He aha ʻo Floxuridine: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau chemotherapy kūikawā ʻo Floxuridine a nā kauka e hoʻohana ai e mālama i kekahi mau ʻano maʻi ʻaʻai, ʻo ia hoʻi nā metastases ate mai ka maʻi ʻaʻai colorectal. No ka pūʻulu lāʻau lapaʻau i kapa ʻia ʻo antimetabolites kēia lāʻau lapaʻau, e hana ana ma ka hoʻopilikia ʻana i ka hiki o nā sela maʻi ʻaʻai ke ulu a māhele. ʻOiai he koho lapaʻau ikaika ia, pono ʻo floxuridine i ka mālama olakino pono a hāʻawi ʻia i nā hoʻonohonoho haukapila ma o nā ʻano hana kūikawā.

He aha ʻo Floxuridine?

He lāʻau lapaʻau anticancer synthetic ʻo Floxuridine e hoʻohālike i nā mea maoli e hoʻohana ai kou kino e kūkulu i ka DNA. Ke hoʻāʻo nā sela maʻi ʻaʻai e hoʻohana i ka floxuridine ma kahi o kēia mau poloka kūkulu maʻamau, ʻaʻole hiki iā lākou ke hoʻopau pono i kā lākou DNA a make hope. He mea maikaʻi loa kēia lāʻau lapaʻau no ka mea hiki ke hāʻawi pololei ʻia i kahi e loaʻa ai nā sela maʻi ʻaʻai, e ʻae ana i nā ʻano kiʻekiʻe ma ke kahua tumora me ka hōʻemi ʻana i ka ʻike ʻana i nā ʻiʻo olakino ma kou kino.

Ua ʻike ʻia ka lāʻau lapaʻau ma kona inoa kemika, 5-fluorodeoxyuridine, a pili pili loa i kekahi lāʻau chemotherapy i kapa ʻia ʻo 5-fluorouracil. Eia naʻe, loaʻa i ka floxuridine nā waiwai kūʻokoʻa e hoʻohana nui ai i ka mālama ʻana i nā metastases ate ke hāʻawi ʻia ma o nā ʻenehana kūikawā.

No ke aha e hoʻohana ʻia ai ʻo Floxuridine?

Hoʻohana nui ʻia ʻo Floxuridine e mālama i nā metastases ate mai ka maʻi ʻaʻai colorectal, ʻo ia hoʻi ka maʻi ʻaʻai i hoʻomaka i loko o ka ʻōpū a i ʻole ka ʻōpū a ua laha i ke ake. Hiki i kāu oncologist ke ʻōlelo aku i kēia lapaʻau ke ʻaʻole pono ka chemotherapy maʻamau a i ʻole ke kaupalena ʻia ka maʻi ʻaʻai i ke ake. He mea waiwai nui ka lāʻau lapaʻau no ka mea hiki ke hāʻawi pololei ʻia i ke ake ma o ke kaʻina hana i kapa ʻia ʻo hepatic arterial infusion.

I kekahi mau hihia, hiki i nā kauka ke noʻonoʻo i ka floxuridine no nā ʻano maʻi ʻaʻai ʻē aʻe i laha i ke ake, ʻoiai ʻaʻole maʻamau kēia. ʻO ka hoʻoholo e hoʻohana i ka floxuridine e pili ana i nā mea he nui, me ka nui a me kahi o nā maʻi, kou olakino holoʻokoʻa, a me ka maikaʻi o kāu pane ʻana i nā lāʻau lapaʻau ʻē aʻe.

Pehea e Hana ai ʻo Floxuridine?

Hana ʻo Floxuridine ma ka hoʻopunipuni ʻana i nā sela maʻi ʻaʻai i ka hoʻohana ʻana iā ia ma ke ʻano he poloka kūkulu no ka DNA. Ke mahele wikiwiki nei nā sela maʻi ʻaʻai a pono e hana i ka DNA hou, e komo lākou i ka floxuridine me ka manaʻo he mea maʻamau ia e pono ai lākou. Eia naʻe, i ka wā i loko o ke keena, hoʻopilikia ka floxuridine i ke kaʻina hana DNA, e hoʻōki ana i ka ulu ʻana o ke keena maʻi ʻaʻai a make hope.

Ua manaʻo ʻia he lāʻau lapaʻau chemotherapy ikaika e kuhikuhi pono ana i nā sela e mahele wikiwiki ana. ʻO ka maikaʻi o ka floxuridine ʻo ia ka hiki ke hoʻopaʻa ʻia i loko o ke ake ma o nā ʻano hana hoʻouna kūikawā, e ʻae ana i nā mea kiʻekiʻe e hiki i nā sela maʻi ʻaʻai i ka wā e hōʻemi ana i ka ʻike ʻana i ke koena o kou kino. Kōkua kēia ʻano hana i ka hōʻemi ʻana i kekahi o nā hopena ʻaoʻao āu e ʻike ai me ka chemotherapy systemic.

Pehea wau e lawe ai i ka Floxuridine?

ʻAʻole lawe ʻia ʻo Floxuridine ma ka waha e like me nā lāʻau lapaʻau maʻamau. Akā, hāʻawi ʻia ia ma ke ʻano he infusion mau pololei i loko o ka hepatic artery, ʻo ia ka moku koko nui e hāʻawi ana i ke ake. Pono kēia i kahi hana ʻoki liʻiliʻi e waiho i kahi catheter liʻiliʻi a i ʻole ka ʻōnaehana pamu e hāʻawi pololei i ka lāʻau lapaʻau i kou ake i nā lā a i ʻole nā ​​pule.

ʻO ka maʻamau o ka lāʻau lapaʻau e pili ana i nā pōʻai kahi e loaʻa ai iā ʻoe ka lāʻau lapaʻau no kahi manawa kikoʻī, a ma hope e hoʻomaha e ʻae i kou kino e ola. E mālama kāu hui lapaʻau i nā ʻano āpau o ka hāʻawi ʻana i ka lāʻau lapaʻau, me ka nānā ʻana i ka helu infusion a me ka hōʻoia ʻana e hana pono ana ka ʻōnaehana catheter. Pono ʻoe e noho i ka haukapila i ka wā o nā manawa lapaʻau ikaika no ka nānā pono ʻana.

ʻAʻole like me nā lāʻau lapaʻau waha, ʻaʻohe kapu meaʻai kūikawā e pili ana i ka lawe ʻana i ka floxuridine no ka mea e hele pololei ana ia i kāu ʻōnaehana digestive. Eia naʻe, e hāʻawi kāu hui mālama ola i nā ʻōlelo kikoʻī e pili ana i ka mālama ʻana i ke kahua catheter a me nā hana hiki iā ʻoe ke hana palekana i ka wā o ka mālama ʻana.

Pehea ka lōʻihi e lawe ai au i ka Floxuridine?

He ʻokoʻa loa ka lōʻihi o ka mālama ʻana i ka floxuridine ma muli o ke ʻano o ka pane ʻana o kāu maʻi maʻi a me ka maikaʻi o kou ʻae ʻana i ka lāʻau lapaʻau. ʻO ka hapa nui o nā hoʻolālā lapaʻau e pili ana i nā pōʻai e mau ana i kekahi mau pule, me kēlā me kēia pōʻai e komo pū ana i nā lā lapaʻau ikaika a me nā manawa hoʻomaha. E hoʻolālā maʻamau kāu oncologist i nā pōʻai he nui, e mau ana i nā mahina he nui.

E nānā mau kāu kauka i kou holomua ma o nā hoʻokolohua koko a me nā haʻawina kiʻi e ʻike i ke ʻano o ka pane ʻana o ka maʻi maʻi. Inā e hana maikaʻi ana ka lapaʻau a ke ʻae nei ʻoe me ka ʻole o nā hopena ʻaoʻao koʻikoʻi, hiki iā ʻoe ke hoʻomau no ka papa i hoʻolālā ʻia. Eia naʻe, inā e ulu nā hopena ʻaoʻao nui a i ʻole ʻaʻole e pane ka maʻi maʻi e like me ka mea i manaʻo ʻia, hiki i kāu kauka ke hoʻololi i ka hoʻolālā lapaʻau a i ʻole e noʻonoʻo i nā ala ʻē aʻe.

Hoʻoholo mau ʻia ka hoʻoholo e pili ana i ka lōʻihi o ka lapaʻau ʻana ma muli o kou kūlana kikoʻī, me ka nui o kāu maʻi maʻi, kou olakino holoʻokoʻa, a me kāu mau makemake pilikino e pili ana i nā pahuhopu lapaʻau.

He aha nā hopena ʻaoʻao o Floxuridine?

E like me nā lāʻau lapaʻau chemotherapy a pau, hiki i ka floxuridine ke hana i nā hopena ʻaoʻao, ʻoiai ʻo ke ʻano o ka hāʻawi ʻana i ke ake e hopena pinepine i nā hopena ʻōnaehana liʻiliʻi i hoʻohālikelike ʻia me ka chemotherapy kuʻuna. ʻO nā hopena ʻaoʻao maʻamau e pili ana i ke ake a me ka ʻōnaehana digestive, no ka mea, ma laila e noho ai ka lāʻau lapaʻau.

Eia nā hopena ʻaoʻao e ʻike ai ʻoe, i hui pū ʻia e ka pinepine o ko lākou hana ʻana:

Nā hopena ʻaoʻao maʻamau

Hana ʻia kēia mau hopena ʻaoʻao i ka nui o nā poʻe e loaʻa ana i ka floxuridine a hiki ke mālama ʻia me ka mālama olakino kūpono:

• Ka luaʻi a me ka luaʻi ʻana, hiki ke mālama ʻia me nā lāʻau anti-nausea
• Ka maʻi palahī a i ʻole nā loli i nā neʻe ʻana o ka ʻōpū
• Ka luhi a me ka manaʻo maʻi maʻamau
• Ka nalowale o ka ʻai
• Ka ʻoluʻolu ʻole a i ʻole ka ʻeha o ka ʻōpū
• Nā loli manawa pōkole i nā hoʻokolohua hana ate

E nānā pono kāu hui mālama ola i kēia mau hopena a hāʻawi i nā lāʻau lapaʻau a i ʻole ke kākoʻo e kōkua iā ʻoe e ʻoluʻolu i ka wā o ka mālama ʻana.

Nā hopena ʻaoʻao liʻiliʻi akā koʻikoʻi

Pono kēia mau hopena ʻaoʻao i ka lāʻau lapaʻau koke inā loaʻa lākou:

• ʻEha nui o ka ʻōpū, hiki ke hōʻike i ka mumū ate
• Melemele o ka ʻili a i ʻole nā maka (jaundice)
• Ka luaʻi mau e pale iā ʻoe mai ka mālama ʻana i nā wai
• Nā hōʻailona o ka maʻi, me ke kuni, nā anu, a i ʻole ka nāwaliwali maʻamau
• Ka maʻi palahī nui e alakaʻi ai i ka maloʻo
• Nā pilikia me ka catheter a i ʻole ka ʻōnaehana pamu

Nā pilikia liʻiliʻi akā koʻikoʻi

ʻOiai ʻaʻole maʻamau, hiki i kēia mau hopena ʻaoʻao koʻikoʻi ke hana a pono i ka lāʻau lapaʻau koke:

• ʻO ka pōʻino ate nui a i ʻole ka hāʻule ʻana o ka ate
• Nā pilikia o ka bile duct e hiki ke hoʻopilikia nui
• Nā koko koko i loko o nā kīʻaha koko o ka ate
• Nā hopena maʻi maʻi nui
• Nā hāʻule nui i nā helu keʻena koko

E nānā pono kāu hui lapaʻau iā ʻoe i ka wā o ka mālama ʻana e hopu i nā hopena ʻaoʻao koʻikoʻi i ka wā mua a hāʻawi i ka lāʻau lapaʻau kūpono.

ʻO wai ka mea ʻaʻole pono e lawe iā Floxuridine?

ʻAʻole kūpono ʻo Floxuridine no nā mea a pau, a e loiloi pono kāu oncologist inā ʻo ia ke koho lapaʻau kūpono iā ʻoe. ʻAʻole paha nā kānaka me ka maʻi ate koʻikoʻi a i ʻole ka hana ate maikaʻi ʻole i nā moho no kēia lapaʻau, no ka mea, ua ʻākoakoa ka lāʻau lapaʻau i loko o ka ate a hiki ke hōʻeha hou.

E noʻonoʻo nō hoʻi kāu kauka i kou kūlana olakino holoʻokoʻa, me ka maikaʻi o ka hana ʻana o kou mau puʻupaʻa, ka helu ʻana o nā pūnaewele koko, a inā he maʻi ʻoe i kēia manawa. Inā hāpai ʻoe a i ʻole e hānai ana i ka waiū, ʻaʻole i ʻōlelo ʻia ka floxuridine no ka mea hiki iā ia ke hōʻeha i nā pēpē e ulu ana.

Eia kekahi, inā ua loaʻa iā ʻoe nā hopena maʻi koʻikoʻi i nā lāʻau chemotherapy like a i ʻole inā he mau kūlana genetic kou e pili ana i ka hana ʻana o kou kino i kēia mau lāʻau lapaʻau, hiki i kāu kauka ke ʻōlelo aku i nā lāʻau lapaʻau ʻē aʻe.

Nā inoa inoa o Floxuridine

Loaʻa ka Floxuridine ma lalo o ka inoa inoa FUDR, i hana ʻia e Roche. Eia naʻe, loaʻa nō hoʻi nā mana generic o ka floxuridine mai nā hui lāʻau lapaʻau like ʻole. Ua like ka lāʻau lapaʻau me ka nānā ʻole i ka inoa inoa, akā e hoʻoholo kāu hale kūʻai lāʻau lapaʻau i ka mana e hoʻohana ai ma muli o ka loaʻa a me kā lākou mau protocols maʻamau.

E mālama kāu hui mālama ola i nā mea a pau o ka loaʻa ʻana a me ka hoʻomākaukau ʻana i ka lāʻau lapaʻau, no laila ʻaʻole pono ʻoe e hopohopo e pili ana i nā makemake inoa inoa a i ʻole nā pilikia loaʻa.

Nā koho ʻē aʻe o Floxuridine

Inā ʻaʻole kūpono ka floxuridine no kou kūlana, aia kekahi mau lāʻau lapaʻau ʻē aʻe no nā metastases ate mai ka maʻi maʻi colorectal. ʻO nā koho chemotherapy systemic e pili ana i nā hui e like me FOLFOX a i ʻole FOLFIRI, e hoʻohana ana i nā lāʻau lapaʻau like ʻole akā hāʻawi ʻia ma kou kahe koko ma mua o ka pololei i ke ake.

ʻO nā lāʻau lapaʻau i manaʻo ʻia e pili ana i nā kaʻina hana e like me ka radiofrequency ablation, kahi e hoʻohana ʻia ai ka wela e luku i nā pūnaewele maʻi maʻi, a i ʻole radioembolization, e hoʻohana ana i nā pōpō radioactive liʻiliʻi i hāʻawi ʻia i ke ake. Hiki i kekahi poʻe maʻi ke lilo i mau moho no ka wehe ʻana i nā metastases ate, ma muli o ka nui a me kahi o nā tumors.

E kūkākūkā kāu oncologist i nā koho a pau me ʻoe, me ka noʻonoʻo ʻana i nā mea e like me kou olakino holoʻokoʻa, ka nui o kāu maʻi maʻi, a me kāu mau makemake pilikino e pili ana i nā ala lapaʻau.

Ua ʻOi aku ka Floxuridine ma mua o ka 5-Fluorouracil?

He mau lāʻau lapaʻau pili loa ka Floxuridine a me ka 5-fluorouracil e hana ana ma nā ʻano like, akā he mau ʻokoʻa nui ko lākou e kūpono ai kēlā me kēia no nā kūlana like ʻole. Hoʻolālā ʻia ka Floxuridine no ka hoʻokomo ʻana i ka arterial hepatic, ʻo ia hoʻi, hāʻawi pololei ʻia i ke ake, ʻoiai hāʻawi ʻia ka 5-fluorouracil ma o kou kahe koko.

No nā metastases ate, hiki i ka floxuridine ke hāʻawi i nā pono no ka mea hiki iā ia ke loaʻa nā kiʻekiʻe kiʻekiʻe i ke ake me ka hana ʻana i nā hopena ʻaoʻao liʻiliʻi. Eia naʻe, ua aʻo nui ʻia ka 5-fluorouracil a hoʻohana ʻia no ka nui o nā maʻi maʻi, me ka mālama mua ʻana i ka maʻi maʻi colorectal.

Aia ke koho ma waena o kēia mau lāʻau lapaʻau i kāu kūlana kikoʻī, me kahi o kāu maʻi maʻi, nā lāʻau lapaʻau āu i loaʻa mua ai, a me kou olakino holoʻokoʻa. E kōkua kāu oncologist iā ʻoe e hoʻomaopopo i ke koho e pono ai no kāu hihia.

Nā Nīnau i Nīnau pinepine ʻia e pili ana i ka Floxuridine

He Palekana ka Floxuridine no ka poʻe me ka maʻi ate?

Pono ka Floxuridine i ka loiloi akahele i ka poʻe me ka maʻi ate, no ka mea, ua ʻākoakoa ka lāʻau lapaʻau i ke ake a hiki ke hōʻeha i ka pōʻino hou i ke ake. E hana kāu kauka i nā hoʻokolohua hana ate piha ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a e nānā pono i kou ate i ke kaʻina hana.

Inā he mau pilikia ate maʻalahi kāu, hiki i kāu kauka ke ʻōlelo aku i ka floxuridine akā me nā hoʻoponopono ʻana i ka mahele a i ʻole ka nānā pinepine ʻana. Eia naʻe, inā he maʻi ate koʻikoʻi a i ʻole cirrhosis, hiki i nā lāʻau lapaʻau ʻē aʻe ke palekana iā ʻoe.

He aha kaʻu e hana ai inā loaʻa iaʻu nā hopena ʻaoʻao koʻikoʻi?

Inā loaʻa iā ʻoe nā hopena ʻino loa e like me ka ʻeha nui o ka ʻōpū, ka luaʻi mau, ka melemele o kou ʻili a i ʻole nā maka, a i ʻole nā hōʻailona o ka maʻi, pono ʻoe e hoʻokaʻaʻike koke i kāu hui mālama ola a i ʻole e hele i ka lumi pilikia. Mai kali e ʻike inā e hoʻomaikaʻi nā hōʻailona iā lākou iho.

E hāʻawi kāu hui lapaʻau iā ʻoe i nā ʻōlelo kikoʻī e pili ana i ka manawa e kāhea ai iā lākou a me nā hōʻailona e koi ai i ka nānā koke. Pono paha lākou e hoʻoponopono i kāu hoʻolālā lapaʻau a i ʻole e hāʻawi i ka mālama kākoʻo e kōkua i ka mālama ʻana i nā hopena ʻino me ka palekana.

He aha ka mea e hana ai inā ʻaʻole hana pono ka ʻōnaehana catheter?

Hiki ke loaʻa nā pilikia catheter me ka hoʻokomo ʻana i ka arterial hepatic, me nā poloka, nā leaka, a i ʻole ka hoʻoneʻe ʻana o ka catheter. Inā ʻike ʻoe i nā hōʻailona maʻamau e like me ka ʻeha nui koke, ka pehu ʻana, a i ʻole inā ʻaʻole e hana pono ka ʻōnaehana pauma, pono ʻoe e hoʻokaʻaʻike koke i kāu hui mālama ola.

E nānā mau kāu hui lapaʻau i ka ʻōnaehana catheter a e aʻo iā ʻoe i ka mea e nānā ai. Hiki ke hoʻoponopono ʻia ka hapa nui o nā pilikia catheter me nā kaʻina hana liʻiliʻi, akā he mea nui ka nānā koke ʻana e pale i nā pilikia a hōʻoia e hoʻomau ʻoe i ka loaʻa ʻana o kāu lapaʻau e like me ka mea i hoʻolālā ʻia.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Floxuridine?

ʻO ka hoʻoholo e hooki i ka lapaʻau floxuridine e hilinaʻi ana i ka maikaʻi o kāna hana a me ke ʻano o kou ʻae ʻana iā ia. E loiloi mau kāu oncologist i kāu holomua ma o nā hoʻokolohua koko a me nā haʻawina kiʻi e hoʻoholo ai inā pono e hoʻomau ʻia ka lapaʻau, hoʻololi ʻia, a i ʻole e hooki ʻia.

Hiki ke hooki ʻia ka lapaʻau inā e pane maikaʻi ana ka maʻi kanesa a ua hoʻopau ʻoe i ka papa i hoʻolālā ʻia, inā e ulu ana nā hopena ʻino loa, a i ʻole inā e hooki ana ka maʻi kanesa i ka pane ʻana i ka lāʻau lapaʻau. E kūkākūkā mau kāu kauka i nā loli lapaʻau me ʻoe a wehewehe i nā kumu ma hope o kā lākou ʻōlelo.

Hiki iaʻu ke hele i ka wā e loaʻa ana iaʻu ka lapaʻau Floxuridine?

Pono ka hoʻolālā a me ka laulima ʻana me kāu hui mālama ola i ka wā e hele ai i ka wā e mālama ʻia ai me ka floxuridine. No ka mea, e hāʻawi ʻia ka lāʻau lapaʻau ma o ka ʻōnaehana catheter e pono ai ka nānā mau ʻana a me ka mālama ʻana, pono ʻoe e noho kokoke i kāu kikowaena lapaʻau i nā wā lapaʻau ikaika.

I nā wā hoʻomaha ma waena o nā pōʻai lapaʻau, hiki ke hele pōkole, akā pono ʻoe e kūkākūkā mau i nā hoʻolālā hele me kāu hui lapaʻau mua. Hiki iā lākou ke aʻo iā ʻoe e pili ana i nā hana e pono ai ʻoe e hana a hōʻoia i ka loaʻa ʻana o ka mālama olakino inā pono ʻoe i ka wā e hele ana.