He aha ʻo Eculizumab: Nā Hoʻohana, Nā Kumu, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

He lāʻau lapaʻau kūikawā ʻo Eculizumab e kōkua ana i ka mālama ʻana i kekahi mau maʻi koko a me nā maʻi kīkī ma ka pale ʻana i kahi ʻāpana o kāu ʻōnaehana pale. Hana kēia lāʻau lapaʻau ma ka hoʻopaʻa ʻana i kahi protein kikoʻī i loko o kāu ʻōnaehana hoʻopili, he ʻāpana o kāu ʻōnaehana pale maoli i kekahi manawa e hoʻouka ai i nā cell olakino me ka hewa.

Ke noʻonoʻo nei paha ʻoe i ke kumu i kauoha ai kāu kauka i kahi lāʻau lapaʻau paʻakikī. ʻO ka ʻoiaʻiʻo, ʻo eculizumab e hōʻike ana i kahi lapaʻau holomua no nā maʻi i paʻakikī loa i ka mālama ʻana, a hiki iā ia ke hana i kahi ʻokoʻa nui i kou ola.

He aha ʻo Eculizumab?

ʻO Eculizumab kahi antibody i hana ʻia i ka hale hana e hoʻohālike i nā protein pale maoli o kou kino. No ka papa o nā lāʻau lapaʻau i kapa ʻia he monoclonal antibodies, i hoʻolālā ʻia e hoʻopaʻa i nā ʻāpana kikoʻī loa o kāu ʻōnaehana pale me ka pololei.

Hoʻopaʻa kikoʻī kēia lāʻau lapaʻau i kahi protein i kapa ʻia ʻo C5 i loko o kāu ʻōnaehana hoʻopili. E noʻonoʻo i ka ʻōnaehana hoʻopili ma ke ʻano he ʻāpana o ka hui palekana o kou kino i kekahi manawa e huikau a hoʻomaka e hoʻouka i kāu mau cell olakino ponoʻī. E komo ʻo Eculizumab e hoʻomaha i kēia pane hana nui.

Hele mai ka lāʻau lapaʻau ma ke ʻano he wai maʻemaʻe, ʻaʻohe kala e pono e hāʻawi ʻia ma o ka IV infusion ma kahi haukapila a i ʻole ke keʻena lapaʻau. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ke ʻano he pill a i ʻole ka injection ma ka home no ka mea pono ia i ka nānā pono ʻana i ka wā e lawelawe ai.

No ke aha e hoʻohana ʻia ai ʻo Eculizumab?

Hoʻomaʻamaʻa ʻo Eculizumab i kekahi mau maʻi laha akā koʻikoʻi kahi e hoʻouka ai kāu ʻōnaehana pale i kāu mau cell koko a i ʻole nā ​​ʻōkana. Ua kauoha paha kāu kauka iā ia no kekahi o kēia mau maʻi kikoʻī e pili ana i ke ʻano o ka hana ʻana o kou koko a i ʻole ke ʻano o ka hana ʻana o kou mau puʻupaʻa.

ʻO nā maʻi maʻamau i mālama ʻia me ka eculizumab, ʻo ia ka paroxysmal nocturnal hemoglobinuria (PNH), he maʻi koko laha ʻole kahi e wāwahi koke ai nā ʻulaʻula koko. Hiki i kēia maʻi ke hana i ka anemia koʻikoʻi, nā ʻōpala koko, a me ka pōʻino o nā ʻōkana inā ʻaʻole mālama ʻia.

ʻO kekahi maʻi ʻo ka atypical hemolytic uremic syndrome (aHUS), e pili ana i kou mau puʻupaʻa a me nā kīʻaha koko. I kēia maʻi, hana nā ʻōpala koko liʻiliʻi ma kou kino a pau, e alakaʻi ana i ka hāʻule ʻana o ka puʻupaʻa a me nā pilikia koʻikoʻi ʻē aʻe.

Hoʻomaʻamaʻa pū ʻo Eculizumab i ka myasthenia gravis maʻamau, kahi maʻi e hoʻouka ai kou ʻōnaehana pale i ka pilina ma waena o kou mau aʻalolo a me nā ʻiʻo. Hiki i kēia ke hana i ka nāwaliwali o ka ʻiʻo a me nā pilikia hanu.

Eia kekahi, hiki i kāu kauka ke kuhikuhi i ka eculizumab no ka maʻi spectrum neuromyelitis optica (NMOSD), kahi maʻi laha ʻole e pili ana i kou iwi kuamoʻo a me nā aʻalolo optic, e hana ana i nā pilikia ʻike a me ka paralysis.

Pehea e hana ai ʻo Eculizumab?

Hana ʻo Eculizumab ma ka pale ʻana i kahi hana kikoʻī i loko o ke kaʻina hana hoʻopili o kou kino, e like me ke kau ʻana i ka wāwae ma luna o kahi pane pale nui. Ua manaʻo ʻia kēia lāʻau lapaʻau he koho lapaʻau i manaʻo nui ʻia a ikaika no nā maʻi e mālama ai.

Ke lilo kou ʻōnaehana hoʻopili i ka hana nui, hiki iā ia ke luku i nā ʻulaʻula koko olakino, hōʻino i nā kīʻaha koko, a i ʻole e hoʻouka i nā pilina nerve. Hoʻopili ʻo Eculizumab i ka protein C5 a pale iā ia mai ka māhele ʻana i nā ʻāpana liʻiliʻi e hana maʻamau i kēia pōʻino.

ʻAʻole e pani ka lāʻau lapaʻau i kāu ʻōnaehana pale holoʻokoʻa, akā e ālai i kahi ala kikoʻī e hana nei i nā pilikia. ʻO kēia ala i manaʻo ʻia e mālama mau ʻoe i ka hapa nui o kou hiki ke hakakā i ka maʻi maoli i ka wā e hoʻōki ai i ka hana autoimmune ʻino.

No ka mea he molekula protein nui ʻo eculizumab, pono e hāʻawi pololei ʻia i loko o kou kahe koko ma o ka IV. E wāwahi mālie kou kino a hoʻopau i ka lāʻau i ka manawa, ʻo ia ke kumu e pono ai ʻoe i nā infusions maʻamau e mālama i kāna mau hopena pale.

Pehea wau e lawe ai iā Eculizumab?

Hāʻawi mau ʻia ʻo Eculizumab ma ke ʻano he infusion intravenous ma kahi haukapila, keʻena lapaʻau, a i ʻole ke kikowaena infusion e nā poʻe loea lapaʻau i aʻo ʻia. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau ma ka home, a pono ia i ka nānā pono ʻana i kēlā me kēia kau lapaʻau.

Ma mua o ka hoʻomaka ʻana i ka lapaʻau, e hāʻawi paha kāu kauka iā ʻoe i nā lāʻau lapaʻau e pale aku i kekahi mau maʻi bacteria, ʻo ia hoʻi ka maʻi meningococcal. He mea nui kēia no ka mea hiki i ka eculizumab ke hoʻolilo iā ʻoe i mea maʻalahi i kēia mau ʻano maʻi.

I ka wā o ka infusion, e noho maʻamau ʻoe i kahi noho ʻoluʻolu i ka wā e kahe mālie ai ka lāʻau lapaʻau i loko o kou vein ma o ka laina IV. ʻO ka maʻamau, lawe ʻia kēlā me kēia infusion ma kahi o 2 a 4 mau hola, ma muli o kāu mahele kikoʻī a me ka maikaʻi o kou ʻae ʻana i ka lapaʻau.

ʻAʻole pono ʻoe e pale i ka meaʻai a i ʻole ka inu ʻana ma mua o kāu infusion, akā he manaʻo maikaʻi e noho maikaʻi i ka wai a ʻai maʻamau. Manaʻo kekahi poʻe he mea kōkua ke lawe mai i nā mea ʻai māmā, wai, a i ʻole nā mea leʻaleʻa e like me nā puke a i ʻole nā papa e hana i ka manawa e hala me ka ʻoluʻolu.

E nānā pono kāu hui mālama ola iā ʻoe i ka wā a ma hope o kēlā me kēia infusion no nā hōʻailona o nā hopena maʻi a i ʻole nā hopena ʻaoʻao. E nānā lākou i kāu mau hōʻailona koʻikoʻi i nā manawa maʻamau a nīnau pehea ʻoe e manaʻo nei i ke kaʻina hana.

Pehea ka lōʻihi e lawe ai au iā Eculizumab?

Pono ka hapa nui o ka poʻe e hoʻomaka ana iā eculizumab e hoʻomau i ka lawe ʻana iā ia no ka manawa pau ʻole e mālama i ka mana o ko lākou maʻi. Mālama kēia lāʻau i kāu mau hōʻailona ma mua o ka hoʻōla ʻana i ka maʻi maʻi, no laila ʻo ka hoʻōki ʻana i ka lapaʻau ʻo ia hoʻi e hoʻi mai kāu mau hōʻailona.

E hoʻomaka maʻamau kāu kauka me nā infusions i kēlā me kēia pule no ka mahina mua, a laila e hoʻokomo ʻia i kēlā me kēia pule ʻelua no ka mālama mau. Kōkua kēia papa manawa i ka hana ʻana i ka lāʻau lapaʻau i loko o kou kino a laila mālama i nā pae pale.

ʻO ka hoʻoholo e hoʻomau a hooki paha i ka eculizumab e pili ana i ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau a inā paha e loaʻa iā ʻoe kekahi hopena ʻaoʻao koʻikoʻi. ʻIke kekahi poʻe i nā hoʻomaikaʻi nui ʻana i kā lākou mau hōʻailona i loko o nā pule, ʻoiai paha e pono nā poʻe ʻē aʻe i kekahi mau mahina e ʻike i nā pōmaikaʻi piha.

E kōkua nā hoʻokolohua koko maʻamau i kāu kauka e nānā i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau a inā pono e hana i nā hoʻoponopono. Kōkua kēia mau hoʻokolohua i ka hōʻoia ʻana e mālama pono ana ka eculizumab i kou maʻi me ka ʻole o ka pilikia ʻē aʻe.

Inā pono ʻoe e hooki i ka eculizumab, e hana pū kāu kauka me ʻoe e hoʻomohala i kahi hoʻolālā nānā pono. Hiki i ka hooki ʻana i ka hikiwawe ke alakaʻi i ka hoʻihoʻi wikiwiki ʻana o nā hōʻailona, ​​no laila pono kēia hoʻoholo i ka mālama olakino kokoke.

He aha nā hopena ʻaoʻao o Eculizumab?

E like me nā lāʻau lapaʻau a pau, hiki i ka eculizumab ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia ke hoʻoponopono ko lākou kino i ka lāʻau lapaʻau. ʻO ka mea nui e hoʻomaopopo ai, e nānā pono kāu hui mālama ola iā ʻoe e hopu a mālama i nā pilikia i ka wā mua.

ʻO ka hopohopo nui loa me ka eculizumab he piʻi nui o kekahi mau maʻi bacteria, ʻo ia hoʻi ka maʻi meningococcal. Hana ʻia kēia no ka mea e ālai ana ka lāʻau lapaʻau i kahi ʻāpana o kāu ʻōnaehana pale e kōkua maʻamau i ka hakakā ʻana i kēia mau bacteria.

ʻO nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike:

• ʻO ka ʻeha o ke poʻo, e maikaʻi pinepine ana i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau
• ʻO ka nausea a i ʻole ka ʻoluʻolu ʻole o ka ʻōpū, ʻoi loa ma hope o nā infusions mua
• ʻO ka luhi a i ʻole ka manaʻo e luhi ana ma mua o ka maʻamau
• Nā maʻi o ka ʻōnaehana hanu luna e like me ke anu a i ʻole nā maʻi sinus
• ʻO ka ʻeha o ke kua a i ʻole nā ʻeha ʻiʻo
• ʻO ka maʻi palahī a i ʻole nā loli i nā neʻe ʻana o ka ʻōpū

He maʻalahi maʻamau kēia mau hopena ʻaoʻao a ʻaʻole e pilikia hou i ka wā e hoʻomau ai ʻoe i ka lāʻau lapaʻau. Hiki i kāu hui mālama ola ke hōʻike i nā ala e mālama ai i kēia mau hōʻailona inā pilikia lākou.

Loaʻa i kekahi poʻe nā hopena infusion i ka wā a i ʻole ma hope koke o ka loaʻa ʻana o ka eculizumab. Hiki i kēia mau hopena ke komo i ke kuni, nā anu, ka nausea, a i ʻole ka manaʻo e ʻulaʻula ana. E nānā kāu hui lapaʻau i kēia mau hopena a hiki ke hoʻolohi i ka infusion a i ʻole e hāʻawi i nā lāʻau lapaʻau e kōkua inā pono.

ʻO nā hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi hiki ke komo i nā maʻi koʻikoʻi, nā loli i ke koko, a i ʻole nā hopena maʻi. E kūkākūkā kāu hui mālama ola i kēia mau pilikia me ʻoe a wehewehe i nā hōʻailona hōʻailona e nānā ai ma waena o nā lāʻau lapaʻau.

He mea nui e hoʻokaʻaʻike koke i kāu kauka inā loaʻa iā ʻoe ke kuni, ka ʻeha nui o ke poʻo, ka ʻoʻoleʻo o ka ʻāʻī, a i ʻole nā hōʻailona o ka maʻi koʻikoʻi. Hiki i kēia mau mea ke hōʻailona o nā maʻi bacteria e ʻoi aku ka maikaʻi o ka eculizumab.

ʻO wai ka mea ʻaʻole pono e lawe i ka Eculizumab?

ʻAʻole kūpono ka Eculizumab no nā mea a pau, a e nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana i kēia lāʻau lapaʻau. ʻO ka mea nui e noʻonoʻo ai inā he maʻi maʻi kou, ʻoi loa nā maʻi bacteria e hiki ke lilo i mea koʻikoʻi.

ʻAʻole pono ʻoe e loaʻa i ka eculizumab inā loaʻa iā ʻoe ka maʻi meningococcal a i ʻole kekahi maʻi bacteria koʻikoʻi. Pono e mālama ʻia kēia mau maʻi ma mua o ka hoʻomaka ʻana i kēia lāʻau lapaʻau, no ka mea, hiki i ka eculizumab ke hoʻonui iā lākou.

ʻO ka poʻe i hiki ʻole ke loaʻa i nā lāʻau lapaʻau meningococcal ke kū nei i nā pilikia me ka mālama ʻana i ka eculizumab. Ma muli o ka mea nui o ka lāʻau lapaʻau, pono i kāu kauka e loiloi pono i nā pilikia a me nā pōmaikaʻi inā ʻaʻole hiki ke hāʻawi ʻia iā ʻoe ka lāʻau lapaʻau.

Inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, pono ʻoe e kūkākūkā pono i kēia me kāu kauka. ʻOiai hiki ke hoʻohana ʻia ka eculizumab i ka wā hāpai i kekahi mau hihia, pono ia i ka nānā pono ʻana a me ka noʻonoʻo ʻana i nā pilikia iā ʻoe a me kāu pēpē.

ʻO ka poʻe me kekahi mau pilikia o ka ʻōnaehana pale a i ʻole ka poʻe e lawe ana i nā lāʻau lapaʻau ʻē aʻe e kāohi ana i ka palekana e pono ai i ka nānā kūikawā a i ʻole nā hoʻoponopono ʻana i ka lāʻau. E nānā kāu kauka i nā lāʻau lapaʻau a pau āu e lawe nei i kēia manawa e nānā i nā pilina hiki.

Inā he moʻolelo kou o nā hopena maʻi koʻikoʻi i nā antibodies monoclonal ʻē aʻe a i ʻole kekahi mau mea o ka eculizumab, ʻaʻole palekana paha kēia lāʻau lapaʻau iā ʻoe. E kūkākūkā kāu kauka i nā koho lapaʻau ʻē aʻe inā pēlā.

Nā inoa inoa o Eculizumab

Loaʻa ka Eculizumab ma lalo o ka inoa inoa ʻo Soliris, ʻo ia ka mea i hana mua ʻia e loaʻa ana i ka hapa nui o nā kānaka. Ua hoʻohana ʻia kēia inoa no nā makahiki he nui a he nui nā noiʻi e kākoʻo ana i kona palekana a me ka pono.

Loaʻa nō hoʻi kahi hana hou i kapa ʻia ʻo Ultomiris (ravulizumab) a hana like me ka eculizumab. ʻOi aku ka lōʻihi o ka Ultomiris i kou kino, no laila pono ʻoe i nā infusions i ka liʻiliʻi - maʻamau i kēlā me kēia 8 pule ma kahi o kēlā me kēia 2 pule.

Hana nā lāʻau lapaʻau ʻelua ma ka pale ʻana i ka protein like i kāu ʻōnaehana hoʻopiha, akā ʻoi aku ka maʻalahi o ka mana lōʻihi no kekahi poʻe. E kōkua kāu kauka iā ʻoe e hoʻoholo i ka mea maikaʻi loa e pili ana i kou kūlana a me nā pono o ke ola.

Nā koho ʻē aʻe o Eculizumab

ʻO nā lapaʻau ʻē aʻe no nā maʻi i mālama ʻia me ka eculizumab e hilinaʻi ana i kāu maʻi kikoʻī a me ke koʻikoʻi o kāu mau hōʻailona. No kekahi mau maʻi, ʻo nā lāʻau lapaʻau immunosuppressive ʻē aʻe a i ʻole ka mālama kākoʻo paha he mau koho, ʻoiai ʻaʻole paha lākou e like ka maikaʻi.

No ka paroxysmal nocturnal hemoglobinuria (PNH), hiki i nā koho ʻē aʻe ke komo i nā hoʻoili koko, nā mea hoʻohui waikawa folic, a i ʻole nā ​​lapaʻau kākoʻo ʻē aʻe. Eia naʻe, ʻo kēia mau koho e mālama maʻamau i nā hōʻailona ma mua o ka hoʻoponopono ʻana i ke kumu kumu e like me ka eculizumab.

Inā loaʻa iā ʻoe ka atypical hemolytic uremic syndrome (aHUS), hiki ke noʻonoʻo ʻia ka hoʻololi plasma a i ʻole nā ​​lāʻau immunosuppressive ʻē aʻe. Hiki i kēia mau lapaʻau ke kōkua akā pono pinepine i ka nānā pinepine ʻana a loaʻa paha nā hopena ʻaoʻao hou aku.

No ka myasthenia gravis, nā koho ʻē aʻe e komo pū ana me nā lāʻau lapaʻau e like me ka pyridostigmine, corticosteroids, a i ʻole nā ​​lāʻau immunosuppressive ʻē aʻe. Loaʻa kekahi poʻe i nā kaʻina hana e like me ka plasmapheresis a i ʻole ka ʻoki thymectomy.

ʻO ka hoʻoholo e pili ana i nā koho ʻē aʻe e hilinaʻi ana i nā mea he nui, me ka maikaʻi o kāu pane ʻana i ka eculizumab, nā hopena ʻaoʻao āu e ʻike ai, a me kou olakino holoʻokoʻa. E hana kāu kauka me ʻoe e ʻimi i ke ala lapaʻau maikaʻi loa no kāu kūlana kikoʻī.

Ua ʻoi aku ka maikaʻi o Eculizumab ma mua o nā mea hoʻopaʻa Complement ʻē aʻe?

ʻO Eculizumab ka mea hoʻopaʻa complement mua i ʻae ʻia no ka mālama ʻana i kēia mau maʻi laha, a ʻo ia ka noiʻi nui a me ka ʻike lapaʻau ma hope ona. Kōkua kēia moʻolelo nui i nā kauka e wānana i ka maikaʻi o kāna hana a me nā hopena ʻaoʻao e manaʻo ai.

Hoʻohālikelike ʻia i nā mea hoʻopaʻa complement hou e like me ravulizumab (Ultomiris), hana ʻo eculizumab ma ke ʻano like akā pono i ka hoʻohana pinepine ʻana. Loaʻa i nā lāʻau lapaʻau ʻelua nā ʻano like a me nā palekana, no laila e iho pinepine ka koho i ka maʻalahi a me ka makemake pilikino.

Ua manaʻo ʻia kekahi mau mea pale i ka complement hou i nā ʻāpana like ʻole o ka ʻōnaehana complement a i ʻole hiki ke hāʻawi ʻia ma ke ʻano he injections ma lalo o ka ʻili ma mua o nā infusions IV. Hiki i kēia mau koho ke kūpono no kekahi poʻe, akā ʻaʻole paha lākou e kūpono no nā kūlana a pau.

ʻO ka mea pale complement

Hiki i kāu kauka ke ʻōlelo aku e kiʻi i ka lāʻau i hala i ka hiki wawe, a laila e hoʻoponopono i kāu papa manawa e hoʻi i ke ala. I kekahi mau hihia, pono paha lākou e nānā i kāu pae koko e ʻike inā pono ʻoe e hoʻoponopono i kāu hoʻolālā lapaʻau.

Mai ho'āʻo e

Inā pono ʻoe e hooki i ka eculizumab, makemake paha kāu kauka e nānā pono iā ʻoe me nā hoʻokolohua koko pinepine a me nā koho lapaʻau. Hiki nō hoʻi iā lākou ke kūkākūkā i nā lāʻau lapaʻau ʻē aʻe e kōkua i ka mālama ʻana i kou maʻi.

Mai hooki i ka lawe ʻana i ka eculizumab ma kou iho, ʻoiai inā ʻoe e maikaʻi ana. Ke mālama nei ka lāʻau i kāu mau hōʻailona, ʻaʻole e hoʻōla i kou maʻi, no laila ʻo ka hooki ʻana i ka lapaʻau e manaʻo pinepine ai e hoʻi mai kāu mau hōʻailona.

Hiki iaʻu ke huakaʻi i ka wā e lawe ana i ka Eculizumab?

ʻAe, hiki iā ʻoe ke huakaʻi i ka wā e lawe ana i ka eculizumab, akā pono ia i kekahi hoʻolālā e hōʻoia ʻaʻole ʻoe e nalo i nā lāʻau lapaʻau a loaʻa ke komo ʻana i ka mālama olakino inā pono. Hiki i kāu hui mālama ola ke kōkua iā ʻoe e hoʻolālā i ka huakaʻi a puni kāu papa hana infusion.

No nā huakaʻi lōʻihi, pono paha ʻoe e hoʻonohonoho i nā infusions eculizumab ma kahi keʻena lapaʻau kokoke i kāu huakaʻi. Hiki i kāu kauka ke kōkua i ka hoʻonohonoho ʻana i kēia a hāʻawi i nā moʻolelo olakino e pono ai nā mea lawelawe mālama ola ʻē aʻe.

E hōʻoia e lawe i nā lako hou o nā lāʻau lapaʻau ʻē aʻe āu e lawe ai, a lawe i kahi hōʻuluʻulu olakino e wehewehe ana i kou maʻi a me ka lapaʻau. Hiki i kēia ʻike ke kōkua inā pono ʻoe i ka mālama olakino i ka wā e huakaʻi ana.

E noʻonoʻo i ka ʻinikua huakaʻi e uhi ana i nā pilikia olakino, ʻoiai inā ʻoe e huakaʻi ana ma ka honua. ʻO ka loaʻa ʻana o ka uhi ʻana no nā pono olakino i manaʻo ʻole ʻia hiki ke hāʻawi i ka maluhia o ka noʻonoʻo i ka wā o kāu huakaʻi.