He aha ʻo Fidaxomicin: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau antibiotic kūikawā ʻo Fidaxomicin e mālama ana i kahi maʻi ʻōpū koʻikoʻi a koʻikoʻi i kapa ʻia ʻo C. difficile colitis. Hana ʻokoʻa kēia lāʻau lapaʻau mai ka hapa nui o nā lāʻau antibiotic no ka mea e noho nui ana i loko o kou ʻōpū, e hakakā ana i ka bacteria ʻino ma kahi e loaʻa ai ka pilikia me ka hoʻopilikia ʻole ʻana i ka bacteria kōkua i loko o kou kino.

He aha ʻo Fidaxomicin?

He lāʻau antibiotic kauoha ʻo Fidaxomicin i hoʻolālā ʻia e mālama i nā maʻi Clostridioides difficile (C. diff) i loko o kou kolonā. ʻAʻole like me nā lāʻau antibiotic ākea e hana ana i loko o kou kino holoʻokoʻa, ʻo fidaxomicin ka mea a nā kauka e kapa ai he lāʻau antibiotic

Pono paha ʻoe i ka fidaxomicin inā loaʻa iā ʻoe ka colitis C. diff ma hope o ka lawe ʻana i nā lāʻau antibiotic ʻē aʻe no kahi maʻi ʻokoʻa. Hana ʻia kēia no ka mea hiki i nā lāʻau antibiotic ke pepehi i kāu bacteria pale i ka ʻōpū, e hana ana i kahi kaiapuni kahi e hiki ai i ka C. diff ke ulu a hana i nā mea ʻawaʻawa e hōʻino i ka uhi ʻana o kou kolonā.

E kauoha maʻamau kāu kauka i ka fidaxomicin ke hōʻoia ʻoe i ka maʻi C. diff ma o ka hoʻāʻo ʻana i ka stool, ʻoiai inā ua loaʻa iā ʻoe nā maʻi hou a ʻaʻole i pane maikaʻi i nā lāʻau lapaʻau ʻē aʻe. He mea waiwai nui ka lāʻau lapaʻau no ka pale ʻana i ka maʻi mai ka hoʻi ʻana mai, he pilikia maʻamau me C. diff.

I kekahi mau hihia, hiki i nā kauka ke koho i ka fidaxomicin ma ke ʻano he lāʻau lapaʻau mua no nā maʻi C. diff koʻikoʻi a i ʻole no nā maʻi i pilikia nui i ka hoʻi hou ʻana. Aia kēia i nā mākua kahiko, nā poʻe me nā ʻōnaehana pale i hoʻopilikia ʻia, a i ʻole ka poʻe i loaʻa i nā hanana he nui.

Pehea e hana ai ka Fidaxomicin?

Hana ʻo Fidaxomicin ma ka pale ʻana i kahi hana koʻikoʻi e pono ai ka bacteria C. diff e hoʻonui a ola. Hoʻopili pono ia i kahi enzyme i kapa ʻia ʻo RNA polymerase e hoʻohana ai ka bacteria e hana i nā protein e pono ai no ko lākou ulu a me ka hana hou ʻana.

Ke komo ka fidaxomicin i loko o kāu ʻōnaehana digestive, noho ia i loko o kou ʻōpū ma mua o ka komo ʻana i loko o kou kahe koko. ʻO ia hoʻi, hiki iā ia ke hāʻawi i nā kiʻekiʻe kiʻekiʻe o ka lāʻau lapaʻau pololei i kahi e hana nei ka bacteria C. diff i nā pilikia, ʻoiai e hōʻemi ana i nā hopena i ka bacteria i nā ʻāpana ʻē aʻe o kou kino.

Manaʻo ʻia ka lāʻau lapaʻau he ikaika a maikaʻi loa i ka C. diff. ʻO ka mea e waiwai ai ia, ʻo ia kona koho - hoʻopā ia i ka bacteria C. diff me ka ikaika nui aʻe ma mua o ka hopena i kāu bacteria ʻōpū maikaʻi, e kōkua ana i ka mālama ʻana i kāu kaulike digestive maoli.

ʻO kēia hana i kuhikuhi ʻia, ʻo ia hoʻi, he haʻahaʻa ka manawa o ka fidaxomicin e hana i ke kūpaʻa antibiotic i hoʻohālikelike ʻia me nā antibiotics ākea. Ke hana mau nei ka lāʻau lapaʻau ma hope o kou pau ʻana i kāu papa lapaʻau, no ka mea, hiki ke noho ikaika i loko o kou kolonā no kekahi mau lā.

Pehea wau e lawe ai i ka Fidaxomicin?

E lawe i ka fidaxomicin e like me ke kauoha a kāu kauka, maʻamau 200 mg ʻelua manawa i ka lā no 10 mau lā. Hiki iā ʻoe ke lawe me ka ʻole o ka meaʻai, akā ʻo ka lawe ʻana me ka ʻai māmā e kōkua paha i ka hōʻemi ʻana i nā pilikia o ka ʻōpū āu e ʻike ai.

E ale i nā papa holoʻokoʻa me ke aniani wai piha - mai ʻokiʻoki, nau, a haki paha iā lākou no ka mea hiki i kēia ke hoʻopilikia i ka hana ʻana o ka lāʻau lapaʻau. E hoʻāʻo e lawe i kāu mau lāʻau i nā manawa like i kēlā me kēia lā, e hoʻokaʻawale iā lākou ma kahi o 12 mau hola e mālama ai i nā pae paʻa i loko o kāu ʻōnaehana.

ʻAʻole pono ʻoe e pale i nā meaʻai kikoʻī i ka wā e lawe ana i ka fidaxomicin, akā ʻo ka ʻai ʻana i ka meaʻai palupalu hiki ke kōkua i kāu ʻōnaehana digestive e ola mai ka maʻi C. diff. ʻO nā meaʻai e like me nā maiʻa, ka laiki, ka ʻāpala, a me ka toast he mea maʻalahi ke ʻae ʻia i ka wā o ka mālama ʻana.

Inā ʻoe e lawe ana i nā lāʻau ʻē aʻe, e hoʻokaʻawale iā lākou ma kahi o 2 mau hola mai ka fidaxomicin ke hiki. Kōkua kēia i ka pale ʻana i nā pilina hiki ke loaʻa a hōʻoia i ka hana pono ʻana o kēlā me kēia lāʻau.

Pehea ka lōʻihi e lawe ai au i ka Fidaxomicin?

Lawe ka hapa nui o nā kānaka i ka fidaxomicin no 10 mau lā, ʻo ia ka lōʻihi o ka papa maʻamau i hōʻike ʻia e nā haʻawina lapaʻau he mea maikaʻi loa. He mea nui e hoʻopau i ka papa holoʻokoʻa inā hoʻomaka ʻoe e ʻoi aku ka maikaʻi ma hope o kekahi mau lā.

Hiki iā ʻoe ke ʻike i ka hoʻomaikaʻi ʻana i kāu mau hōʻailona i loko o 2-3 mau lā o ka hoʻomaka ʻana i ka mālama ʻana, akā hiki nō ke loaʻa nā bacteria a hiki ke hōʻeha inā e hooki ʻoe i ka lāʻau lapaʻau i ka wā mua. ʻO ka hooki ʻana i ka wā mua e hoʻonui i kou pilikia o ka hoʻi ʻana mai o ka maʻi, hiki ke paʻakikī ke mālama.

I nā hihia kakaʻikahi, hiki i kāu kauka ke hoʻololi i ka lōʻihi o ka lapaʻau e pili ana i kou kūlana kikoʻī, e like me ke koʻikoʻi o kāu maʻi a i ʻole kou olakino holoʻokoʻa. Eia naʻe, e pili ka hapa nui o nā mea maʻi i ka papa hana maʻamau he 10 lā no nā hopena maikaʻi loa.

ʻAʻole like me kekahi mau lapaʻau C. diff ʻē aʻe, ʻaʻole pono ka fidaxomicin i nā papa hana lōʻihi a i ʻole nā papa hana tapering. ʻO nā waiwai kūʻokoʻa o ka lāʻau lapaʻau e hiki ai iā ia ke hana mau no kekahi mau lā ma hope o kou lawe ʻana i kāu mahele hope loa, e hāʻawi ana i ka pale mau ʻana i ka hoʻi hou ʻana.

He aha nā hopena ʻaoʻao o Fidaxomicin?

Hoʻomanawanui maikaʻi ʻia ka Fidaxomicin, me ka hapa nui o nā kānaka e ʻike ana i nā hopena ʻaoʻao liʻiliʻi a ʻaʻole paha. ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a pili pinepine i kāu ʻōnaehana digestive i ka wā e ola ana mai ka maʻi C. diff.

Eia nā hopena ʻaoʻao āu e ʻike ai, me ka noʻonoʻo ʻana e lawe ana ka nui o nā kānaka i ka fidaxomicin me ka ʻole o nā pilikia:

• Nausea a i ʻole ka ʻoluʻolu o ka ʻōpū
• ʻEha ʻōpū a i ʻole ka ʻūlū
• Luaʻi (ʻaʻole maʻamau)
• Poʻo
• ʻĀwili
• Paʻa i ka wā e hoʻoponopono ai kāu neʻe ʻana o ka ʻōpū

Hoʻomaikaʻi pinepine kēia mau hopena maʻalahi i ka wā e hoʻoponopono ai kou kino i ka lāʻau a hoʻomaʻemaʻe kāu maʻi. ʻIke ka hapa nui o nā kānaka he hiki ke mālama ʻia ka ʻoluʻolu ma mua o nā hōʻailona C. diff mua.

He kakaikahi nā hopena ʻaoʻao koʻikoʻi akā hiki ke hana. E kelepona koke i kāu kauka inā ʻike ʻoe i nā hopena maʻi koʻikoʻi e like me ka pilikia o ka hanu ʻana, ka pehu ʻana o kou maka a i ʻole ka ʻāʻī, a i ʻole nā hopena ʻili koʻikoʻi. E ʻimi pū i ka lāʻau lapaʻau inā loaʻa iā ʻoe ka ʻeha o ka ʻōpū nui, ke koko i loko o kāu ʻōpala, a i ʻole nā hōʻailona o kahi maʻi hou.

Hopohopo kekahi poʻe e pili ana i ka hoʻomohala ʻana i ka maʻi maʻi e pili ana i ka antibiotic mai ka fidaxomicin, akā ʻoi aku ka liʻiliʻi o kēia i hoʻohālikelike ʻia me nā antibiotics ʻē aʻe ma muli o kāna hana i manaʻo ʻia. Eia naʻe, inā loaʻa iā ʻoe ka maʻi maʻi hou a i ʻole ka ʻino i ka wā o ka lapaʻau, e hōʻike i kāu mea mālama ola.

ʻO wai ka mea pono ʻole e lawe iā Fidaxomicin?

ʻAʻole kūpono ʻo Fidaxomicin no nā mea a pau, akā, he pōkole ka papa inoa o nā kānaka i hiki ʻole ke lawe. ʻO ka hopohopo nui inā ua loaʻa iā ʻoe kahi hopena maʻi koʻikoʻi iā fidaxomicin a i ʻole kekahi o kāna mau mea i hala.

Pono kāu kauka e noʻonoʻo pono iā fidaxomicin inā loaʻa iā ʻoe ka maʻi kīkī a i ʻole ka maʻi ate, no ka mea, hiki i kēia mau maʻi ke hoʻopilikia i ke ʻano o ka hana ʻana o kou kino i nā lāʻau lapaʻau. ʻOiai ʻaʻole i komo nui ʻia ʻo fidaxomicin i loko o kou kahe koko, makemake paha kāu kauka e nānā pono iā ʻoe.

Pono nā kānaka me kekahi mau maʻi genetic kakaʻikahi e pili ana i ko lākou hiki ke hana i nā kōpaʻa kikoʻī e kūkākūkā i kēia me kā lākou kauka, no ka mea, aia nā papa fidaxomicin i nā mea liʻiliʻi o ka lactose. Eia naʻe, ʻo ka nui he liʻiliʻi loa ia e hoʻopilikia ai i ka hapa nui o nā kānaka me ka lactose intolerance.

Inā hāpai ʻoe a i ʻole e hānai ana i ka waiū, e ana kāu kauka i nā pōmaikaʻi e kūʻē i nā pilikia hiki. ʻOiai ʻaʻole i hōʻike nā haʻawina i nā hopohopo nui, hiki i nā maʻi C. diff ke koʻikoʻi i ka wā hāpai, no laila pono pinepine ka lapaʻau. E kōkua kāu mea mālama ola iā ʻoe e hana i ka hoʻoholo maikaʻi loa no kāu kūlana.

Nā inoa inoa o Fidaxomicin

Loaʻa pinepine ʻo Fidaxomicin ma lalo o ka inoa inoa ʻo Dificid ma ʻAmelika Hui Pū ʻIa. ʻO kēia ka inoa inoa kumu e ʻike ai ka hapa nui o nā kauka a me nā lāʻau lapaʻau i ka wā e kauoha ai a i ʻole e hāʻawi ana i ka lāʻau.

Ma nā ʻāina ʻē aʻe, hiki iā ʻoe ke loaʻa iā fidaxomicin i kūʻai ʻia ma lalo o nā inoa inoa like ʻole, e like me Dificlir ma kekahi mau mākeke ʻEulopa. Eia naʻe, ʻo ka mea hana a me ka pono e like nō ia me ka inoa inoa ma ka pūʻolo.

Ke lilo nei nā mana generic o fidaxomicin i mea i loaʻa ma kekahi mau mākeke, hiki ke kōkua i ka hōʻemi ʻana i ke kumukūʻai o ka lapaʻau. Hiki i kāu lāʻau lapaʻau ke haʻi iā ʻoe inā loaʻa kahi mana generic ma kou wahi a inā kūpono ia no kāu kauoha.

Ma ka nānā ʻole ʻana i ka inoa inoa, e hōʻoia e loaʻa ana iā ʻoe ka fidaxomicin no ka mālama ʻana i ka C. diff, no ka mea, he ʻokoʻa loa ia mai nā lāʻau antibiotic ʻē aʻe a ʻaʻole hiki ke hoʻololi ʻia me nā lāʻau ʻē aʻe.

Nā Koho ʻē aʻe no Fidaxomicin

Nui nā lāʻau antibiotic ʻē aʻe e hiki ke mālama i nā maʻi C. diff, akā he mau pono ko ka fidaxomicin i ka pale ʻana i ka hoʻi hou ʻana. ʻO Vancomycin ka mea i hoʻohana nui ʻia a he lāʻau lapaʻau maʻamau no nā makahiki he nui.

Ua hoʻohana pinepine ʻia ʻo Metronidazole no nā maʻi C. diff maʻalahi, akā ʻōlelo nā alakaʻi lapaʻau i kēia manawa i ka vancomycin a i ʻole fidaxomicin ma ke ʻano he koho mua maikaʻi. Hiki nō i kāu kauka ke noʻonoʻo i ka metronidazole i nā kūlana kikoʻī, ʻoi aku ka nui inā he pilikia nui ke kumukūʻai.

No nā hihia koʻikoʻi a paʻakikī paha, hiki i kāu kauka ke ʻōlelo aku i nā lāʻau hui pū a i ʻole nā lāʻau lapaʻau hou e like me bezlotoxumab, he lāʻau antibody e kōkua ana i ka pale ʻana i ka hoʻi hou ʻana. I nā hihia koʻikoʻi loa, pono paha ke ʻoki ʻana, akā he mea maʻamau kēia.

Aia ke koho ma waena o nā koho ʻē aʻe i nā mea e like me ke koʻikoʻi o kāu maʻi, kāu mōʻaukala olakino, nā hanana C. diff i hala, a me kou kūlana olakino holoʻokoʻa. E noʻonoʻo kāu kauka i kēia mau mea a pau i ka wā e hoʻoholo ai i ke ala lapaʻau maikaʻi loa no kāu kūlana kikoʻī.

Ua ʻoi aku ka maikaʻi o Fidaxomicin ma mua o Vancomycin?

Ua hōʻike ʻo Fidaxomicin i kekahi mau pono ma luna o vancomycin, ʻoi aku ka nui o ka pale ʻana i nā maʻi C. diff mai ka hoʻi ʻana mai. Ua ʻike nā haʻawina lapaʻau i ka poʻe i mālama ʻia me fidaxomicin ʻaʻole paha e loaʻa nā maʻi hou e like me ka poʻe i mālama ʻia me vancomycin.

He mea maikaʻi loa nā lāʻau ʻelua i ka hoʻomaʻemaʻe ʻana i ka maʻi C. diff mua, me nā helu kūleʻa e like loa. Eia naʻe, ʻo ka hiki o fidaxomicin ke mālama i ka nui o kāu bacteria maikaʻi i ka wā e hakakā ana i ka C. diff, me he mea lā e hāʻawi ana i ka pale lōʻihi.

ʻO ka mea nui e noʻonoʻo ai no nā maʻi he nui ke kumukūʻai, no ka mea, ʻoi aku ke kumukūʻai o ka fidaxomicin ma mua o ka vancomycin. Eia naʻe, ke noʻonoʻo ʻoe i ka emi ʻana o ka pilikia o ka hoʻi hou ʻana a me ka pono e loaʻa i nā lāʻau lapaʻau hou, hiki i ka fidaxomicin ke kūpono i ke kumukūʻai i ka wā lōʻihi.

E noʻonoʻo kāu kauka i nā mea pilikia o kou pilikino no ka hoʻi hou ʻana, ka paʻakikī o kāu maʻi, a me kou olakino holoʻokoʻa i ke koho ʻana ma waena o kēia mau koho. He mau lāʻau lapaʻau maikaʻi ʻelua, a ʻo ke koho maikaʻi loa e hilinaʻi ana i kou mau kūlana kikoʻī ma mua o ka mea i ʻoi aku ka maikaʻi.

Nā Nīnau i Nīnau pinepine ʻia e pili ana i ka Fidaxomicin

He palekana anei ka Fidaxomicin no ka poʻe me ka maʻi diabetes?

ʻAe, palekana ka fidaxomicin no ka poʻe me ka maʻi diabetes. ʻAʻole pili nui ka lāʻau lapaʻau i nā pae kōpaʻa koko no ka mea e noho nui ana ia i loko o kou ʻōpū digestive ma mua o ka komo ʻana i loko o kou kahe koko.

Eia naʻe, hiki i nā maʻi C. diff ke hoʻopilikia i kou ʻai a me nā ʻano ʻai, hiki ke hoʻopilikia i kāu kaohi kōpaʻa koko. E nānā i kāu mau pae glucose koko e like me ka maʻamau a e hoʻokaʻaʻike i kāu mea mālama ola inā ʻike ʻoe i nā loli ʻokoʻa i ka wā o ka mālama ʻana.

He aha kaʻu e hana ai inā ua lawe hewa au i ka nui o ka Fidaxomicin?

Inā ua lawe hewa ʻoe i kahi lāʻau hou o ka fidaxomicin, mai hopohopo. No ka mea, ʻaʻole i komo nui ka lāʻau lapaʻau i loko o kou kahe koko, ʻaʻole paha e koʻikoʻi nā hōʻailona overdose.

E hoʻokaʻaʻike i kāu kauka a i ʻole ka mea kūʻai lāʻau no ke alakaʻi ʻana, ʻoiai inā ua lawe ʻoe i ka nui o ka lāʻau i kuhikuhi ʻia. Hiki iā lākou ke aʻo iā ʻoe inā pono ʻoe i ka lāʻau lapaʻau a pehea e hoʻoponopono ai i kāu papa hana dosing i mua.

He aha kaʻu e hana ai inā ua hala au i kahi lāʻau o Fidaxomicin?

Inā ua hala ʻoe i kahi lāʻau, e lawe iā ia i ka wā e hoʻomanaʻo ai ʻoe, ke ʻole kokoke i ka manawa no kāu lāʻau i hoʻonohonoho ʻia. I kēlā hihia, e lele i ka lāʻau i hala a e hoʻomau me kāu papa hana maʻamau - mai pāpālua i nā lāʻau.

E hoʻāʻo e mālama i ka manawa 12-hola ma waena o nā lāʻau i ka wā hiki. Inā poina pinepine ʻoe i nā lāʻau, e noʻonoʻo e hoʻonohonoho i nā mea hoʻomanaʻo kelepona a i ʻole e hoʻohana i kahi mea hoʻonohonoho pila e kōkua iā ʻoe e noho ma ke ala me kāu lapaʻau.

I ka wā hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Fidaxomicin?

E hooki wale i ka lawe ʻana iā fidaxomicin ke pau ʻoe i ka papa 10-lā i kauoha ʻia e kāu kauka, ʻoiai inā maikaʻi loa ʻoe. ʻO ka hooki ʻana i ka wā mua e hoʻonui nui i kou pilikia o ka hoʻi ʻana mai o ka maʻi.

Inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi a i ʻole nā hopena maʻi, e kelepona koke i kāu kauka no ke alakaʻi. Pono paha lākou e hoʻoponopono i kāu lapaʻau, akā mai hooki i ka lāʻau lapaʻau ma kāu iho me ka ʻole o ka mālama olakino.

Hiki iaʻu ke lawe i nā Probiotics me Fidaxomicin?

He nui nā kauka e ʻōlelo nei e kali a hiki i ka pau ʻana o kāu papa fidaxomicin ma mua o ka hoʻomaka ʻana i nā probiotics. Hāʻawi kēia i ka antibiotic e hana pono me ka ʻole o ke keakea ʻana mai nā bacteria i hoʻohui ʻia, ʻoiai nā mea maikaʻi.

Ma hope o ka pau ʻana o ka fidaxomicin, hiki i nā probiotics ke kōkua i ka hoʻihoʻi ʻana i kāu kaulike bacteria gut, akā e kūkākūkā mua i kēia me kāu mea mālama ola. Hiki iā lākou ke ʻōlelo i ka manawa kūpono a me nā ʻano probiotics e pili ana i kāu mau pono hoʻōla.