He aha ʻo Etelcalcetide: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Etelcalcetide e kōkua ana i ka mālama ʻana i nā pae calcium i loko o kou koko ke hana pono ʻole kāu mau ʻōpū parathyroid. Ua hoʻolālā ʻia no ka poʻe me ka maʻi kīkī maʻi e loaʻa ana i ka dialysis a ua loaʻa iā lākou kahi maʻi i kapa ʻia ʻo secondary hyperparathyroidism. E noʻonoʻo iā ia he mea kōkua mālie e haʻi ana i kāu mau ʻōpū parathyroid e mālie i ka wā e hana nui ana lākou, ʻo ia ka mea e hana pinepine ai ke hiki ʻole i kou mau kīkī ke hana i kā lākou hana o ka kānana ʻana i ka ʻōpala mai kou koko.

He aha ʻo Etelcalcetide?

He lāʻau lapaʻau synthetic ʻo Etelcalcetide e hoʻohālike i kahi hormone maoli i loko o kou kino i kapa ʻia he calcimimetic. Hana ia ma ka hoʻopaʻa ʻana i nā mea hoʻokipa ʻike calcium ma kāu mau ʻōpū parathyroid, ʻo ia nā ʻōpū liʻiliʻi ʻehā i kou ʻāʻī e kōkua ana i ka mālama ʻana i nā pae calcium i loko o kou koko. Ke ʻike kēia mau ʻōpū i ka calcium ʻoi aku ma mua o ka mea a lākou e ʻike ai, hoʻemi lākou i kā lākou hana ʻana i ka hormone parathyroid (PTH).

No kēia lāʻau lapaʻau i kahi papa o nā lāʻau i kapa ʻia he calcimimetics, a hāʻawi pololei ʻia i loko o kou kahe koko ma o kahi laina IV i ka wā o kāu mālama dialysis. Ua ʻike ʻia ka lāʻau lapaʻau e kona inoa inoa ʻo Parsabiv, a ua hoʻokumu ʻia e hana maikaʻi me ke kaʻina hana dialysis e kōkua nei i kāu mau kīkī e kānana i ka ʻōpala mai kou kino.

No ke aha e hoʻohana ʻia ai ʻo Etelcalcetide?

Hoʻohana nui ʻia ʻo Etelcalcetide e mālama i ka secondary hyperparathyroidism i nā pākeke me ka maʻi kīkī maʻi e loaʻa ana i ka hemodialysis. Hana ʻia ka secondary hyperparathyroidism ke hiki ʻole i kou mau kīkī ke hana pono i ka huaora D a wehe i ka phosphorus mai kou koko, kahi e hana ai kāu mau ʻōpū parathyroid i ka hana nui e hana ana i ka hormone parathyroid nui.

I ka wā e hana nui ai nā ʻōpū parathyroid i ka hormone, hiki ke alakaʻi i nā pilikia iwi koʻikoʻi, nā pilikia o ka naʻau, a me nā pilikia ʻē aʻe. Hiki i kāu kauka ke ʻōlelo aku i ka etelcalcetide inā kiʻekiʻe mau kāu pae PTH me ka nānā ʻole i nā lāʻau lapaʻau ʻē aʻe, a i ʻole inā pilikia ʻoe i ka ʻae ʻana i nā lāʻau lapaʻau waha e lawelawe ana i kahi kumu like. Hoʻolālā ʻia kēia lāʻau lapaʻau no ka poʻe e pono ai i ka lāʻau lapaʻau dialysis, no ka mea, hāʻawi ʻia i ka wā o kāu mau kau dialysis maʻamau.

Pehea e Hana ai ʻo Etelcalcetide?

Hana ʻo Etelcalcetide ma ka

Hāʻawi ʻia ka lāʻau lapaʻau i ʻekolu manawa i ka pule, e like me ka papa hana hemodialysis maʻamau e hahai ai ka hapa nui o nā kānaka. E hoʻokomo kāu hui mālama ola kino i loko o kāu laina dialysis i nā minuke hope loa o kāu kau dialysis, i ka wā e hoʻihoʻi ʻia ai kou koko i kou kino. Kōkua kēia manawa e hōʻoia i ka hana maikaʻi loa o ka lāʻau lapaʻau me kāu lapaʻau.

Mai ka wā e loaʻa ai iā ʻoe ka etelcalcetide ma ke kikowaena dialysis, ʻaʻole pono ʻoe e hopohopo e pili ana i nā pilina meaʻai a i ʻole ka manawa me nā meaʻai. Eia naʻe, he mea nui e mālama i kāu papa hana dialysis maʻamau a mai haʻalele i nā kau, no ka mea, e pili ana kēia i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau. E nānā pono kāu hui dialysis iā ʻoe i ka wā a ma hope o kēlā me kēia mahele e hōʻoia e ʻae maikaʻi ana ʻoe i ka lapaʻau.

Pehea ka lōʻihi e lawe ai au i ka Etelcalcetide?

ʻO ka lōʻihi o ka manawa e pono ai ʻoe i ka etelcalcetide e pili ana i ka maikaʻi o ka mālama ʻana i kāu pae hormone parathyroid a me ka pane ʻana o kou kino i ka lapaʻau. Pono ka hapa nui o nā kānaka e hoʻomau i kēia lāʻau lapaʻau i ka wā e hana ana lākou i ka dialysis a loaʻa iā lākou ka hyperparathyroidism lua, ʻo ia hoʻi, lilo ia i ʻāpana lōʻihi o kāu hoʻolālā lapaʻau.

E nānā mau kāu kauka i kāu pae koko, e nānā maʻamau i kāu hormone parathyroid, calcium, a me ka phosphorus i kēlā me kēia pule i ka wā mua, a laila ʻaʻole pinepine i ka wā e paʻa ai kou pae. Inā iho kāu pae PTH i kahi pae olakino a noho ma laila, hiki paha iā ʻoe ke hōʻemi i ke alapine o nā mahele, akā pono paha ʻoe e hoʻomau i kekahi pae o ka lapaʻau.

Hiki i kekahi poʻe ke hooki i ka etelcalcetide inā loaʻa iā lākou kahi transplant kidney, no ka mea, hiki i ka puʻupaʻa olakino ke hoʻoponopono maikaʻi i ka pae calcium a me ka phosphorus maoli. Eia naʻe, pono e hana mau kēia hoʻoholo ma ke kūkākūkā ʻana me kāu hui mālama ola kino, nāna e noʻonoʻo i kou kūlana olakino pilikino a me nā pahuhopu lapaʻau.

He aha nā hopena ʻaoʻao o Etelcalcetide?

E like me nā lāʻau lapaʻau a pau, hiki i ka etelcalcetide ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole i loaʻa i nā mea a pau. ʻO nā hopena ʻaoʻao maʻamau ka maʻamau a hiki ke mālama ʻia, ʻoiai ʻo nā hopena ʻaoʻao koʻikoʻi ʻaʻole maʻamau akā pono e mālama koke ʻia.

ʻO nā hopena ʻaoʻao i hōʻike pinepine ʻia, ʻo ia ka nausea, ka luaʻi, a me ka maʻi palahī, e pili ana i ka 10-15% o nā kānaka e lawe ana i kēia lāʻau lapaʻau. Hiki nō hoʻi iā ʻoe ke ʻike i nā spasms ʻiʻo, ʻoi loa i kou mau lima, wāwae, a i ʻole ka maka, hiki ke hana inā e emi ana kou pae calcium. Hōʻike kekahi poʻe i ka luhi a i ʻole ke poʻo, ʻoi loa i nā pule mua o ka mālama ʻana i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau.

ʻO nā hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi, hiki ke komo i nā spasms ʻiʻo koʻikoʻi a i ʻole nā ʻūhā, ka ʻūlū a i ʻole ka ʻūlū ʻana a puni kou waha a i ʻole i kou mau manamana lima a me nā manamana wāwae, a me nā loli o ka puʻuwai. Hōʻike pinepine kēia mau hōʻailona i ka emi ʻana o kou pae calcium, kahi maʻi i kapa ʻia ʻo hypocalcemia. Inā ʻike ʻoe i kekahi o kēia mau hōʻailona, ​​he mea nui e hoʻokaʻaʻike i kāu hui dialysis a i ʻole ke kauka.

ʻO nā hopena ʻaoʻao koʻikoʻi akā kakaʻikahi loa, e komo pū ana me nā hopena maʻi maʻi koʻikoʻi, hiki ke hana i ka pilikia o ka hanu ʻana, ka pehu ʻana o kou maka a i ʻole ka ʻāʻī, a i ʻole nā ​​pilikia ʻili koʻikoʻi. Ua hōʻike ʻia nā maʻi maʻi maʻi hanu kiʻekiʻe a me ka mālama wai i kekahi poʻe maʻi. E nānā pono kāu hui mālama ola iā ʻoe no kēia mau hopena a hoʻoponopono i kāu lapaʻau inā pono.

ʻO wai ka mea ʻaʻole pono e lawe i ka Etelcalcetide?

ʻAʻole kūpono ka Etelcalcetide no nā mea a pau, a aia kekahi mau kūlana kahi e ʻōlelo ai kāu kauka i kahi ala lapaʻau ʻokoʻa. ʻAʻole pono ka poʻe me nā pae calcium haʻahaʻa loa (hypocalcemia) e lawe i kēia lāʻau lapaʻau, no ka mea, hiki iā ia ke hoʻohaʻahaʻa i nā pae calcium, hiki ke pilikia.

Inā he maʻi ʻoe i ʻike ʻia i ka etelcalcetide a i ʻole kekahi o kāna mau mea, ʻaʻole pono ʻoe e loaʻa i kēia lāʻau. Pono paha nā kānaka me kekahi mau maʻi puʻuwai, ʻo ia hoʻi ka poʻe i loaʻa i ka pilikia o ka puʻuwai, i ka nānā ʻana kūikawā a i ʻole ʻaʻole paha he moho maikaʻi no kēia lapaʻau. E nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ka ʻōlelo ʻana i ka etelcalcetide.

Pono nā wāhine hāpai e pale i ka etelcalcetide ke ʻole ka maikaʻi e ʻoi aku ka nui o nā pilikia, no ka mea, ua kaupalena ʻia ka ʻikepili palekana i ka wā hāpai. Inā ʻoe e hānai ana i ka waiū, pono ʻoe e kūkākūkā me kāu kauka inā ʻoi aku ka maikaʻi o ka lāʻau lapaʻau ma mua o nā pilikia i kāu pēpē. Pono paha nā kānaka me ka maʻi ate koʻikoʻi i nā hoʻoponopono ʻana i ka maʻi a i ʻole nā ​​lapaʻau ʻē aʻe.

Eia kekahi, inā ʻaʻole ʻoe ma ka dialysis akā loaʻa iā ʻoe ka maʻi kīkī maʻi, ʻaʻole kūpono ka etelcalcetide iā ʻoe. Hoʻolālā ʻia kēia lāʻau lapaʻau no ka poʻe e loaʻa ana i ka lapaʻau hemodialysis a ua loaʻa i ka hyperparathyroidism lua ma muli o kā lākou maʻi kīkī.

Inoa Brand Etelcalcetide

Kūʻai ʻia ʻo Etelcalcetide ma lalo o ka inoa brand Parsabiv, i hana ʻia e Amgen. ʻO Parsabiv wale nō ka inoa brand o etelcalcetide i loaʻa i kēia manawa ma ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe. Ke loaʻa iā ʻoe kēia lāʻau lapaʻau ma kāu kikowaena dialysis, e kuhikuhi ʻia ia e kekahi inoa - etelcalcetide a i ʻole Parsabiv.

Hele mai ka lāʻau lapaʻau i loko o nā vials hoʻohana hoʻokahi i loaʻa nā ikaika like ʻole, maʻamau 2.5 mg, 5 mg, a i ʻole 10 mg no ka vial. E hoʻohana kāu hui dialysis i ka ikaika kūpono e pili ana i ke kau ʻana a kāu kauka a me kāu mau pono lapaʻau. Hoʻolālā ʻia nā vials e hoʻohana koke ʻia ma hope o ka wehe ʻana a ua hoʻokumu ʻia no ka hoʻohana intravenous i ka wā dialysis.

Nā Koho ʻē aʻe o Etelcalcetide

Inā ʻaʻole kūpono ʻo etelcalcetide iā ʻoe, aia kekahi mau lapaʻau ʻē aʻe no ka hyperparathyroidism lua e noʻonoʻo ai kāu kauka. ʻO ka mea maʻamau ʻo cinacalcet (inoa inoa Sensipar), he lāʻau lapaʻau waha e hana like me etelcalcetide akā lawe ʻia ma ke ʻano he mau pila ma mua o ka hāʻawi ʻia ʻana i loko o ka vein.

ʻO nā koho lapaʻau ʻē aʻe e pili ana i nā analog vitamin D e like me calcitriol a i ʻole paricalcitol, e kōkua ana i kou kino e hana i ka calcium me ka maikaʻi. Loaʻa kekahi poʻe i ka pōmaikaʻi mai nā mea hoʻopaʻa phosphorus, he mau lāʻau lapaʻau i lawe ʻia me nā meaʻai e hōʻemi i ka absorption phosphorus mai ka meaʻai. I nā hihia koʻikoʻi, hiki ke noʻonoʻo ʻia ka wehe ʻana i nā ʻāpana parathyroid overactive (parathyroidectomy).

E noʻonoʻo kāu kauka i nā mea e like me kou ola, nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, pehea ka maikaʻi o kou ʻae ʻana i nā lapaʻau like ʻole, a me kāu mau waiwai lab kikoʻī i ka wā e ʻōlelo ai i ka mea ʻē aʻe maikaʻi loa nāu. Hana maikaʻi kekahi poʻe me ka hui pū ʻana o nā lapaʻau ma mua o hoʻokahi lāʻau lapaʻau.

Ua ʻoi aku ka maikaʻi o Etelcalcetide ma mua o Cinacalcet?

He mau lapaʻau maikaʻi ʻo Etelcalcetide a me cinacalcet no ka hyperparathyroidism lua, akā loaʻa iā lākou nā mea maikaʻi kūʻokoʻa e hiki ke kūpono kekahi iā ʻoe ma mua o kekahi. Hāʻawi ʻia ʻo Etelcalcetide i ka wā dialysis, ʻo ia hoʻi, ʻaʻole pono ʻoe e hoʻomanaʻo e lawe i nā pila ma ka home, a hiki iā ia ke hana i nā hopena ʻaoʻao e pili ana i ka ʻōpū ma mua o cinacalcet.

ʻO Cinacalcet, ma kekahi ʻaoʻao, lawe ʻia ma ke ʻano he lāʻau lapaʻau waha, kahi mea makemake kekahi poʻe no ka mea hāʻawi ia iā lākou i ka mana hou aʻe ma luna o kā lākou papa hana lapaʻau. Eia naʻe, hoʻoulu pinepine ʻo cinacalcet i ka nausea a me ka luaʻi, a pono e lawe ʻia me ka meaʻai e hana pono ai. Manaʻo kekahi poʻe he paʻakikī ke hoʻomanaʻo e lawe i nā pila.

Ua hōʻike nā haʻawina ua like ka maikaʻi o nā lāʻau ʻelua i ka hoʻohaʻahaʻa ʻana i nā pae hormone parathyroid, akā hiki i ka etelcalcetide ke hana wikiwiki iki a hoʻoulu i nā hopena ʻaoʻao gastrointestinal liʻiliʻi. ʻO ka koho ma waena o lākou e pili pinepine ana i kāu mau makemake pilikino, kou ʻae ʻana i nā hopena ʻaoʻao, a me nā mea e pono ai e like me kou hiki ke hoʻomanaʻo i nā lāʻau lapaʻau i kēlā me kēia lā.

E kōkua kāu kauka iā ʻoe e kaupaona i nā pono a me nā pōʻino o kēlā me kēia lāʻau lapaʻau e pili ana i kou kūlana pilikino, me kou mau maʻi olakino ʻē aʻe, nā lāʻau lapaʻau āu e lawe nei, a me kāu mau pahuhopu lapaʻau.

Nā Nīnau i Nīnau pinepine ʻia e pili ana iā Etelcalcetide

Q1. He palekana anei ʻo Etelcalcetide no ka poʻe me ka maʻi puʻuwai?

Hiki ke hoʻohana ʻia ʻo Etelcalcetide i ka poʻe me ka maʻi puʻuwai, akā pono ia i ka nānā pono ʻana a me ke kamaʻilio pili ʻana me kāu hui mālama ola. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i kāu mau pae calcium, a laila hiki ke hoʻopilikia i kāu puʻuwai, no laila pono ka poʻe me nā maʻi puʻuwai i ka nānā kūikawā i ka wā o ka mālama ʻana.

E makemake paha kāu kauka e nānā i kāu puʻuwai i nā manawa pinepine a hiki ke hoʻoponopono i kāu mahele i ka lohi inā he moʻolelo kou o nā pilikia puʻuwai. He mea nui e haʻi i kāu hui dialysis e pili ana i nā hōʻailona e pili ana i ka puʻuwai āu e ʻike ai, e like me ka ʻeha o ka umauma, ka puʻuwai ʻole, a i ʻole ka pōkole o ka hanu, ʻoiai i nā pule mua o ka mālama ʻana.

Q2. He aha kaʻu e hana ai inā loaʻa iaʻu ka nui o Etelcalcetide?

Inā loaʻa iā ʻoe ka nui o ka etelcalcetide, ʻo ka mea nui e noho mālie a hoʻomaopopo koke i kāu hui dialysis a i ʻole ke kauka. Hiki i ka overdose ke hoʻohaʻahaʻa i kāu mau pae calcium, hiki ke alakaʻi i nā spasms ʻiʻo, ka ʻeha, ka ʻūlū, a i ʻole nā ​​hoʻololi ʻana o ka puʻuwai.

E makemake paha kāu hui mālama ola e nānā pono iā ʻoe a e nānā pinepine paha i nā pae calcium o kou koko. Hiki paha iā lākou ke hāʻawi iā ʻoe i nā mea hoʻohui calcium a i ʻole e hoʻoponopono i kāu lapaʻau dialysis e kōkua i ka hoʻoponopono ʻana i nā kaulike ʻole. Hiki ke mālama pono ʻia ka hapa nui o nā kūlana overdose me ka nānā ʻana i ka lāʻau lapaʻau.

Q3. He aha kaʻu e hana ai inā e hala wau i kahi mahele o Etelcalcetide?

Inā e hala ʻoe i kahi hālāwai dialysis a no laila e hala i kahi mahele o etelcalcetide, mai hoʻāʻo e hana i luna ma ka lawe ʻana i ka lāʻau hou aʻe i kāu hālāwai aʻe. E hoʻomau wale i kāu papa hana maʻamau i kāu manawa dialysis maʻamau a e hōʻike i kāu hui mālama ola ua hala ʻoe i ka mahele mua.

ʻAʻole pilikia ka hala ʻana i hoʻokahi mahele i kekahi manawa, akā e hoʻāʻo ʻaʻole e hana i mea maʻamau, no ka mea, he mea nui ka kūlike no ka mālama ʻana i nā pae hormone parathyroid paʻa. Inā pono ʻoe e hala i ka dialysis no nā kumu olakino a i ʻole nā pilikia, e hoʻokaʻaʻike i kāu kikowaena dialysis i ka hiki wawe e kūkākūkā i nā koho hoʻonohonoho hou.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Etelcalcetide?

ʻAʻole pono ʻoe e hooki i ka lawe ʻana iā etelcalcetide me ka ʻole e kūkākūkā mua me kāu kauka. Pono pinepine kēia lāʻau lapaʻau i ka wā e loaʻa ana iā ʻoe ka hyperparathyroidism lua a aia ʻoe ma ka dialysis. ʻO ka hooki ʻana i ka hikiwawe hiki ke hoʻonui hou i nā pae hormone parathyroid, hiki ke alakaʻi i nā pilikia iwi a me nā pilikia ʻē aʻe.

Hiki i kāu kauka ke noʻonoʻo e hōʻemi i kāu mahele a i ʻole e hooki i ka lāʻau lapaʻau inā e lilo ana kāu mau pae PTH i haʻahaʻa loa, inā ʻoe e ʻike i nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia, a i ʻole inā loaʻa iā ʻoe kahi transplant kidney. Pono e hana mālie ʻia nā hoʻololi i kāu hoʻolālā lapaʻau a me ka nānā pono ʻana i nā pae o kou koko.

Q5. Hiki iā Etelcalcetide ke launa pū me kaʻu mau lāʻau lapaʻau ʻē aʻe?

Hiki i ka Etelcalcetide ke launa pū me kekahi mau lāʻau lapaʻau, ʻo ia hoʻi nā mea e pili ana i nā pae calcium i loko o kou kino. He mea nui e haʻi aku i kāu kauka e pili ana i nā mea hoʻohui calcium, nā mea hoʻohui huaora D, a me nā lāʻau lapaʻau ʻē aʻe i hoʻohana ʻia e mālama i nā maʻi iwi a me nā mineral.

Hiki nō hoʻi i ka lāʻau lapaʻau ke launa pū me kekahi mau lāʻau lapaʻau puʻuwai, ʻo ia hoʻi nā mea e pili ana i ka puʻuwai. E hāʻawi mau i kāu hui dialysis a me ke kauka i kahi papa inoa piha o nā lāʻau lapaʻau a pau, nā mea hoʻohui, a me nā huahana over-the-counter āu e lawe nei. Hiki iā lākou ke kōkua iā ʻoe e mālama i nā pilina kūpono a hoʻoponopono i nā dosages inā pono.