He aha ʻo Fruquintinib: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi ʻo Fruquintinib e kōkua ana i ka hoʻolohi ʻana i ka ulu ʻana o ka maʻi maʻi ma o ka pale ʻana i nā kīʻaha koko e hānai ana i nā pūnaewele maʻi maʻi. No ka papa o nā lāʻau lapaʻau i kapa ʻia he kinase inhibitors kēia lāʻau lapaʻau waha, e hana ana e like me nā hoʻololi molekala e hoʻopau i nā hōʻailona e kōkua ana i nā maʻi maʻi e ulu a laha.

Ke heluhelu nei paha ʻoe i kēia no ka mea ua ʻōlelo kāu kauka iā fruquintinib ma ke ʻano he koho lapaʻau, a i ʻole ke noiʻi nei paha ʻoe ma ka inoa o kekahi āu e mālama ai. ʻO ka hoʻomaopopo ʻana i kāu lāʻau lapaʻau hiki ke kōkua iā ʻoe e manaʻoʻiʻo e pili ana i kāu huakaʻi lapaʻau.

He aha ʻo Fruquintinib?

He lāʻau lapaʻau maʻi maʻi ʻo Fruquintinib e kuhikuhi ana i nā protein kikoʻī e pili ana i ka ulu ʻana o ka maʻi maʻi. Hana ia ma ka pale ʻana i ka VEGFR (vascular endothelial growth factor receptor), e ʻoki ana i ka lako koko e pono ai nā maʻi maʻi e ulu nui.

E noʻonoʻo e like me ka pani ʻana i nā alaloa e hāʻawi ai i nā meaʻai i nā pūnaewele maʻi maʻi. Me ka ʻole o kēia mau ala, ʻoi aku ka paʻakikī o nā maʻi maʻi i ka ulu ʻana a me ka laha ʻana i nā ʻāpana ʻē aʻe o kou kino.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau i manaʻo ʻia, ʻo ia hoʻi e kālele ana i nā pahuhopu molekala kikoʻī ma mua o ka hoʻopilikia ʻana i nā pūnaewele e mahele wikiwiki ana e like me ka chemotherapy kuʻuna.

No ke aha e hoʻohana ʻia ai ʻo Fruquintinib?

Hoʻohana nui ʻia ʻo Fruquintinib e mālama i ka maʻi maʻi colorectal i laha i nā ʻāpana ʻē aʻe o ke kino (metastatic colorectal cancer). Hoʻonohonoho maʻamau kāu kauka i kēia lāʻau lapaʻau i ka wā i hana ʻole ai nā lāʻau lapaʻau ʻē aʻe e like me ka mea i manaʻo ʻia.

Ua ʻae ʻia no nā maʻi nona ka maʻi maʻi i hoʻomau i ka ulu ʻana me ka nānā ʻole i nā lāʻau lapaʻau chemotherapy ʻē aʻe. ʻO kēia ka mea e hana ai ʻo fruquintinib i ka mea a nā kauka e kāhea ai he

Pehea e Hana ai ʻo Fruquintinib?

Hana ʻo Fruquintinib ma ka pale ʻana i nā ala protein he nui e hoʻohana ai nā sela maʻi ʻaʻai e ulu a hana i nā kīʻaha koko hou. Manaʻo ʻia he lāʻau lapaʻau i manaʻo ʻia e hoʻopau pono i nā hōʻailona e pono ai nā ʻōpū e ulu.

Hoʻopaʻa ka lāʻau i ʻekolu mau mea loaʻa nui: VEGFR1, VEGFR2, a me VEGFR3. He like kēia mau mea loaʻa me nā ala kamaʻilio kelepona e haʻi ana i nā kīʻaha koko e ulu i nā ʻōpū, e hāʻawi ana iā lākou i ka oxygen a me nā meaʻai.

Ma ka pale ʻana i kēia mau hōʻailona, ​​kōkua ʻo fruquintinib i ka hoʻolohi ʻana i ka ulu ʻana o ka ʻōpū a hiki ke hōʻemi i nā ʻōpū e kū nei. Hoʻopilikia pū ia i nā sela maʻi ʻaʻai e laha i nā wahi hou o kou kino.

Pehea e Lawe ai au iā Fruquintinib?

E lawe iā fruquintinib e like me ke kauoha a kāu kauka, i kēlā me kēia lā me ka meaʻai. ʻO ka lawe ʻana me ka ʻai e kōkua i kou kino e komo i ka lāʻau lapaʻau a hiki ke hōʻemi i ka ʻōpū.

E ale i nā capsules holoʻokoʻa me ke aniani wai piha. Mai ʻoki, nau, a wehe paha i nā capsules, no ka mea, hiki i kēia ke hoʻopilikia i ka hana ʻana o ka lāʻau lapaʻau i kou kino.

E hoʻāʻo e lawe i kāu mahele i ka manawa like i kēlā me kēia lā e kōkua iā ʻoe e hoʻomanaʻo a mālama i nā pae paʻa o ka lāʻau lapaʻau i kāu ʻōnaehana. Inā ʻai ʻoe i ka ʻaina kakahiaka, ʻo ka lawe ʻana me kāu ʻai kakahiaka e hana maikaʻi.

E hoʻomaka paha kāu kauka iā ʻoe ma kahi papa hana dosing kikoʻī, e pili ana i nā manawa o ka lawe ʻana i ka lāʻau lapaʻau a ukali ʻia e nā wā pōkole. Kōkua kēia ala i ka mālama ʻana i nā hopena ʻaoʻao i ka wā e mālama ana i ka pono o ka lāʻau.

Pehea ka lōʻihi e lawe ai au iā Fruquintinib?

E lawe ʻoe iā fruquintinib no ka lōʻihi e kōkua ana i ka mālama ʻana i kāu maʻi ʻaʻai a ke ʻae maikaʻi nei ʻoe. ʻAʻohe lā pau i hoʻoholo mua ʻia no kēia ʻano lāʻau lapaʻau i manaʻo ʻia.

E nānā kāu kauka i kāu pane ma o nā scans maʻamau a me nā hoʻokolohua koko, maʻamau i kēlā me kēia 6-8 pule i ka wā mua. Kōkua kēia mau nānā ʻana e hoʻoholo inā e hana ana ka lāʻau lapaʻau a inā pono e hoʻoponopono i ka mahele.

He nui ka poʻe e lawe ana i ka fruquintinib no nā mahina a i ʻole nā makahiki, a ʻo nā mea ʻē aʻe paha e pono e hooki koke ma muli o nā hopena ʻaoʻao a i ʻole inā hoʻomaka hou ka maʻi kanesa e ulu. Aia ka lōʻihi o kāu lapaʻau ʻana ma kāu pane pilikino.

He aha nā hopena ʻaoʻao o ka Fruquintinib?

E like me nā lāʻau lapaʻau maʻi kanesa a pau, hiki i ka fruquintinib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole nā mea a pau e ʻike iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ka mālama kūpono a me ka nānā ʻana mai kāu hui mālama ola.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike:

• ʻO ka maʻi lima-wāwae (ʻulaʻula, pehu, a i ʻole ka ʻeha ma nā pālima a me nā kapuaʻi)
• Pāpaʻa
• Ke koko kiʻekiʻe
• Luhi
• Hoʻemi ʻia ka ʻai
• Nausea
• Nā loli leo a i ʻole ka ʻū

Na kāu kauka e aʻo iā ʻoe pehea e mālama ai i kēia mau hopena ʻaoʻao a hiki ke kauoha i nā lāʻau lapaʻau e kōkua. ʻIke ka hapa nui o ka poʻe e lilo nā hopena ʻaoʻao i mea hiki ke mālama ʻia i ka wā e hoʻoponopono ai ko lākou kino i ka lapaʻau.

Hiki ke hana kekahi mau hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi, a he mea nui e ʻike i ka wā e hoʻopili ai i kāu hui mālama ola:

• Ke kahe nui ʻana a i ʻole ka ʻeha maʻamau
• Nā hōʻailona o nā pilikia o ka naʻau (ʻeha umauma, pōkole o ka hanu)
• ʻEha ʻōpū nui
• Melemele o ka ʻili a i ʻole nā maka
• Poʻo nui koke
• Nā koko koko (pehu wāwae, ʻeha umauma)

He kakaikahi kēia mau hopena ʻaoʻao koʻikoʻi, akā e nānā pono kāu hui lapaʻau iā ʻoe me nā nānā maʻamau a me nā hoʻokolohua koko e hopu i nā pilikia i ka wā mua.

ʻO wai ka mea ʻaʻole pono e lawe i ka Fruquintinib?

ʻAʻole pono kekahi poʻe e lawe i ka fruquintinib ma muli o nā hopohopo palekana. E nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana i kēia lāʻau.

ʻAʻole pono ʻoe e lawe i ka fruquintinib inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, no ka mea, hiki iā ia ke hōʻeha i kahi pēpē i hānau ʻole ʻia. Pono nā wahine o ka makahiki hānau ke hoʻohana i ka mana hānau kūpono i ka wā o ka lapaʻau a no kekahi mau mahina ma hope o ka hooki ʻana.

ʻAʻole paha kūpono nā kānaka me kekahi mau maʻi puʻuwai, ke koko kiʻekiʻe ʻaʻole i mālama ʻia, a i ʻole ke ʻoki nui ʻana i kēia lāʻau lapaʻau. E noʻonoʻo nō kāu kauka i ka hana o kou ate a me kou puʻupaʻa ma mua o ke kau ʻana i ka fruquintinib.

Inā ʻoe e lawe ana i nā mea lahilahi koko a i ʻole he moʻolelo o nā pilikia koko, e ana kāu kauka i nā pilikia a me nā pōmaikaʻi ma mua o ka ʻōlelo ʻana i kēia lapaʻau.

Nā inoa inoa o Fruquintinib

Kūʻai ʻia ʻo Fruquintinib ma lalo o ka inoa inoa ʻo Fruzaqla ma ʻAmelika Hui Pū ʻIa. Ma nā ʻāina ʻē aʻe, loaʻa paha ia ma lalo o nā inoa inoa like ʻole a i ʻole he lāʻau lapaʻau maʻamau.

Ke kiʻi ʻana i kāu kauoha, e hōʻoia i ka hāʻawi ʻana o ka hale kūʻai lāʻau lapaʻau iā ʻoe i ka lāʻau lapaʻau kūpono ma ka nānā ʻana i ka inoa maʻamau (fruquintinib) a me ka inoa inoa me kāu kauka lāʻau.

Nā koho ʻē aʻe o Fruquintinib

He nui nā lāʻau lapaʻau i manaʻo ʻia e hana like me ka fruquintinib no ka maʻi ʻaʻai colorectal. Aia kēia mau koho ʻē aʻe i ka regorafenib (Stivarga) a me ka trifluridine/tipiracil (Lonsurf).

Hiki nō hoʻi i kāu kauka ke noʻonoʻo i nā lāʻau lapaʻau i manaʻo ʻia e like me bevacizumab (Avastin) a i ʻole ramucirumab (Cyramza), ma muli o nā ʻano maʻi ʻaʻai kikoʻī a me nā lāʻau lapaʻau i hala.

Aia ke koho ma waena o kēia mau lāʻau lapaʻau i nā mea e like me ke ʻano genetic o kāu maʻi ʻaʻai, nā lāʻau lapaʻau i hala, ka ʻaoʻao hopena, a me kou olakino holoʻokoʻa. E kōkua kāu oncologist e hoʻoholo i ke koho e hāʻawi ana i ke kaulike maikaʻi loa o ka pono a me ka ʻae ʻana no kou kūlana.

ʻOi aku ka maikaʻi o Fruquintinib ma mua o Regorafenib?

He mau lāʻau lapaʻau i manaʻo ʻia ʻo Fruquintinib a me regorafenib no ka maʻi ʻaʻai colorectal holomua, akā he ʻano ʻokoʻa ko lākou hopena. Hōʻike nā haʻawina e hiki i ka fruquintinib ke kumu i nā hopena ʻaoʻao koʻikoʻi liʻiliʻi i ka wā e hāʻawi ana i nā pōmaikaʻi like i ka mālama ʻana i ka maʻi ʻaʻai.

He mea maʻalahi ka fruquintinib i ka maʻi lima-wāwae a me ka luhi ma mua o ka regorafenib, a he mea maʻalahi paha ia no kekahi poʻe maʻi. Eia naʻe, hiki i nā lāʻau ʻelua ke hoʻolohi i ka ulu ʻana o ka maʻi maʻi ke hoʻohana ʻia i ke kūlana kūpono.

E noʻonoʻo kāu kauka i kāu moʻolelo olakino, nā lāʻau i hala, a me ke kūlana olakino i kēia manawa i ke koho ʻana ma waena o kēia mau koho. ʻO ka mea e hana maikaʻi loa e loli mai kēlā kanaka i kēia kanaka.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana i ka Fruquintinib

He Palekana anei ka Fruquintinib no ka poʻe me ka maʻi puʻuwai?

Hiki i ka Fruquintinib ke hoʻopilikia i ke koko a me ka hana o ka puʻuwai, no laila pono ka poʻe me nā maʻi puʻuwai e nānā pono. E loiloi kāu kauka i ke olakino o kou puʻuwai ma mua o ka hoʻomaka ʻana i ka lāʻau a hiki ke kauoha i nā hoʻokolohua hou e like me ka echocardiogram.

Inā he maʻi puʻuwai maikaʻi kāu, hiki nō paha iā ʻoe ke lawe i ka fruquintinib me ka nānā pono ʻana. E hana pū kāu cardiologist a me ka oncologist e hōʻoia i ka palekana o kāu lāʻau.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o ka Fruquintinib?

Inā lawe hewa ʻoe i ka nui o ka fruquintinib ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau. Mai kali e ʻike inā e ulu nā hōʻailona, ​​no ka mea, he mea nui ka loaʻa ʻana o ka ʻōlelo aʻo olakino.

E mālama i ka hue lāʻau me ʻoe i ka wā e ʻimi ai i ke kōkua, no ka mea, e kōkua kēia ʻike i nā mea mālama ola e hāʻawi iā ʻoe i ka mālama maikaʻi loa. Mai hoʻāʻo e

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Fruquintinib?

Mai hooki i ka lawe ʻana iā fruquintinib me ke kamaʻilio ʻole me kāu kauka mua, ʻoiai inā ʻoe e maikaʻi ana a i ʻole e ʻike ana i nā hopena ʻaoʻao. ʻO ka hooki koke ʻana e hiki ai i kāu maʻi maʻi ke ulu wikiwiki.

Na kāu kauka e hoʻoholo i ka manawa kūpono e hooki ai ma muli o ka maikaʻi o ka hana ʻana o ka lāʻau a me ke ʻano o kou hoʻomanawanui ʻana iā ia. Hiki iā lākou ke ʻōlelo aku i ka hoʻemi ʻana i ka nui a i ʻole nā hoʻomaha lapaʻau e mālama i nā hopena ʻaoʻao i ka wā e hoʻomau ana i ka lapaʻau.

Hiki iaʻu ke lawe i nā lāʻau ʻē aʻe me Fruquintinib?

Hiki i kekahi mau lāʻau lapaʻau ke launa pū me fruquintinib, no laila he mea nui e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau a pau, nā lāʻau lapaʻau i kūʻai ʻia ma luna o ka pāʻani, a me nā mea hoʻohui āu e lawe nei.

Pono paha kekahi mau lāʻau lapaʻau koko, nā mea hoʻokahe koko, a me kekahi mau lāʻau antibiotic i ka hoʻoponopono ʻana i ka nui ke lawe ʻia me fruquintinib. Hiki i kāu kauka lapaʻau ke kōkua i ka ʻike ʻana i nā pilina kūpono i ka wā e hoʻopiha ai i kāu mau kauoha.