He aha ʻo Galcanezumab: Nā Hoʻohana, Nā Ana, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

He lāʻau lapaʻau i kauoha ʻia ʻo Galcanezumab i hoʻolālā ʻia e pale i nā ʻehaʻeha migraine i nā pākeke. He lapaʻau i manaʻo ʻia e hana ana ma ka pale ʻana i kahi protein i kapa ʻia ʻo CGRP (calcitonin gene-related peptide) e hana nui ana i ka hoʻoulu ʻana i nā migraine. Hāʻawi kēia injection mahina i ka manaʻolana no ka poʻe e hakakā nei me nā ʻehaʻeha pinepine, nāwaliwali e hoʻopilikia i ko lākou ola i kēlā me kēia lā.

He aha ʻo Galcanezumab?

No ka papa hou o nā lāʻau lapaʻau i kapa ʻia ʻo CGRP inhibitors a i ʻole monoclonal antibodies ʻo Galcanezumab. E noʻonoʻo iā ia he pale kūikawā loa e hoʻohana ai kou kino e pale i nā hōʻailona e hiki ke hoʻoulu i nā hōʻeha migraine. ʻAʻole like me nā lāʻau lapaʻau migraine kahiko i hoʻomohala mua ʻia no nā maʻi ʻē aʻe, ua hana ʻia ʻo galcanezumab no ka pale ʻana i ka migraine.

Hele mai ka lāʻau lapaʻau ma ke ʻano he peni i hoʻopiha mua ʻia a i ʻole ka syringe āu e hoʻokomo ai ma lalo o kou ʻili i hoʻokahi manawa i ka mahina. Ua hoʻolālā ʻia no ka poʻe e loaʻa ana i nā migraine pinepine a pono i ka pale mau, wā lōʻihi ma mua o ka mālama ʻana i nā ʻehaʻeha ma hope o ka hoʻomaka ʻana.

No ke aha e hoʻohana ʻia ai ʻo Galcanezumab?

Hoʻonohonoho mua ʻia ʻo Galcanezumab e pale i nā ʻehaʻeha migraine i nā pākeke e loaʻa pinepine iā lākou. Hiki i kāu kauka ke ʻōlelo aku i kēia lāʻau lapaʻau inā loaʻa iā ʻoe ʻehā a ʻoi aku paha nā lā migraine i kēlā me kēia mahina a ʻaʻole i hana maikaʻi nā lapaʻau pale ʻē aʻe iā ʻoe.

Ua ʻae ʻia ka lāʻau lapaʻau no ka mālama ʻana i nā ʻehaʻeha cluster episodic, ʻo ia nā ʻehaʻeha ʻeha loa e hana ana i nā ʻano cyclical. He ʻokoʻa kēia mau ʻehaʻeha mai nā migraine a makemake e hana i nā pūʻulu a i ʻole

Hana ʻo Galcanezumab ma ka pahuhopu ʻana i ka CGRP, he protein i hoʻokuʻu ʻia e kou kino i ka wā o nā hōʻeha migraine. Ke hoʻokuʻu ʻia ka CGRP, hoʻoulu ia i nā kīʻaha koko i kou poʻo e hoʻonui a hoʻoulu i ka mumū a me nā hōʻailona ʻeha. Hana kēia lāʻau lapaʻau e like me ke kī e kūpono i ka laka CGRP, e pale ana iā ia mai ka hana ʻana i kēia mau loli ʻeha.

Ua manaʻo ʻia he lāʻau lapaʻau pale ikaika, ʻo ia hoʻi he mea maikaʻi loa akā mālama ʻia no ka poʻe i pane ʻole i nā lāʻau lapaʻau laina mua. ʻAʻole like me kekahi mau lāʻau lapaʻau migraine e pili ana i kāu ʻōnaehana nerve holoʻokoʻa, hana ʻo galcanezumab ma ke ala migraine.

Hoʻonui nā hopena i ka manawa, no laila ʻaʻole paha ʻoe e ʻike i nā pōmaikaʻi piha i ka manawa koke. Hoʻomaka ka hapa nui o nā kānaka e ʻike i nā hoʻomaikaʻi ʻana i loko o ka mahina mua, akā hiki ke lawe i ʻekolu mahina e ʻike i nā hopena pale piha o ka lāʻau lapaʻau.

Pehea wau e lawe ai iā Galcanezumab?

Hāʻawi ʻia ʻo Galcanezumab ma ke ʻano he injection subcutaneous, ʻo ia hoʻi e hoʻokomo ʻoe iā ia i loko o ka ʻiʻo momona ma lalo pono o kou ʻili. E aʻo kāu mea mālama ola iā ʻoe pehea e hāʻawi ai iā ʻoe iho i kēia mau injections me ka palekana ma ka home. ʻO nā wahi injection maʻamau ʻo kou ʻūhā, ka lima luna, a i ʻole ka ʻōpū.

E hoʻomaka maʻamau ʻoe me kahi dosis hoʻouka o 240 mg (ʻelua 120 mg injections) i kou lā mua, a laila 120 mg (hoʻokahi injection) i hoʻokahi manawa i ka mahina. E lawe i ka lāʻau lapaʻau mai ka pahu hau ma kahi o 30 mau minuke ma mua o ka hoʻokomo ʻana e ʻae iā ia e hiki i ka mahana lumi, e ʻoluʻolu ai ka injection.

Hiki iā ʻoe ke lawe iā galcanezumab me ka ʻole o ka meaʻai no ka mea ua hoʻokomo ʻia ma mua o ka lawe ʻia e ka waha. E hoʻāʻo e hoʻokomo iā ia i ka lā like i kēlā me kēia mahina e mālama i nā pae kūlike i kāu ʻōnaehana. Inā ʻoluʻolu ʻole ʻoe i ka hoʻokomo ʻana iā ʻoe iho, hiki i ke keʻena o kāu kauka ke lawelawe iā ia nāu.

Pehea ka lōʻihi e lawe ai au iā Galcanezumab?

ʻO ka hapa nui o nā kānaka e lawe i ka galcanezumab no ka liʻiliʻi o ʻekolu a ʻeono mahina e loiloi pono i kona pono. E ʻōlelo paha kāu kauka e hāʻawi i kahi manawa hoʻokolokolo kūpono no ka mea hiki ke lawe i ka manawa e ʻike i nā pōmaikaʻi piha. ʻIke kekahi poʻe i nā hoʻomaikaʻi i loko o ka mahina mua, a ʻo nā mea ʻē aʻe e pono paha i ʻekolu mahina.

Inā hana maikaʻi ka galcanezumab iā ʻoe, e ʻōlelo paha kāu kauka e hoʻomau i ka wā lōʻihi. Nui ka poʻe e lawe ana i hoʻokahi makahiki a ʻoi aku paha e mālama i ko lākou maikaʻi o ke ola. Me he mea lā e mau ana ka lāʻau lapaʻau me ka hoʻomau ʻana i ka hoʻohana ʻana, a ʻaʻohe hōʻike e nalowale ana kona hopena pale i ka manawa.

E nānā mau kāu mea mālama ola me ʻoe e loiloi i ka maikaʻi o ka hana ʻana o ka lāʻau a inā paha e ʻike nei ʻoe i nā hopena ʻaoʻao. E kōkua lākou iā ʻoe e hoʻoholo inā e hoʻomau, hoʻoponopono i ka manawa, a i ʻole e ʻimi i nā koho ʻē aʻe e pili ana i kāu pane pilikino.

He aha nā hopena ʻaoʻao o Galcanezumab?

E like me nā lāʻau lapaʻau a pau, hiki i ka galcanezumab ke hana i nā hopena ʻaoʻao, ʻoiai he nui ka poʻe e ʻae maikaʻi iā ia. ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a maʻa mau e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia e ʻike ai ʻoe:

• Nā hopena ma ka pūnaewele injection e like me ka ʻulaʻula, ka pehu, a i ʻole ka ʻeha maʻalahi
• Nā maʻi o ka ʻōnaehana hanu luna a i ʻole nā ​​hōʻailona e like me ke anu
• Ka paʻa ʻana a i ʻole nā ​​hoʻololi i nā neʻe ʻana o ka ʻōpū
• ʻO ka luhi a i ʻole ka piʻi ʻana o ka luhi ma mua o ka maʻamau
• ʻO ka ʻūlū a i ʻole ka māmā
• Nausea a i ʻole ka ʻoluʻolu o ka ʻōpū

ʻO ka hapa nui o nā hopena ma ka pūnaewele injection he maʻalahi a hoʻoponopono i loko o hoʻokahi a ʻelua paha lā. Hiki iā ʻoe ke hoʻopili i kahi compress anu ma mua o ka injection a me kahi compress mahana ma hope e hōʻemi i ka ʻoluʻolu.

ʻOiai ʻaʻole maʻamau, hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi e koi ai i ka lāʻau lapaʻau:

• Nā hopena maʻi ʻino me ka pilikia o ka hanu ʻana a i ʻole ka pehu ʻana o ka maka, nā lehelehe, a i ʻole ka ʻāʻī
• Ka paʻa ʻana o ka ʻōpū i ʻoi loa ka paʻakikī ʻaʻole e hoʻomaikaʻi me nā lāʻau maʻamau
• Nā hopena ma ka wahi i hoʻokomo ʻia e hoʻomau ana a i ʻole e ʻinoʻino ana
• Nā loli ʻokoʻa i ke ʻano a i ʻole ke ʻano o ka hana

He kakaikahi kēia mau hopena koʻikoʻi, akā he mea nui e hoʻokaʻaʻike koke aku i kāu mea mālama ola inā loaʻa iā ʻoe kekahi mau hōʻailona e hopohopo ai. ʻO ka hapa nui o nā kānaka e ʻike ana i nā pōmaikaʻi o ka hōʻemi ʻana i nā migraines e ʻoi aku ana ma mua o nā hopena ʻaoʻao maʻalahi e hiki ke loaʻa iā lākou.

ʻO wai ka mea pono ʻole e lawe iā Galcanezumab?

ʻAʻole kūpono ʻo Galcanezumab no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia nāu. Pono nā kānaka me nā maʻi āpau i ʻike ʻia iā galcanezumab a i ʻole kekahi o kāna mau mea pono e pale loa i kēia lāʻau.

E makemake kāu mea mālama ola e kūkākūkā i kāu mōʻaukala olakino ma mua o ke kau ʻana iā galcanezumab, ʻoiai inā loaʻa iā ʻoe:

• He mōʻaukala o nā hopena maʻi ʻino i nā lāʻau ʻē aʻe
• Nā maʻi e hana nei a i ʻole kahi ʻōnaehana pale i hoʻopilikia ʻia
• Nā pilikia kīkī a i ʻole ke ake nui
• He mōʻaukala o ka maʻi cardiovascular
• Nā hoʻolālā e hāpai a i ʻole e hānai ana i ka waiū i kēia manawa

ʻAʻole i aʻo nui ʻia ka lāʻau lapaʻau i nā wahine hāpai, no laila e kaupaona kāu kauka i nā pōmaikaʻi kūpono e kūʻē i nā pilikia i ʻike ʻole ʻia inā ʻoe e hoʻolālā ana e hāpai. Pēlā nō, ʻaʻole ʻike ʻia inā hele ʻo galcanezumab i loko o ka waiū umauma.

ʻAʻole pono nā keiki a me nā ʻōpio ma lalo o 18 mau makahiki e lawe iā galcanezumab no ka mea ʻaʻole i hōʻoia ʻia he palekana a i ʻole he pono i nā hui makahiki ʻōpio. E noʻonoʻo kāu kauka i nā lāʻau lapaʻau ʻē aʻe inā aia ʻoe i kēia pae makahiki.

Nā inoa inoa o Galcanezumab

Kūʻai ʻia ʻo Galcanezumab ma lalo o ka inoa inoa ʻo Emgality ma ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe. Hiki iā ʻoe ke ʻike i kēia inoa ma kāu lepili kauoha, nā palapala ʻinikua, a i ʻole ke kūkākūkā ʻana i ka lāʻau lapaʻau me kāu hui mālama ola.

Hana ʻia ʻo Emgality e Eli Lilly and Company a loaʻa i nā peni i hoʻopiha mua ʻia a me nā syringes i hoʻopiha mua ʻia. Loaʻa i nā ʻano ʻelua ka lāʻau lapaʻau like a hana like, ʻoiai ʻoi aku ka ʻoluʻolu o kekahi poʻe i kekahi ʻano hāʻawi ma mua o kekahi.

Ke kamaʻilio ʻana me kāu lāʻau lapaʻau a i ʻole ka hui ʻinikua, hiki iā ʻoe ke hoʻohana i ka inoa generic (galcanezumab) a i ʻole ka inoa brand (Emgality). E ʻike maoli lākou i ke ʻano o ka lāʻau lapaʻau āu e kuhikuhi nei.

Nā Koho ʻē aʻe o Galcanezumab

Inā ʻaʻole kūpono ʻo galcanezumab iā ʻoe, aia kekahi mau koho pale migraine ʻē aʻe. Hiki i kāu kauka ke kōkua iā ʻoe e ʻimi i kēia mau koho ʻē aʻe e pili ana i kāu kūlana kikoʻī, ka mōʻaukala olakino, a me nā pahuhopu lapaʻau.

Hana like nā mea pale CGRP ʻē aʻe me galcanezumab a he mau koho maikaʻi paha:

• Fremanezumab (Ajovy) - kahi koho injection mahina ʻē aʻe
• Erenumab (Aimovig) - e kuhikuhi ana i kahi ʻāpana ʻokoʻa o ke ala CGRP
• Eptinezumab (Vyepti) - hāʻawi ʻia e ka IV infusion i kēlā me kēia mahina ʻekolu

Hiki ke noʻonoʻo ʻia nā lāʻau lapaʻau pale migraine kuʻuna, ʻoi aku ka maikaʻi inā makemake ʻoe i nā pila i kēlā me kēia lā ma mua o nā injections mahina. Aia kēia mau mea i kekahi mau antidepressants, nā lāʻau anti-seizure, a me nā beta-blockers i hōʻike i ka pono i ka pale ʻana i nā migraines.

E noʻonoʻo kāu mea mālama ola i nā mea e like me kāu mau maʻi olakino ʻē aʻe, nā lāʻau lapaʻau o kēia manawa, nā makemake o ke ola, a me ka uhi ʻinikua i ka wā e ʻōlelo ai i nā koho ʻē aʻe. ʻO ka pahuhopu ka loaʻa ʻana o ka lāʻau lapaʻau maikaʻi loa e kūpono i kou ola.

Ua ʻoi aku ka maikaʻi o Galcanezumab ma mua o Sumatriptan?

Hoʻohana ʻo Galcanezumab a me sumatriptan i nā kumu like ʻole i ka mālama ʻana i ka migraine, no laila ʻo ka hoʻohālikelike ʻana iā lākou e like me ka hoʻohālikelike ʻana i nā ʻāpala a me nā ʻalani. He lāʻau lapaʻau pale ʻo Galcanezumab āu e lawe ai i kēlā me kēia mahina e hōʻemi i ke alapine o nā migraines, ʻoiai ʻo sumatriptan kahi lāʻau lapaʻau acute āu e lawe ai ke hoʻomaka kahi migraine.

He nui nā kānaka e hoʻohana pū ana i nā lāʻau lapaʻau ʻelua ma ke ʻano he ʻāpana o ka hoʻolālā mālama migraine piha. Hiki iā ʻoe ke lawe i ka galcanezumab i kēlā me kēia mahina e pale ai i nā migraine a mālama i ka sumatriptan no nā poʻo e hiki mai ana.

Inā ʻoe e hoʻohana pinepine ana i ka sumatriptan (ʻoi aku ma mua o 10 mau lā i kēlā me kēia mahina), hiki i kāu kauka ke ʻōlelo aku e hoʻohui i ka galcanezumab e hōʻemi i kāu pilikia migraine holoʻokoʻa. Hiki i kēia ala ke kōkua iā ʻoe e hilinaʻi liʻiliʻi i nā lāʻau lapaʻau acute a pale aku i nā poʻo e pili ana i ka hoʻohana nui ʻana i ka lāʻau lapaʻau.

Aia ka koho

Mai hoʻāʻo e "hoʻopau" i ka lāʻau lapaʻau keu ma kāu iho. Hiki i kāu kauka ke makemake e nānā iā ʻoe no ka hoʻonui ʻia ʻana o nā hopena ʻaoʻao a i ʻole e hoʻoponopono i kāu mahele i hoʻonohonoho ʻia e hiki mai ana. E mālama i ka pūʻolo lāʻau lapaʻau me ʻoe i ka wā e ʻimi ana i ke kōkua olakino i ʻike pono nā mea mālama ola i ke ʻano a me ka nui āu i lawe ai.

He aha kaʻu e hana ai inā e poina iaʻu kahi mahele o Galcanezumab?

Inā e poina iā ʻoe kāu pahu galcanezumab i kēlā me kēia mahina, e lawe koke iā ia ke hoʻomanaʻo ʻoe, a laila e hoʻomau me kāu papa hana maʻamau i kēlā me kēia mahina mai ia manawa. Mai pāpālua i nā mahele a i ʻole e hoʻāʻo e hana i ka injection i poina ma ka lawe ʻana i ka lāʻau lapaʻau keu.

E hoʻonohonoho i nā mea hoʻomanaʻo kelepona a i ʻole nā ​​ʻōlelo aʻo kalena e kōkua iā ʻoe e hoʻomanaʻo i kāu lā injection i kēlā me kēia mahina. Manaʻo kekahi poʻe he mea kōkua ke hoʻonohonoho i kā lākou injections a puni kahi lā hoʻomanaʻo i kēlā me kēia mahina, e like me ka Pōʻaono mua a i ʻole ka 15.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Galcanezumab?

Hiki iā ʻoe ke hooki i ka lawe ʻana iā galcanezumab i kēlā me kēia manawa, akā ʻoi aku ka maikaʻi e kūkākūkā i kēia hoʻoholo me kāu mea mālama ola mua. ʻAʻole like me kekahi mau lāʻau lapaʻau, ʻaʻole pono ʻoe e hōʻemi mālie i ka mahele - hiki iā ʻoe ke hooki wale i ka lawe ʻana i kāu injections i kēlā me kēia mahina.

E hoʻi hou ana kāu migraines i ko lākou alapine ma mua i loko o kekahi mau mahina ma hope o ka hooki ʻana i ka lāʻau lapaʻau. Hiki i kāu kauka ke kōkua iā ʻoe e hoʻolālā no kēia hoʻololi a kūkākūkā i nā lāʻau lapaʻau ʻē aʻe inā pono.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana iā Galcanezumab?

ʻAʻohe pilina i ʻike ʻia ma waena o galcanezumab a me ka waiʻona, no laila ua manaʻo ʻia ka inu ʻana i ka maʻalahi he palekana. Eia naʻe, he mea hoʻoulu migraine maʻamau ka waiʻona no ka nui o nā kānaka, no laila makemake paha ʻoe e nānā i ke ʻano o kāna hopena i kou mau poʻo.

ʻOiai ke kōkua nei ʻo galcanezumab i ka pale ʻana i kāu migraines, hiki i ka waiʻona ke hoʻoulu i nā poʻo poʻo. E hoʻolohe i kāu pane pilikino a kūkākūkā i nā hopohopo me kāu mea mālama ola.