He aha ʻo Edaravone: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Edaravone i hāʻawi ʻia ma o ka laina IV (intravenous) e kōkua i ka hoʻolohi ʻana i ka holomua o ALS, i ʻike ʻia ʻo ka maʻi o Lou Gehrig. Hana kēia lāʻau lapaʻau ma ke ʻano he antioxidant ikaika, ʻo ia hoʻi, kōkua ia i ka pale ʻana i kāu mau cell nerve mai ka pōʻino i hana ʻia e nā molekala ʻino i kapa ʻia he radical manuahi.

Inā ua ʻike ʻia ʻoe a i ʻole kekahi āu e mālama nei me ALS, hiki ke manaʻo nui ka aʻo ʻana e pili ana iā edaravone. ʻO ka nūhou maikaʻi, ʻo kēia lāʻau lapaʻau e hōʻike ana i ka manaʻolana - ua hoʻolālā kūikawā ʻia e kōkua i ka mālama ʻana i ka hana o nā neurons kaʻa, nā cell nerve e hoʻomalu i kou mau ʻiʻo.

He aha ʻo Edaravone?

He lāʻau lapaʻau neuroprotective ʻo Edaravone e pili ana i kahi papa o nā lāʻau i kapa ʻia he scavengers radical manuahi. E noʻonoʻo iā ia he pale e kōkua ana i ka pale ʻana i kāu mau cell nerve mai ke kaumaha oxidative - kahi ʻano o ka pōʻino cellular e pāʻani nui i ka holomua o ALS.

Ua hoʻomohala mua ʻia ka lāʻau lapaʻau ma Iapana no ka mālama ʻana i nā maʻi hahau. Ua ʻike nā mea noiʻi i nā hopena pale like i loaʻa iā ia ma nā cell lolo hiki ke pōmaikaʻi i ka poʻe me ALS. Ua ʻae ʻo FDA iā edaravone no ka mālama ʻana iā ALS i ka makahiki 2017, e lilo ana ia i ka lāʻau lapaʻau ʻelua i ʻae ʻia no kēia maʻi.

ʻAʻole kēia he lāʻau lapaʻau no ALS, akā hiki ke kōkua i ka hoʻolohi ʻana i ka holomua o ka maʻi i kekahi mau maʻi. E hoʻoholo kāu kauka inā he moho maikaʻi ʻoe e pili ana i kou kūlana kikoʻī a me ka wā mua o ke kaʻina o ka maʻi.

No ke aha e hoʻohana ʻia ai ʻo Edaravone?

Ua ʻae ʻia ʻo Edaravone no ka mālama ʻana i ka amyotrophic lateral sclerosis (ALS), kahi maʻi neurodegenerative holomua e pili ana i nā cell nerve i kou lolo a me ke kuamoʻo. Hoʻonāwaliwali mālie ʻo ALS i nā ʻiʻo ma kou kino, e pili ana i kou hiki ke neʻe, ʻōlelo, ʻai, a ma hope e hanu.

He hana maikaʻi ka lāʻau lapaʻau ke hoʻomaka koke ʻia i ka wā o ka maʻi. E ʻōlelo maʻamau kāu kauka iā edaravone inā he ALS maopopo a i ʻole paha kāu a aia nō ʻoe i nā pae mua. Hōʻike nā haʻawina hiki iā ia ke kōkua i ka mālama ʻana i kou hiki ke hana i kēlā me kēia lā no ka manawa lōʻihi ke hoʻohālikelike ʻia me ka mālama ʻole.

ʻAʻole e pōmaikaʻi nā mea a pau me ALS mai edaravone. E loiloi kāu hui mālama ola i nā mea e like me ka wikiwiki o ka holomua o kāu maʻi, ke olakino holoʻokoʻa, a me ka hiki ke ʻae i nā lāʻau IV ma mua o ka ʻōlelo ʻana i kēia lāʻau.

Pehea e hana ai ʻo Edaravone?

Hana ʻo Edaravone ma ka hopu ʻana a me ka hoʻopau ʻana i nā radical manuahi - nā molekala paʻa ʻole e hiki ke hōʻino i kāu mau cell nerve. I ka ALS, kūkulu kēia mau radical manuahi a kōkua i ka make ʻana o nā neurons kaʻa, nā cell kūikawā e hoʻomalu i kou mau ʻiʻo.

Ua manaʻo ʻia kēia lāʻau lapaʻau he mea pale neuroprotective ikaika. ʻAʻole ia e hoʻōki loa i ka ALS, akā hiki iā ia ke hoʻolohi i ka pōʻino cellular e alakaʻi ana i ka maʻi i mua. E noʻonoʻo e like me ka hoʻopili ʻana i ka pale lā - ʻaʻole ia e pale i nā pōʻino o ka lā, akā hoʻemi nui ia.

Kōkua pū ka lāʻau lapaʻau i ka hōʻemi ʻana i ka mumū i loko o kāu ʻōnaehana nerve a hiki ke hoʻomaikaʻi i ka hana o mitochondria, nā hale mana liʻiliʻi i loko o kāu mau cell. Ma ka pale ʻana i kēia mau hale cellular, kōkua ʻo edaravone i kāu mau neurons kaʻa e noho olakino no nā manawa lōʻihi.

Pehea wau e lawe ai iā Edaravone?

Hāʻawi ʻia ʻo Edaravone ma o ka IV infusion wale nō ma kahi keʻena lapaʻau - ʻaʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka home ma ka waha. E hahai ana ka lapaʻau i kahi ʻano pōʻaiapuni kikoʻī e hoʻololi ana ma waena o nā manawa lapaʻau a me nā manawa hoʻomaha.

Eia ke ʻano o ka papa hana lapaʻau maʻamau:

• Pōʻai mua: Nā hoʻokomo IV i kēlā me kēia lā no 14 mau lā, a laila 14 mau lā hoʻomaha
• Nā pōʻai e hiki mai ana: Nā hoʻokomo IV i kēlā me kēia lā no 10 mau lā o kēlā me kēia manawa 14-lā, a laila 14 mau lā hoʻomaha
• Lawe ka hoʻokomo ʻana ma kahi o 60 mau minuke e hoʻopau ai
• Pono ʻoe e kipa i kahi keʻena lapaʻau a i ʻole ke kikowaena hoʻokomo no kēlā me kēia lapaʻau

ʻAʻole pono ʻoe e ʻai i kekahi mea kūikawā ma mua o kāu hoʻokomo ʻana, akā ʻo ka noho ʻana i ka wai e kōkua i kou kino e hana i ka lāʻau lapaʻau me ka maikaʻi. Manaʻo kekahi poʻe he mea kōkua ke lawe mai i kahi puke a i ʻole papa e hala ai ka manawa i ka wā o ka hoʻokomo ʻana i hoʻokahi hola.

E nānā kāu hui mālama ola iā ʻoe i ka wā o kēlā me kēia hoʻokomo ʻana e nānā i nā hopena ʻaoʻao. E nānā pū lākou i kāu mau hōʻailona ALS i ka manawa e ʻike ai i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau iā ʻoe.

Pehea ka lōʻihi e lawe ai au i ka Edaravone?

He ʻokoʻa ka lōʻihi o ka lapaʻau edaravone mai kēlā me kēia kanaka a hilinaʻi i ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau. Hoʻomau ka hapa nui o ka poʻe i ka lapaʻau inā e pōmaikaʻi ana lākou mai ia mea a hiki ke ʻae i nā hopena ʻaoʻao.

E loiloi kāu kauka i kāu holomua i kēlā me kēia mau mahina me ka hoʻohana ʻana i nā unahi helu ALS maʻamau. Kōkua kēia mau loiloi e hoʻoholo inā e lohi ana ka lāʻau lapaʻau i ka holomua o kou maʻi. Inā e hōʻike ana ʻoe i nā pōmaikaʻi maopopo, e ʻōlelo paha kāu hui mālama ola e hoʻomau i ka lapaʻau.

Lawe kekahi poʻe i ka edaravone no nā mahina he nui a i ʻole nā makahiki, a ʻo nā mea ʻē aʻe e pono e hooki koke ma muli o nā hopena ʻaoʻao a i ʻole ka holomua o ka maʻi. Pono e hana mau ka hoʻoholo e hoʻomau a hooki paha i ka lapaʻau me kāu hui mālama ola, me ka noʻonoʻo ʻana i kou maikaʻi o ke ola a me nā pahuhopu lapaʻau.

He aha nā hopena ʻaoʻao o Edaravone?

E like me nā lāʻau lapaʻau a pau, hiki i ka edaravone ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā mea a pau iā lākou. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a hilinaʻi i kāu lapaʻau.

He maʻalahi a hiki ke mālama ʻia nā hopena ʻaoʻao maʻamau:

• Ka ʻeha a i ʻole ka pehu ʻana ma kahi o ka IV
• ʻEha poʻo
• Pāpaʻa ʻili a i ʻole ka ʻū
• Luaʻi a i ʻole ka ʻōpū
• Pōniuniu a i ʻole ka māmā
• Luhi ma hope o ka lapaʻau

Hoʻomaikaʻi maʻamau kēia mau hopena ʻaoʻao i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Hiki i kāu hui mālama ola ke hōʻike i nā ala e mālama ai iā lākou, e like me ka hoʻopili ʻana i ka hau i ka pūnaewele IV a i ʻole ka lawe ʻana i nā lāʻau no ka luaʻi.

ʻAʻole maʻamau nā hopena ʻaoʻao koʻikoʻi, akā pono lākou i ka lāʻau lapaʻau koke:

• Nā hopena maʻi maʻi koʻikoʻi (paʻakikī ka hanu ʻana, ka pehu ʻana o ka maka a i ʻole ka ʻāʻī)
• Nā loli nui i ka hana o ka puʻupaʻa
• Nā hopena ʻili koʻikoʻi a i ʻole ka pāpaʻa ākea
• Ke kahe koko a i ʻole ka ʻeha maʻamau
• Nā hōʻailona o ka maʻi ma kahi o ka IV (hoʻonui ʻia ka ʻulaʻula, ka mahana, a i ʻole ka ʻōpala)

E nānā pono kāu hui lapaʻau iā ʻoe no kēia mau hopena koʻikoʻi. E nānā lākou i ka hana o kou puʻupaʻa maʻamau ma o nā hoʻokolohua koko a nānā i nā hōʻailona o nā hopena maʻi maʻi i ka wā o kāu infusions.

ʻO wai ka mea pono ʻole e lawe iā Edaravone?

ʻAʻole kūpono ʻo Edaravone no nā mea a pau me ALS. E loiloi pono kāu kauka inā kūpono kēia lāʻau lapaʻau iā ʻoe ma muli o kekahi mau mea nui.

ʻAʻole pono ʻoe e lawe iā edaravone inā loaʻa iā ʻoe:

• He maʻi maʻi i ʻike ʻia iā edaravone a i ʻole kekahi o kāna mau meaʻai
• Maʻi puʻupaʻa koʻikoʻi a i ʻole ka maʻi puʻupaʻa
• He moʻolelo o nā hopena maʻi maʻi koʻikoʻi i nā lāʻau IV
• ALS holomua kahi i manaʻo ʻole ai ka lāʻau lapaʻau e hāʻawi i ka pōmaikaʻi
• Nā ʻano ALS i pane ʻole maikaʻi iā edaravone i nā haʻawina

E noʻonoʻo pū kāu kauka i kou kūlana olakino holoʻokoʻa, me ka hana o kou puʻuwai, ke olakino o ke akepaʻa, a me ka hiki ke ʻae i nā lapaʻau IV maʻamau. Inā hāpai ʻoe a i ʻole e hānai ana i ka umauma, pono e kūkākūkā pono ʻia nā pilikia a me nā pōmaikaʻi me kāu hui mālama ola.

ʻAʻole e hōʻole wale ka makahiki iā ʻoe mai ka mālama ʻana iā edaravone, akā pono paha nā mākua kahiko i ka nānā pono ʻana ma muli o ka piʻi ʻana o ka naʻau i nā lāʻau a me ka piʻi ʻana o ka pilikia o nā hopena ʻaoʻao.

Inoa Brand Edaravone

Kūʻai ʻia ʻo Edaravone ma lalo o ka inoa brand Radicava ma ʻAmelika Hui Pū ʻIa. Hana ʻia ka lāʻau lapaʻau e Mitsubishi Tanabe Pharma a ʻo ia ka lāʻau lapaʻau ALS hou mua i ʻae ʻia e ka FDA i loko o 20 mau makahiki.

Hiki paha iā ʻoe ke ʻike iā ia e pili ana i kona inoa generic, edaravone, i nā palapala lapaʻau a i ʻole nā palapala ʻinikua. E pili ana nā inoa ʻelua i ka lāʻau lapaʻau like me ka mea hana like.

No ka huaʻōlelo

Ua ʻoi aku ka maikaʻi o Edaravone ma mua o Riluzole?

Hana ʻo Edaravone a me riluzole ma nā ʻano hana like ʻole, no laila ʻaʻole hiki ke hoʻohālikelike pololei ʻia – e noʻonoʻo iā lākou he mau mea hana like ʻole i kāu pahu hana lapaʻau ma mua o nā koho hoʻokūkū. Nui nā kauka e ʻōlelo nei e hoʻohana i nā lāʻau ʻelua i ka wā kūpono.

Ua lōʻihi ka riluzole a loaʻa nā ʻikepili noiʻi nui aʻe. Lawe ʻia ia ma ke ʻano he pila ʻelua i ka lā, e maʻalahi ai ma mua o nā infusions IV o edaravone. Eia naʻe, hiki i ka edaravone ke hāʻawi i nā pōmaikaʻi ʻaʻole i hāʻawi ʻia e riluzole ma muli o kāna ʻano hana like ʻole.

Hōʻike nā haʻawina e hiki i ka edaravone ke ʻoi aku ka maikaʻi i ka mālama ʻana i nā hiki ke hana i kēlā me kēia lā, ʻoiai ʻo riluzole ke ʻoi aku ka maikaʻi i ka hoʻolōʻihi ʻana i ka manawa ola holoʻokoʻa. E kōkua kāu kauka iā ʻoe e hoʻomaopopo i ka lāʻau lapaʻau a i ʻole ka hui pū ʻana o nā lāʻau lapaʻau e kūpono loa i kāu kūlana.

Aia ke koho ma waena o kēia mau lāʻau lapaʻau i nā mea e like me ke kahua o kou maʻi, ka hiki ke ʻae i nā lāʻau IV, ka ʻinikua, a me nā makemake pilikino e pili ana i ka maʻalahi o ka lapaʻau me nā pōmaikaʻi.

Nā Nīnau i Nīnau Pinepine e pili ana iā Edaravone

He palekana anei ʻo Edaravone no ka poʻe me ka maʻi puʻuwai?

Hiki ke hoʻohana maʻamau ʻia ʻo Edaravone me ka palekana i ka poʻe me ka maʻi puʻuwai, akā pono kāu cardiologist a me ka neurologist e hana pū e nānā pono iā ʻoe. ʻAʻole pili pololei ka lāʻau lapaʻau i ka hana o ka puʻuwai, akā hoʻohui nā infusions IV i ka wai i kāu ʻōnaehana.

Inā loaʻa iā ʻoe ka puʻuwai ʻole a i ʻole nā ​​kūlana ʻē aʻe kahi e pilikia ai ka wai hou, e nānā pono kāu hui mālama ola iā ʻoe i ka wā o nā infusions. Hiki iā lākou ke hoʻoponopono i ka helu infusion a i ʻole e ʻōlelo i nā lāʻau lapaʻau hou e kōkua i kou kino e mālama i ka wai hou.

Ma mua o ka hoʻomaka ʻana iā edaravone, e hōʻoia i kāu kauka e pili ana i nā maʻi puʻuwai, nā lāʻau lapaʻau koko, a i ʻole ka mōʻaukala o nā pilikia o ka puʻuwai. Kōkua kēia ʻike iā lākou e hāʻawi i ka mālama palekana loa.

He aha kaʻu e hana ai inā ua hala au i kahi mahele o Edaravone?

Inā ua hala ʻoe i kahi hoʻokomo edaravone i hoʻonohonoho ʻia, e hoʻokaʻaʻike i kāu hui mālama ola i ka hiki wawe e hoʻonohonoho hou. Mai ho'āʻo e "hopu" ma ka hoʻonohonoho ʻana i nā hoʻokomo keu - hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao me ka hāʻawi ʻole ʻana i nā pōmaikaʻi hou.

E kōkua kāu hui lapaʻau iā ʻoe e hoʻoholo i ke ala maikaʻi loa e hoʻi ai i ke ala me kāu papa hana lapaʻau. I ka hapanui o nā hihia, e hoʻomau wale lākou me kāu ʻano pōʻai maʻamau mai kahi āu i haʻalele ai.

ʻO ka hala ʻana i hoʻokahi a ʻelua paha hoʻokomo i kekahi manawa ʻaʻole ia e hoʻopilikia nui i ka pono o kāu lapaʻau. Eia naʻe, ʻo ka hala mau ʻana i nā lapaʻau hiki ke hōʻemi i ka hiki o ka lāʻau lapaʻau e hoʻolohi i ka holomua o ka maʻi, no laila he mea nui e mālama i ka lapaʻau mau i ka wā hiki.

He aha kaʻu e hana ai inā loaʻa iaʻu nā hopena ʻaoʻao i ka wā o ka hoʻokomo ʻana?

Inā loaʻa iā ʻoe kekahi mau hōʻailona ʻoluʻolu ʻole i ka wā o kāu hoʻokomo edaravone, e haʻi koke i kāu hui mālama ola. Ua aʻo ʻia lākou e ʻike a mālama i nā hopena ʻaoʻao e pili ana i ka hoʻokomo ʻana me ka wikiwiki a me ka maikaʻi.

Hiki ke mālama pinepine ʻia nā hopena maʻamau e like me ka nausea maʻalahi, ke poʻo, a i ʻole ka ʻūlū ma ka hoʻolohi ʻana i ka helu hoʻokomo a i ʻole ka hāʻawi ʻana iā ʻoe i nā lāʻau lapaʻau e kōkua i nā hōʻailona. Hiki nō hoʻi i kāu hui lapaʻau ke hāʻawi i nā wai IV e kōkua iā ʻoe e ʻoi aku ka maikaʻi.

No nā hopena koʻikoʻi e like me ka pilikia o ka hanu ʻana, ka ʻūlū nui, a i ʻole ka ʻeha o ka umauma, e hoʻōki koke kāu hui mālama ola i ka hoʻokomo ʻana a hāʻawi i ka lāʻau lapaʻau kūpono. E hana pū lākou me kāu kauka e hoʻoholo inā palekana ke hoʻomau i ka lapaʻau edaravone i ka wā e hiki mai ana.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Edaravone?

ʻO ka hoʻoholo e hooki i ka edaravone e hana mau ʻia me kāu hui mālama ola ma hope o ka noʻonoʻo pono ʻana i kāu kūlana pilikino. ʻAʻohe manawa i hoʻonohonoho mua ʻia i ka wā e pono ai ʻoe e hooki i ka lapaʻau inā e ʻae maikaʻi ana ʻoe a e hōʻike ana i nā pōmaikaʻi.

Hiki paha iā ʻoe ke noʻonoʻo e hooki i ka edaravone inā loaʻa iā ʻoe nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia, inā e holomua ana kāu ALS i kahi e hāʻawi ʻole ai ka lāʻau lapaʻau i ka pōmaikaʻi nui, a i ʻole inā e loli nui ana kou olakino holoʻokoʻa.

Ke koho nei kekahi poʻe e hooki i ka lāʻau lapaʻau ma muli o ka pilikia o nā kipa maʻamau i nā keʻena lapaʻau, ʻoiai inā e lilo ana ko lākou hiki ke hele i ka palena. Hiki i kāu hui mālama ola ke kōkua iā ʻoe e ana i nā pōmaikaʻi o ka hoʻomau ʻana i ka lāʻau lapaʻau e kūʻē i nā pilikia kūpono e hōʻike ʻia ana.

Hiki iaʻu ke hele i ka wā e lawe ana i ka Edaravone?

Pono ka hoʻolālā mua ʻana i ka wā e hele ai i ka edaravone, akā hiki pinepine me ka hoʻoponopono kūpono. Pono ʻoe e hoʻonohonoho i ka lāʻau lapaʻau ma kahi kikowaena infusion a i ʻole ka haukapila ma kou wahi e hele ai.

Hiki i kāu hui mālama ola ke kōkua iā ʻoe e ʻimi i nā keʻena lapaʻau kūpono ma nā kūlanakauhale ʻē aʻe a hoʻoponopono i kāu mālama. Hiki iā lākou ke hāʻawi iā ʻoe i nā palapala lapaʻau nui a me ka ʻike pili i ka wā pilikia i kou hele ʻana.

No nā huakaʻi lōʻihi, pono paha ʻoe e hoʻoponopono i kāu papa hana lapaʻau a i ʻole e lawe i kahi hoʻomaha i hoʻolālā ʻia mai ka edaravone. Hiki i kāu kauka ke kōkua iā ʻoe e hoʻoholo i ke ala maikaʻi loa e pili ana i kāu mau hoʻolālā huakaʻi a me ke kūlana olakino o kēia manawa.