He aha ʻo Efgartigimod Alfa a me Hyaluronidase: Nā Hoʻohana, Dosage, Nā ʻaoʻao ʻaoʻao a me nā mea hou aku

ʻO Efgartigimod alfa a me hyaluronidase he lāʻau lapaʻau i kauoha ʻia e kōkua i ka mālama ʻana i kekahi mau maʻi autoimmune kahi e hoʻouka hewa ai kou ʻōnaehana pale i kou kino ponoʻī. Hana kēia lāʻau hui ma ka hōʻemi ʻana i nā antibodies ʻino e hoʻoulu ai i ka nāwaliwali o ka ʻiʻo a me nā hōʻailona ʻē aʻe i nā maʻi e like me ka myasthenia gravis.

Hele mai ka lāʻau lapaʻau ma ke ʻano he injection subcutaneous, ʻo ia hoʻi, hāʻawi ʻia ma lalo o kou ʻili ma mua o ke komo ʻana i loko o kahi vein. E noʻonoʻo iā ia he lāʻau lapaʻau i manaʻo ʻia e kōkua i ka hoʻihoʻi ʻana i ke kaulike i kāu ʻōnaehana pale ke hana nei ia iā ʻoe.

He aha ʻo Efgartigimod Alfa a me Hyaluronidase?

ʻO Efgartigimod alfa a me hyaluronidase he lāʻau immunotherapy hui i hoʻolālā ʻia e mālama i ka myasthenia gravis maʻamau i nā pākeke. ʻO ka mea mua, ʻo efgartigimod alfa, ʻo ia ka mea e hana ai i ka hana therapeutic nui ma ka pale ʻana i kekahi mau mea hoʻokipa e hana hou i nā antibodies ʻino i kou kino.

ʻO ka mea ʻelua, ʻo hyaluronidase, hana e like me ke kōkua e hiki ai i ka lāʻau lapaʻau ke laha maʻalahi ma lalo o kou ʻili ke hoʻokomo ʻia. Hiki i kēia hui ke loaʻa ka lāʻau lapaʻau ma ka home ma mua o ka koi ʻana i nā kipa pinepine i ka haukapila no nā infusions intravenous.

Hiki i kāu kauka ke kauoha i kēia lāʻau lapaʻau ke loaʻa iā ʻoe nā hoʻokolohua koko maikaʻi no nā antibodies kikoʻī i kapa ʻia ʻo acetylcholine receptor antibodies. Hoʻopilikia kēia mau antibodies i ke kamaʻilio maʻamau o ka nerve-muscle, e alakaʻi ana i ka nāwaliwali a me ka luhi e hōʻike ana i ka myasthenia gravis.

No ke aha e hoʻohana ʻia ai ʻo Efgartigimod Alfa a me Hyaluronidase?

Ua ʻae ʻia kēia lāʻau lapaʻau no ka mālama ʻana i ka myasthenia gravis maʻamau i nā pākeke i hoʻāʻo maikaʻi ʻia no nā acetylcholine receptor antibodies. ʻO Myasthenia gravis kahi maʻi autoimmune maʻi e hoʻoulu ai i ka nāwaliwali o ka ʻiʻo, e pili ana i nā ʻiʻo āu e hoʻohana ai no ka ʻōlelo ʻana, ka nau ʻana, ka ʻai ʻana, a me ka hanu ʻana.

Kōkua ka lapaʻau ʻana i ka hoʻēmi ʻana i ka paʻakikī o nā manawa nāwaliwali o ka ʻiʻo a hiki ke hoʻomaikaʻi i kou ola maikaʻi holoʻokoʻa. Nui nā maʻi e ʻike i ka hoʻomaikaʻi ʻana i ko lākou hiki ke hana i nā hana o kēlā me kēia lā, ʻoiai ʻaʻole e hoʻōla ka lāʻau i ke kūlana kumu.

E noʻonoʻo maʻamau kāu mea mālama ola i kēia lapaʻau ʻana ke hāʻawi ʻole nā lāʻau lapaʻau maʻamau i ka mana kūpono o nā hōʻailona. Hoʻohana pinepine ʻia ia me nā lāʻau lapaʻau myasthenia gravis ʻē aʻe ma mua o ka pani piha ʻana i kāu hoʻolālā lapaʻau o kēia manawa.

Pehea e Hana ai ʻo Efgartigimod Alfa a me Hyaluronidase?

Hana kēia lāʻau lapaʻau ma ka ʻimi ʻana i kahi protein kikoʻī i loko o kou kino i kapa ʻia ʻo ka neonatal Fc receptor, ka mea e kōkua maʻamau i ka hana hou ʻana i nā antibodies. I ka myasthenia gravis, hana kou ʻōnaehana pale i nā antibodies ʻino e hoʻouka i nā wahi pili ma waena o kou mau aʻalolo a me nā ʻiʻo.

Ma ka ālai ʻana i ka neonatal Fc receptor, pale ʻo efgartigimod alfa i kēia mau antibodies ʻino mai ka hana hou ʻana i loko o kou kahe koko. Ma kahi o, ua wāwahi ʻia lākou a hoʻopau ʻia mai kou kino me ka wikiwiki, e hōʻemi ana i ko lākou hopena ʻino i kou mau ʻiʻo.

Manaʻo ʻia kēia he lapaʻau immunotherapy ikaika me ka manaʻo nui i ke kaʻina hana maʻi ma mua o ka hoʻopau ākea ʻana i kāu ʻōnaehana pale holoʻokoʻa. He manawa pōkole nā hopena, ʻo ia ke kumu e pono ai ʻoe i nā injections maʻamau e mālama i nā pōmaikaʻi.

Pehea wau e lawe ai iā Efgartigimod Alfa a me Hyaluronidase?

Hāʻawi ʻia kēia lāʻau lapaʻau ma ke ʻano he injection subcutaneous, maʻamau i hoʻokahi manawa i ka pule no ʻehā pule e pili ana, a ukali ʻia e kahi manawa lapaʻau ʻole. E hoʻokomo kāu mea mālama ola a i ʻole kekahi lālā o ka ʻohana i aʻo ʻia i loko o ka ʻili o kou ʻūhā, lima luna, a i ʻole ka ʻōpū.

ʻAʻole pono ʻoe e lawe i kēia lāʻau lapaʻau me ka meaʻai no ka mea ua hoʻokomo ʻia ma mua o ka lawe ʻia ʻana e ka waha. Eia naʻe, pono ʻoe e noho hydrated a mālama i kāu papa ʻai maʻamau e kākoʻo i kou olakino holoʻokoʻa i ka wā o ka lapaʻau.

Ma mua o kēlā me kēia injection, pono e hiki i ka lāʻau lapaʻau i ka mahana o ka lumi, kahi e lawe ai ma kahi o 30 mau minuke ma hope o ka lawe ʻana mai ka pahu hau. Mai lulu i ka vial a i ʻole e hoʻomehana me nā kumu wela e like me nā microwaves a i ʻole ka wai wela.

Na kāu kauka e aʻo iā ʻoe a i ʻole kāu mea mālama i ke ʻano o ka injection kūpono, me ka hoʻololi ʻana i nā wahi injection e pale ai i ka huhū o ka ʻili. E mālama i kahi moʻolelo o kahi āu e hoʻokomo ai i kēlā me kēia mahele e hōʻoia ai e hoʻololi ana ʻoe i nā wahi kūpono.

Pehea ka lōʻihi e lawe ai au i ka Efgartigimod Alfa a me Hyaluronidase?

He ʻokoʻa nui ka lōʻihi o ka mālama ʻana mai kēlā me kēia kanaka, ma muli o ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau a me kāu maʻi pilikino. Loaʻa i ka hapa nui o nā maʻi nā pōʻaiapuni lapaʻau e loaʻa ana i ʻehā mau injections i kēlā me kēia pule a ukali ʻia e kahi manawa hoʻomaha e hiki ke lōʻihi i kekahi mau pule a i ʻole mau mahina.

Na kāu kauka e nānā i kāu mau hōʻailona a me nā pae antibody e hoʻoholo ai i ka wā e pono ai ʻoe i kāu pōʻaiapuni lapaʻau e hiki mai ana. Pono paha kekahi poʻe maʻi i nā pōʻaiapuni lapaʻau i kēlā me kēia 8-12 pule, ʻoiai e lōʻihi paha nā mea ʻē aʻe ma waena o nā pōʻaiapuni.

ʻAʻole kēia he lāʻau lapaʻau āu e lawe mau ai no ke ola e like me kekahi mau lāʻau lapaʻau ʻē aʻe. Akā, hoʻohana ʻia ia i nā pōʻaiapuni e hōʻemi i nā antibodies ʻino ke kūkulu hou lākou i loko o kāu ʻōnaehana.

He aha nā hopena ʻaoʻao o Efgartigimod Alfa a me Hyaluronidase?

Hoʻomanawanui ka hapa nui o nā kānaka i kēia lāʻau lapaʻau, ʻoiai e like me nā lāʻau lapaʻau a pau, hiki iā ia ke hana i nā hopena ʻaoʻao. ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a pili i ka wahi injection a i ʻole ka pane o kou kino i ka lāʻau lapaʻau.

Eia nā hopena ʻaoʻao e ʻike nui ai ʻoe, me ka noʻonoʻo ʻana he liʻiliʻi a ʻaʻohe pilikia o ka poʻe he nui me kēia lāʻau lapaʻau:

• Nā hopena o ka wahi injection e like me ka ʻulaʻula, ka pehu, a i ʻole ke aloha
• ʻEha poʻo a i ʻole ka luhi maʻalahi
• ʻEha ʻiʻo a i ʻole nā hui
• Nausea a i ʻole ka ʻōpū maʻalahi
• Nā hōʻailona e like me ke anu maʻamau
• Fiva maʻalahi a i ʻole nā haʻalulu

ʻO ka hapa nui o kēia mau hopena he manawa pōkole a hoʻomaikaʻi i loko o hoʻokahi a ʻelua paha lā ma hope o kāu injection. Hoʻoponopono maʻamau nā hopena ma ka pūnaewele injection i loko o 24-48 mau hola.

ʻAʻole maʻamau akā ʻoi aku ka koʻikoʻi o nā hopena ʻaoʻao, ʻoiai he mea maʻamau lākou me kēia lāʻau lapaʻau:

• Nā hopena maʻi maʻi koʻikoʻi me ka pilikia o ka hanu ʻana a i ʻole ka pehu ʻana o ka maka a me ka ʻāʻī
• Nā maʻi koʻikoʻi ma muli o nā loli ʻōnaehana pale maʻi manawa
• Ke kahe koko ʻano ʻē a i ʻole ka ʻeha
• Nāwaliwali ʻiʻo koʻikoʻi a mau paha
• Nā hōʻailona o nā pilikia o ke ake e like me ka melemele o ka ʻili a i ʻole nā maka

ʻOiai ʻaʻole maʻamau kēia mau hopena koʻikoʻi, he mea nui e hoʻokaʻaʻike koke i kāu mea mālama ola inā ʻike ʻoe i nā hōʻailona e pili ana, ʻoiai ka pilikia o ka hanu ʻana a i ʻole nā hōʻailona o ka maʻi koʻikoʻi.

ʻO wai ka mea pono ʻole e lawe iā Efgartigimod Alfa a me Hyaluronidase?

ʻAʻole kūpono kēia lāʻau lapaʻau no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia no kāu kūlana kikoʻī. Pono paha ka poʻe me kekahi mau maʻi olakino a i ʻole nā kūlana e pale i kēia lapaʻau a i ʻole e hoʻohana me ka akahele.

ʻAʻole pono ʻoe e loaʻa i kēia lāʻau lapaʻau inā loaʻa iā ʻoe kahi hopena maʻi koʻikoʻi i ʻike ʻia iā efgartigimod alfa, hyaluronidase, a i ʻole kekahi o nā mea ʻē aʻe i loko o ka formulation. E nānā kāu kauka i ka papa inoa piha o nā meaʻai me ʻoe ma mua o ka hoʻomaka ʻana i ka lapaʻau.

Pono ka poʻe me nā maʻi koʻikoʻi e kali a hiki i ka wā e mālama ʻia ai ka maʻi ma mua o ka hoʻomaka ʻana i kēia lāʻau lapaʻau. No ka mea e pili ana i kāu ʻōnaehana pale, hiki iā ia ke hoʻonui i nā maʻi a i ʻole e paʻakikī ke kaua aku.

Pono nā wahine hāpai a i ʻole ka hānai ʻana i ka umauma i ka noʻonoʻo kūikawā, no ka mea, he palena ka ʻikepili palekana no kēia lāʻau lapaʻau i ka wā hāpai a me ka lactation. E kaupaona kāu kauka i nā pōmaikaʻi kūpono e kūʻē i nā pilikia hiki iā ʻoe a me kāu pēpē.

ʻO nā kānaka me kekahi mau maʻi o ka ʻōnaehana pale e pili ana i ka myasthenia gravis, pono nō hoʻi e loiloi pono ʻia ma mua o ka hoʻomaka ʻana i ka lapaʻau. Hāʻawi kāu moʻolelo olakino piha i kāu kauka e hoʻoholo inā kūpono kēia lāʻau lapaʻau iā ʻoe.

ʻO ka inoa inoa o Efgartigimod Alfa a me Hyaluronidase

Hoʻolaha ʻia kēia lāʻau lapaʻau ma lalo o ka inoa inoa ʻo Vyvgart Hytrulo. Hana ʻia e argenx a hōʻike i kahi hoʻohui subcutaneous o ka lāʻau lapaʻau efgartigimod alfa intravenous mua.

Kōkua ka inoa inoa e hoʻokaʻawale i kēia hui subcutaneous mai ka mana intravenous-only i kapa ʻia ʻo Vyvgart, aia wale nō ka efgartigimod alfa me ka ʻole o ka mea hyaluronidase. Mālama nā mana ʻelua i ke kūlana like akā hāʻawi ʻia i nā ʻano like ʻole.

Ke kūkākūkā ʻana i kēia lāʻau lapaʻau me kāu mau mea mālama ola a i ʻole ka mea kūʻai lāʻau lapaʻau, ʻo ka hoʻohana ʻana i ka inoa inoa ʻo Vyvgart Hytrulo e kōkua i ka hōʻoia ʻana e hoʻomaopopo nā mea a pau e pili ana ʻoe i ka injection subcutaneous ma mua o ka formulation intravenous.

Nā koho ʻē aʻe o Efgartigimod Alfa a me Hyaluronidase

Nui nā koho lapaʻau ʻē aʻe no ka myasthenia gravis, ʻoiai ʻo ke koho maikaʻi loa e hilinaʻi ana i kāu mau hōʻailona kikoʻī, ke ʻano antibody, a me ka maikaʻi o kāu pane ʻana i nā lapaʻau mua. E noʻonoʻo kāu kauka i kāu kūlana pilikino i ka wā e ʻimi ana i nā koho ʻē aʻe.

Hoʻohana pinepine ʻia nā lāʻau immunosuppressive kuʻuna e like me prednisone, azathioprine, a i ʻole mycophenolate mofetil ma ke ʻano he lapaʻau laina mua. Hana kēia mau lāʻau lapaʻau i nā ʻano like ʻole ma ka hoʻopau ʻana i ka hana ʻōnaehana pale ma mua o ka hoʻopaʻa ʻana i ka hana hou ʻana o ka antibody.

ʻO nā lāʻau lapaʻau i manaʻo ʻia ʻo rituximab, e hoʻopau ana i kekahi mau pūnaewele immune, a i ʻole eculizumab, e ālai ana i kahi ʻāpana ʻokoʻa o ka ʻōnaehana pale i kapa ʻia ʻo ka hoʻāla ʻana i ka complement. ʻO ka hoʻololi plasma a me ka immunoglobulin intravenous he mau koho nō hoʻi no ka mālama ʻana i nā hōʻailona koʻikoʻi.

Loaʻa ka pōmaikaʻi o kekahi mau maʻi mai nā mea pale cholinesterase e like me pyridostigmine, e kōkua ana i ka hoʻomaikaʻi ʻana i ke kamaʻilio ʻana o ke aʻalolo-muscle me ka hoʻopilikia ʻole ʻana i ka ʻōnaehana pale. Hiki ke hoʻohana ʻia kēia mau lāʻau lapaʻau wale nō a i ʻole i hui pū ʻia me nā lāʻau lapaʻau ʻē aʻe.

Ua ʻoi aku ka maikaʻi o Efgartigimod Alfa a me Hyaluronidase ma mua o Rituximab?

ʻAʻole maʻalahi ka hoʻohālikelike ʻana i kēia mau lāʻau lapaʻau ʻelua no ka mea e hana lākou ma o nā ʻano hana like ʻole a hoʻohana pinepine ʻia i nā kūlana like ʻole. Hiki ke maikaʻi nā mea ʻelua no ka myasthenia gravis, akā he mau pono a me nā manaʻo ʻokoʻa ko lākou.

Hāʻawi ʻo Efgartigimod alfa a me hyaluronidase i nā hopena i ʻike mua ʻia, i ka wā pōkole me ka liʻiliʻi o ka pilikia o ka hoʻopaʻa ʻana i ka ʻōnaehana pale lōʻihi. E ʻike maʻamau ʻoe i nā hopena i loko o nā pule, a e pau nā hopena, e ʻae ana i ka hoʻolālā lapaʻau maʻalahi.

ʻO Rituximab, ma kekahi ʻaoʻao, hāʻawi i nā hopena lōʻihi akā e lawe i kekahi mau mahina e hōʻike i nā pōmaikaʻi piha a hiki ke hoʻopaʻa i kāu ʻōnaehana pale no nā wā lōʻihi. ʻO kēia ka mea e kūpono ai no nā maʻi e pono ai ka mālama ʻana i nā hōʻailona.

E noʻonoʻo kāu kauka i nā mea e like me ke koʻikoʻi o kāu mau hōʻailona, ​​nā pane lapaʻau mua, nā makemake o ke ola, a me ka ʻae ʻana i nā ʻano ʻaoʻao like ʻole i ka wā e hoʻoholo ai i ka lāʻau lapaʻau e hana maikaʻi ai no kāu kūlana.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Efgartigimod Alfa a me Hyaluronidase

Q1. Palekana ʻo Efgartigimod Alfa a me Hyaluronidase no ka poʻe me ka maʻi diabetes?

Hiki ke hoʻohana maʻamau ʻia kēia lāʻau lapaʻau me ka palekana i ka poʻe me ka maʻi diabetes, ʻoiai pono paha e nānā pono ʻia kāu mau pae kō koko i ka wā o ka mālama ʻana. ʻAʻole pili pololei ka lāʻau lapaʻau i ka glucose koko, akā hiki i ke koʻikoʻi o ka mālama ʻana i kahi maʻi maʻi a me nā hopena ʻaoʻao e like me ka nausea ke hoʻopilikia i kāu mālama ʻana i ka maʻi diabetes.

E makemake ana kāu hui mālama ola e hoʻopili i kāu mālama maʻi diabetes me kāu lapaʻau myasthenia gravis e hōʻoia i ka mālama maikaʻi ʻia ʻana o nā maʻi ʻelua. Hiki i kēia ke komo i ka hoʻoponopono ʻana i kāu mau lāʻau lapaʻau diabetes a i ʻole ka papa hana nānā i nā pōʻai lapaʻau.

Q2. He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o Efgartigimod Alfa a me Hyaluronidase?

Inā hoʻokomo hewa ʻoe i ka nui o ka lāʻau i kuhikuhi ʻia, e hoʻokaʻaʻike koke i kāu mea mālama ola no ke alakaʻi. ʻOiai ʻaʻohe lāʻau lapaʻau kikoʻī no ka overdose, hiki i kāu kauka ke nānā iā ʻoe no nā hōʻailona maʻamau a hāʻawi i ke kākoʻo inā pono.

Mai hoʻāʻo e uku ma ka lele ʻana i kāu lāʻau i hoʻonohonoho ʻia aʻe a i ʻole ka hoʻokomo ʻana i ka liʻiliʻi ma mua o ka mea i kuhikuhi ʻia. E aʻo aku kāu kauka iā ʻoe pehea e hoʻomau ai me kāu papa hana lapaʻau a inā pono kekahi nānā hou.

Q3. He aha kaʻu e hana ai inā hala au i kahi lāʻau o Efgartigimod Alfa a me Hyaluronidase?

Inā hala ʻoe i kahi lāʻau i loko o kāu pōʻai lapaʻau ʻehā pule, e hoʻokaʻaʻike i kāu mea mālama ola no ke alakaʻi kikoʻī i ka manawa. Ma keʻano maʻamau, pono ʻoe e lawe i ka lāʻau i hala i ka wā e hoʻomanaʻo ai ʻoe, akā pono paha ʻoe e hoʻoponopono i ka mamao ma waena o nā lāʻau i koe i kāu pōʻai.

Mai pāpālua i nā lāʻau e hoʻopiha ai i kahi injection i hala. E kōkua kāu kauka iā ʻoe e hoʻoholo i ke ala maikaʻi loa e hoʻopau ai i kāu pōʻai lapaʻau me ka mālama ʻana i nā manawa kūpono ma waena o nā lāʻau.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Efgartigimod Alfa a me Hyaluronidase?

ʻAʻole pono ʻoe e hooki i kēia lāʻau me ka ʻole e kūkākūkā mua i kāu mea mālama ola. ʻO ka hoʻoholo e hooki i ka lapaʻau e hilinaʻi ana i ka maikaʻi o ka mālama ʻia ʻana o kāu mau hōʻailona, ​​nā hopena ʻaoʻao āu e ʻike nei, a me kāu mau pahuhopu lapaʻau holoʻokoʻa.

Mai ka mea e hāʻawi ʻia nei ka lāʻau lapaʻau i nā pōʻaiapuni ma mua o ka hoʻomau ʻana, e loiloi mau kāu kauka inā pono ʻoe i nā pōʻaiapuni lapaʻau hou. Hiki i kekahi poʻe maʻi ke hoʻolōʻihi i ka manawa ma waena o nā pōʻaiapuni a i ʻole e hooki i ka lapaʻau inā paʻa ko lākou kūlana.

Q5. Hiki iaʻu ke hele i ka wā e lawe ana iā Efgartigimod Alfa a me Hyaluronidase?

Hiki iā ʻoe ke hele maʻamau i ka wā e loaʻa ana kēia lapaʻau, akā pono ia i ka hoʻolālā pono e hōʻoia i ka mālama pono ʻia ʻana o kāu lāʻau lapaʻau a mālama ʻia kāu papa hana injection. E hoʻokaʻaʻike i kāu mea mālama ola ma mua o nā hoʻolālā huakaʻi e kūkākūkā i nā logistics.

Pono ʻoe e lawe i kāu lāʻau lapaʻau i loko o kahi pahu i hoʻomalu ʻia e ka mahana a pono paha i kahi leka mai kāu kauka e wehewehe ana i kāu pono olakino no nā lako injection. E noʻonoʻo i ka manawa o kāu huakaʻi i nā manawa lapaʻau ʻole ma waena o nā pōʻaiapuni i ka hiki ke pale i nā pilikia.