He aha ʻo Durvalumab: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He ʻano lāʻau lapaʻau immunotherapy ʻo Durvalumab e kōkua ana i kāu ʻōnaehana pale e hakakā i kekahi mau ʻano maʻi maʻi maikaʻi. Hāʻawi ʻia ma o ka IV (intravenous) infusion, ʻo ia hoʻi e kahe pololei ana i loko o kou kahe koko ma o ka vein i kou lima a i ʻole ka umauma.

No kēia lāʻau lapaʻau i kahi papa o nā lāʻau i kapa ʻia ʻo checkpoint inhibitors, e hana ana ma ka wehe ʻana i nā

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau i manaʻo ʻia ma mua o ka chemotherapy kuʻuna. He ʻoluʻolu maʻamau ia i kou kino ma mua o nā lāʻau lapaʻau maʻamau, ʻoiai hiki nō ke hana i nā hopena ʻaoʻao i ka wā e ʻoi aku ai ka hana o kou ʻōnaehana pale.

Pehea e lawe ai au i ka Durvalumab?

Hāʻawi ʻia ka Durvalumab ma ke ʻano he IV infusion ma kahi haukapila a i ʻole ke kikowaena lapaʻau maʻi maʻi. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka home a i ʻole ma ka waha - pono e hāʻawi ʻia e nā poʻe loea mālama ola i aʻo ʻia.

Ma kahi o 60 mau minuke e hoʻopau ai ka infusion. E noho ʻoluʻolu ʻoe ma kahi noho i ka wā e kahe ana ka lāʻau lapaʻau ma kahi laina IV i loko o kou kahe koko. Loaʻa ka hapa nui o nā kānaka i nā lāʻau lapaʻau i kēlā me kēia 2 a 4 pule, ma muli o ko lākou kūlana.

Ma mua o kēlā me kēia infusion, e nānā kāu hui mālama ola i kāu mau hōʻailona koʻikoʻi a hiki ke hāʻawi iā ʻoe i nā lāʻau lapaʻau e pale ai i nā hopena maʻi. ʻAʻole pono ʻoe e hoʻokē ʻai ma mua o ka lāʻau lapaʻau, a hiki iā ʻoe ke ʻai maʻamau i nā lā lapaʻau. He mea kōkua ka noho ʻana i ka wai ma ka inu ʻana i ka wai.

Pehea ka lōʻihi e lawe ai au i ka Durvalumab?

He ʻokoʻa nui ka lōʻihi o ka lāʻau lapaʻau durvalumab ma muli o kāu ʻano maʻi maʻi a me ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau. Loaʻa i kekahi poʻe ka lāʻau lapaʻau no nā mahina he nui, a hiki i nā poʻe ʻē aʻe ke hoʻomau no hoʻokahi makahiki.

No ka maʻi maʻi maʻi, hoʻomau ka lāʻau lapaʻau a hiki i 12 mau mahina inā maikaʻi ʻoe a ʻaʻole e holomua ana kāu maʻi maʻi. No ka maʻi maʻi ʻōpū, hiki ke hoʻomau ʻia ka lāʻau lapaʻau inā e kōkua ana ia i ka mālama ʻana i kāu maʻi maʻi a ʻaʻole e hana i nā hopena ʻaoʻao koʻikoʻi.

E nānā mau kāu kauka i kou holomua ma o nā scans a me nā hoʻokolohua koko. E hoʻoponopono lākou i kāu hoʻolālā lapaʻau ma muli o ke ʻano o ka pane ʻana o kāu maʻi maʻi a me ke ʻano o kou kino e mālama ai i ka lāʻau lapaʻau. ʻO ka pahuhopu ka hoʻomau i ka lāʻau lapaʻau inā e pōmaikaʻi ana iā ʻoe me ka hana ʻole i nā hopena ʻaoʻao ʻae ʻole.

He aha nā hopena ʻaoʻao o Durvalumab?

Hiki i ka Durvalumab ke hana i nā hopena ʻaoʻao no ka mea e hoʻāla ai i kāu ʻōnaehana pale, i kekahi manawa e hoʻouka ana i nā ʻiʻo olakino me nā pūnaewele maʻi ʻaʻai. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao, akā hiki ke koʻikoʻi kekahi a pono e mālama koke ʻia.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike i ka wā o ka mālama ʻana:

• Luhi a piʻi ka luhi ma mua o ka maʻamau
• ʻUhu a i ʻole ka hanu ʻana
• Pāpaʻa ʻili a i ʻole ka ʻūlū
• Pāpaʻa a i ʻole nā loli i nā neʻe ʻana o ka ʻōpū
• Hoʻemi ʻia ka ʻai
• ʻEha ʻiʻo a i ʻole nā hui
• Nausea

Hoʻomohala maʻamau kēia mau hopena ʻaoʻao maʻamau a hiki ke mālama pinepine ʻia me ka mālama kākoʻo a me nā lāʻau lapaʻau. E hana pū kāu hui mālama ola me ʻoe e hōʻemi i nā pilikia.

ʻOiai ʻaʻole maʻamau, hiki i ka durvalumab ke hana i nā hopena ʻaoʻao koʻikoʻi e pono ai ka mālama olakino koke. Hiki kēia i ka wā e hoʻouka ai kāu ʻōnaehana pale i nā ʻōkana olakino i kou kino.

ʻO nā hopena ʻaoʻao koʻikoʻi e pono ai ka mālama wikiwiki, e komo pū ana:

• Ka mumū nui o ka māmā (pneumonitis) e hana ana i ka ʻuʻu mau a i ʻole nā pilikia hanu
• Nā pilikia o ke ake me nā hōʻailona e like me ka melemele o ka ʻili, ka mimi ʻeleʻele, a i ʻole ka ʻeha nui o ka ʻōpū
• Pāpaʻa nui a i ʻole colitis me ke koko i loko o ka ʻōpū
• Nā pilikia thyroid e hana ana i ka luhi nui, nā loli kaumaha, a i ʻole nā puʻuwai
• Nā pilikia o ka puʻupaʻa me ka hoʻemi ʻia o ka mimi a i ʻole ka pehu
• Nā hopena ʻili koʻikoʻi me ka pāpaʻa ākea a i ʻole ka ʻōpū
• Nā pilikia o ka ʻāʻī adrenal e hana ana i ka luhi nui, ka ʻūlū, a i ʻole ka hāʻule

E nānā pono kāu hui lapaʻau iā ʻoe no kēia mau kūlana ma o nā hoʻokolohua koko maʻamau a me nā hoʻokolohua kino. Hiki ke hoʻohuli ʻia ka hapa nui o nā hopena ʻaoʻao koʻikoʻi me ka mālama wikiwiki, e pili pinepine ana i nā lāʻau lapaʻau e hoʻomaha ai i kāu ʻōnaehana pale.

ʻO wai ka mea ʻaʻole pono e lawe i ka Durvalumab?

ʻAʻole kūpono ʻo Durvalumab no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia no ʻoe ma mua o ka hoʻomaka ʻana i ka lāʻau. ʻO kekahi mau maʻi a me nā kūlana e hoʻoweliweli paha i kēia lāʻau.

ʻAʻole pono ʻoe e loaʻa iā durvalumab inā he maʻi maʻi koʻikoʻi ʻoe i kēia lāʻau a i ʻole nā mea i loko. E akahele loa kāu kauka inā he maʻi autoimmune ikaika kou kahi e hoʻouka mua ai kou ʻōnaehana pale i nā ʻiʻo olakino.

ʻO nā kūlana e pono ai ka noʻonoʻo kūikawā e komo pū ana:

• Nā maʻi autoimmune ikaika e like me ka rheumatoid arthritis, lupus, a i ʻole ka maʻi ʻōpū inflammatory
• Mōʻaukala o nā hopena ʻaoʻao pili i ka immune mai nā lāʻau immunotherapy ʻē aʻe
• Nā maʻi ikaika e hakakā nei kou ʻōnaehana pale
• ʻO nā mea loaʻa i ka transplant organ e lawe ana i nā lāʻau immunosuppressive
• Hāpai a hānai paha
• Maʻi ate a i ʻole maʻi kīkī koʻikoʻi

E kaupaona kāu kauka i nā pōmaikaʻi kūpono e kūʻē i nā pilikia i kāu kūlana kikoʻī. I kekahi manawa hiki ke hoʻohana ʻia ʻo durvalumab me ka nānā pono ʻana a me nā hana hou, ʻoiai inā he mau maʻi kou.

Nā inoa inoa o Durvalumab

Kūʻai ʻia ʻo Durvalumab ma lalo o ka inoa inoa ʻo Imfinzi. ʻO kēia wale nō ka inoa inoa i loaʻa no kēia lāʻau, no ka mea, aia nō ia ma lalo o ka pale patent e ka mea hana mua.

Ke loaʻa iā ʻoe kāu lāʻau, e ʻike ʻoe iā "Imfinzi" ma kāu mau lepili lāʻau a me nā moʻolelo lapaʻau. ʻAʻole i loaʻa nā mana generic o durvalumab, no laila e loaʻa i nā mea maʻi a pau ka lāʻau inoa like me ka ʻole o kā lākou ʻinikua a i ʻole ke kikowaena lapaʻau.

Nā koho ʻē aʻe o Durvalumab

Nui nā lāʻau lapaʻau checkpoint inhibitor ʻē aʻe e hana like me durvalumab no ka mālama ʻana i ka maʻi kanesa. Hiki i kāu kauka ke noʻonoʻo i kēia mau koho ʻē aʻe inā ʻaʻole kūpono ʻo durvalumab iā ʻoe a i ʻole inā ʻaʻole pane maikaʻi kāu maʻi kanesa.

ʻO nā koho ʻē aʻe maʻamau e komo pū ana me ka pembrolizumab (Keytruda), nivolumab (Opdivo), a me atezolizumab (Tecentriq). Hana kēia mau lāʻau lapaʻau a pau ma ka pale ʻana i nā protein checkpoint like ʻole, e ʻae ana i kāu ʻōnaehana pale e hoʻouka i ka maʻi maʻi me ka ʻoi aku ka maikaʻi.

Aia ke koho ma waena o kēia mau lāʻau lapaʻau i kāu ʻano maʻi maʻi kikoʻī, nā lāʻau lapaʻau ma mua, a me nā mea olakino pilikino. E ʻōlelo aku kāu oncologist i ke koho maikaʻi loa e pili ana i ka noiʻi o kēia manawa a me kāu kūlana olakino kūikawā.

Hiki ke noʻonoʻo ʻia nā koho ʻē aʻe kuʻuna e like me ka chemotherapy, radiation therapy, a i ʻole nā lāʻau lapaʻau i manaʻo ʻia e pili ana i nā ʻano o kāu maʻi maʻi a me ke kahua.

Ua ʻoi aku ka maikaʻi o Durvalumab ma mua o Pembrolizumab?

He mea maikaʻi ʻo Durvalumab a me pembrolizumab i nā mea pale checkpoint, akā hana maikaʻi lākou no nā ʻano maʻi maʻi a me nā kūlana like ʻole. ʻAʻole ʻoi aku ka maikaʻi o kekahi lāʻau lapaʻau - pili ke koho i kāu ʻano maʻi maʻi kikoʻī a me ka mōʻaukala lapaʻau.

Ua ʻae ʻia ʻo Durvalumab no kekahi mau maʻi maʻi maʻi māmā a me ka ʻōpū, ʻoiai ʻo pembrolizumab e mālama i kahi ākea o nā maʻi maʻi e pili ana i ka māmā, ka ʻōpū, ka ʻili, a me nā mea ʻē aʻe. No ka maʻi maʻi māmā, hoʻohana pinepine ʻia ʻo durvalumab ma hope o ka radiation therapy, ʻoiai e hoʻohana ʻia ʻo pembrolizumab ma ke ʻano he lapaʻau laina mua.

Ua like loa nā ʻaoʻao hopena ma waena o kēia mau lāʻau lapaʻau, ʻoiai e ʻae paha nā kānaka i kekahi ma mua o kekahi. E koho kāu oncologist e pili ana i ka lāʻau lapaʻau i loaʻa ka hōʻike ikaika loa no kāu ʻano maʻi maʻi kikoʻī a me ke kahua.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Durvalumab

He palekana anei ʻo Durvalumab no ka poʻe me ka maʻi puʻuwai?

Hiki ke hoʻohana maʻamau ʻia ʻo Durvalumab i ka poʻe me ka maʻi puʻuwai paʻa, akā pono ia i ka nānā pono ʻana. Hiki i ka lāʻau lapaʻau ke kumu i nā hopena ʻaoʻao e pili ana i ka puʻuwai, e pili ana i ka mumū o ka ʻiʻo puʻuwai (myocarditis), ʻoiai he mea maʻamau kēia.

E loiloi kāu kauka i ke olakino o kou puʻuwai ma mua o ka hoʻomaka ʻana i ka lapaʻau a e nānā pono iā ʻoe i ka wā o ka lapaʻau. Inā he moʻolelo kou o nā pilikia o ka puʻuwai, pono paha ʻoe i nā hoʻokolohua hana puʻuwai maʻamau a me ka hoʻopili ʻana ma waena o kāu oncologist a me cardiologist.

He aha kaʻu e hana ai inā ua hala au i kahi mahele Durvalumab?

Inā hala ʻoe i kahi hoʻokomo durvalumab i hoʻonohonoho ʻia, e hoʻokaʻaʻike koke i kāu hui mālama ola e hoʻonohonoho hou. Mai hoʻāʻo e "hopu" ma ka hoʻonohonoho ʻana i nā mahele kokoke loa - hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao.

Na kāu kauka e hoʻoholo i ka manawa maikaʻi loa no kāu mahele aʻe e pili ana i ka lōʻihi o ka manawa mai kāu lapaʻau hope loa. I ka hapanui o nā hihia, e hoʻomau wale ʻoe i kāu papa hana maʻamau mai ka lā manawa hou.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Durvalumab?

Pono ʻoe e hooki i ka lapaʻau durvalumab ma hope o ke kūkākūkā ʻana me kāu oncologist. Aia ka hoʻoholo i ka maikaʻi o ka pane ʻana o kāu maʻi maʻi, nā hopena ʻaoʻao āu e ʻike nei, a me kou kūlana olakino holoʻokoʻa.

ʻO nā kumu maʻamau e hooki ai, ʻo ia ka holomua o ka maʻi maʻi me ka lapaʻau ʻana, nā hopena ʻaoʻao koʻikoʻi ʻaʻole e hoʻomaikaʻi me ka mālama ʻana, a i ʻole ka hoʻopau ʻana i ka lōʻihi o ka lapaʻau i hoʻolālā ʻia. E hoʻohana kāu kauka i nā scans a me nā hoʻokolohua koko e kōkua i ka hana ʻana i kēia hoʻoholo nui.

Hiki iaʻu ke kiʻi i nā lāʻau lapaʻau i ka wā e lawe ana iā Durvalumab?

Pono e pale ʻia nā lāʻau lapaʻau ola i ka wā e lawe ana iā durvalumab no ka mea hiki i kāu ʻōnaehana pale i hoʻāla ʻia ke hana ʻole. Eia naʻe, palekana nā lāʻau lapaʻau i hoʻopau ʻia (e like me ka pana flu) a ua ʻōlelo pinepine ʻia e pale iā ʻoe mai nā maʻi.

E hōʻike mau i kāu poʻe mālama ola e loaʻa ana iā ʻoe ka durvalumab ma mua o ka loaʻa ʻana o nā lāʻau lapaʻau. Hiki iā lākou ke aʻo iā ʻoe i ka manawa maikaʻi loa a me nā lāʻau lapaʻau kūpono no kou kūlana.

E pili anei ʻo Durvalumab i koʻu momona?

Hiki i ka Durvalumab ke hoʻopilikia i ka momona i nā kāne a me nā wahine, ʻoiai ʻaʻole i maopopo loa ka hopena. Inā ʻoe e hoʻolālā ana e loaʻa nā keiki, e kūkākūkā me kāu kauka i nā koho mālama momona ma mua o ka hoʻomaka ʻana i ka lāʻau.

Hiki i ka lāʻau lapaʻau ke hōʻeha i nā pēpē e ulu ana, no laila he mea nui ka pale ʻana i ka hāpai ʻana i ka wā o ka lāʻau a no kekahi mau mahina ma hope o kāu mahele hope loa. E hāʻawi kāu hui mālama ola kino i ke alakaʻi kikoʻī e pili ana i ka hoʻolālā ʻohana i ka wā o kāu lāʻau.