He aha ʻo Fexinidazole: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau waha ʻo Fexinidazole i hoʻolālā ʻia e mālama i ka human African trypanosomiasis, i ʻike nui ʻia ʻo ka maʻi hiamoe. ʻO kēia lapaʻau holomua e hōʻike ana i kahi holomua nui i ka hakakā ʻana i kahi maʻi i hoʻopilikia i nā kaiāulu ma Sub-Saharan Africa no nā hanauna. ʻAʻole like me nā lāʻau lapaʻau mua i koi i ka haukapila a me ka hoʻokele intravenous, hiki ke lawe ʻia ʻo fexinidazole ma ke ʻano he mau pila ma ka home, e maʻalahi ai ka mālama ʻana a ʻaʻole i kaumaha no nā maʻi a me ko lākou ʻohana.

He aha ʻo Fexinidazole?

No ka papa o nā lāʻau lapaʻau i kapa ʻia ʻo nitroimidazoles ʻo Fexinidazole, e hana ana ma ka hoʻopilikia ʻana i ka DNA o nā parasites. Ua hoʻomohala ʻia ka lāʻau lapaʻau e hakakā i ka Trypanosoma brucei gambiense, ka parasite e kuleana ana no ke ʻano maʻamau o ka maʻi hiamoe ma West a me Central Africa.

Ua loaʻa i kēia lāʻau lapaʻau ka ʻae mai ka European Medicines Agency i ka makahiki 2018 a ua hoʻokomo ʻia ma ka World Health Organization's List of Essential Medicines. ʻO ka hoʻomohala ʻana o fexinidazole i komo i ka hui pū ʻana ma waena o nā hui lāʻau lapaʻau, nā hui waiwai ʻole, a me nā ʻoihana olakino lehulehu e hoʻoponopono i kahi maʻi tropical i mālama ʻole ʻia.

No ke aha i hoʻohana ʻia ai ʻo Fexinidazole?

Hoʻomaʻamaʻa ʻo Fexinidazole i ka human African trypanosomiasis i hoʻokumu ʻia e Trypanosoma brucei gambiense i nā pae mua a me ka lua o ka maʻi. Hiki mai ka pae mua i ka wā e noho ai ka parasite i loko o ke koko a me ka ʻōnaehana lymphatic, aʻo ka pae lua e ulu ana i ka wā e hele ai ka parasite i loko o ka ʻōnaehana nerve waena.

Ma mua, pono nā maʻi i nā lāʻau lapaʻau like ʻole ma muli o ko lākou pae maʻi, e koi pinepine ana i nā punctures lumbar ʻeha e hoʻoholo i ka holomua. Hoʻomaʻamaʻa ʻo Fexinidazole i kēia kaʻina hana ma ka mālama pono ʻana i nā pae ʻelua me ka regimen waha like, e hoʻopau ana i ka pono no nā kaʻina hana i nā hihia he nui.

Pehea e hana ai ʻo Fexinidazole?

Hana ʻo Fexinidazole ma ka pahuhopu ʻana i ka hiki o ka parasite ke mālama i kona ʻano kelepona a hana hou. Ke lawe ʻoe i ka lāʻau lapaʻau, hoʻololi kou kino iā ia i nā mea hana e hoʻopilikia i ka DNA o ka parasite a me nā hana kelepona nui.

Ua manaʻo ʻia kēia lāʻau lapaʻau he mea maikaʻi loa i nā parasites maʻi hiamoe ʻoiai e mālie ana i nā keena ponoʻī o kou kino. Hōʻike maʻamau ka lāʻau lapaʻau i nā hopena i loko o nā lā a i ʻole nā ​​pule, ʻoiai pono ʻoe e hoʻopau i ka papa piha inā hoʻomaka ʻoe e maikaʻi.

Pehea wau e lawe ai iā Fexinidazole?

E lawe iā fexinidazole e like me ke kau ʻia e kāu mea mālama ola, maʻamau ma ke ʻano he papa 10-lā me ka hoʻohana ʻana i ka nui e pili ana i kou kaumaha. Pono ʻoe e lawe i nā papa me ka meaʻai e hoʻomaikaʻi i ka absorption a hōʻemi i ka manawa o ka ʻōpū.

Hana maikaʻi ka lāʻau lapaʻau ke lawe ʻia me ka meaʻai i loaʻa i kekahi momona, e like me ka waiū, nā nati, a i ʻole ka meaʻai maʻamau me ka protein a me nā mea kanu. E pale i ka lawe ʻana iā fexinidazole ma ka ʻōpū ʻole, no ka mea, hiki i kēia ke hōʻemi i kona pono a hoʻonui i ka likelika o ka nausea.

Inā pilikia ʻoe i ka ale ʻana i nā papa, hiki iā ʻoe ke ʻoki iā lākou a hui pū me kahi meaʻai palupalu liʻiliʻi e like me ka applesauce a i ʻole yogurt. E lawe koke i ka hui ʻana a e hōʻoia e ʻai piha iā ia.

Pehea ka lōʻihi e lawe ai au iā Fexinidazole?

ʻO ka papa hana maʻamau he 10 mau lā, a he mea nui e hoʻopau i ka papa holoʻokoʻa inā hoʻomaka ʻoe e maikaʻi ma mua o ka pau ʻana o nā papa āpau. ʻO ka hooki ʻana i ka wā mua hiki ke ʻae i nā parasites e ola a hiki ke hoʻomohala i ke kūʻē ʻana i ka lāʻau lapaʻau.

E nānā kāu mea mālama ola i kou holomua i ka wā a ma hope o ka lāʻau lapaʻau. Pono paha kekahi poʻe maʻi i nā manawa e hahai ai ma 3, 6, 12, a me 18 mau mahina e hōʻoia i ka hoʻomaʻemaʻe ʻia ʻana o ka maʻi.

He aha nā hopena ʻaoʻao o Fexinidazole?

ʻO ka hapa nui o nā kānaka e ʻae maikaʻi i ka fexinidazole, akā hiki ke loaʻa kekahi mau hopena ʻaoʻao i ka wā o ka lapaʻau. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hoʻokaʻaʻike aku ai i kāu mea mālama ola.

ʻO nā hopena ʻaoʻao maʻamau i ʻike ʻia e nā maʻi he nui, ʻo ia:

• Ka maʻi a me ka luaʻi ʻana, ʻoi loa i nā lā mua
• Nā ʻeha poʻo e hiki ke mai ka maʻi maʻalahi a i ka maʻi kūpono
• Ka wili a i ʻole ka manaʻo māmā
• Ka luhi a me ka nāwaliwali maʻamau
• Ka nalowale o ka ʻai
• Ka ʻeha o ka ʻōpū a i ʻole ka ʻoluʻolu ʻole

Hoʻomaikaʻi maʻamau kēia mau hopena ʻaoʻao maʻamau i ka wā e hoʻoponopono ai kou kino i ka lāʻau a hoʻopau maʻamau ma hope o ka pau ʻana o ka papa lapaʻau.

ʻO nā hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi e koi ai i ka lāʻau lapaʻau koke, ʻo ia:

• Nā hopena maʻi koʻikoʻi me ka ʻōpala, ka pehu, a i ʻole ka pilikia o ka hanu ʻana
• Ka luaʻi mau e pale ana i ka mālama ʻana i ka meaʻai a i ʻole nā wai
• Ka wili nui a i ʻole ka huikau
• Nā loli ʻokoʻa i ka puʻuwai
• Nā hōʻailona o nā pilikia o ke ake e like me ka melemele o ka ʻili a i ʻole nā maka

E hoʻokaʻaʻike koke i kāu mea mālama ola inā loaʻa iā ʻoe kekahi o kēia mau hopena ʻaoʻao koʻikoʻi a i ʻole inā lilo nā hopena ʻaoʻao maʻamau i mea koʻikoʻi a ʻaʻole e hoʻomaikaʻi.

ʻO wai ka mea pono ʻole e lawe i ka Fexinidazole?

ʻAʻole kūpono paha ka Fexinidazole no nā mea a pau, a e loiloi pono kāu mea mālama ola inā ʻo ia ka lāʻau kūpono no ʻoe. Pono kekahi mau maʻi olakino a me nā kūlana i ka noʻonoʻo kūikawā ma mua o ka hoʻomaka ʻana i kēia lāʻau.

ʻAʻole pono ʻoe e lawe i ka fexinidazole inā loaʻa iā ʻoe:

• ʻIke ʻia ka maʻi i ka fexinidazole a i ʻole nā lāʻau nitroimidazole ʻē aʻe
• Maʻi ate koʻikoʻi a i ʻole ka hāʻule ʻana o ke ake
• Nā maʻi puʻuwai puʻuwai
• Nā maʻi hopu ʻeleu ʻaʻole i mālama maikaʻi ʻia

Pono nā hana kūikawā inā hāpai ʻoe, hānai waiū, a i ʻole e hoʻolālā ana e hāpai. ʻOiai ʻaʻole i hōʻike nā haʻawina holoholona i nā hopena ʻino, ua kaupalena ʻia ka ʻikepili palekana kanaka i ka wā hāpai.

E noʻonoʻo nō hoʻi kāu mea mālama ola i kāu mau lāʻau lapaʻau ʻē aʻe, no ka mea, hiki i ka fexinidazole ke launa pū me kekahi mau lāʻau lapaʻau me nā mea hoʻoheheʻe koko, nā lāʻau lapaʻau hopu, a me kekahi mau lāʻau antibiotic.

Nā inoa inoa o Fexinidazole

Loaʻa mua ka Fexinidazole ma lalo o ka inoa inoa Fexinidazole Winthrop, i hana ʻia e Sanofi. Hoʻolaha ʻia kēia lāʻau lapaʻau ma o nā papahana kūikawā i hoʻonohonoho ʻia me ka World Health Organization a me nā keʻena olakino aupuni ma nā ʻāina i hoʻopilikia ʻia.

Hāʻawi pinepine ʻia ka lāʻau lapaʻau me ka uku ʻole i nā maʻi ma o nā papahana olakino lehulehu, no ka mea, pili nui ka maʻi hiamoe i nā kaiāulu i nā wahi i kaupalena ʻia nā kumuwaiwai. Hiki i kāu mea mālama ola a i ʻole nā ​​mana olakino kūloko ke hāʻawi i ka ʻike e pili ana i ke komo ʻana i ka lāʻau lapaʻau ma kou wahi.

Nā koho ʻē aʻe o Fexinidazole

Ma mua o ka loaʻa ʻana o ka fexinidazole, ʻoi aku ka paʻakikī o nā koho lapaʻau no ka maʻi hiamoe a pono pinepine ka haukapila. ʻO ka hoʻomaopopo ʻana i kēia mau koho ʻē aʻe e kōkua i ka hoʻokomo ʻana i nā pōmaikaʻi o ka fexinidazole i ka manaʻo.

ʻO nā lāʻau lapaʻau kuʻuna no ka maʻi hiamoe i ke kahua mua me ka pentamidine, e koi ana i nā injections intramuscular a hiki ke hoʻoulu i nā hopena ʻaoʻao nui. No ka maʻi i ke kahua ʻelua, ʻo nā lāʻau lapaʻau maʻamau ma mua he melarsoprol (he hui i hoʻokumu ʻia i ka arsenic me ka ʻona nui) a i ʻole eflornithine i hui pū ʻia me nifurtimox.

Pono kēia mau lāʻau lapaʻau kahiko i nā pule o ka haukapila, ka lawelawe intravenous, a me ka nānā pono ʻana i nā hopena ʻaoʻao koʻikoʻi. Hōʻike ʻo Fexinidazole i kahi hoʻomaikaʻi nui e pili ana i ka maʻalahi, ka palekana, a me ka pono.

ʻOi aku ka maikaʻi o Fexinidazole ma mua o nā lāʻau lapaʻau maʻi hiamoe ʻē aʻe?

He nui nā pōmaikaʻi o Fexinidazole ma mua o nā lāʻau lapaʻau ma mua no ka maʻi hiamoe. ʻO ka pōmaikaʻi nui loa, hiki ke lawe ʻia ma ka waha ma ka home, e hoʻopau ana i ka pono no ka hoʻopaʻa ʻia ʻana i ka haukapila a me ka lāʻau intravenous i hōʻike ʻia e nā lāʻau lapaʻau kahiko.

Ua hōʻike nā haʻawina lapaʻau he kiʻekiʻe ka pono o ka fexinidazole, me nā helu hoʻōla ma mua o 95% no nā pae ʻelua o ka maʻi. Hoʻohālikelike a ʻoi aku paha kēia pono ma mua o nā lāʻau lapaʻau kahiko me ka hana ʻana i nā hopena ʻaoʻao liʻiliʻi.

Hoʻomaʻamaʻa pū ka lāʻau lapaʻau i ka mālama ʻana ma ka hana ʻana i nā pae ʻelua o ka maʻi me ka regimen like. Hoʻopau kēia i ka pono no nā lumbar punctures e hoʻoholo i ke kahua o ka maʻi a hoʻemi i ka paʻakikī o nā hoʻoholo lapaʻau.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Fexinidazole

He Palekana anei ʻo Fexinidazole no nā keiki?

Hiki ke hoʻohana ʻia ʻo Fexinidazole i nā keiki e kaupaona ana ma ka liʻiliʻi he 20 kg (ma kahi o 44 paona), me ka hoʻoponopono ʻana i ka dosage e pili ana i ke kaumaha o ke kino. Ua aʻo ʻia ka lāʻau lapaʻau i nā maʻi pediatric a hōʻike i nā ʻano like a me ka palekana e like me nā pākeke.

Hiki i nā keiki ke ʻike i ka nausea a me ka luaʻi, no laila, ʻoi aku ka mea nui o ka lawe ʻana i ka lāʻau lapaʻau me ka meaʻai. E nānā pono kāu mea mālama ola i kāu keiki i ka wā o ka mālama ʻana a hiki ke ʻōlelo i nā hoʻolālā e mālama i nā hopena ʻaoʻao.

He aha kaʻu e hana ai inā lawe au i ka nui o ka Fexinidazole?

Inā lawe ʻoe i ka nui o ka fexinidazole ma mua o ka mea i kuhikuhi ʻia, e kelepona koke i kāu mea mālama ola a i ʻole ke kikowaena mana ʻawaʻawa. ʻO ka lawe ʻana i ka nui o ka lāʻau lapaʻau hiki ke hoʻonui i ka pilikia o nā hopena ʻaoʻao, ʻo ka nausea, ka luaʻi, a me ka dizziness.

Mai hoʻāʻo e hoʻokomo iā ʻoe iho e luaʻi ke ʻole i kuhikuhi ʻia e kahi loea mālama ola. E mālama i ka nui o ka lāʻau lapaʻau keu āu i lawe ai a me ka manawa, no ka mea, e kōkua kēia ʻike i nā loea lapaʻau e hoʻoholo i ke ala maikaʻi loa o ka hana.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele o Fexinidazole?

Inā ʻoe e poina i ka lāʻau, e lawe koke ʻoe i ka wā e hoʻomanaʻo ai ʻoe, inā he mau hola wale nō mai kou manawa i hoʻonohonoho ʻia. Inā kokoke ka manawa no kāu lāʻau aʻe, e lele i ka lāʻau i poina a e hoʻomau me kāu papa manawa maʻamau.

Mai lawe ʻoe i ʻelua lāʻau i ka manawa hoʻokahi e uku ai i ka lāʻau i poina, no ka mea, hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao. Inā ʻoe e poina i nā lāʻau he nui a i ʻole he hopohopo e pili ana i nā lāʻau i poina e pili ana i kāu lapaʻau, e hoʻokaʻaʻike i kāu mea mālama ola no ke alakaʻi.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Fexinidazole?

Pono ʻoe e hoʻopau i ka papa 10-lā piha o ka fexinidazole, ʻoiai inā e hoʻomaka ana ʻoe e ʻoi aku ka maikaʻi ma mua o ka pau ʻana o nā papa a pau. ʻO ka hooki ʻana i ka wā mua hiki ke ʻae i nā parasites e ola a hiki ke hoʻomohala i ke kūʻē ʻana i ka lāʻau.

Na kāu mea mālama ola e hoʻoholo i ka wā e pau ai ka lapaʻau ma muli o ka lōʻihi o ka papa i kauoha ʻia, ʻaʻole ma ke ʻano o kou manaʻo. Ma hope o ka pau ʻana o ka lapaʻau, pono ʻoe i nā manawa huli e hōʻoia i ka hoʻomaʻemaʻe ʻia ʻana o ka maʻi.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana iā Fexinidazole?

ʻOi aku ka maikaʻi e pale i ka waiʻona i ka wā e lawe ana iā fexinidazole, no ka mea, hiki i ka waiʻona ke hoʻonui i ka pilikia o nā hopena ʻaoʻao e like me ka nausea, ka luaʻi, a me ka dizziness. Hiki nō hoʻi i ka waiʻona ke keakea i ka hiki o kou kino ke hakakā i ka maʻi me ka pono.

Inā koho ʻoe e ʻai i ka waiʻona, e hana pēlā i nā mea liʻiliʻi loa a e nānā i kou manaʻo. E hooki koke i ka inu ʻana inā ʻoe e ʻike i nā hopena ʻaoʻao i hoʻonui ʻia, a e hoʻokau mau i ka hoʻopau ʻana i kāu lapaʻau me ka holomua.