He aha ʻo Gefitinib: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi ʻo Gefitinib e ālai ana i nā protein kikoʻī e kōkua ana i kekahi mau maʻi maʻi maʻi e ulu. He ʻāpana ia o kahi pūʻulu lāʻau lapaʻau i kapa ʻia ʻo tyrosine kinase inhibitors, e hana ana e like me nā kī pololei e komo i loko o nā laka cell maʻi e hoʻōki i ko lākou ulu ʻana. Ua lilo kēia lāʻau lapaʻau waha i mea koho lapaʻau nui no ka poʻe me nā ʻano maʻi maʻi maʻi liʻiliʻi ʻole, e hāʻawi ana i ka manaʻolana ma o kāna hana i manaʻo ʻia.

He aha ʻo Gefitinib?

He lāʻau lapaʻau kauoha ʻo Gefitinib i hoʻolālā ʻia e mālama i ka maʻi maʻi maʻi liʻiliʻi ʻole (NSCLC). No kahi papa o nā lāʻau i kapa ʻia ʻo epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. E noʻonoʻo iā ia he mea ālai molekala e hoʻōki ana i nā cell maʻi mai ka loaʻa ʻana o nā hōʻailona e pono ai lākou e hoʻonui a laha.

Hele mai kēia lāʻau lapaʻau ma ke ʻano o nā papa waha, e maʻalahi ai ma mua o nā lāʻau lapaʻau maʻi he nui e koi ai i nā kipa i ka haukapila no ka hoʻokomo ʻana. Hoʻopili ʻo Gefitinib i nā cell maʻi me kekahi mau loli genetic, ʻo ia hoʻi nā EGFR mutations, i loaʻa ma kahi o 10-15% o nā maʻi maʻi maʻi maʻi ma ʻAmelika Hui Pū ʻIa a hiki i 50% i kekahi mau heluna kanaka Asia.

No ke aha e hoʻohana ʻia ai ʻo Gefitinib?

Hoʻohana nui ʻia ʻo Gefitinib e mālama i ka maʻi maʻi maʻi liʻiliʻi ʻole metastatic i nā maʻi i loaʻa i nā tumors i loaʻa i nā EGFR mutations kikoʻī. E hoʻāʻo kāu kauka i kāu ʻiʻo maʻi e hōʻoia i kēia mau mutations ma mua o ke kau ʻana i kēia lāʻau lapaʻau. He mea nui kēia hana hoʻāʻo no ka mea e hana maikaʻi ʻo gefitinib ke loaʻa kēia mau loli genetic kikoʻī i loko o kāu mau cell maʻi.

Hoʻohana pinepine ʻia ka lāʻau lapaʻau ke laha ka maʻi ʻaʻai māmā i nā wahi ʻē aʻe o ke kino a i ʻole ke ʻole ka ʻoki ʻana i kahi koho. Hoʻohana pinepine ʻia ma ke ʻano he lapaʻau mua no ka poʻe me ka maʻi ʻaʻai māmā EGFR-positive, ʻo ia hoʻi, ʻo ia paha ka lāʻau lapaʻau maʻi ʻaʻai mua a kāu kauka e ʻōlelo ai. Hiki i kekahi mau kauka ke kuhikuhi iā ia ma hope o ka hana ʻole ʻana o nā lapaʻau ʻē aʻe.

Pehea e Hana ai ʻo Gefitinib?

Hana ʻo Gefitinib ma ka pale ʻana i ka protein EGFR, e hana ana e like me ke kuapo ulu i loko o nā pūnaewele maʻi ʻaʻai. Ke hana nui kēia protein ma muli o nā loli genetic, hoʻouna ia i nā hōʻailona

Inā pilikia ʻoe i ka ʻai ʻana i nā papa, hiki iā ʻoe ke hoʻoheheʻe i ka gefitinib i ka wai maʻemaʻe. E hoʻokuʻu i ka papa i loko o ka hapalua o ke aniani wai, e hoʻoulu a hiki i ka pau ʻana o ka hoʻoheheʻe ʻana, a inu koke i ka hui. E holoi i ke aniani me ka wai hou a inu pū i mea e loaʻa ai ka lāʻau piha.

E hoʻāʻo e lawe i ka gefitinib i ka manawa like i kēlā me kēia lā e mālama i nā pae paʻa i loko o kou kino. Nui ka poʻe i ʻike he mea kōkua ka hoʻopili ʻana i ka lawe ʻana i kā lākou lāʻau i kahi hana maʻamau i kēlā me kēia lā, e like me ka ʻaina kakahiaka a i ʻole ka palaki ʻana i ko lākou niho. Kōkua kēia kūlike i ka hōʻoia ʻana e hana pono ka lāʻau.

Pehea ka lōʻihi e lawe ai au i ka Gefitinib?

He ʻokoʻa nui ka lōʻihi o ka mālama ʻana i ka gefitinib mai kēlā kanaka i kēia kanaka a pili i ka maikaʻi o ka pane ʻana o kāu maʻi maʻi i ka lāʻau. Hiki i kekahi poʻe ke lawe iā ia no kekahi mau mahina, a ʻo nā mea ʻē aʻe e hoʻomau i ka mālama ʻana no nā makahiki. E nānā kāu kauka i kāu pane ma o nā scans maʻamau a me nā hoʻokolohua koko e hoʻoholo ai i ka lōʻihi o ka mālama ʻana maikaʻi loa no kou kūlana.

E hoʻomau ʻoe i ka lawe ʻana i ka gefitinib inā e kāohi ana ia i kāu maʻi maʻi a ke ʻae nei ʻoe i nā hopena ʻaoʻao me ka maikaʻi. E loiloi mau kāu kauka inā e hana pono ana ka lāʻau ma o nā hoʻokolohua kiʻi e like me CT scans a i ʻole PET scans, maʻamau i kēlā me kēia 2-3 mahina i ka wā mua.

Inā pau ka pane ʻana o kāu maʻi maʻi i ka gefitinib a i ʻole e loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, e hana kāu kauka me ʻoe e hoʻoponopono i kāu hoʻolālā lapaʻau. Hiki i kēia ke hoʻololi i ka mahele, ka lawe ʻana i nā wā hoʻomaha, a i ʻole ka hoʻololi ʻana i kahi lāʻau ʻokoʻa. ʻO ka pahuhopu ka loaʻa mau ʻana o ke kaulike kūpono ma waena o ka mālama ʻana i kāu maʻi maʻi a me ka mālama ʻana i kou maikaʻi o ke ola.

He aha nā hopena ʻaoʻao o ka Gefitinib?

E like me nā lāʻau lapaʻau maʻi 'aʻai a pau, hiki i ka gefitinib ke hana i nā hopena ʻē aʻe, ʻoiai ua ʻoi aku ka maikaʻi o ka poʻe he nui ma mua o ka chemotherapy kuʻuna. ʻO nā hopena ʻē aʻe maʻamau ka mea e mālama ʻia me ka mālama kūpono a me ka nānā ʻana. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a hilinaʻi i kāu lapaʻau.

Eia nā hopena ʻē aʻe i hōʻike pinepine ʻia e pili ana i ka poʻe he nui e lawe ana i ka gefitinib:

• Nā pilikia ʻili: ʻO ka ʻōpala e like me ka ʻakena, ka ʻili maloʻo, a i ʻole ka huhū ʻili, ʻoi loa ma ka maka a me ke kino luna
• Nā pilikia digestive: ʻO ka maʻi maʻi, ka nausea, ka luaʻi, a i ʻole ka nalowale o ka ʻai
• Nā loli kui: Nā kui palupalu, nahā, a i ʻole nā moena kui i maʻi ʻia
• Nā ʻeha waha: Nā ʻōpala liʻiliʻi a i ʻole ka huhū i loko o ka waha
• Luhi: ʻOi aku ka luhi ma mua o ka maʻamau a i ʻole ka nele o ka ike
• Nā pilikia maka: Nā maka maloʻo, ka huhū, a i ʻole ka piʻi ʻana o ka ʻike i ka mālamalama

ʻO ka hapa nui o kēia mau hopena ʻē aʻe maʻamau he maʻalahi a i ka waena a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Hiki i kāu hui mālama ola ke hāʻawi i nā hoʻolālā kikoʻī e mālama pono i kēlā me kēia o kēia mau hōʻailona.

Hiki i kekahi poʻe ke ʻike i nā hopena ʻē aʻe koʻikoʻi e koi ai i ka lāʻau lapaʻau koke. ʻOiai ʻaʻole maʻamau kēia mau mea, he mea nui e ʻike i ka mea e nānā ai:

• Nā pilikia hanu koʻikoʻi: ʻO ka pōkole o ka hanu hou a i ʻole ka ʻino, ka ʻū, a i ʻole ka ʻeha o ka umauma
• Nā pilikia ate: ʻO ka melemele o ka ʻili a i ʻole nā maka, ka mimi ʻeleʻele, a i ʻole ka ʻeha o ka ʻōpū nui
• Nā hopena ʻili koʻikoʻi: ʻO ka ʻōpala ākea, ka ʻōpala, a i ʻole ka ʻili peeling
• Nā pilikia o ka naʻau: Ka puʻuwai puʻuwai ʻole, ka ʻeha o ka umauma, a i ʻole ka pehu ʻana i nā wāwae a i ʻole nā wāwae
• Maʻi maʻi nui: ʻOi aku ma mua o 6 mau noho palupalu i kēlā me kēia lā a i ʻole nā hōʻailona o ka dehydration

Inā loaʻa iā ʻoe kekahi o kēia mau hopena ʻaoʻao koʻikoʻi, e kelepona koke i kāu kauka a i ʻole e ʻimi i ka mālama olakino pilikia. Pono kēia mau hōʻailona, ʻoiai ʻaʻole maʻamau, i ka nānā koke ʻana e hōʻoia i kou palekana a me kou olakino.

Aia kekahi mau hopena ʻaoʻao laha akā hiki ke koʻikoʻi i loaʻa i kahi pākēneka liʻiliʻi o nā kānaka. Aia kēia mau mea i ka mumū nui o ka māmā (maʻi māmā interstitial), ka pōʻino nui o ke ake, a i ʻole nā pilikia maka nui e hiki ke hoʻopilikia i ka ʻike. E nānā mau kāu kauka iā ʻoe ma o nā hoʻokolohua koko a me nā nānā ʻana e hopu koke i kekahi o kēia mau pilikia.

ʻO wai ka mea pono ʻole e lawe iā Gefitinib?

ʻAʻole kūpono ʻo Gefitinib no nā mea a pau, a hiki i kekahi mau maʻi olakino a i ʻole nā kūlana ke palekana ʻole iā ʻoe ke lawe i kēia lāʻau. E nānā pono kāu kauka i kāu moʻolelo olakino a me ke kūlana olakino o kēia manawa ma mua o ke kau ʻana iā gefitinib. Kōkua kēia loiloi piha i ka hōʻoia ʻana i ka palekana a me ke kūpono o ka lāʻau lapaʻau no kāu kūlana kikoʻī.

ʻAʻole pono ʻoe e lawe iā gefitinib inā ʻike ʻoe i ka maʻi maʻi i ka lāʻau a i ʻole kekahi o kāna meaʻai. ʻO nā hōʻailona o ka hopena maʻi e komo paha i ka ʻeha nui, ka pilikia o ka hanu ʻana, a i ʻole ka pehu ʻana o kou maka, nā lehelehe, ke alelo, a i ʻole ka ʻāʻī. Inā loaʻa iā ʻoe nā hopena maʻi i nā lāʻau lapaʻau like i ka wā ma mua, e hōʻoia e haʻi i kāu kauka.

Pono kekahi mau maʻi olakino i ka noʻonoʻo kūikawā a i ʻole e hiki ke hana i ka gefitinib kūpono ʻole iā ʻoe. Pono kēia mau kūlana i ka loiloi akahele e kāu hui mālama ola:

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• Maʻi ate nui: Hoʻoponopono kou ate i ka gefitinib, no laila he pilikia nui o ka ate he mea weliweli paha
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• Maʻi kīkī nui: ʻOiai ʻaʻole maʻamau, hiki i nā pilikia kīkī ke hoʻopilikia i ke ʻano o kou kino e mālama ai i ka lāʻau
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• Nā maʻi māmā ikaika: Hiki ke huikau ʻia kēia mau mea a i ʻole e hoʻonui ʻia e nā hopena ʻaoʻao māmā
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• Nā pilikia puʻuwai nui: Hiki i ka Gefitinib ke hoʻopilikia i ka puʻuwai a i ʻole ka hana
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• Nā maʻi maka ikaika: Hiki i ka lāʻau ke hoʻoulu i nā pilikia o ka maka, i hiki ke hoʻopilikia ʻia e nā maʻi i loaʻa
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Pono ka hāpai ʻana a me ka hānai ʻana i ka umauma i ka nānā kūikawā i ka wā e noʻonoʻo ai i ka gefitinib. Hiki i kēia lāʻau ke hōʻino i nā pēpē e ulu ana, no laila inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, e kūkākūkā pono me kāu kauka. Pono nā kāne a me nā wahine e lawe ana i ka gefitinib e hoʻohana i ka mana hānau kūpono i ka wā o ka mālama ʻana a no kekahi mau mahina ma hope o ka hoʻōki ʻana i ka lāʻau.

Inā hānai ʻoe i ka umauma, pono paha ʻoe e hooki ma mua o ka hoʻomaka ʻana i ka gefitinib, no ka mea, hiki i ka lāʻau ke hele i loko o ka waiū umauma a hiki ke hōʻino i kāu pēpē. Hiki i kāu kauka ke kōkua iā ʻoe e kaupaona i nā pilikia a me nā pōmaikaʻi a kūkākūkā i ka manawa inā e hoʻolālā ana ʻoe e hānai i ka umauma i ka wā e hiki mai ana.

Nā inoa inoa Gefitinib

Loaʻa ka Gefitinib ma lalo o ka inoa inoa Iressa. ʻO kēia ka inoa inoa mua i hoʻohana ʻia i ka wā i ʻae mua ʻia ai ka lāʻau a ke mau nei ka inoa i ʻike nui ʻia no ka gefitinib ma ka honua holoʻokoʻa. Ke kauoha kāu kauka i ka gefitinib, e ʻike paha ʻoe i ka

Ma kekahi mau ʻāina, hiki ke loaʻa ʻo gefitinib ma lalo o nā inoa inoa like ʻole a i ʻole nā mana generic. Inā ʻoe e hele ana a i ʻole e kiʻi ana i nā palapala kauoha ma nā wahi like ʻole, he mea kōkua ke ʻike i ka inoa generic (gefitinib) a me ka inoa inoa (Iressa) e pale aku i ka huikau. E hōʻoia mau me kāu kauka lāʻau lapaʻau e loaʻa ana iā ʻoe ka lāʻau lapaʻau kūpono.

Nā Koho ʻē aʻe no Gefitinib

Nui nā lāʻau lapaʻau ʻē aʻe e like ana me gefitinib no ka mālama ʻana i ka maʻi maʻi maʻi māmā EGFR-positive. Hiki ke noʻonoʻo ʻia kēia mau koho ʻē aʻe inā ʻaʻole e hana pono ʻo gefitinib, inā e kūkulu ʻoe i ke kūpaʻa ʻana iā ia, a i ʻole inā ʻoe e ʻike i nā hopena ʻaoʻao hiki ʻole ke ʻae ʻia. E kōkua kāu kauka e hoʻoholo i ke koho maikaʻi loa e pili ana i kāu mau ʻano maʻi maʻi kikoʻī a me ka mōʻaukala lapaʻau.

ʻO nā koho maʻamau e pili ana i nā mea pale EGFR ʻē aʻe e like me erlotinib (Tarceva) a me afatinib (Gilotrif). Hana kēia mau lāʻau lapaʻau ma nā ʻano like akā loaʻa paha nā ʻano hopena ʻaoʻao like ʻole a i ʻole nā ʻano hana. Hiki i kekahi poʻe i pane ʻole i ka gefitinib ke holomua maikaʻi me kēia mau koho ʻē aʻe.

No ka poʻe i kūkulu ʻia ko lākou maʻi maʻi i ke kūpaʻa ʻana i nā mea pale EGFR hanauna mua e like me gefitinib, hiki ke ʻōlelo ʻia nā lāʻau lapaʻau hou e like me osimertinib (Tagrisso). Hiki i kēia mea pale EGFR hanauna ʻekolu ke lanakila pinepine i kekahi mau ʻano kūpaʻa e kūkulu ʻia me ka mālama ʻana iā gefitinib.

ʻO nā koho lapaʻau ʻē aʻe e pili ana i ka chemotherapy kuʻuna, immunotherapy, a i ʻole nā lapaʻau hui pū ʻana, e pili ana i nā ʻano kikoʻī o kāu maʻi maʻi a me kou olakino holoʻokoʻa. E hana pū kāu oncologist me ʻoe e hana i kahi hoʻolālā lapaʻau piha e noʻonoʻo ana i nā koho a pau i loaʻa.

Ua ʻoi aku ka maikaʻi o Gefitinib ma mua o Erlotinib?

He mea pono ʻo Gefitinib a me Erlotinib i ka pale ʻana i ka EGFR, a hōʻike ka noiʻi he like ka pono o lāua i ka mālama ʻana i ka maʻi ʻaʻai māmā EGFR-positive. ʻO ka koho ma waena o lāua e pili pinepine ana i nā mea pilikino e like me ka ʻae ʻana i nā hopena ʻaoʻao, nā makemake o ka lāʻau, a me nā ʻano maʻi ʻaʻai kikoʻī ma mua o ka mea i manaʻo ʻia he

E makemake ana kāu mau kauka e nānā pono i nā pae kōpa koko i ka wā e hoʻomaka ai ʻoe i ka gefitinib, ʻoiai i nā pule mua o ka mālama ʻana. Inā ʻike ʻoe i ka nausea nui a i ʻole nā loli i ka ʻai, pono paha ʻoe e hoʻoponopono i kāu mau lāʻau lapaʻau maʻi diabetes a i ʻole ka hoʻolālā ʻai e mālama i ka mana kōpa koko maikaʻi.

Q2. He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o ka Gefitinib?

Inā lawe hewa ʻoe i ka nui o ka gefitinib ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka a i ʻole ke kikowaena mana ʻawa, ʻoiai inā maikaʻi ʻoe. ʻO ka lawe ʻana i ka nui o ka gefitinib hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi, ʻo ia hoʻi ka maʻi maʻi nui, nā pilikia ʻili, a i ʻole nā pilikia ate. Mai kali e ʻike inā e ulu nā hōʻailona ma mua o ka ʻimi ʻana i ke kōkua.

Ke kāhea ʻoe i ke kōkua, e loaʻa kāu hue lāʻau me ʻoe i hiki iā ʻoe ke hāʻawi i ka ʻike pololei e pili ana i ka nui āu i lawe ai a me ka manawa. Inā hiki, e loaʻa pū kekahi papa inoa o kāu mau lāʻau lapaʻau ʻē aʻe. Mai hoʻāʻo e

Pono ʻoe e hooki i ka lawe ʻana i ka gefitinib ma lalo o ke alakaʻi pololei ʻana a kāu oncologist. ʻO ka hoʻoholo e hooki e hilinaʻi ana i nā mea he nui, me ka maikaʻi o ka lāʻau e kāohi ana i kāu maʻi ʻaʻai, nā hopena ʻaoʻao āu e ʻike nei, a inā paha ua kūkulu kou maʻi ʻaʻai i ke kūʻē ʻana i ka lāʻau. Mai hooki i ka lawe ʻana i ka gefitinib ma kāu iho, ʻoiai inā ʻoe e maikaʻi ana.

E nānā mau kāu kauka i kāu pane ʻana i ka gefitinib ma o nā hoʻokolohua kiʻi, nā hana koko, a me nā hoʻokolohua kino. Inā ʻaʻole e pane hou ana kāu maʻi ʻaʻai i ka lāʻau a i ʻole inā e loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi ʻaʻole hiki ke mālama ʻia, e hana kāu kauka me ʻoe e hoʻololi i kahi ala lapaʻau ʻē aʻe me ka palekana.

Q5. Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Gefitinib?

ʻOiai ʻaʻohe pilina pololei ma waena o ka gefitinib a me ka waiʻona, ua ʻōlelo ʻia e kaupalena a pale paha i ka waiʻona i ka wā o ka mālama ʻana i ka maʻi ʻaʻai. Hiki i ka gefitinib a me ka waiʻona ke hoʻopilikia i kou ate, a ʻo ka hui pū ʻana iā lākou e hoʻonui i ka pilikia o nā pilikia o ke ake. Eia kekahi, hiki i ka waiʻona ke hoʻonui i kekahi mau hopena ʻaoʻao e like me ka nausea, ka luhi, a i ʻole ka maloʻo.

Inā koho ʻoe e inu i ka waiʻona i kekahi manawa, e kūkākūkā mua me kāu kauka. Hiki iā lākou ke hāʻawi i ke alakaʻi pilikino e pili ana i kou olakino holoʻokoʻa, ka hana o ke ake, a me ka maikaʻi o kou hoʻomanawanui ʻana i ka gefitinib. Hiki i kāu kauka ke ʻōlelo aku e pale loa i ka waiʻona a i ʻole e kaupalena iā ia i nā mea liʻiliʻi loa i nā manawa kakaikahi.