He aha ʻo Glasdegib: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi ʻo Glasdegib e kōkua ana i ka hakakā ʻana i kekahi mau ʻano maʻi koko, ʻo ia hoʻi ka acute myeloid leukemia (AML). Hana kēia lāʻau lapaʻau waha ma ka pale ʻana i nā protein kikoʻī e pono ai nā sela maʻi e ulu a ola, e hāʻawi ana i kou ʻōnaehana pale i kahi manawa maikaʻi e hakakā i ka maʻi.

Inā ua kauoha ʻia ʻo glasdegib iā ʻoe a i ʻole kekahi āu e mālama nei, nui paha kāu mau nīnau e pili ana i ke ʻano o ka hana ʻana, ka mea e manaʻo ai, a pehea e lawe ai me ka palekana. E hele kākou i nā mea a pau e pono ai ʻoe e ʻike e pili ana i kēia lāʻau lapaʻau koʻikoʻi ma nā huaʻōlelo maʻalahi a maopopo.

He aha ʻo Glasdegib?

He lāʻau lapaʻau maʻi ʻo Glasdegib i kuhikuhi ʻia e pili ana i kahi papa o nā lāʻau i kapa ʻia ʻo hedgehog pathway inhibitors. Ua hoʻolālā ʻia e mālama i ka acute myeloid leukemia (AML), kahi ʻano maʻi koko e pili ana i kou iwi iwi a me nā sela koko.

Hele mai ka lāʻau lapaʻau ma ke ʻano o nā papa waha āu e lawe ai ma ka waha, e maʻalahi ai ka mālama ʻana ma mua o nā lāʻau lapaʻau maʻi e koi ai i nā kipa i ka haukapila. Hana ʻo Glasdegib ma ka ʻimi ʻana a me ka pale ʻana i kahi ala cellular kikoʻī e hoʻohana ai nā sela maʻi e ulu a hoʻonui.

E kuhikuhi maʻamau kāu kauka iā glasdegib me kahi lāʻau chemotherapy ʻē aʻe i kapa ʻia ʻo cytarabine. Kōkua kēia hui pū ʻana i ka hoʻouka ʻana i ka maʻi mai nā kihi he nui, e hoʻomaikaʻi ana i nā hopena o kāu mālama ʻana.

No ke aha i hoʻohana ʻia ai ʻo Glasdegib?

Hoʻohana nui ʻia ʻo Glasdegib e mālama i ka acute myeloid leukemia (AML) i nā pākeke he 75 mau makahiki a ʻoi aku paha, a i ʻole he mau maʻi olakino ʻē aʻe e kūpono ʻole ai lākou i ka chemotherapy ikaika. Kōkua kēia ala i nā maʻi i lawa ʻole no nā lāʻau lapaʻau maʻi maʻamau a ʻoi aku ka ikaika.

Ua ʻae ʻia ka lāʻau lapaʻau no nā maʻi AML i hōʻike ʻia. He maʻi ʻaʻai wikiwiki ka AML e pili ana i ke koko a me ka iwi iwi, kahi e hana ai kou kino i nā keena koko hou. Inā ʻaʻole mālama ʻia, hiki i kēia ʻano leukemia ke hoʻoweliweli i ke ola.

Hiki i kāu oncologist ke noʻonoʻo i ka glasdegib inā loaʻa iā ʻoe kekahi mau hōʻailona genetic i loko o kāu mau keena maʻi ʻaʻai e hōʻike ana e pono paha kēia lāʻau lapaʻau no kāu ʻano AML. Hiki i nā hoʻokolohua koko a me nā biopsies iwi iwi ke kōkua i ka hoʻoholo ʻana inā ʻo glasdegib ke koho kūpono no kāu hoʻolālā lapaʻau.

Pehea e hana ai ʻo Glasdegib?

Hana ʻo Glasdegib ma ka pale ʻana i kahi ala kamaʻilio kelepona i kapa ʻia ʻo ke ala hedgehog. E noʻonoʻo i kēia ala he pūʻulu hōʻailona e haʻi ana i nā keena i ka wā e ulu ai a māhele ai. I nā maʻi ʻaʻai he nui, me ka AML, paʻa kēia mau hōʻailona i ke kūlana

E ale i nā papa holoʻokoʻa me ke aniani wai. Mai ʻoki, nau, a wāwahi paha i nā papa, no ka mea, hiki i kēia ke hoʻopilikia i ke ʻano o ka lāʻau lapaʻau a hiki ke hana i nā hopena ʻaoʻao. Inā pilikia ʻoe i ka ale ʻana i nā pila, e kamaʻilio me kāu kauka e pili ana i nā koho ʻē aʻe.

ʻOi aku ka maikaʻi o ka lawe ʻana iā glasdegib i ka manawa e hiki ai iā ʻoe ke kūlike i kēlā me kēia lā. Nui ka poʻe i ʻike he mea kōkua ke lawe me ka ʻaina kakahiaka a i ʻole ka ʻaina ahiahi e lilo ia i ʻāpana o kā lākou hana maʻamau i kēlā me kēia lā. ʻAʻole pili nui nā mea i loko o kou ʻōpū i ke ʻano o ka hana ʻana o ka lāʻau lapaʻau, no laila hiki iā ʻoe ke koho i ka mea e ʻoluʻolu ai iā ʻoe.

Pehea ka lōʻihi e lawe ai au iā Glasdegib?

Aia ka lōʻihi o kāu mālama ʻana iā glasdegib i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau a me ke ʻano o kou ʻae ʻana iā ia. Lawe ka hapa nui o ka poʻe iā glasdegib no kekahi mau mahina, a pono paha kekahi e hoʻomau i ka mālama ʻana no hoʻokahi makahiki a ʻoi aku paha.

E nānā mau kāu kauka i kāu helu koko a me ke olakino holoʻokoʻa e hoʻoholo ai inā e kōkua ana ka lāʻau lapaʻau i ka hakakā ʻana i kāu maʻi maʻi. Hana pinepine ʻia kēia mau nānā ʻana i kēlā me kēia pule i ka mua, a laila ʻoi aku ka liʻiliʻi i ka holomua ʻana o kāu mālama ʻana.

Mai hooki i ka lawe ʻana iā glasdegib me ka ʻole e kamaʻilio mua me kāu kauka, ʻoiai inā ʻoe e maikaʻi ana. ʻOi aku ka maikaʻi o nā lāʻau lapaʻau maʻi maʻi ke lawe ʻia me ke kūlike, a ʻo ka hooki ʻana i ka wā mua e hiki ai i ka maʻi maʻi ke hoʻi a ʻoi aku ka maikaʻi. E haʻi aku kāu hui mālama ola iā ʻoe i ka wā e palekana ai ke hooki a i ʻole inā pono ʻoe e hoʻomau i ka mālama ʻana.

He aha nā hopena ʻaoʻao o Glasdegib?

E like me nā lāʻau lapaʻau maʻi maʻi a pau, hiki i ka glasdegib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole i loaʻa i nā mea a pau. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ka mālama kūpono a me ka nānā ʻana mai kāu hui mālama ola.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike i ka wā e lawe ana iā glasdegib:

• Luhi a me ka nāwaliwali
• Luaʻi a me ka emi ʻana o ka ʻai
• Nā ʻiʻo ʻūlū a i ʻole nā ʻeha
• Nā loli i ka ʻono
• Pāpaʻa a i ʻole ka paʻa ʻana o ka ʻōpū
• Pehu i nā lima, nā wāwae, a i ʻole nā wāwae
• Pōkole o ka hanu

Hoʻomaikaʻi maʻamau kēia mau hopena ʻaoʻao i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Hiki i kāu kauka ke hōʻike i nā ala e mālama ai iā lākou, e like me nā lāʻau anti-nausea a i ʻole nā loli ʻai.

Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau e koi ana i ka lāʻau lapaʻau koke:

• Nā pilikia o ka puʻuwai (puʻuwai ʻole, ʻeha umauma)
• Nāwaliwali a i ʻole ka ʻeha o ka ʻiʻo
• Nā hōʻailona o ka maʻi (fiva, nā anu, ka ʻūlū mau)
• Ke kahe koko ʻano ʻē a i ʻole ka ʻeha
• Pāpaʻa koʻikoʻi a i ʻole ka luaʻi
• Paʻakikī ka hanu a i ʻole ka paʻa o ka umauma

E hoʻokaʻaʻike koke i kāu mea mālama ola inā ʻike ʻoe i kekahi o kēia mau hopena ʻaoʻao koʻikoʻi. Hiki iā lākou ke hoʻoponopono i kāu hoʻolālā lapaʻau a i ʻole e hāʻawi i nā lāʻau lapaʻau hou e kōkua i ka mālama ʻana i kēia mau hōʻailona me ka palekana.

ʻO wai ka mea ʻaʻole pono e lawe iā Glasdegib?

ʻAʻole kūpono ʻo Glasdegib no nā mea a pau, a e nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana. Hiki i kekahi mau maʻi olakino a me nā lāʻau lapaʻau ke hoʻolilo iā glasdegib i mea palekana ʻole a i ʻole ka liʻiliʻi o ka pono.

ʻAʻole pono ʻoe e lawe iā glasdegib inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai. Hiki i ka lāʻau lapaʻau ke hana i nā kīnā hānau koʻikoʻi a me ka pōʻino i nā pēpē i hānau ʻole ʻia. Pono nā kāne a me nā wahine e hoʻohana i ka mana hānau maikaʻi i ka wā o ka lapaʻau a no kekahi mau mahina ma hope o ka hoʻōki ʻana i ka lāʻau.

E makaʻala loa kāu kauka e pili ana i ke kau ʻana iā glasdegib inā loaʻa iā ʻoe:

• Nā pilikia o ka puʻuwai a i ʻole ka maʻi puʻuwai
• Maʻi ate a i ʻole maʻi kīkī
• He moʻolelo o nā maʻi ʻiʻo
• Nā helu koko haʻahaʻa
• Nā maʻi ikaika

Hiki i kekahi mau lāʻau lapaʻau ke launa pū me ka glasdegib, e hoʻolilo ana i mea ʻoi aku ka maikaʻi a i ʻole ka liʻiliʻi. E haʻi mau i kāu kauka e pili ana i nā lāʻau lapaʻau a pau, nā mea hoʻohui, a me nā huahana lāʻau lapaʻau āu e lawe nei ma mua o ka hoʻomaka ʻana i ka mālama ʻana me ka glasdegib.

Inoa Brand Glasdegib

Kūʻai ʻia ʻo Glasdegib ma lalo o ka inoa brand Daurismo. ʻO kēia wale nō ka inoa brand i loaʻa i kēia manawa no kēia lāʻau lapaʻau, no ka mea, he lāʻau lapaʻau maʻi maʻi hou a kūikawā.

Ke kiʻi ʻoe i kāu kauoha, e ʻike ʻoe iā "Daurismo" ma ka lepili o ka hue me ka inoa generic "glasdegib." E pili ana nā inoa ʻelua i ka lāʻau lapaʻau like, no laila, mai hopohopo inā ʻike ʻoe i kekahi o lākou ma kāu mau mea kauoha.

Hana ʻia ʻo Daurismo e Pfizer a loaʻa wale nō ma o nā hale kūʻai lāʻau lapaʻau kūikawā e mālama ana i nā lāʻau lapaʻau maʻi maʻi. E kōkua kāu hui mālama ola kino i ka hoʻonohonoho ʻana i ka loaʻa ʻana o kāu kauoha ma o ka hale kūʻai lāʻau lapaʻau kūpono.

Nā Koho ʻē aʻe o Glasdegib

ʻOiai he lāʻau lapaʻau kū hoʻokahi ʻo glasdegib, aia nā koho lapaʻau ʻē aʻe no ka leukemia myeloid acute e pili ana i kāu kūlana kikoʻī. E koho kāu oncologist i ke ala maikaʻi loa e pili ana i kou makahiki, ke olakino holoʻokoʻa, a me nā ʻano o kāu maʻi maʻi.

ʻO nā lāʻau lapaʻau ʻē aʻe no AML e komo paha i nā lāʻau chemotherapy kuʻuna e like me daunorubicin, idarubicin, a i ʻole cytarabine kiʻekiʻe. Hana ʻokoʻa kēia mau lāʻau lapaʻau ma mua o glasdegib akā hiki ke maikaʻi no nā maʻi he nui, ʻoi aku ka poʻe ʻōpio e hiki ke ʻae i ka mālama ʻana.

ʻO nā lāʻau lapaʻau i manaʻo ʻia e like me venetoclax a i ʻole FLT3 inhibitors paha he mau koho inā loaʻa i kāu maʻi maʻi nā hiʻohiʻona genetic kikoʻī. E hana kāu kauka i nā hoʻokolohua e hoʻoholo ai i nā lāʻau lapaʻau e hana nui loa no kāu ʻano AML.

Ua ʻoi aku ka maikaʻi o Glasdegib ma mua o Cytarabine wale nō?

Hōʻike ka noiʻi ʻana he ʻoi aku ka maikaʻi o ka glasdegib i hui pū ʻia me ka cytarabine haʻahaʻa ma mua o ka cytarabine wale nō no ka mālama ʻana i ka AML i nā mākua ʻelemakule a i ʻole ka poʻe hiki ʻole ke ʻae i ka chemotherapy ikaika. Kōkua ke ala hui i ka hoʻouka ʻana i nā cella maʻi ma o nā ʻano hana he nui.

Ua ʻike nā haʻawina i ka poʻe e lawe ana i ka glasdegib me ka cytarabine i ola lōʻihi ma mua o ka poʻe e lawe ana i ka cytarabine wale nō. Ua hōʻike pū ka hui i nā helu pane maikaʻi aʻe, ʻo ia hoʻi ka nui o ka poʻe i ʻike i ka pane ʻana o kā lākou maʻi i ka lāʻau lapaʻau.

Eia naʻe, hele pū ka hui me nā hopena ʻaoʻao hou aʻe i hoʻohālikelike ʻia me ka cytarabine wale nō. E loiloi kāu kauka i nā pōmaikaʻi kūpono e kūʻē i nā pilikia e pili ana i kou kūlana olakino. ʻO ka pahuhopu ka loaʻa ʻana o ka lāʻau lapaʻau e hāʻawi iā ʻoe i ka manawa maikaʻi loa e hakakā i kāu maʻi maʻi me ka mālama ʻana i kou maikaʻi o ke ola.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Glasdegib

Q1. Palekana ʻo Glasdegib no ka poʻe me nā pilikia o ka naʻau?

Hiki i ka Glasdegib ke hoʻopilikia i ka puʻuwai, no laila e loiloi pono kāu kauka i kou olakino puʻuwai ma mua o ke kau ʻana. Inā he pilikia kou puʻuwai, pono ʻoe i ka nānā ʻana i ka wā o ka lāʻau lapaʻau, me nā electrocardiograms (EKGs) maʻamau e nānā i kou puʻuwai.

E hana pū kāu cardiologist a me ka oncologist e hoʻoholo inā palekana ʻo glasdegib iā ʻoe. Hiki iā lākou ke hoʻoponopono i kāu mahele a i ʻole e ʻōlelo i nā lāʻau lapaʻau puʻuwai hou e mālama iā ʻoe i ka wā o ka lāʻau lapaʻau maʻi. Mai kānalua e hōʻike i kekahi ʻeha o ka umauma, ka puʻuwai ʻole, a i ʻole ka hanu ʻana i kāu hui mālama ola.

Q2. He aha kaʻu e hana ai inā lawe hewa au i ka nui o Glasdegib?

Inā lawe hewa ʻoe i ka glasdegib ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena hoʻomalu lāʻau make. Mai kali e ʻike inā maʻi ʻoe, no ka mea, ʻoi aku ka maikaʻi o ka hana mua me nā lāʻau lapaʻau.

ʻO ka lawe ʻana i ka glasdegib nui loa e hoʻonui i kou pilikia o nā hopena ʻaoʻao koʻikoʻi, ʻo ia hoʻi nā pilikia o ka puʻuwai a i ʻole ka nāwaliwali o ka ʻiʻo. E mālama i ka hue lāʻau me ʻoe ke kelepona ʻoe i hiki iā ʻoe ke hāʻawi i ka ʻike pololei e pili ana i ka nui āu i lawe ai a me ka manawa.

Q3. He aha kaʻu e hana ai inā ua hala au i kahi mahele o Glasdegib?

Inā hala ʻoe i kahi mahele o glasdegib, e lawe koke iā ia ke hoʻomanaʻo ʻoe, ke ʻole kokoke ka manawa no kāu mahele i hoʻonohonoho ʻia. I kēlā hihia, e lele i ka mahele i hala a hoʻomau me kāu papa manawa maʻamau. Mai lawe i ʻelua mahele i ka manawa hoʻokahi e hoʻoponopono ai i kahi mahele i hala.

E hoʻāʻo e lawe i kāu mahele i hala i loko o 12 mau hola o ka manawa āu e lawe ai. Inā ua hala ma mua o 12 mau hola, ʻoi aku ka maikaʻi o ke kali ʻana a hiki i kāu mahele i hoʻonohonoho ʻia. E kelepona i kāu hui mālama ola inā ʻaʻole ʻoe maopopo e pili ana i ka manawa a i ʻole inā ua hala ʻoe i nā mahele he nui.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Glasdegib?

E hooki wale i ka lawe ʻana iā glasdegib ke haʻi aku kāu kauka iā ʻoe he palekana ke hana pēlā. E nānā mau kāu hui mālama ola i kāu helu koko a me ka pane holoʻokoʻa i ka lāʻau lapaʻau e hoʻoholo ai i ka manawa maikaʻi loa e hooki ai a i ʻole e hoʻololi i kāu lāʻau.

Pono paha kekahi poʻe e hoʻomau i ka glasdegib no nā mahina he nui a i ʻole nā makahiki, ma muli o ka maikaʻi o kāna hana a me ka maikaʻi o kā lākou ʻae ʻana. Hiki i nā mea ʻē aʻe ke hooki koke inā loaʻa iā lākou ke kala ʻana a i ʻole inā lilo nā hopena ʻaoʻao i mea paʻakikī loa e mālama. Hoʻopilikino ʻia kāu hoʻolālā lapaʻau i kāu kūlana kikoʻī.

Q5. Hiki iaʻu ke lawe iā Glasdegib me nā lāʻau ʻē aʻe?

Nui nā lāʻau lapaʻau e hiki ke launa pū me glasdegib, no laila he mea nui e haʻi i kāu kauka e pili ana i nā mea a pau āu e lawe nei, me nā lāʻau lapaʻau ma luna o ka pāʻani, nā mea hoʻohui, a me nā huahana lāʻau. Hiki i kekahi mau lāʻau lapaʻau ke hoʻemi i ka maikaʻi o ka glasdegib a i ʻole e hoʻonui i kou pilikia o nā hopena ʻaoʻao.

E nānā kāu kauka i nā lāʻau lapaʻau a pau āu e lawe nei ma mua o ka hoʻomaka ʻana i ka glasdegib a pono paha e hoʻoponopono i nā ʻano lāʻau a i ʻole e hoʻololi iā ʻoe i nā lāʻau lapaʻau ʻē aʻe. E nānā pū lākou iā ʻoe me ka hoʻokokoke inā pono ʻoe e lawe i nā lāʻau lapaʻau e launa pū me ka glasdegib. E nānā mau me kāu hui mālama ola ma mua o ka hoʻomaka ʻana i nā lāʻau lapaʻau hou i ka wā e lawe ana i ka glasdegib.