He aha ʻo Edaravone: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau neuroprotective ʻo Edaravone e kōkua ana i ka hoʻolohi ʻana i ka holomua o ka ALS (maʻi o Lou Gehrig). Hana kēia lāʻau lapaʻau waha ma ka pale ʻana i nā cell nerve mai ka pōʻino i hana ʻia e nā molekala ʻino i kapa ʻia he free radicals. ʻOiai ʻaʻole hiki iā ia ke hoʻōla i ka ALS, hiki i ka edaravone ke kōkua i ka mālama ʻana i ka hana ʻana o ka ʻiʻo a hoʻolohi i ka emi ʻana o nā hana i kēlā me kēia lā no kekahi poʻe e noho ana me kēia maʻi.

He aha ʻo Edaravone?

He lāʻau lapaʻau kauoha ʻo Edaravone i hoʻolālā ʻia e mālama i ka amyotrophic lateral sclerosis (ALS). He maʻi neurological holomua ka ALS e pili ana i nā cell nerve e mālama ana i ka neʻe ʻana o ka ʻiʻo manawaleʻa. No ka papa o nā lāʻau lapaʻau i kapa ʻia he antioxidants ka lāʻau lapaʻau, ʻo ia hoʻi, kōkua ia i ka pale ʻana i nā cell mai ka pōʻino.

I ka wā i hoʻomohala mua ʻia ma Iapana, ua ʻae mua ʻia ʻo edaravone ma ke ʻano he lāʻau intravenous. Hāʻawi ke ʻano waha i kahi koho kūpono no nā maʻi e pono ai ka lāʻau lapaʻau lōʻihi. Hōʻike kēia lāʻau lapaʻau i kekahi o nā lāʻau lapaʻau i ʻae ʻia e ka FDA i loaʻa no nā maʻi ALS.

Hana ka lāʻau lapaʻau ma ke kelepona e hakakā i ke koʻikoʻi oxidative, kahi e pāʻani ai i kahi hana nui i ka make ʻana o nā cell nerve i ka ALS. Ma ka hōʻemi ʻana i kēia pōʻino cellular, hiki i ka edaravone ke kōkua i ka mālama ʻana i ka hana neurological no nā wā lōʻihi.

No ke aha i hoʻohana ʻia ai ʻo Edaravone?

Hoʻohana nui ʻia ʻo Edaravone e mālama i ka ALS i nā pākeke. Hōʻike ʻia ka lāʻau lapaʻau no nā maʻi e kū ana i kekahi mau pae a hōʻike i nā hōʻike o ka holomua o ka maʻi. E loiloi pono kāu kauka inā kūpono kēia lapaʻau no kāu kūlana.

ʻAʻole he lāʻau lapaʻau no ka ALS ka lāʻau lapaʻau, akā hiki iā ia ke kōkua i ka hoʻolohi ʻana i ka helu o ka emi ʻana o ka hana kino. Ua hōʻike nā haʻawina lapaʻau i ka ʻike ʻana o kekahi mau maʻi i ka holomua lohi o nā hōʻailona i ka wā e lawe ana i ka edaravone i hoʻohālikelike ʻia me ka poʻe i loaʻa ʻole ka lāʻau lapaʻau.

I kēia manawa, ʻaʻole i ʻae ʻia ʻo edaravone no nā maʻi neurological ʻē aʻe, ʻoiai ke hoʻomau nei ka noiʻi e ʻimi i kona mau pono i nā maʻi ʻē aʻe e pili ana i ke koʻikoʻi oxidative. Na kāu mea mālama ola e hoʻoholo inā he moho kūpono ʻoe e pili ana i kāu mōʻaukala olakino a me ke kūlana o kēia manawa.

Pehea e Hana ai ʻo Edaravone?

Hana ʻo Edaravone ma ka hana ʻana ma ke ʻano he antioxidant ikaika e pale ai i nā cell nerve mai ka pōʻino. I ka ALS, hōʻiliʻili nā molekala ʻino i kapa ʻia he mau radical manuahi a hoʻoulu i ke koʻikoʻi oxidative, e hōʻino a pepehi i nā neurons kaʻa. ʻO kēia nā cell nerve e hoʻomalu i ka neʻe ʻana o ka ʻiʻo manawaleʻa.

Hoʻomaʻemaʻe ka lāʻau lapaʻau i kēia mau radical manuahi ma mua o ka hiki iā lākou ke hōʻino i ke kelepona. E noʻonoʻo iā ia he pale pale a puni kāu mau cell nerve, e kōkua ana e mālama i kā lākou hana no ka lōʻihi e hiki ai. Hiki i kēia pale ke kōkua i ka mālama ʻana i ka ikaika o ka ʻiʻo a me ka hana ʻana ma mua o ka hana ʻole ʻana me ka mālama ʻole.

ʻOiai ua manaʻo ʻia ʻo edaravone he lāʻau lapaʻau maikaʻi, he mea nui e hoʻomaopopo e hana mālie ana. ʻAʻole paha e ʻike koke ʻia nā pōmaikaʻi, a pono e lawe mau ʻia ka lāʻau lapaʻau e mālama i kāna mau hopena pale.

Pehea wau e lawe ai iā Edaravone?

Pono e lawe ʻia ka hoʻokuʻu waha ʻo Edaravone e like me ke kauoha a kāu kauka. He wai ka lāʻau lapaʻau e ana pono ai ʻoe me ka hoʻohana ʻana i ka mea ana i hāʻawi ʻia. Lawe ka hapa nui o nā maʻi i ʻelua manawa i ka lā, akā e hilinaʻi kāu papa hana ma kāu mau pono pilikino.

Hiki iā ʻoe ke lawe iā edaravone me ka ʻole o ka meaʻai, ʻoiai ʻo ka lawe ʻana me ka ʻai e kōkua i ka hōʻemi ʻana i ka ʻōpū inā loaʻa iā ʻoe kekahi. Pono e mālama ʻia ka lāʻau lapaʻau i loko o ka pahu hau a lulu maikaʻi ʻia ma mua o kēlā me kēia hoʻohana ʻana e hōʻoia i ka hui pono.

He mea nui e lawe i kāu mau lāʻau i nā manawa like i kēlā me kēia lā e mālama i nā pae kūlike i loko o kou ʻōnaehana. Inā pilikia ʻoe i ka ale ʻana a i ʻole ka mālama ʻana i ke ʻano wai, e kamaʻilio me kāu hui mālama ola e pili ana i nā ʻenehana e kōkua ai i ka maʻalahi o ka lawelawe ʻana.

Pehea ka lōʻihi e lawe ai au i ka Edaravone?

Hoʻonohonoho pinepine ʻia ka Edaravone ma ke ʻano he lapaʻau lōʻihi no ka ALS. Hoʻomau ka hapa nui o nā mea maʻi i ka lawe ʻana i ka lāʻau no ka lōʻihi e hiki ai iā lākou ke ʻae a no ka lōʻihi e manaʻoʻiʻo ai kā lākou kauka e hāʻawi ana i ka pōmaikaʻi. Hiki i kēia ke lawe iā ia no nā mahina a i ʻole nā makahiki.

E nānā kāu kauka i kāu pane ʻana i ka lāʻau lapaʻau ma o nā loiloi maʻamau a me nā loiloi. E loiloi lākou inā e kōkua ana ka lapaʻau ʻana i ka lohi ʻana i ka holomua o kou maʻi a inā ʻoe e ʻike nei i nā hopena ʻaoʻao e pili ana.

ʻO ka hoʻoholo e hoʻomau a hoʻōki paha i ka edaravone e hilinaʻi ana i nā mea he nui, me ka maikaʻi o kou ʻae ʻana i ka lāʻau, kou kūlana olakino holoʻokoʻa, a me nā hōʻike o ka pōmaikaʻi mau. Mai hooki i ka lawe ʻana i ka edaravone me ka ʻole e kūkākūkā mua me kāu mea mālama ola.

He aha nā hopena ʻaoʻao o Edaravone?

E like me nā lāʻau lapaʻau a pau, hiki i ka edaravone ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā mea a pau iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao a maʻa mau e hoʻomaikaʻi i ka hoʻoponopono ʻana o kou kino i ka lāʻau.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia ke poʻo, ka ʻūlū, ka nausea, a me ka luhi. He maʻalahi kēia mau hōʻailona a pinepine e hoʻomaikaʻi i ka wā e maʻa ai kou kino i ka lāʻau.

Eia nā hopena ʻaoʻao i hui pū ʻia e like me ka maʻamau o ko lākou hana ʻana:

Nā hopena ʻaoʻao maʻamau (e pili ana i ka 10% o nā mea maʻi):

• Poʻo
• ʻŪlū
• Nausea a i ʻole ka ʻōpū
• Luhi a i ʻole ka luhi
• Paʻakikī i ka hiamoe

Nā hopena ʻaoʻao liʻiliʻi (e pili ana i ka 1-10% o nā mea maʻi):

• Luaʻi
• Pāpaʻa
• Nalo o ka ʻai
• Hū ʻili a i ʻole ka ʻū
• Wāwali ʻiʻo
• Paʻakikī o ka hanu

Nā hopena ʻaoʻao kakaʻikahi akā koʻikoʻi (e pili ana i ka liʻiliʻi ma mua o 1% o nā maʻi):

• Nā hopena maʻi ʻaʻai koʻikoʻi me ka pehu o ka maka, nā lehelehe, a i ʻole ka ʻāʻī
• Nā hopena ʻili koʻikoʻi
• Nā pilikia o ke ake me ka melemele o ka ʻili a i ʻole nā maka
• Nā loli nui i nā helu o nā cell koko

Inā loaʻa iā ʻoe kekahi hopena ʻaoʻao koʻikoʻi a i ʻole nā hopena maʻi ʻaʻai, e ʻimi koke i ka lāʻau lapaʻau. ʻO ka hapa nui o nā hopena ʻaoʻao he manawa pōkole a hiki ke mālama ʻia me ke alakaʻi olakino kūpono.

ʻO wai ka mea pono ʻole e lawe iā Edaravone?

ʻAʻole kūpono ʻo Edaravone no nā mea a pau, a ʻo kekahi mau maʻi olakino a i ʻole nā kūlana e hiki ke palekana ʻole iā ʻoe ke lawe i kēia lāʻau. E nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana iā edaravone.

ʻAʻole pono ʻoe e lawe iā edaravone inā ʻike ʻoe i ka maʻi ʻaʻai i ka lāʻau a i ʻole kekahi o kāna mau mea. Eia kekahi, pono paha ka poʻe me ka maʻi ate koʻikoʻi a i ʻole nā pilikia o ka puʻupaʻa e pale i kēia lāʻau a i ʻole e pono ai ka nānā ʻana.

Eia nā kūlana kikoʻī kahi i kūpono ʻole ai ʻo edaravone:

Nā hōʻike kūʻē loa (ʻaʻole pono ʻoe e lawe iā edaravone):

• ʻIke ʻia ka maʻi ʻaʻai iā edaravone a i ʻole kāna mau meaʻai
• Maʻi ate koʻikoʻi a i ʻole ka hāʻule ʻana o ke ake
• Maʻi puʻupaʻa pae hope e koi ana i ka dialysis
• Hāpai a i ʻole ka hānai ʻana i ka waiū

Nā kūlana e koi ana i ka akahele kūikawā:

• Nā pilikia o ke ake māmā a i ʻole ka maʻalahi
• Maʻi puʻupaʻa
• Mōʻaukala o nā hopena maʻi ʻaʻai koʻikoʻi
• Maʻi puʻuwai a i ʻole ka puʻuwai ʻole
• Nā pilikia hanu a i ʻole ka maʻi māmā
• Nā maʻi koko

E loiloi ana kāu mea mālama ola i nā pōmaikaʻi kūpono e kūʻē i nā pilikia no kou kūlana kikoʻī. Hiki iā lākou ke ʻōlelo aku i ka nānā hou ʻana a i ʻole nā lāʻau lapaʻau ʻē aʻe inā ʻaʻole kūpono ʻo edaravone iā ʻoe.

Nā inoa inoa o Edaravone

Loaʻa ʻo Edaravone ma lalo o nā inoa inoa like ʻole e pili ana i kou wahi a me ke ʻano kikoʻī. ʻO ka inoa inoa maʻamau no ke ʻano waha ʻo Radicava ORS (Oral Suspension), ʻo ia ka mana i kauoha pinepine ʻia ma ʻAmelika Hui Pū ʻIa.

ʻO ke ʻano intravenous kumu i kapa ʻia ʻo Radicava. Loaʻa i nā ʻano ʻelua ka mea hana like akā ua lawelawe ʻia ma nā ʻano like ʻole. E kuhikuhi kāu kauka i ke ʻano a me ka inoa i kūpono loa no kāu hoʻolālā lapaʻau.

Hiki ke loaʻa nā mana generic o edaravone i ka wā e hiki mai ana, hiki ke hāʻawi i nā koho lapaʻau ʻoi aku ka maikaʻi. E hoʻohana mau i ka inoa inoa a i ʻole ka mana generic i kauoha ʻia e kāu kauka e hōʻoia e loaʻa iā ʻoe ke ʻano kūpono.

Nā koho ʻē aʻe o Edaravone

ʻOiai ʻo edaravone kekahi o nā lāʻau lapaʻau i ʻae ʻia e ka FDA no ALS, aia nā lāʻau lapaʻau ʻē aʻe a me nā ala e hiki ke noʻonoʻo ʻia. ʻO Riluzole kekahi lāʻau lapaʻau i ʻae ʻia no ka mālama ʻana iā ALS e hana ana ma o kahi ʻano ʻokoʻa.

Kōkua ʻo Riluzole i ka hōʻemi ʻana i ka ʻona glutamate i ka lolo, ʻo ia kekahi ala e pili ana i ka holomua o ALS. Hiki i kekahi poʻe maʻi ke lawe i nā lāʻau lapaʻau ʻelua, aʻo nā mea ʻē aʻe e hoʻohana i kekahi a i ʻole kekahi e pili ana i kā lākou pane a me ka ʻae ʻana.

Ma waho aʻe o nā lāʻau lapaʻau, ʻo ka mālama ʻana iā ALS e pili ana i ka lāʻau lapaʻau kino, ka lāʻau lapaʻau hana, ka lāʻau lapaʻau ʻōlelo, a me ke kākoʻo meaʻai. Hana kēia mau lāʻau lapaʻau kākoʻo me nā lāʻau lapaʻau e kōkua i ka mālama ʻana i ka maikaʻi o ke ola a me ka hana no ka manawa lōʻihi.

ʻOi aku ka maikaʻi o Edaravone ma mua o Riluzole?

He mea nui nā lāʻau lapaʻau ʻo edaravone a me riluzole no ka maʻi ALS, akā hana lākou ma nā ʻano hana like ʻole a hiki ke kōkua i nā maʻi like ʻole. Ma mua o ka maikaʻi o kekahi ma mua o kekahi, ua ʻike pinepine ʻia lākou he mau lāʻau lapaʻau e hoʻopili ana i kekahi i kekahi a hiki ke hoʻohana pū ʻia.

Ua loaʻa ʻo Riluzole no ka manawa lōʻihi a he nui nā ʻikepili palekana no ka wā lōʻihi. Hana ia ma ka hoʻēmi ʻana i ka mea ʻawaʻawa glutamate, a ʻo edaravone e kālele ana i ka pale antioxidant. Hōʻike kekahi mau haʻawina i ka hui pū ʻana o nā lāʻau lapaʻau ʻelua e hāʻawi i nā pōmaikaʻi nui aʻe ma mua o ka hoʻohana ʻana i kekahi wale nō.

E noʻonoʻo kāu kauka i nā mea e like me ka holomua o kou maʻi, nā maʻi olakino ʻē aʻe, nā hopena ʻaoʻao, a me kāu mau makemake pilikino i ka wā e hoʻoholo ai i ka lāʻau lapaʻau a i ʻole ka hui pū ʻana o nā lāʻau lapaʻau i kūpono iā ʻoe. Pono e hoʻoholo mau ʻia ka hoʻoholo ʻana ma muli o kou kūlana kikoʻī.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Edaravone

Q1. Palekana ʻo Edaravone no ka poʻe me ka maʻi puʻuwai?

Hiki ke hoʻohana ʻia ʻo Edaravone i ka poʻe me ka maʻi puʻuwai, akā pono ka nānā pono ʻana a me ka loiloi ʻana e kāu mea mālama ola. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka puʻuwai i kekahi poʻe, no laila pono kāu kauka e loiloi i kou kūlana puʻuwai.

Inā loaʻa iā ʻoe ka maʻi puʻuwai, hiki i kāu kauka ke ʻōlelo aku i ka nānā ʻana i ka puʻuwai hou i ka wā o ka lāʻau lapaʻau. Hiki i kēia ke komo i nā electrocardiograms (ECGs) maʻamau e nānā i kou puʻuwai a hōʻoia ʻaʻole e hoʻokumu ka lāʻau lapaʻau i nā loli e pili ana.

Hiki i ka nui o nā kānaka me nā maʻi puʻuwai ke lawe palekana iā edaravone, akā pono ka hoʻoholo ʻana i ke kaulike ʻana i nā pōmaikaʻi e hiki mai ana no kāu ALS e kūʻē i nā pilikia puʻuwai. Pono kāu cardiologist a me ka neurologist e hana pū e hana i ka hoʻolālā lapaʻau palekana loa iā ʻoe.

Q2. He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o Edaravone?

Inā ua lawe ʻoe i ka edaravone ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka a i ʻole ke kikowaena mana ʻawa. ʻO ka lawe ʻana i ka lāʻau lapaʻau nui loa e hoʻonui i kou pilikia o nā hopena ʻaoʻao a pono paha i ka nānā ʻana i ka lāʻau lapaʻau.

Mai hoʻāʻo e

Pono paha kekahi poʻe maʻi e hoʻōki no ka manawa pōkole i ka edaravone inā loaʻa iā lākou kekahi mau maʻi olakino a i ʻole pono e lawe i nā lāʻau ʻē aʻe e launa pū me ia. Na kāu kauka e alakaʻi iā ʻoe ma nā loli lapaʻau a kōkua iā ʻoe e hoʻomaopopo i ke kumu o kā lākou ʻōlelo aʻoaʻo.

Q5. Hiki iaʻu ke lawe i ka Edaravone me nā lāʻau ALS ʻē aʻe?

Hiki ke lawe pinepine ʻia ka Edaravone me nā lāʻau ALS ʻē aʻe e like me ka riluzole, a he nui nā maʻi e pōmaikaʻi mai kēia hui pū ʻana. E nānā pono kāu kauka i kāu mau lāʻau lapaʻau a pau e hōʻoia i ka hana maikaʻi ʻana.

Hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka edaravone a i ʻole e hoʻopilikia i ka maikaʻi o kāna hana. E hōʻike mau i kāu mea mālama ola e pili ana i nā lāʻau lapaʻau a pau, nā mea hoʻohui, a me nā lāʻau lapaʻau i kūʻai ʻia ma luna o ka pāʻani āu e lawe nei ma mua o ka hoʻomaka ʻana i ka edaravone.

Pono paha kāu kauka e hoʻoponopono i nā dosages a i ʻole ka manawa o nā lāʻau lapaʻau ʻē aʻe ke hoʻomaka ʻoe i ka edaravone. E nānā pono lākou iā ʻoe no nā pilina a hana i nā hoʻoponopono e pono ai e hōʻoia i ka loaʻa ʻana o ka hui pū ʻana o ka lapaʻau palekana a me ka maikaʻi.