He aha ka Ecallantide: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i kauoha ʻia ʻo Ecallantide i hoʻolālā ʻia e mālama i nā hōʻeha ʻana o ka pehu ʻana i ka poʻe me ka hereditary angioedema (HAE). Hana kēia lāʻau lapaʻau injectable kūikawā ma ka pale ʻana i kekahi mau protein i loko o kou kino e hoʻoulu ai i nā hanana pehu weliweli, ʻo ia hoʻi a puni kou maka, ʻāʻī, a me nā wahi koʻikoʻi ʻē aʻe.

Inā ua ʻike ʻia ʻoe a i ʻole kekahi āu e ʻike nei me HAE, hiki i ka hoʻomaopopo ʻana i kēia lāʻau lapaʻau ke kōkua iā ʻoe e mākaukau a hilinaʻi i ka mālama ʻana i kēia maʻi kakaʻikahi akā koʻikoʻi. E hele kākou i nā mea a pau e pono ai ʻoe e ʻike e pili ana i ka ecallantide ma nā huaʻōlelo maʻalahi a maopopo.

He aha ka Ecallantide?

He lāʻau lapaʻau biologic i manaʻo ʻia ʻo Ecallantide e hana e like me ke kī kūikawā, e ālai ana i nā protein kikoʻī i kapa ʻia ʻo kallikreins e hoʻoulu ai i nā hōʻeha pehu i nā maʻi HAE. E noʻonoʻo iā ia he mea hana pololei e komo i loko o kahi pilikia e kōkua i ka hoʻōki ʻana i ke kaʻina hana pehu ma mua o ka hoʻoweliweli ʻana i ke ola.

No ka papa i kapa ʻia ʻo kallikrein inhibitors kēia lāʻau lapaʻau, ʻo ia hoʻi e kuhikuhi pono ana i ke kumu kumu o nā hōʻeha HAE ma mua o ka mālama ʻana i nā hōʻailona. Manaʻo nā mea mālama ola he lāʻau lapaʻau hoʻopakele no ka mea e hoʻohana ʻia i ka wā o nā hanana pehu ikaika, ʻaʻole ma ke ʻano he lāʻau pale i kēlā me kēia lā.

Hele mai ka lāʻau lapaʻau ma ke ʻano he hopena maopopo a ʻaʻohe kala e pono e hāʻawi ʻia ma ke ʻano he injection ma lalo o ka ʻili (subcutaneous injection). Pono e hāʻawi ʻia kēia lāʻau lapaʻau e nā poʻe loea mālama ola i hoʻomaʻamaʻa ʻia, maʻamau i ka haukapila a i ʻole ke keʻena lapaʻau kahi e hiki ai iā ʻoe ke nānā ʻia no nā hopena.

No ke aha e hoʻohana ʻia ai ka Ecallantide?

Ua ʻae ʻia ʻo Ecallantide e mālama i nā hōʻeha nui o ka hereditary angioedema i nā pākeke a me nā ʻōpio 12 mau makahiki a ʻoi aku paha. He maʻi genetic kakaʻikahi ʻo HAE kahi e mālama pono ʻole ai kou kino i kekahi mau protein e hoʻoponopono i ka pehu a me ka mumū.

I ka wā o ka hoʻouka ʻana o ka HAE, hiki iā ʻoe ke ʻike i ka pehu koke a koʻikoʻi ma kou maka, nā lehelehe, ke alelo, ka ʻāʻī, nā lima, nā wāwae, a i ʻole nā ʻōpū. ʻAʻole wale nō ka ʻoluʻolu ʻole o kēia pehu ʻana, akā he mea weliweli paha, ʻoiai ke pili i kou hanu a i ʻole ka ʻai ʻana.

He mea waiwai nui ka lāʻau lapaʻau no ka mālama ʻana i nā hoʻouka ʻana e pili ana i kou ala ea luna a i ʻole ka ʻāʻī, kahi e hiki ai i ka pehu ke ālai i kou hanu. Hiki i nā mea mālama ola ke hoʻohana ia mea no nā hanana pehu koʻikoʻi ʻē aʻe ke ʻoi aku ka maikaʻi ma mua o nā pilikia.

Pehea e hana ai ʻo Ecallantide?

Hana ʻo Ecallantide ma ka ālai ʻana i ka plasma kallikrein, kahi protein e pāʻani nui i ka hoʻoulu ʻana i ka cascade pehu i nā maʻi HAE. Ke loaʻa iā ʻoe kahi hoʻouka HAE, hana kou kino i ka nui o kahi mea i kapa ʻia ʻo bradykinin, e hoʻoulu ai i nā kīʻaha koko e kahe i ka wai i loko o nā ʻiʻo a puni.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau ikaika a wikiwiki e hiki ke kōkua i ka hoʻōki ʻana i ka hoʻouka ʻana. Ma ka ālai ʻana i ka kallikrein, kōkua ʻo ecallantide i ka hōʻemi ʻana i ka hana ʻana o bradykinin, e kōkua ana i ka hōʻemi ʻana i ka pehu a me ka mumū āu e ʻike nei.

Hoʻomaka maʻamau nā hopena i loko o nā hola o ka injection, ʻoiai hiki ke ʻokoʻa nā manawa pane pilikino. He ʻokoʻa kēia mai nā lāʻau lapaʻau pale e hiki ai iā ʻoe ke lawe i kēlā me kēia lā e hōʻemi i ke alapine o nā hoʻouka.

Pehea e lawe ai au i ka Ecallantide?

Pono e hāʻawi ʻia ʻo Ecallantide ma ke ʻano he injection ma lalo o kou ʻili e kekahi mea mālama ola i aʻo ʻia i loko o kahi keʻena lapaʻau. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka home a i ʻole e hāʻawi iā ʻoe iho, no ka mea, pono ia i ka nānā pono ʻana a me ke ʻano o ka injection kūpono.

ʻO ka maʻamau maʻamau he 30 mg i hāʻawi ʻia ma ke ʻano he ʻekolu mau injection 10 mg ma lalo o ka ʻili, maʻamau i nā wahi like ʻole e like me kou ʻūhā, ʻōpū, a i ʻole ka lima luna. E hoʻoholo kāu mea mālama ola i nā wahi injection pololei a hiki ke hoʻokaʻawale iā lākou e hōʻemi i ka hōʻoluʻolu.

ʻAʻole pono ʻoe e hopohopo e pili ana i ka lawe ʻana i kēia lāʻau me ka meaʻai a i ʻole ka pale ʻana i kekahi mau meaʻai, no ka mea, hāʻawi ʻia ia ma ke ʻano he injection ma mua o ka lawe ʻia ʻana ma ka waha. Eia naʻe, he mea nui e noho hydrated a e hahai i nā ʻōlelo aʻo ʻē aʻe a kāu hui mālama ola e hāʻawi ai i ka wā o kāu lapaʻau.

Pehea ka lōʻihi e lawe ai au i ka Ecallantide?

Hāʻawi ʻia ʻo Ecallantide ma ke ʻano he lapaʻau hoʻokahi i ka wā o ka hoʻouka ʻana o ka HAE, ʻaʻole ma ke ʻano he lāʻau lōʻihi. Loaʻa ka hapa nui o nā kānaka i ka mahele piha i ka wā o hoʻokahi kipa ʻana i ka hale mālama ola, a hiki i nā hopena ke mau no ka lōʻihi o kēlā hoʻouka ʻana.

Inā loaʻa iā ʻoe kahi hoʻouka HAE ʻē aʻe i ka wā e hiki mai ana, hiki i kāu kauka ke ʻōlelo hou i ka ecallantide, akā ua manaʻo ʻia kēlā me kēia lapaʻau he kaʻawale a pili i kāu mau hōʻailona a me nā pono olakino i kēlā manawa.

E nānā kāu mea mālama ola iā ʻoe no kekahi mau hola ma hope o ka loaʻa ʻana o ka injection e hōʻoia i ka maikaʻi o kāu pane ʻana a e nānā i nā hopena ʻino. He ʻāpana koʻikoʻi kēia manawa nānā i ke kaʻina hana lapaʻau.

He aha nā hopena ʻaoʻao o Ecallantide?

E like me nā lāʻau lapaʻau a pau, hiki i ka ecallantide ke hoʻoulu i nā hopena ʻaoʻao, ʻoiai ʻaʻole i loaʻa i nā mea a pau. ʻO ka mea nui e hoʻomaopopo ai, ʻo ia ka hiki ke loaʻa nā hopena maʻi maʻi koʻikoʻi, ʻoiai he mea maʻamau, a pono e mālama koke ʻia.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike:

• ʻEha poʻo a i ʻole ka noʻonoʻo māmā
• Nausea a i ʻole ka ʻōpū
• Luhi a i ʻole ka manaʻo luhi
• ʻEha, ʻulaʻula, a i ʻole ka pehu ʻana ma ke kahua injection
• Fiva māmā a i ʻole nā anu

He maʻalahi a he manawa pōkole kēia mau hopena ʻaoʻao maʻamau, e hoʻoponopono ana i loko o hoʻokahi a ʻelua paha lā ma hope o ka lapaʻau.

ʻO nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau:

• Nā hopena maʻi koʻikoʻi (anaphylaxis)
• Paʻakikī ka hanu ʻana a i ʻole ka paʻa ʻana o ka umauma
• Nā hopena ʻili koʻikoʻi a i ʻole ka ʻōpala ākea
• Ke kahe koko ʻano ʻē a i ʻole ka ʻeha
• Nā hōʻailona o ka maʻi ma nā wahi i hoʻokomo ʻia ai ka lāʻau

ʻO ka pilikia o nā hopena maʻi koʻikoʻi ke kumu e hāʻawi ʻia ai kēia lāʻau lapaʻau ma nā keʻena lapaʻau wale nō kahi e loaʻa koke ai ka lāʻau lapaʻau pilikia. Ua aʻo ʻia kāu hui mālama ola e ʻike a mālama koke i kēia mau hopena inā loaʻa.

ʻO wai ka mea pono ʻole e lawe iā Ecallantide?

ʻAʻole kūpono ʻo Ecallantide no nā mea a pau, a e loiloi pono kāu kauka inā ʻo ia ke koho kūpono no kāu kūlana kikoʻī. ʻAʻole pono ka poʻe i ʻike ʻia he maʻi i ka ecallantide a i ʻole kekahi o kāna mau mea pono e loaʻa i kēia lāʻau lapaʻau.

E mālama nui kāu mea mālama ola inā loaʻa iā ʻoe:

• He moʻolelo o nā hopena maʻi koʻikoʻi i nā lāʻau lapaʻau ʻē aʻe
• Nā maʻi ikaika a i ʻole ka ʻōnaehana pale i hoʻopilikia ʻia
• Nā maʻi kahe koko a i ʻole nā pilikia o ka hoʻopaʻa ʻana o ke koko
• Nā pilikia o ka puʻupaʻa a i ʻole ke akepaʻa
• Hāpai a i ʻole ke hānai ʻana i ka waiū

ʻAʻole pono nā keiki ma lalo o 12 mau makahiki e loaʻa iā ecallantide, no ka mea, ʻaʻole i hoʻokumu ʻia ka palekana a me ka pono i kēia pūʻulu makahiki. ʻAʻole i hoʻokumu piha ʻia ka palekana o ka lāʻau lapaʻau i ka wā hāpai a me ka hānai ʻana i ka waiū, no laila e kaupaona kāu kauka i nā pōmaikaʻi kūpono e kūʻē i nā pilikia.

Inoa Brand Ecallantide

ʻO ka inoa brand no ecallantide ʻo Kalbitor. ʻO kēia ka inoa kalepa āu e ʻike ai ma nā lepili kauoha a me nā moʻolelo lapaʻau ke kauoha ʻia kēia lāʻau lapaʻau no kāu mālama HAE.

Hana ʻia ʻo Kalbitor e kahi hui lāʻau lapaʻau kūikawā a loaʻa wale nō ma o nā keʻena mālama ola i lako e mālama i nā lāʻau lapaʻau pilikia. Hiki i kāu ʻinikua a me kahi mālama kikoʻī ke hoʻopilikia i ka loaʻa a me ke kumukūʻai.

Nā Koho ʻē aʻe o Ecallantide

He nui nā lāʻau lapaʻau ʻē aʻe e hiki ke mālama i nā hōʻeha HAE nui, a hiki i kāu kauka ke noʻonoʻo i nā koho ʻē aʻe e pili ana i kāu mōʻaukala olakino a me ka pane ʻana i ka lāʻau. Hana kēia mau koho ʻē aʻe ma o nā ʻano hana like ʻole akā manaʻo e hoʻokō i nā hopena like.

ʻO nā lāʻau lapaʻau hōʻeha HAE ʻē aʻe e komo pū ana:

• Icatibant (Firazyr) - he pahu hou e ālai ana i nā mea hoʻokipa bradykinin
• Human C1 esterase inhibitor concentrates - pani i ka protein nalowale i ka HAE
• Plasma hau hou - hoʻohana ʻia i nā kūlana pilikia ke loaʻa ʻole nā lāʻau lapaʻau ʻē aʻe
• Recombinant C1 esterase inhibitor - he mana i hana ʻia i ka genetically o ka protein nalowale

E kōkua kāu mea mālama ola e hoʻoholo i ke koho lapaʻau kūpono loa no kāu ʻano HAE a me nā kūlana olakino pilikino.

Ua ʻoi aku ka maikaʻi o Ecallantide ma mua o Icatibant?

He mau lāʻau lapaʻau maikaʻi ʻo Ecallantide a me icatibant no nā hōʻeha HAE, akā hana lākou ma o nā ʻano hana like ʻole a loaʻa nā pōmaikaʻi like ʻole. Aia ke koho ma waena o lākou i kāu kūlana olakino pilikino, ka paʻakikī o ka hōʻeha, a me ke ʻano o ka pane ʻana o kou kino i kēlā me kēia lāʻau.

Ke ālai nei ʻo Ecallantide i ka hana ʻana o ka bradykinin, ʻoiai ʻo icatibant e ālai i nā mea hoʻokipa bradykinin ma hope o ka hana ʻia ʻana o ka mea. Hiki i kekahi poʻe maʻi ke pane maikaʻi i kekahi ala ma mua o kekahi, a e noʻonoʻo kāu kauka i nā mea e like me kāu mau hiʻohiʻona hōʻeha a me ka mōʻaukala olakino.

ʻO ka ʻokoʻa nui i ka hana ʻana, hiki ke hoʻokele iā icatibant iā ia iho ma ka home ma hope o ke aʻo kūpono ʻana, ʻoiai pono e hāʻawi ʻia ʻo ecallantide i kahi keʻena mālama ola. Hana kēia i ka icatibant i mea maʻalahi no kekahi poʻe maʻi, akā ʻoi aku ka kūpono o ka ecallantide no nā hōʻeha nui e koi ana i ka nānā pono.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Ecallantide

He palekana ʻo Ecallantide no ka poʻe me ka maʻi puʻuwai?

Hiki ke hoʻohana ʻia ʻo Ecallantide i ka poʻe me ka maʻi puʻuwai, akā pono e hana pū kāu cardiologist a me ka loea HAE e hōʻoia i ka palekana no kou kūlana kikoʻī. ʻAʻole maʻamau ka lāʻau lapaʻau i nā pilikia puʻuwai pololei, akā hiki i ke koʻikoʻi o ka hoʻouka ʻana o HAE ke hoʻopilikia i kāu ʻōnaehana cardiovascular.

E nānā kāu hui mālama ola i kou puʻuwai a me ke koko i ka wā o ka mālama ʻana a hiki ke hoʻololi i kā lākou ala nānā inā he maʻi puʻuwai kou. E hōʻoia e haʻi i kāu mau kauka a pau e pili ana i kāu mōʻaukala olakino piha ma mua o ka loaʻa ʻana o kekahi lapaʻau HAE.

He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o ka Ecallantide?

No ka mea, hāʻawi ʻia ʻo ecallantide e nā poʻe loea olakino i nā keʻena lapaʻau, ʻaʻole hiki ke loaʻa ka overdose. Eia naʻe, inā manaʻo ʻoe ua loaʻa iā ʻoe kahi mahele hewa, e haʻi koke i kāu hui mālama ola i hiki iā lākou ke nānā pono iā ʻoe.

E nānā kāu hui lapaʻau i nā hōʻailona o ka piʻi ʻana o nā hopena ʻaoʻao a hiki ke hoʻolōʻihi i kāu manawa nānā ma hope o ka mālama ʻana. ʻAʻohe antidote kikoʻī no ka overdose ecallantide, no laila e kālele ana ka mālama ʻana i ka mālama ʻana i nā hōʻailona e ulu ana a me ka hāʻawi ʻana i ka mālama kākoʻo.

He aha kaʻu e hana ai inā haʻalele au i kahi lapaʻau Ecallantide i hoʻonohonoho ʻia?

Hāʻawi ʻia ʻo Ecallantide ma ke ʻano he lapaʻau hoʻokahi i ka wā o ka hoʻouka ʻana o HAE, no laila ʻaʻohe

ʻAʻole he lāʻau lapaʻau mau ʻo Ecallantide e hoʻomaka a hoʻōki e like me nā pila i kēlā me kēia lā. He lāʻau lapaʻau hoʻopakele i hāʻawi ʻia i ka wā o nā hoʻouka HAE pākahi, no laila ua pau kēlā me kēia lapaʻau ke loaʻa iā ʻoe ka mahele piha a ua nānā ʻia no kekahi mau hola.

ʻAʻole pono ʻoe e