He aha ʻo Evinacumab: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau injectable kūikawā ʻo Evinacumab i hoʻolālā ʻia e hoʻohaʻahaʻa i nā pae cholesterol kiʻekiʻe loa i ka poʻe me kahi maʻi genetic laha ʻole i kapa ʻia ʻo homozygous familial hypercholesterolemia (HoFH). Hana ʻokoʻa kēia lapaʻau ikaika mai nā lāʻau cholesterol maʻamau ma ka pale ʻana i kahi protein kikoʻī e pale ai i kou kino mai ka wehe ʻana i ka cholesterol maikaʻi ʻole mai kou koko.

Inā ua ʻike ʻia ʻoe a i ʻole kekahi āu e mālama nei me HoFH, e manaʻo paha ʻoe i ka piʻi ʻana e nā huaʻōlelo lapaʻau a me nā koho lapaʻau. Hōʻike kēia lāʻau lapaʻau i kahi holomua nui no ka poʻe nona nā pae cholesterol e noho kiʻekiʻe loa me ka hoʻāʻo ʻana i nā lāʻau lapaʻau ʻē aʻe.

He aha ʻo Evinacumab?

He lāʻau lapaʻau monoclonal antibody ʻo Evinacumab e kuhikuhi ana i kahi protein i kapa ʻia ʻo ANGPTL3 (angiopoietin-like protein 3). Hoʻopilikia maʻamau kēia protein i ka hiki o kou kino ke wāwahi i nā momona a me ka cholesterol i loko o kou kahe koko.

E noʻonoʻo i ka ANGPTL3 ma ke ʻano he kaʻa e hoʻolohi i ka ʻōnaehana hoʻomaʻemaʻe cholesterol maoli o kou kino. Hoʻokuʻu ʻo Evinacumab i kēlā kaʻa, e ʻae ana i kou kino e hana a wehe i ka cholesterol ʻoi aku ka maikaʻi. Hoʻolālā kūikawā ʻia kēia lāʻau lapaʻau no ka poʻe me ka homozygous familial hypercholesterolemia, kahi maʻi genetic laha ʻole e pili ana i ka 1 i 300,000 poʻe ma ka honua holoʻokoʻa.

Hele mai ka lāʻau lapaʻau ma ke ʻano he hopena maʻemaʻe, ʻaʻohe kala i hāʻawi ʻia ma o ka intravenous (IV) infusion pololei i loko o kou kahe koko. Hōʻoia kēia ʻano hāʻawi ʻana i ka lāʻau lapaʻau e hiki koke i kāu ʻōnaehana a hana i ka ikaika piha.

No ke aha i hoʻohana ʻia ai ʻo Evinacumab?

Ua ʻae ʻia ʻo Evinacumab e mālama i ka homozygous familial hypercholesterolemia (HoFH) i nā pākeke a me nā keiki 12 makahiki a ʻoi aku. He maʻi genetic koʻikoʻi ʻo HoFH kahi e hāʻawi ai nā mākua ʻelua i nā genes hewa e mālama ana i ka hana cholesterol.

ʻO ka poʻe me HoFH ka mea maʻamau i nā pae cholesterol LDL i 4-6 mau manawa kiʻekiʻe ma mua o ka maʻamau, pinepine ma mua o 400-500 mg/dL. Hiki i kēia mau pae kiʻekiʻe loa ke alakaʻi i nā puʻuwai, nā hahau, a me nā pilikia cardiovascular ʻē aʻe i ka wā ʻōpio loa, i kekahi manawa i ka wā kamaliʻi a i ʻole nā makahiki ʻōpio.

E kauoha maʻamau kāu kauka i ka evinacumab ke ʻaʻole i lawa nā lāʻau lapaʻau hoʻohaʻahaʻa cholesterol ʻē aʻe. Aia kēia i nā kūlana i ka wā i lawe ʻole ai nā statins, PCSK9 inhibitors, a me nā lāʻau lapaʻau ʻē aʻe i kāu cholesterol i nā pae palekana.

Hoʻohana ʻia ka lāʻau lapaʻau me nā loli meaʻai a me nā lāʻau lapaʻau hoʻohaʻahaʻa lipid ʻē aʻe ma ke ʻano he ʻāpana o kahi hoʻolālā lapaʻau piha. ʻAʻole i manaʻo ʻia e pani i nā lāʻau lapaʻau ʻē aʻe akā e hana pū me lākou no ka pono kiʻekiʻe.

Pehea e hana ai ʻo Evinacumab?

Hana ʻo Evinacumab ma ka pale ʻana iā ANGPTL3, kahi protein e pale maʻamau i kou kino mai ka wāwahi ʻana i nā triglycerides a me ka cholesterol maikaʻi. Ke ālai ʻia kēia protein, hiki i kou kino ke hoʻomaʻemaʻe i nā momona mai kou kahe koko me ka ʻoi aku ka maikaʻi.

He lāʻau lapaʻau ikaika loa kēia e pili ana i ka hoʻohaʻahaʻa cholesterol. Hōʻike nā haʻawina lapaʻau hiki iā ia ke hoʻohaʻahaʻa i ka LDL cholesterol e 47% ma ka awelika, he mea nui ia no ka poʻe i pane ʻole i nā lāʻau lapaʻau ʻē aʻe.

ʻAʻole like me nā statins e hana i kou ate e hōʻemi i ka hana cholesterol, hana ʻo evinacumab i kou kahe koko e kōkua i ka wehe ʻana i ka cholesterol e holo nei. ʻO kēia ala pālua ke kumu e hoʻohana pinepine ʻia ai me nā lāʻau lapaʻau ʻē aʻe ma mua o ka pani ʻana iā lākou.

He lōʻihi ka hopena o ka lāʻau lapaʻau, me kēlā me kēia infusion e hāʻawi ana i nā pōmaikaʻi hoʻohaʻahaʻa cholesterol no kahi o hoʻokahi mahina. ʻO kēia hana i hoʻolōʻihi ʻia ke ʻano ʻaʻole pono ʻoe i ka dosing pinepine, hiki ke maʻalahi i ka mālama ʻana i kāu lapaʻau.

Pehea wau e lawe ai iā Evinacumab?

Hāʻawi ʻia ʻo Evinacumab ma ke ʻano he hoʻokomo intravenous i kēlā me kēia ʻehā pule ma kahi keʻena mālama ola a i ʻole ke kikowaena hoʻokomo. ʻO ka mahele maʻamau he 15 mg no ke kilokani o kou kaumaha kino, e hāʻawi mālie ʻia ma kahi o 60 mau minuke.

ʻAʻole pono ʻoe e hoʻokē ʻai a pale paha i ka ʻai ʻana ma mua o kāu hoʻokomo ʻana. ʻO ka ʻoiaʻiʻo, ʻo ka ʻai ʻana i ka ʻai māmā ma mua hiki ke kōkua iā ʻoe e ʻoluʻolu i ka wā o ka mālama ʻana. ʻO ka noho ʻana i ka wai maikaʻi ma ka inu ʻana i ka wai nui ma mua a ma hope o kāu hoʻokomo ʻana he mea kōkua nō hoʻi.

E nānā pono kāu hui mālama ola iā ʻoe i ka wā o kēlā me kēia hoʻokomo ʻana a no ka liʻiliʻi o 30 mau minuke ma hope. E nānā lākou i kāu mau hōʻailona koʻikoʻi a nānā i nā hopena koke. ʻO ka lumi hoʻokomo maʻamau he ʻoluʻolu, a hiki iā ʻoe ke lawe mai i nā puke, nā papa, a i ʻole nā hana mālie ʻē aʻe e hala ai ka manawa.

Ma mua o kēlā me kēia hoʻokomo ʻana, hiki i kāu mea mālama ola ke hāʻawi iā ʻoe i nā lāʻau lapaʻau e pale ai i nā hopena maʻi. Hiki i kēia mau mea ke komo i nā antihistamines a i ʻole corticosteroids, ma muli o kāu mau pono pilikino a me ka mōʻaukala olakino.

Pehea ka lōʻihi e lawe ai au i ka Evinacumab?

Manaʻo ʻia ʻo Evinacumab he lapaʻau lōʻihi no ka mālama ʻana i ka homozygous familial hypercholesterolemia. No ka mea he maʻi genetic ola ʻo HoFH, pono ka hapa nui o nā kānaka i ka mālama mau ʻana e mālama i kā lākou pae cholesterol.

E nānā mau kāu kauka i kāu pae cholesterol, maʻamau i kēlā me kēia 3-6 mahina, e loiloi i ka maikaʻi o ka hana ʻana o ka lāʻau. E nānā pū lākou i nā hopena ʻaoʻao a hoʻoponopono i kāu hoʻolālā lapaʻau holoʻokoʻa e like me ka mea e pono ai.

ʻO ka hoʻoholo e pili ana i ka hoʻomau ʻana i ka mālama ʻana e hilinaʻi ana i nā mea he nui: pehea ka maikaʻi o kāu pae cholesterol, inā ʻoe e ʻike i nā hopena ʻaoʻao nui, a me kou kūlana olakino holoʻokoʻa. Pono paha kekahi poʻe e hoʻomau i ka mālama ʻana no ka manawa pau ʻole, a ʻo nā mea ʻē aʻe e hiki ke hōʻemi i ke alapine a i ʻole e hoʻāʻo i nā ala ʻē aʻe i ka manawa.

Mai hooki i ka lawe ʻana i ka evinacumab me ka ʻole e kūkākūkā mua me kāu kauka. Hiki ke piʻi koke kou pae cholesterol, e hoʻonui ana i kou pilikia no nā pilikia cardiovascular.

He aha nā hopena ʻaoʻao o Evinacumab?

ʻO ka hapa nui o nā kānaka e ʻae maikaʻi i ka evinacumab, akā e like me nā lāʻau lapaʻau a pau, hiki iā ia ke hana i nā hopena ʻaoʻao. ʻO nā hopena maʻamau ka maʻalahi a hiki ke mālama ʻia me ka nānā pono a me ka mālama.

Eia nā hopena ʻaoʻao e ʻike nui ʻia e ʻoe, me ka noʻonoʻo ʻana he kakaikahi a ʻaʻohe pilikia o ka poʻe me kēia lāʻau:

• Nā hopena e pili ana i ka infusion e like me ke kuni maʻalahi, nā anu, a i ʻole ka manaʻo ʻulaʻula i ka wā a i ʻole ma hope koke o ka mālama ʻana
• Nā maʻi o ka ʻōnaehana hanu luna e like me nā hōʻailona e like me ke anu a i ʻole ka congestion sinus
• ʻO ka luhi a i ʻole ka manaʻo luhi ma mua o ka maʻamau no hoʻokahi a ʻelua paha lā ma hope o ka infusion
• Nā poʻo e maʻalahi a pane maikaʻi i nā mea hoʻomaha ʻeha ma luna o ka counter
• Nausea a i ʻole ka ʻōpū maʻalahi, ʻoi loa i nā lā infusion
• ʻO ka dizziness a i ʻole ka māmā, ʻoi loa i ka wā e kū koke ai

Hoʻomaikaʻi maʻamau kēia mau hopena ʻaoʻao maʻamau i loko o kekahi mau lā a lilo i mea liʻiliʻi ke hoʻololi kou kino i ka lāʻau.

ʻOiai ʻaʻole maʻamau, aia kekahi mau hopena ʻaoʻao koʻikoʻi e koi ai i ka lāʻau lapaʻau koke:

• Nā hopena maʻi koʻikoʻi me nā hōʻailona e like me ka pilikia o ka hanu ʻana, ka pehu ʻana o ka maka a i ʻole ka ʻāʻī, a i ʻole ka ʻōpala ākea
• Nā loli nui i nā hoʻokolohua hana ate, a kāu kauka e nānā ai ma o ka hana koko maʻamau
• Ke kahe koko ʻano ʻē a i ʻole ka ʻeha ʻana ʻaʻole i loaʻa ke kumu maopopo
• Ke kuni kiʻekiʻe mau a i ʻole nā ​​hōʻailona o ka maʻi koʻikoʻi
• ʻO ka luhi koʻikoʻi a i ʻole ka ʻino e hoʻopilikia i nā hana i kēlā me kēia lā

Ua ʻike kāu hui mālama ola pehea e ʻike ai a e mālama koke i kēia mau hopena. E loaʻa mau iā lākou nā lāʻau lapaʻau pilikia i ka wā o kāu infusions a e aʻo lākou iā ʻoe i nā hōʻailona hōʻailona e nānā ai ma ka home.

ʻO wai ka mea pono ʻole e lawe iā Evinacumab?

ʻAʻole kūpono ʻo Evinacumab no nā mea a pau, a aia nā kūlana kikoʻī kahi e ʻōlelo ai kāu kauka e kūʻē i ka hoʻohana ʻana i kēia lāʻau lapaʻau. ʻO ka mea nui loa, ʻo ia ka loaʻa ʻana o kahi hōʻailona i hōʻoia ʻia o ka homozygous familial hypercholesterolemia, no ka mea, ua hoʻolālā ʻia kēia lāʻau lapaʻau no kēia maʻi laha.

ʻAʻole pono ʻoe e loaʻa iā evinacumab inā ua loaʻa iā ʻoe kahi hopena maʻi koʻikoʻi i kēia lāʻau lapaʻau a i ʻole kekahi o kāna mau mea i hala. ʻO nā hōʻailona o ia mau hopena e pili ana i ka pilikia o ka hanu ʻana, ka pehu nui ʻana, a i ʻole nā hopena ʻili ākea i koi ʻia i ka mālama pilikia.

E loiloi pono kāu kauka inā kūpono kēia lāʻau lapaʻau iā ʻoe inā loaʻa iā ʻoe kekahi mau maʻi olakino:

• Maʻi ate hana a i ʻole nā enzyme ate i hoʻokiʻekiʻe nui ʻia
• Maʻi kīkī koʻikoʻi a i ʻole ma ka dialysis
• Nā maʻi hana a i ʻole kahi ʻōnaehana pale i hoʻopilikia ʻia
• Nā maʻi koko a i ʻole e lawe ana i nā lāʻau lahilahi koko
• Hāpai a i ʻole e hoʻolālā ana e hāpai
• Hānai umauma a i ʻole e hoʻolālā ana e hānai umauma

ʻAʻole pono nā keiki ma lalo o 12 mau makahiki e loaʻa iā evinacumab, no ka mea, ʻaʻole i hoʻokumu ʻia ka palekana a me ka pono i kēia pūʻulu makahiki. Eia naʻe, ke hana nei ka noiʻi e hoʻoholo inā palekana a pono paha ia no nā keiki ʻōpio me HoFH.

Inā ʻoe e lawe ana i nā lāʻau lapaʻau ʻē aʻe, ʻoiai nā mea e pili ana i kāu ʻōnaehana pale a i ʻole ka hana ate, pono kāu kauka e nānā pono i kāu mau lāʻau lapaʻau a pau ma mua o ka hoʻomaka ʻana i ka evinacumab.

Nā inoa inoa Evinacumab

Hoʻolaha ʻia ʻo Evinacumab ma lalo o ka inoa inoa ʻo Evkeeza ma ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe. ʻO kēia wale nō ka inoa inoa i loaʻa no kēia lāʻau lapaʻau.

ʻO ka inoa maʻamau piha ʻo evinacumab-dgnb, e kōkua ana i ka hoʻokaʻawale ʻana mai nā mea pale monoclonal ʻē aʻe i hana ʻia i ka wā e hiki mai ana. Ke loaʻa iā ʻoe kāu lāʻau lapaʻau, e ʻike ʻoe iā "Evkeeza" ma ka ʻōpala a me nā ʻeke hoʻokomo.

Mai ka wā he lāʻau lapaʻau hou kēia i ʻae mua ʻia i ka makahiki 2021, ʻaʻohe mana maʻamau i loaʻa i kēia manawa. Hana ʻia ka lāʻau lapaʻau e Regeneron Pharmaceuticals a hāʻawi ʻia ma o nā hale kūʻai lāʻau lapaʻau kūikawā a me nā kikowaena hoʻokomo.

Nā Koho ʻē aʻe no Evinacumab

ʻOiai ua hoʻolālā ʻia ʻo evinacumab no ka homozygous familial hypercholesterolemia, aia nā koho lapaʻau ʻē aʻe e noʻonoʻo ai kāu kauka ma muli o kāu kūlana kikoʻī a me ka maikaʻi o kou pane ʻana i nā lāʻau lapaʻau like ʻole.

ʻO nā lāʻau lapaʻau hoʻohaʻahaʻa cholesterol kuʻuna i hoʻohana pinepine ʻia me a i ʻole ma kahi o evinacumab, e like me nā statins kiʻekiʻe e like me atorvastatin a i ʻole rosuvastatin. Hana kēia mau mea ma ka hoʻemi ʻana i ka hana cholesterol i loko o kou ate, ʻoiai ʻaʻole ikaika pinepine lākou no HoFH.

ʻO nā mea pale PCSK9 e like me evolocumab (Repatha) a i ʻole alirocumab (Praluent) e hōʻike ana i kahi papa ʻē aʻe o nā lāʻau lapaʻau injectable e hiki ke hoʻohaʻahaʻa nui i ka cholesterol. Hana ʻokoʻa kēia mau mea mai evinacumab a hoʻohana ʻia i kekahi manawa me ia.

No kekahi poʻe me HoFH, hiki i ka LDL apheresis ke koho. He hana like kēia me ka dialysis kahi e kānana ʻia ai kou koko e wehe pololei i ka cholesterol. Hana ʻia ia i kēlā me kēia 1-2 pule a hiki ke maikaʻi loa, ʻoiai ʻoi aku ka manawa ma mua o ka lāʻau lapaʻau.

ʻO nā lāʻau lapaʻau ʻē aʻe e hiki ke lilo i ʻāpana o kāu hoʻolālā lapaʻau e pili ana i ka ezetimibe (Zetia), e ālai ana i ka absorption cholesterol i loko o kou ʻōpū, a me nā mea hoʻopaʻa waikawa bile e like me colesevelam (Welchol).

Ua ʻoi aku ka maikaʻi o Evinacumab ma mua o nā mea pale PCSK9?

Hana ʻo Evinacumab a me nā mea pale PCSK9 ma nā ʻano hana like ʻole, no laila ʻaʻole maʻalahi ka hoʻohālikelike pololei ʻana iā lākou. He mau lāʻau lapaʻau hoʻohaʻahaʻa cholesterol ikaika lāua ʻelua, akā hoʻohana pinepine ʻia lāua i nā kūlana like ʻole a i ʻole pū.

Hoʻāʻo mua ʻia nā mea pale PCSK9 no ka mea ua loaʻa lākou no ka manawa lōʻihi a loaʻa nā ʻikepili palekana nui aʻe. Ua ʻae ʻia lākou no ka laulā ākea o nā maʻi cholesterol, ʻaʻole wale ʻo HoFH. Hiki i kēia mau lāʻau lapaʻau ke hoʻohaʻahaʻa i ka LDL cholesterol e 50-60% i ka hapa nui o nā kānaka.

Hāʻawi ʻo Evinacumab i kekahi mau mea maikaʻi no ka poʻe me HoFH. Hana ia ʻoiai ʻaʻole hana pono nā mea loaʻa LDL, ʻo ia ka hihia ma HoFH. ʻO kēia ka mea e pono ai no ka poʻe i pane ʻole i nā mea pale PCSK9 a i ʻole statins.

Aia ke koho ma waena o kēia mau lāʻau lapaʻau i kāu ʻano genetic kikoʻī o HoFH, pehea ʻoe i pane ai i nā lāʻau lapaʻau ʻē aʻe, a me kāu mau mea olakino pilikino. Nui ka poʻe e hoʻohana maoli i nā ʻano lāʻau lapaʻau ʻelua no ka hoʻohaʻahaʻa cholesterol kiʻekiʻe.

E noʻonoʻo kāu kauka i nā mea e like me kāu pae cholesterol o kēia manawa, nā pane lapaʻau mua, nā mea ola, a me nā makemake pilikino i ka wā e hoʻoholo ai i ke ala maikaʻi loa no ʻoe.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Evinacumab

He Palekana ʻo Evinacumab no ka poʻe me ka maʻi diabetes?

He palekana ʻo Evinacumab no ka poʻe me ka maʻi diabetes, a ʻo ka loaʻa ʻana o ka maʻi diabetes ʻaʻole ia e pale iā ʻoe mai ka hoʻohana ʻana i kēia lāʻau lapaʻau. ʻO ka ʻoiaʻiʻo, pono pinepine ka poʻe me HoFH a me ka maʻi diabetes i ka mālama cholesterol ikaika no ka mea e hoʻonui ka maʻi diabetes i ka pilikia cardiovascular.

E nānā kāu kauka i kāu pae kō koko koko ke hoʻomaka ʻoe i ka evinacumab, no ka mea, ʻike kekahi poʻe i nā loli liʻiliʻi i ka mana glucose. He liʻiliʻi a hiki ke mālama ʻia kēia mau loli me nā hoʻoponopono i kāu mau lāʻau lapaʻau diabetes inā pono.

ʻO nā pōmaikaʻi o ka puʻuwai a me nā kīʻaha koko mai ka hoʻohaʻahaʻa ʻana i ka cholesterol kiʻekiʻe loa, ʻoi aku ka maikaʻi ma mua o nā hopena liʻiliʻi ma ke kō koko. E hana pū kāu hui mālama ola me ʻoe e hoʻomaikaʻi i kāu cholesterol a me ka mālama ʻana i ka maʻi diabetes i ka manawa like.

He aha kaʻu e hana ai inā ua hala au i kahi mahele o Evinacumab?

Inā ua hala ʻoe i kāu hoʻokomo ʻana i ka evinacumab i hoʻonohonoho ʻia, e kelepona i kāu mea mālama ola a i ʻole ke kikowaena hoʻokomo i ka hiki wawe e hoʻonohonoho hou. Mai kali a hiki i kāu manawa i hoʻonohonoho mau ʻia, no ka mea, ʻo ka hala ʻana i nā mahele hiki ke ʻae i kou pae cholesterol e piʻi.

Ma keʻano maʻamau, inā ua hala ʻoe i kahi mahele no kekahi mau lā wale nō, hiki iā ʻoe ke loaʻa ka hoʻokomo ʻana a laila e hoʻomau me kāu papa hana mahina maʻamau. Inā ua hala ʻoe i kahi mahele no ʻoi aku ma mua o hoʻokahi pule, makemake paha kāu kauka e nānā i kou pae cholesterol ma mua o ka hoʻoholo ʻana i ka manawa o kāu hoʻokomo hou ʻana.

E hoʻāʻo e hoʻonohonoho hou i loko o kekahi mau lā o kāu manawa i hala inā hiki. Hoʻomaopopo kāu hui mālama ola i kekahi manawa e kū mai nā paio hoʻonohonoho a e hana pū me ʻoe e ʻimi i kahi manawa kūpono.

He aha kaʻu e hana ai inā loaʻa iaʻu nā hopena ʻaoʻao koʻikoʻi?

Inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi i ka wā o kāu hoʻokomo ʻana, e hoʻōki koke ka hui mālama ola i ka hoʻokomo ʻana a hāʻawi i ka lāʻau kūpono. Ua aʻo ʻia lākou e mālama i nā hopena hoʻokomo a loaʻa nā lāʻau lapaʻau pilikia i loaʻa.

No nā hopena ʻaoʻao koʻikoʻi e kū mai ma hope o kou haʻalele ʻana i ke kikowaena hoʻokomo, e like me ka pilikia o ka hanu ʻana, ka pehu nui ʻana, a i ʻole nā hōʻailona o kahi hopena maʻi maʻi koʻikoʻi, e ʻimi koke i ka mālama olakino pilikia. Mai kali e ʻike inā e hoʻomaikaʻi nā hōʻailona iā lākou iho.

No nā hopena ʻaoʻao liʻiliʻi akā e pili ana i ka mea e ulu ana ma waena o nā hoʻokomo ʻana, e kelepona i kāu mea mālama ola i nā hola ʻoihana maʻamau. Hiki iā lākou ke kōkua i ka hoʻoholo ʻana inā pili nā hōʻailona i ka lāʻau a me nā hana e hana ai.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Evinacumab?

Pono e hana mau ka hoʻoholo e hooki i ka evinacumab ma ke kūkākūkā ʻana me kāu mea mālama ola. No ka mea he maʻi genetic ola ʻo HoFH, pono ka hapa nui o nā kānaka i ka mālama mau e mālama i nā pae cholesterol palekana.

Hiki i kāu kauka ke noʻonoʻo e hooki a hoʻemi paha i ka lāʻau lapaʻau inā loaʻa iā ʻoe nā hopena ʻaoʻao nui e ʻoi aku ana ma mua o nā pōmaikaʻi, inā e hoʻomalu maikaʻi ʻia kāu mau pae cholesterol me nā lāʻau lapaʻau ʻē aʻe, a i ʻole inā loaʻa nā koho lapaʻau hou.

Hiki i kekahi poʻe ke hoʻokaʻawale i kā lākou infusions ma hope o ka hoʻopaʻa ʻana o kā lākou pae cholesterol, akā pili kēia i ka pane pilikino a pono e hana ʻia ma lalo o ka mālama olakino.

Hiki iaʻu ke loaʻa nā lāʻau lapaʻau i ka wā e lawe ana i ka Evinacumab?

ʻAe, hiki iā ʻoe ke loaʻa i nā lāʻau lapaʻau i ka wā e lawe ana i ka evinacumab. ʻAʻole kēia lāʻau lapaʻau e kāohi nui i kāu ʻōnaehana pale e like me kekahi mau lāʻau lapaʻau ʻē aʻe, no laila ua palekana a paipai ʻia nā lāʻau lapaʻau maʻamau.

Eia naʻe, ʻoi aku ka maikaʻi e haʻi i kāu mea mālama ola e pili ana i nā lāʻau lapaʻau āu e manaʻo ai e loaʻa. Hiki iā lākou ke paipai i ka manawa o nā lāʻau lapaʻau ma waena o nā infusions a i ʻole ka nānā ʻana iā ʻoe ma hope, ʻoiai no nā lāʻau lapaʻau ola.

He mea nui ka noho ʻana i ka lā me nā lāʻau lapaʻau i ʻōlelo ʻia no ka poʻe me nā maʻi maʻi e like me HoFH, no ka mea hiki i nā maʻi ke hoʻonui i ke olakino cardiovascular no kekahi manawa.