ola. Kapa ʻia kēia he palena nui o ka nui, a he mea nui ia no ka mea hiki i ka doxorubicin ke hoʻopilikia i kou puʻuwai inā nui loa ka hōʻiliʻili ʻana i loko o kāu ʻōnaehana.

ʻO ka maʻamau, mau nā pōʻai lapaʻau ma nā wahi a pau mai 3 a 6 mau mahina, akā pono paha kekahi poʻe i nā papa lōʻihi a pōkole paha. E nānā mau kāu kauka i kāu helu koko a me ka hana o ka puʻuwai e hoʻoholo ai inā pono ʻoe e hoʻomau i ka lapaʻau.

Inā pane maikaʻi kāu maʻi maʻi i ka lapaʻau, hiki i kāu oncologist ke hoʻololi iā ʻoe i kahi lāʻau lapaʻau ʻē aʻe a i ʻole e hōʻemi i ke alapine o nā lapaʻau. Mai hooki i ka lapaʻau ma mua o kou iho – e kūkākūkā mau i nā hopohopo me kāu hui lapaʻau.

He aha nā hopena ʻaoʻao o Doxorubicin?

Hiki i ka Doxorubicin ke hana i nā hopena ʻaoʻao no ka mea e pili ana i nā cell maʻi a me kekahi mau cell olakino i kou kino. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ke kākoʻo kūpono a me ka nānā ʻana mai kāu hui mālama ola.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia:

• Nausea a me ka luaʻi (hoʻomalu ʻia me nā lāʻau anti-nausea)
• Ka nalowale o ka lauoho (manawa pōkole – e ulu hou ana kou lauoho ma hope o ka lapaʻau)
• Nā ʻeha waha a i ʻole nā loli i ka ʻono
• Luhi a me ka nāwaliwali
• Hoʻonui ʻia ka pilikia o ka maʻi ma muli o ka helu haʻahaʻa o nā keʻena koko keʻokeʻo
• Maʻalahi ka ʻeha a i ʻole ke kahe ʻana ma muli o ka helu haʻahaʻa o nā platelet
• Mimi ʻulaʻula a ʻulaʻula paha no 1-2 mau lā ma hope o ka lapaʻau (he maʻamau kēia)

Pono nā hopena ʻaoʻao koʻikoʻi i ka lāʻau lapaʻau koke. Aia kēia mau mea i nā hōʻailona o ka maʻi e like me ke kuni, ka ʻū mau, a i ʻole ka luhi ʻole e hoʻomaikaʻi me ka hoʻomaha.

ʻO ka hopena ʻaoʻao e pili ana i ka pōʻino o ka naʻau, hiki ke hana inā loaʻa iā ʻoe ka nui o ka doxorubicin i ka manawa. E nānā mau kāu kauka i ka hana o kou naʻau me nā hoʻokolohua e like me nā echocardiograms a i ʻole nā scan MUGA.

I kekahi manawa, hiki i kekahi poʻe ke hoʻomohala i nā maʻi maʻi lua ma hope o nā makahiki o ka lapaʻau, ʻoiai ua ʻoi aku ka maikaʻi o kēia pilikia ma mua o nā pono o ka mālama ʻana i kāu maʻi maʻi i kēia manawa. E kūkākūkā kāu oncologist i kēia pilikia me ʻoe inā pili ia i kou kūlana.

ʻO wai ka mea pono ʻole e lawe i ka Doxorubicin?

ʻAʻole palekana ka Doxorubicin no nā mea a pau, a e nānā pono kāu oncologist i kāu mōʻaukala olakino ma mua o ke kau ʻana. ʻAʻole kūpono paha ka poʻe me kekahi mau maʻi naʻau no kēia lāʻau lapaʻau.

ʻAʻole pono ʻoe e loaʻa i ka doxorubicin inā loaʻa iā ʻoe:

• Maʻi naʻau koʻikoʻi a i ʻole ka naʻau ʻole
• Hoʻouka naʻau hou a i ʻole nā pilikia puʻuwai koʻikoʻi
• Lapaʻau mua me ka nui o ka doxorubicin palekana
• Maʻi ate koʻikoʻi e pili ana i ke ʻano o kou kino e hana ai i nā lāʻau lapaʻau
• Kaomi iwi iwi koʻikoʻi a i ʻole nā helu koko haʻahaʻa loa
• Maʻi ikaika, ʻaʻole i hoʻomalu ʻia

E akahele nō hoʻi kāu kauka i ka ʻōlelo ʻana i ka doxorubicin inā hāpai ʻoe a i ʻole e hānai ana i ka waiū, no ka mea, hiki iā ia ke hōʻeha i nā pēpē e ulu ana. Inā he makahiki hānau keiki kāu, pono ʻoe e hoʻohana i ka mana hānau kūpono i ka wā o ka mālama ʻana.

Pono paha nā kānaka ma luna o 65 a i ʻole ka poʻe me nā pilikia o ka puʻupaʻa e hoʻoponopono i ka lāʻau e loaʻa ai ka doxorubicin me ka palekana. E noʻonoʻo kāu hui lapaʻau i kēia mau mea a pau i ka wā e hana ai i kāu hoʻolālā lapaʻau.

Nā inoa inoa o Doxorubicin

Loaʻa ka Doxorubicin ma lalo o nā inoa inoa like ʻole, ʻo Adriamycin ka mea i ʻike nui ʻia. Hiki i kāu hale kūʻai lāʻau a i ʻole ke kikowaena lapaʻau ke hoʻohana i ka inoa generic

Hiki nō i kāu kauka ke noʻonoʻo i ka lāʻau lapaʻau radiation a i ʻole ke ʻoki ʻana ma ke ʻano he koho ʻē aʻe, ma muli o kahi a me ke kahua o kāu maʻi ʻaʻai. ʻO ke koho ʻē aʻe maikaʻi loa e pili ana i kou kūlana pilikino a me nā pahuhopu lapaʻau.

Ua ʻoi aku ka maikaʻi o Doxorubicin ma mua o Epirubicin?

He mau lāʻau chemotherapy anthracycline maikaʻi ʻo Doxorubicin a me epirubicin, akā he mau ʻano like ʻole ko lākou. ʻAʻole i

No ka poʻe me ka maʻi puʻuwai koʻikoʻi, hiki i kāu oncologist ke koho i nā lāʻau lapaʻau ʻē aʻe a i ʻole e noʻonoʻo i ka mana liposomal o doxorubicin, he mea maʻalahi i ka puʻuwai. Hoʻohālikelike mau ka hoʻoholo i nā pōmaikaʻi o ka mālama ʻana i kāu maʻi maʻi me nā pilikia e hiki ke loaʻa i kou puʻuwai.

He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o ka Doxorubicin?

He mea maʻamau loa ka overdose o Doxorubicin no ka mea e hāʻawi ʻia e nā poʻe loea mālama ola i aʻo ʻia i nā wahi i mālama ʻia. Inā hopohopo ʻoe e pili ana i ka loaʻa ʻana o ka nui o ka lāʻau lapaʻau, e kamaʻilio koke me kāu kahu hānai a i ʻole kauka.

ʻO nā hōʻailona o ka loaʻa ʻana o ka nui o ka doxorubicin e komo paha i ka nausea koʻikoʻi, ka luaʻi, a i ʻole ka maʻi nui ma hope koke o ka mālama ʻana. Mālama kāu hui lapaʻau iā ʻoe i ka wā a ma hope o kēlā me kēia infusion e hopu i nā pilikia i ka wā mua.

Inā loaʻa kahi overdose, e hāʻawi kāu hui lapaʻau i ka mālama kākoʻo e kōkua i kou kino e hana i ka lāʻau lapaʻau me ka palekana. Hiki i kēia ke komo i nā wai hou, nā lāʻau lapaʻau e pale i kou puʻuwai, a me ka nānā pono ʻana i kāu helu koko a me ka hana ʻana o nā ʻōpū.

He aha kaʻu e hana ai inā haʻalele wau i kahi mahele o Doxorubicin?

Inā haʻalele ʻoe i kahi mālama doxorubicin i hoʻonohonoho ʻia, e hoʻokaʻaʻike koke i ke keʻena o kāu oncologist e hoʻonohonoho hou. Mai kali a hiki i kāu manawa e hiki mai ana - he mea nui ka manawa i ka mālama chemotherapy.

E hoʻoholo kāu hui lapaʻau i ke ala maikaʻi loa e hoʻihoʻi ai i kāu papa hana lapaʻau. I kekahi manawa hiki iā lākou ke hoʻoponopono i kāu mahele aʻe a i ʻole e hoʻomau i kāu papa hana maʻamau, ma muli o ka lōʻihi o kou haʻalele ʻana i ka mālama ʻana.

ʻO ka haʻalele ʻana i hoʻokahi mālama ʻaʻole ia e hōʻino i kāu hoʻolālā lapaʻau holoʻokoʻa, akā he mea nui e kamaʻilio me kāu hui mālama ola. Pono lākou e ʻike e pili ana i nā mahele i haʻalele ʻia e hōʻoia i ka loaʻa ʻana o ka pōmaikaʻi piha o kāu mālama ʻana.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Doxorubicin?

E pono ʻoe e hooki i ka lāʻau doxorubicin ke haʻi aku kāu kauka oncologist iā ʻoe he palekana ke hana pēlā. Hoʻokumu ʻia kēia hoʻoholo ma ke ʻano o ka pane ʻana o kāu maʻi ʻaʻai i ka lāʻau a me kou olakino holoʻokoʻa.

E nānā mau kāu kauka i kou holomua ma o nā hoʻokolohua koko, nā kiʻi kiʻi, a me nā hoʻokolohua kino. Inā e pane maikaʻi ana kāu maʻi ʻaʻai a ua hoʻopau ʻoe i kāu pōʻai lapaʻau i hoʻolālā ʻia, e haʻi lākou iā ʻoe i ka manawa e hooki ai.

Mai hooki i ka lāʻau i ka wā mua ma kāu iho, ʻoiai inā ʻoe e ʻoi aku ka maikaʻi a i ʻole e ʻike ana i nā hopena ʻaoʻao. Inā e hoʻopilikia ana nā hopena ʻaoʻao iā ʻoe, e kamaʻilio me kāu hui lapaʻau e pili ana i nā ala e mālama ai iā lākou ma mua o ka hooki ʻana i ka lāʻau.

Hiki iaʻu ke lawe i nā lāʻau ʻē aʻe i ka wā e lawe ana i ka Doxorubicin?

E haʻi mau i kāu kauka oncologist e pili ana i nā lāʻau a pau āu e lawe nei, me nā lāʻau lapaʻau i kau ʻia, nā lāʻau lapaʻau ma luna o ka pāʻani, a me nā mea hoʻohui. Hiki i kekahi mau lāʻau lapaʻau ke launa pū me doxorubicin a i ʻole e pili i ke ʻano o kou kino e mālama ai i ka chemotherapy.

E nānā kāu hui lapaʻau i nā lāʻau lapaʻau a pau a hiki ke noi iā ʻoe e hooki a hoʻoponopono paha i kekahi i ka wā o ka lāʻau. Aia kēia i kekahi mau lāʻau lapaʻau maʻamau e like me kekahi mau antibiotics, nā lāʻau lapaʻau puʻuwai, a i ʻole nā mea lahilahi koko.

Mai hoʻomaka i nā lāʻau lapaʻau hou a i ʻole nā mea hoʻohui me ka nānā ʻole ʻana i kāu kauka oncologist. ʻOiai ʻo nā lāʻau lapaʻau ma luna o ka pāʻani i ʻike ʻia he palekana hiki ke hoʻopilikia i kāu lāʻau maʻi ʻaʻai a i ʻole e hoʻonui i nā hopena ʻaoʻao.