He aha ʻo Givinostat: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau i kauoha ʻia ʻo Givinostat i hoʻolālā ʻia e mālama i ka maʻi muscular dystrophy (DMD) iā Duchenne i nā keiki a me nā mākua. Hana kēia lāʻau lapaʻau waha ma ka ʻimi ʻana i kekahi mau enzymes i loko o kou kino e kōkua i ka mumū ʻana o ka ʻiʻo a me ka pōʻino i nā maʻi DMD.

Inā ua ʻike ʻia ʻoe a i ʻole kāu mea aloha me DMD, e noʻonoʻo paha ʻoe e pili ana i nā koho lapaʻau e hiki ke kōkua i ka mālama ʻana i kēia maʻi. Hōʻike ʻo Givinostat i kahi ala hou i ka mālama ʻana iā DMD, e hāʻawi ana i ka manaʻolana no ka hoʻolohi ʻana i ka holomua o ka maʻi a me ka hoʻomaikaʻi ʻana i ka maikaʻi o ke ola.

He aha ʻo Givinostat?

ʻO Givinostat kahi mea hoʻopaʻa HDAC (histone deacetylase) e kōkua ana i ka hōʻemi ʻana i ka mumū a me ka pōʻino o ka ʻiʻo i ka poʻe me Duchenne muscular dystrophy. E noʻonoʻo iā ia he lāʻau lapaʻau e kōkua ana i ka hoʻomaha ʻana i ka pane mumū ʻino o ke kino e hoʻouka ana i ka ʻiʻo i DMD.

Hele mai ka lāʻau lapaʻau i ke ʻano hoʻokuʻu waha, e maʻalahi ai i nā maʻi o nā makahiki like ʻole e lawe. Hana ʻia ma lalo o nā alakaʻi koʻikoʻi a koi i kahi kauoha mai kahi mea mālama ola kino e loea i nā maʻi neuromuscular.

He mea hou kēia lāʻau lapaʻau i ka mākeke, ua loaʻa iā ia ka ʻae ʻia ma hope o nā hoʻokolohua lapaʻau nui i hōʻike i kāna mau pono no nā maʻi DMD. E loiloi pono kāu kauka inā kūpono ʻo givinostat no kāu kūlana.

No ke aha i hoʻohana ʻia ai ʻo Givinostat?

Hoʻohana nui ʻia ʻo Givinostat e mālama i ka Duchenne muscular dystrophy, kahi maʻi genetic e hoʻoulu ai i ka nāwaliwali o ka ʻiʻo a me ka degeneration. Manaʻo ka lāʻau lapaʻau e hoʻolohi i ka pōʻino o ka ʻiʻo e hana ʻia i nā maʻi DMD.

Hoʻopilikia ʻo DMD i ka hana ʻana o ka dystrophin, kahi protein e kōkua ana i ka mālama ʻana i nā cell muscle. Me ka lawa ʻole o ka dystrophin, e mumū a pōʻino nā ʻiʻo i ka manawa. Hana ʻo Givinostat e hōʻemi i kēia mumū, e kōkua ana i ka mālama ʻana i ka hana ʻana o ka ʻiʻo no ka lōʻihi.

Hiki i kāu kauka ke ʻōlelo aku iā givinostat inā he DMD i hōʻoia ʻia ʻoe a i ʻole kāu keiki a ua kūpono i nā pae hoʻohālike no ka mālama ʻana. Hoʻomaopopo ʻia ka lāʻau lapaʻau ma ke ʻano he ʻāpana o kahi hoʻolālā lapaʻau piha e komo pū ana i ka lāʻau kino, nā lāʻau lapaʻau ʻē aʻe, a me ka mālama kākoʻo.

Pehea e Hana ai ʻo Givinostat?

Hana ʻo Givinostat ma ka pale ʻana i kekahi mau enzymes i kapa ʻia ʻo histone deacetylases (HDACs) e kōkua i ka mumū a me ka pōʻino o ka ʻiʻo i ka DMD. Ma ka pale ʻana i kēia mau enzymes, kōkua ka lāʻau lapaʻau i ka hōʻemi ʻana i ka pane mumū e luku ai i ka ʻiʻo.

Ua manaʻo ʻia kēia lāʻau lapaʻau he koho lapaʻau ikaika no ka DMD. ʻOiai ʻaʻole ia he lāʻau lapaʻau, hiki iā ia ke kōkua i ka hoʻolohi ʻana i ka holomua o ka ʻinoʻino o ka ʻiʻo ke hoʻohana ʻia ma ke ʻano he ʻāpana o kahi ala lapaʻau piha.

Pono ka lāʻau lapaʻau i ka manawa e kūkulu ai i loko o kou ʻōnaehana a hoʻomaka e hana pono. ʻAʻole paha ʻoe e ʻike i nā loli koke, akā ma hope o ka manawa, hiki i ka givinostat ke kōkua i ka mālama ʻana i ka ikaika o ka ʻiʻo a me ka hana ʻoi aku ka maikaʻi ma mua o ka ʻole o ka lāʻau.

Pehea wau e lawe ai iā Givinostat?

Pono e lawe ʻia ʻo Givinostat e like me ke kauoha a kāu kauka, ʻelua manawa i ka lā me ka meaʻai. ʻO ka lawe ʻana me nā meaʻai e kōkua i kou kino e komo pono i ka lāʻau lapaʻau a hiki ke hōʻemi i ka pilikia o ka ʻōpū.

Pono e ana pono ʻia ka hoʻokuʻu waha me ka hoʻohana ʻana i ka syringe dosing i hāʻawi ʻia me kāu lāʻau lapaʻau. E lulu mālie i ka ʻōmole ma mua o kēlā me kēia mahele e hōʻoia i ka hui like ʻana o ka lāʻau lapaʻau. Hiki iā ʻoe ke lawe me ka wai, ka waiū, a i ʻole ka wai hua inā pono.

E hoʻāʻo e lawe i kāu mau mahele i nā manawa like i kēlā me kēia lā e mālama i nā pae kūlike i kou kino. Inā ʻoe e mālama ana i kahi keiki e lawe ana i kēia lāʻau lapaʻau, e hoʻokumu i kahi hana e hana pū me nā manawa ʻai a me nā hana o kēlā me kēia lā.

Mai ʻoki, nau, a hoʻololi paha i ka lāʻau lapaʻau ma kekahi ʻano. Inā pilikia ʻoe i ka ʻai ʻana a i ʻole ka lawe ʻana i ka hoʻokuʻu ʻana, e kamaʻilio me kāu mea mālama ola e pili ana i nā hoʻolālā e kōkua ai.

Pehea ka lōʻihi e lawe ai au iā Givinostat?

He lāʻau lōʻihi ʻo Givinostat, a pono ʻoe e hoʻomau i ka lawe ʻana i ka lāʻau lapaʻau inā e hōʻike ana i nā pōmaikaʻi a ʻōlelo kāu kauka. He maʻi holomua ka DMD, no laila pono ka mālama ʻana i ka wā e kōkua ai i ka mālama ʻana i nā hōʻailona.

E nānā mau kāu kauka i kou pane ʻana i ka lāʻau lapaʻau ma o nā loiloi lapaʻau a me nā hoʻokolohua koko paha. Kōkua kēia mau loiloi e hoʻoholo inā e hana pono ana ka lāʻau lapaʻau a inā pono e hana i nā hoʻoponopono.

Mai hooki koke i ka lawe ʻana iā givinostat me ka ʻole e kamaʻilio mua me kāu mea mālama ola. ʻOiai inā ʻaʻole ʻoe e ʻike i nā hoʻomaikaʻi nui, hiki i ka lāʻau lapaʻau ke kōkua i ka hoʻolohi ʻana i ka holomua o ka maʻi ma nā ʻano i ʻike ʻole ʻia.

He aha nā hopena ʻaoʻao o Givinostat?

E like me nā lāʻau lapaʻau a pau, hiki i ka givinostat ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole i ʻike nā mea a pau iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao a maʻa mau e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike:

• Nausea a i ʻole ka ʻōpū
• Pāpaʻa a i ʻole nā loli i nā neʻe ʻana o ka ʻōpū
• Hoʻemi ʻia ka ʻai
• Luhi a i ʻole ka manaʻo luhi
• Pōpō
• Luaʻi

Hoʻomaikaʻi pinepine kēia mau hopena ʻaoʻao digestive ke lawe ʻoe i ka lāʻau lapaʻau me ka meaʻai a i ka wā e maʻa ai kou kino i ka lāʻau lapaʻau.

Pono kekahi mau hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi i ka nānā ʻana i ka lāʻau lapaʻau koke:

• Nā hōʻailona o ka maʻi (fiva, nā anu, ʻeha ʻeha mau)
• ʻO ka ʻeha a i ʻole ke kahe ʻana o ke koko
• ʻEha ʻōpū nui
• Luaʻi mau e pale ana i ka mālama ʻana i ka meaʻai
• Nā loli nui i ka puʻuwai

ʻO nā hopena ʻaoʻao kakaʻikahi akā koʻikoʻi paha e pili ana i nā loli helu koko a i ʻole nā maʻi hana ate. E nānā kāu kauka i kēia mau mea ma o nā hoʻokolohua koko maʻamau, no laila he mea nui e mālama i nā manawa i hoʻonohonoho ʻia.

ʻO wai ka mea pono ʻole e lawe iā Givinostat?

ʻAʻole kūpono ʻo Givinostat no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia no ʻoe a i ʻole kāu keiki. Pono paha nā kānaka me kekahi mau maʻi e pale i kēia lāʻau a i ʻole e pono ai ke nānā kūikawā.

ʻAʻole pono ʻoe e lawe i ka givinostat inā loaʻa iā ʻoe:

• ʻIke ʻia ka maʻi allergies i ka givinostat a i ʻole kekahi o kāna mau meaʻai
• Maʻi ate koʻikoʻi a i ʻole ka hāʻule ʻana o ke ake
• Nā maʻi ikaika, ʻaʻole i mālama ʻia
• Nā maʻi puʻuwai puʻuwai
• Maʻi kīkī koʻikoʻi

E noʻonoʻo nō hoʻi kāu kauka i nā mea ʻē aʻe e pili ana i kou hiki ke lawe i kēia lāʻau me ka palekana, me nā lāʻau ʻē aʻe āu e lawe nei a me kou olakino holoʻokoʻa.

Pono nā wāhine hāpai a i ʻole e hānai ana i ka waiū e kūkākūkā i nā pilikia a me nā pōmaikaʻi me kā lākou mea mālama ola, no ka mea, ʻaʻole i ʻike ʻia nā hopena o ka givinostat i ka wā e hāpai ana a me ka hānai ʻana i ka waiū.

Nā inoa inoa o Givinostat

Loaʻa ʻo Givinostat ma lalo o ka inoa inoa ʻo Duvyzat ma ʻAmelika Hui Pū ʻIa. ʻO kēia ka inoa kalepa āu e ʻike ai ma kāu ʻōmole kauoha a me ka ʻeke lāʻau.

Hiki i ka lāʻau lapaʻau ke loaʻa nā inoa inoa like ʻole ma nā ʻāina ʻē aʻe, akā like ka mea hana. E nānā mau me kāu lāʻau lapaʻau inā he nīnau kāu e pili ana i kāu lāʻau lapaʻau.

ʻAʻole i loaʻa nā mana generic o givinostat i kēia manawa, no laila ʻo Duvyzat wale nō ke koho no ka loaʻa ʻana o kēia lāʻau i kēia manawa.

Nā koho ʻē aʻe o Givinostat

ʻOiai ʻo givinostat kekahi koho lapaʻau no DMD, aia nā lāʻau lapaʻau a me nā lāʻau lapaʻau ʻē aʻe e noʻonoʻo ai kāu kauka. Aia ke koho i kāu kūlana kikoʻī, makahiki, a me ke ʻano o ka holomua ʻana o kou maʻi.

ʻO nā lāʻau lapaʻau ʻē aʻe i ʻae ʻia e ka FDA no DMD:

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• Deflazacort (he corticosteroid e kōkua ana i ka mālama ʻana i ka ikaika o ka ʻiʻo)
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• Eteplirsen (no nā maʻi me nā loli genetic kikoʻī)
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• Golodirsen (he lāʻau lapaʻau genetic-specific ʻē aʻe)
\n
• Casimersen (no kekahi mau loli DMD)
\n

Hiki nō hoʻi i kāu kauka ke ʻōlelo aku i nā lāʻau lapaʻau kākoʻo e like me ka lāʻau kino, ke kākoʻo hanu, a i ʻole ka nānā ʻana i ka puʻuwai ma ke ʻano he ʻāpana o kāu hoʻolālā mālama holoʻokoʻa.

ʻO ke ala lapaʻau maikaʻi loa e pili pinepine ana i ka hui pū ʻana i nā lāʻau lapaʻau like ʻole i hoʻopilikino ʻia i kāu mau pono kikoʻī a me ka holomua o ka maʻi.

Ua ʻOi aku ka maikaʻi o Givinostat ma mua o nā Lāʻau Lapaʻau DMD ʻē aʻe?

Hana ʻokoʻa ʻo Givinostat mai nā lāʻau lapaʻau DMD ʻē aʻe, no laila ʻaʻole pono e

Pono nā keiki e lawe ana i ka givinostat i nā loiloi maʻamau e nānā i ka ulu ʻana, ka ulu ʻana, a me nā hopena ʻaoʻao. E hoʻoponopono kāu kauka i ka mahele lāʻau e pili ana i ke kaumaha a me ka pane ʻana i ka lāʻau lapaʻau.

He aha kaʻu e hana ai inā ua hoʻohana hewa au i ka nui o ka Givinostat?

Inā ʻoe a i ʻole kāu keiki i lawe hewa i ka nui o ka givinostat, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make. Mai kali e ʻike inā e ulu ana nā hōʻailona, ​​no ka mea, he mea nui ka mālama olakino wikiwiki.

E lawe i ka hue lāʻau me ʻoe i ka lumi pilikia a i ʻole e loaʻa iā ia ke kāhea ʻoe no ke alakaʻi. Pono nā mea mālama ola e ʻike pono i ka mea i lawe ʻia a me ka nui.

He aha kaʻu e hana ai inā ua hala au i kahi mahele lāʻau o Givinostat?

Inā ua hala ʻoe i kahi mahele lāʻau, e lawe koke iā ia ke hoʻomanaʻo ʻoe, ke ʻole kokoke ka manawa no kāu mahele lāʻau i hoʻonohonoho ʻia. I kēlā hihia, e lele i ka mahele lāʻau i hala a hoʻomau me kāu papa manawa maʻamau.

Mai lawe i ʻelua mahele lāʻau i ka manawa hoʻokahi e hana ai no kahi mahele lāʻau i hala. Hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao me ka ʻole e hāʻawi i nā pōmaikaʻi hou.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Givinostat?

Pono ʻoe e hooki i ka lawe ʻana i ka givinostat ma hope o ke kūkākūkā ʻana me kāu kauka. No ka mea he maʻi holomua ka DMD, hiki i ka hooki ʻana i ka lāʻau lapaʻau ke ʻae i ka maʻi e holomua wikiwiki.

E kōkua kāu kauka iā ʻoe e kaupaona i nā pōmaikaʻi a me nā pilikia o ka hoʻomau ʻana i ka lāʻau lapaʻau e pili ana i ke ʻano o kou pane ʻana a me nā hopena ʻaoʻao āu e ʻike nei. I kekahi manawa, hiki i ka hoʻoponopono ʻana i ka mahele lāʻau a i ʻole ka papa manawa lapaʻau ke hoʻoponopono i nā hopohopo me ka ʻole e hooki i ka lāʻau lapaʻau.

Hiki iaʻu ke lawe i nā lāʻau lapaʻau ʻē aʻe i ka wā e hoʻohana ana i ka Givinostat?

Hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka givinostat, no laila he mea nui e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau i kauoha ʻia, nā lāʻau lapaʻau ma luna o ka counter, a me nā mea hoʻohui āu e lawe nei. Aia kēia me nā huaora, nā huahana lāʻau, a me nā lāʻau lapaʻau ʻē aʻe.

Hiki i kāu kauka a i ʻole ka mea kūʻai lāʻau lapaʻau ke nānā i nā pilina e hiki mai ana a e aʻo iā ʻoe i ke ala palekana loa e lawe ai i nā lāʻau he nui. Mai hoʻomaka a hoʻōki paha i nā lāʻau ʻē aʻe me ka ʻole e kūkākūkā mua me kāu mea mālama ola.