He aha ʻo Goserelin: Nā Hoʻohana, Ka Leka, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

ʻO Goserelin he lāʻau lapaʻau hormone synthetic e hoʻōki ana i kou kino mai ka hana ʻana i kekahi mau hormones moe kolohe. Hoʻohana ʻia ia ma ke ʻano he mea kanu liʻiliʻi i waiho ʻia ma lalo o kou ʻili, maʻamau i kou ʻōpū, kahi e hoʻokuʻu mālie ai i ka lāʻau lapaʻau no kekahi mau mahina.

No kēia lāʻau lapaʻau i kahi papa o nā lāʻau i kapa ʻia ʻo GnRH agonists, e hana ana ma ka hoʻokomo ʻana i kāu ʻōnaehana hānau i kahi hoʻomaha manawa. E noʻonoʻo iā ia ma ke ʻano he ala hiki ke hoʻohuli ʻia e hōʻemi nui i nā hormones e like me ka testosterone a me ka estrogen i kou kino.

No ke aha e hoʻohana ʻia ai ʻo Goserelin?

Hoʻonohonoho mua ʻia ʻo Goserelin e mālama i nā maʻi maʻi hormone-sensitive a me kekahi mau maʻi olakino hānau. Hiki i kāu kauka ke ʻōlelo i kēia lāʻau lapaʻau ke hiki ke kōkua i ka hōʻemi ʻana i nā hormones moe kolohe i ka mālama ʻana i kou maʻi.

Hoʻohana pinepine ʻia ka lāʻau lapaʻau no ka maʻi maʻi prostate i nā kāne, kahi e hiki ai i ka hoʻohaʻahaʻa ʻana i nā pae testosterone ke hoʻolohi i ka ulu ʻana o ka maʻi maʻi. I nā wahine, ua kauoha pinepine ʻia no ka maʻi maʻi umauma, endometriosis, a me nā fibroids uterine ke pono ka hoʻemi ʻana i ka hormone.

I kekahi manawa hoʻohana nā kauka iā goserelin ma mua o kekahi mau lāʻau lapaʻau momona a i ʻole nā kaʻina hana ʻoki. Hiki i ka hoʻopaʻa ʻana i ka hormone manawa ke kōkua i ka hoʻomākaukau ʻana i kou kino no kēia mau hana ma ka hana ʻana i nā kūlana i mālama ʻia.

Pehea e hana ai ʻo Goserelin?

Hana ʻo Goserelin ma ka hoʻopunipuni ʻana i ke kikowaena hoʻomalu hormone o kou lolo i ka pani ʻana i ka hana hormone moe kolohe. Hoʻokumu mua ia i kahi spike manawa i nā hormones, akā hōʻemi nui iā lākou no kekahi mau mahina.

Hoʻouna maʻamau kou lolo i nā hōʻailona i kou ovaries a i ʻole testicles e hana i nā hormones. Kāohi ʻo Goserelin i kēia mau hōʻailona ma ka lanakila ʻana i nā mea loaʻa e loaʻa iā lākou. Ma hope o 2-4 mau pule, hāʻule nui nā pae hormone a noho haʻahaʻa i ka wā e hana ana ka lāʻau lapaʻau.

He manaʻo ʻia he lāʻau lapaʻau ikaika no ka mea e hoʻololi nui ai i nā pae hormone o kou kino. He nui nā hopena akā hiki ke hoʻohuli ʻia ke pau ka lāʻau lapaʻau, maʻamau i loko o 3-6 mahina ma hope o kāu mahele hope loa.

Pehea e lawe ai au i ka Goserelin?

Hāʻawi ʻia ʻo Goserelin ma ke ʻano he mea kanu liʻiliʻi i waiho ʻia ma lalo o kou ʻili e kekahi mea mālama ola. ʻAʻole ʻoe e lawe i kēia lāʻau lapaʻau ma ka home - pono ia i kahi koho lapaʻau no ka lawelawe pono.

Hana ʻia ke kaʻina hana ma ke keʻena o kāu kauka a he mau minuke wale nō. E hoʻomaʻemaʻe kāu mea mālama ola i ka ʻili ma kou ʻōpū, e hoʻopōpō me ka anesthetic kūloko, a e hoʻokomo i ka mea kanu liʻiliʻi me ka nila kūikawā. He like ka nui o ka mea kanu me ka hua raiki.

ʻAʻole pono ʻoe e hoʻokē ʻai a pale paha i ka ʻai ʻana ma mua o ke kaʻina hana. Eia naʻe, pono ʻoe e ʻaʻahu i nā lole ʻoluʻolu a me nā lole ʻoluʻolu e hiki ai ke komo maʻalahi i kou ʻōpū. Hiki i ka hapa nui o nā kānaka ke hoʻi i nā hana maʻamau ma hope koke o ka injection.

Hiki ke ʻoluʻolu ke kahua injection no hoʻokahi a ʻelua paha lā, e like me nā injection ʻē aʻe. Hiki iā ʻoe ke hoʻopili i ka hau inā pono a lawe i nā mea hōʻoluʻolu ʻeha ma luna o ka counter inā ʻae kāu kauka.

Pehea ka lōʻihi e lawe ai au i ka Goserelin?

He ʻokoʻa nui ka lōʻihi o ka mālama ʻana i ka goserelin ma muli o kou kūlana a me nā pahuhopu lapaʻau. E hoʻoholo kāu kauka i ka lōʻihi kūpono ma muli o kāu pono olakino a me ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau.

No ka mālama ʻana i ka maʻi kanesa, hiki iā ʻoe ke loaʻa iā goserelin no kekahi mau mahina a i kekahi mau makahiki. Pono kekahi poʻe i 6 mahina, aʻo nā mea ʻē aʻe e koi i nā manawa lapaʻau lōʻihi. E nānā kāu oncologist i kāu holomua a hoʻoponopono i ka hoʻolālā lapaʻau.

No nā kūlana e like me ka endometriosis a i ʻole nā ​​fibroids, ʻoi aku ka pōkole o ka mālama ʻana - pinepine 3-6 mahina. ʻAʻole maʻamau ka pale ʻana i nā manawa lapaʻau lōʻihi no kēia mau kūlana no ka mea hiki i ka hoʻopaʻa ʻana i ka hormone ke hoʻopilikia i ke olakino o ka iwi.

Hoʻokuʻu ka mea kanu i ka lāʻau lapaʻau me ka paʻa no 1 mahina a i ʻole 3 mahina, ma muli o ka hoʻohui āu e loaʻa ai. E hoʻonohonoho kāu kauka i kāu manawa e hiki mai ana e like me ia e mālama ai i ka hoʻopaʻa ʻana o ka hormone.

He aha nā hopena ʻaoʻao o Goserelin?

Pili nui nā hopena ʻaoʻao o Goserelin i ka hōʻemi nui ʻana o nā hormones moe kolohe i hana ʻia. ʻO ka hapa nui o nā kānaka e ʻike i kekahi mau hōʻailona e like me ka menopause a i ʻole andropause, akā he mea pōkole a hiki ke hoʻohuli ʻia.

ʻO nā hopena ʻaoʻao maʻamau āu e ʻike ai, ʻo ia nā wela wela, nā loli o ke ʻano, ka emi ʻana o ka makemake i ke kāne, a me ka luhi. Hoʻomaikaʻi pinepine kēia mau hōʻailona i ka wā e hoʻoponopono ai kou kino i nā pae hormone haʻahaʻa, ʻoiai e mau ana lākou i ka wā o ka mālama ʻana.

Nā hopena ʻaoʻao maʻamau

Hoʻopilikia kēia mau hopena ʻaoʻao i ka nui o nā kānaka e lawe ana iā goserelin a hiki ke mālama ʻia me ke kākoʻo kūpono a me ka mālama:

• Nā wela wela a me nā pō
• Nā loli o ke ʻano, ka huhū, a i ʻole ke kaumaha
• Ua emi ka makemake a me ka hana
• Luhi a me ka nāwaliwali
• Nā poʻo
• Nā ʻeha hui a me nā ʻiʻo
• Nā pilikia hiamoe
• Nā loli kaumaha
• Nā hopena o ka pūnaewele injection (ʻulaʻula, pehu, ʻeha)

ʻO ka hapa nui o kēia mau hopena he mea pōkole a e hoʻomaikaʻi mālie ma hope o kou hooki ʻana i ka mālama ʻana. Hiki i kāu hui mālama ola ke hōʻike i nā hoʻolālā e kōkua i ka mālama ʻana i kēia mau hōʻailona i ka wā e lawe ana ʻoe i ka lāʻau.

Nā hopena ʻaoʻao liʻiliʻi akā koʻikoʻi

ʻOiai ʻaʻole pinepine, pono kekahi mau hopena ʻaoʻao i ka nānā hou a me ka nānā ʻana mai kāu mea mālama ola:

• Nui ka nalowale o ka iwi a i ʻole osteoporosis
• Kaumaha nui a i ʻole nā maʻi o ke ʻano
• Nā loli o ka puʻuwai
• Nā hopena maʻi maʻi koʻikoʻi
• Nā koko koko
• Nā pilikia o ke akepaʻa
• Nā hopu (rare)

E nānā mau kāu kauka iā ʻoe no kēia mau pilikia e hiki mai ana a e ʻōlelo aku paha i nā lāʻau lapaʻau a i ʻole nā mea hoʻohui e pale i kou olakino i ka wā o ka lāʻau goserelin.

Nā hopena ʻaoʻao kakaʻikahi akā koʻikoʻi

ʻOiai ʻaʻole maʻamau, hiki i kekahi poʻe ke ʻike i nā pilikia koʻikoʻi e pono ai ka lāʻau lapaʻau koke:

• Pituitary apoplexy (hōʻeha poʻo nui koke, nā loli ʻike, nausea)
• Spinal cord compression (i ka poʻe me nā metastases iwi)
• Nā hanana cardiovascular koʻikoʻi
• Anaphylactic shock
• Tumor flare (hoʻonui manawa o nā hōʻailona maʻi maʻi)

He kakaʻikahi kēia mau pilikia akā hiki ke koʻikoʻi. E hoʻokaʻaʻike koke i kāu mea mālama ola inā ʻike ʻoe i nā hōʻailona koʻikoʻi koke a i ʻole nā loli e pili ana i kou olakino.

ʻO wai ka mea ʻaʻole pono e lawe iā Goserelin?

ʻAʻole kūpono ʻo Goserelin no nā mea a pau, a ʻo kekahi mau maʻi olakino a i ʻole nā kūlana e hana ʻole ai a i ʻole e koi ai i nā hana kūikawā. E loiloi pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana i kēia lāʻau.

He contraindication piha ka hāpai ʻana no ka goserelin, no ka mea, hiki iā ia ke hōʻeha i nā pēpē e ulu ana. Pono nā wahine o ka makahiki hānau ke hoʻohana i ka contraception non-hormonal hilinaʻi i ka wā o ka lāʻau a no kekahi mau mahina ma hope o ka pau ʻana.

Pono paha ka poʻe me kekahi mau maʻi puʻuwai, ke kaumaha nui, a i ʻole ka osteoporosis i nā lāʻau lapaʻau ʻē aʻe a i ʻole ka nānā ʻana. E kaupaona kāu kauka i nā pōmaikaʻi e kūʻē i nā pilikia no kāu kūlana kikoʻī.

Nā Contraindications Kūpono

ʻO kēia mau kūlana e pale maʻamau i ka hoʻohana ʻana i ka goserelin:

• Hāpai a i ʻole ka hānai ʻana
• ʻIke ʻia ka maʻi i ka goserelin a i ʻole nā lāʻau lapaʻau like
• ʻO ke kaumaha nui ʻole a i ʻole nā manaʻo suicidal
• Maʻi ate koʻikoʻi

Nā Kūlana e Koi ana i ka Makaʻala Kūikawā

Inā loaʻa iā ʻoe kekahi o kēia mau kūlana, hiki nō i kāu kauka ke kau iā goserelin akā e nānā pono iā ʻoe:

• Mōʻaukala o ke kaumaha a i ʻole nā maʻi naʻau
• Osteoporosis a i ʻole ka haʻahaʻa o ka iwi
• Maʻi puʻuwai a i ʻole ka puʻuwai ʻole
• Maʻi diabetes
• Nā maʻi hopu
• Nā pilikia o ka puʻupaʻa a i ʻole ke akepaʻa
• Mōʻaukala o nā koko koko

E hoʻomohala kāu hui mālama ola i kahi hoʻolālā nānā e hōʻoia i kou palekana i ka wā o ka mālama ʻana inā loaʻa iā ʻoe kekahi o kēia mau maʻi.

Nā inoa inoa o Goserelin

Loaʻa ʻo Goserelin ma lalo o kekahi mau inoa inoa, ʻo Zoladex ka mea maʻamau a ʻike nui ʻia. Hoʻohana ʻia kēia inoa inoa ma nā ʻāina he nui a puni ka honua.

ʻO nā inoa inoa ʻē aʻe e pili ana i nā mea kanu Goserelin Acetate mai nā mea hana like ʻole. Noho mau ka mea hana ikaika like, akā ʻokoʻa iki paha ka hoʻohui ʻana a i ʻole ka ʻōnaehana hāʻawi.

E hāʻawi maʻamau kāu hale kūʻai lāʻau i ka inoa inoa i loaʻa maʻalahi a i uhi ʻia e kāu ʻinikua. Hoʻokō nā mana i ʻae ʻia e ka FDA o goserelin i nā kūlana palekana a me ka pono.

Nā koho ʻē aʻe o Goserelin

Hana like kekahi mau lāʻau lapaʻau ʻē aʻe me goserelin ma ka hoʻemi ʻana i nā pae hormone moe kolohe. Hiki i kāu kauka ke noʻonoʻo i kēia mau koho ʻē aʻe inā ʻaʻole kūpono ʻo goserelin iā ʻoe a i ʻole inā loaʻa iā ʻoe nā hopena ʻaoʻao nui.

ʻO Leuprolide (Lupron) paha ka koho ʻē aʻe like loa, hāʻawi ʻia hoʻi ma ke ʻano he injection akā me nā papa hana ʻokoʻa. ʻO nā agonists GnRH ʻē aʻe e pili ana iā triptorelin a me histrelin, e hana ana ma o ka mīkini like akā loaʻa paha nā ʻaoʻao ʻokoʻa.

No kekahi mau maʻi, kūpono paha nā ala like ʻole. Hiki i kēia ke komo i nā lāʻau lapaʻau hormone ʻē aʻe, nā koho ʻoki, a i ʻole nā lāʻau lapaʻau i manaʻo ʻia e hana ana ma o nā mīkini like ʻole.

Nā lāʻau lapaʻau e hoʻopau ana i ka hormone like

• Leuprolide (Lupron, Eligard)
• Triptorelin (Trelstar)
• Histrelin (Vantas, Supprelin)
• Degarelix (Firmagon) - hana ʻokoʻa akā loaʻa nā hopena like i ka hoʻopaʻa ʻana i ka hormone

Nā Ala Lapaʻau ʻē aʻe

• Wehe ʻia nā ʻōkana hana hormone ma ke ʻoki
• Lapaʻau radiation i nā ovaries a i ʻole nā testicles
• Nā lāʻau anti-estrogen e like me tamoxifen
• Nā mea pale aromatase no nā wahine ma hope o ka menopause
• Nā lāʻau anti-androgen no nā kāne

E kūkākūkā kāu kauka i kēia mau koho ʻē aʻe me ʻoe inā ʻaʻole kūpono ʻo goserelin no kou kūlana.

Ua ʻoi aku ka maikaʻi o Goserelin ma mua o Leuprolide?

Ua like loa ʻo Goserelin a me leuprolide i nā lāʻau lapaʻau e hana ana ma o ke ʻano like a loaʻa nā hopena like. ʻAʻole ʻoi aku kekahi ma mua o kekahi - pinepine ka koho ʻana i nā mea e pili ana i nā mea kūpono a me nā mea pilikino.

Hoʻopaʻa pono nā lāʻau lapaʻau ʻelua i ka hana hormone a loaʻa nā hopena ʻaoʻao like. Aia nā ʻokoʻa nui i kā lākou papa hana dosing a me nā ʻano hoʻokele, kahi e maʻalahi ai kekahi no kou ola.

Loaʻa ʻo Goserelin ma ke ʻano he 1-mahina a me 3-mahina implants, ʻoiai ʻo leuprolide e hāʻawi i nā koho dosing hou aku me ka mahina, 3-mahina, 4-mahina, a me 6-mahina formulations. Makemake kekahi poʻe i nā manawa lōʻihi ma waena o nā injections, ʻoiai makemake kekahi i nā manawa nānā pinepine.

E noʻonoʻo kāu kauka i nā mea e like me kou kūlana kikoʻī, nā pahuhopu lapaʻau, ka uhi ʻinikua, a me nā makemake pilikino i ke koho ʻana ma waena o kēia mau lāʻau lapaʻau. He mau lapaʻau maikaʻi a maikaʻi lāua ʻelua me nā makahiki he nui o ka hoʻohana ʻana i ka lāʻau lapaʻau.

Nā Nīnau i Nīnau Pinepine e pili ana iā Goserelin

Q1. He palekana anei ʻo Goserelin no ka poʻe me ka maʻi diabetes?

Hiki ke hoʻohana ʻia ʻo Goserelin i ka poʻe me ka maʻi diabetes, akā pono ka nānā pono ʻana a me ka hoʻoponopono ʻana i nā lāʻau lapaʻau diabetes. Hiki i nā loli hormonal i hana ʻia e goserelin ke hoʻopilikia i ka mālama ʻana i ke kō koko i kekahi poʻe.

E hana pū kāu kauka me ʻoe e nānā pinepine i kāu pae kō koko i nā mahina mua o ka mālama ʻana. Pono kekahi poʻe e hoʻoponopono i kā lākou lāʻau lapaʻau diabetes, ʻoiai ʻaʻole ʻike nā mea ʻē aʻe i nā loli nui.

ʻO ke kī ka mālama ʻana i ke kamaʻilio hāmama me kāu hui mālama ola e pili ana i nā loli i kāu mau hiʻohiʻona kō koko a i ʻole nā ​​hōʻailona diabetes. Me ka nānā pono ʻana, hiki i ka hapa nui o ka poʻe me ka maʻi diabetes ke hoʻohana palekana iā goserelin ke pono ia i ka lāʻau lapaʻau.

Q2. He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o Goserelin?

ʻAʻole hiki ke loaʻa ka overdose Goserelin no ka mea e lawelawe ʻia e nā mea mālama ola i nā hoʻonohonoho lāʻau lapaʻau i mālama ʻia. Hāʻawi ʻia ka lāʻau lapaʻau ma ke ʻano he mea kanu i ana mua ʻia, no laila ʻaʻohe pilikia o ka lawe ʻana i ka nui iā ʻoe iho.

Inā loaʻa iā ʻoe ʻelua injections kokoke i kekahi i kekahi ma muli o kahi hewa hoʻonohonoho, e hoʻokaʻaʻike koke i kāu mea mālama ola. Makemake lākou e nānā pono iā ʻoe no nā hopena ʻaoʻao a hiki ke hoʻoponopono i kāu papa hana lapaʻau.

ʻO nā hōʻailona e hōʻike ana i ka nui o ka lāʻau lapaʻau e pili ana i nā wela wela nui, nā loli nui o ke ʻano, a i ʻole ka ʻino ʻana o nā hopena ʻē aʻe. Mai kānalua e kelepona i kāu kauka inā loaʻa iā ʻoe kekahi mau hōʻailona e pili ana ma hope o kāu injection.

Q3. He aha kaʻu e hana ai inā hala wau i kahi mahele o Goserelin?

Inā hala ʻoe i kāu manawa goserelin i hoʻonohonoho ʻia, e hoʻokaʻaʻike i kāu mea mālama ola i ka hiki wawe e hoʻonohonoho hou. He mea nui ka manawa o kāu mau injections no ka mālama ʻana i ka hoʻopaʻa ʻana i ka hormone.

ʻO ka hala ʻana i kahi mahele i kekahi mau lā ʻaʻole ia he mea weliweli, akā hiki iā ia ke ʻae i kāu pae hormone e hoʻomaka e ola hou, hiki ke hoʻopilikia i ka pono o kāu lapaʻau. Hiki i kāu kauka ke ʻōlelo i nā hoʻokolohua koko e nānā i kāu pae hormone.

Mai hoʻāʻo e hoʻoponopono i kahi lāʻau i hala ma ka loaʻa ʻana i ʻelua injections kokoke. E hoʻoholo kāu mea mālama ola i ke ala maikaʻi loa e hoʻi ai i ke ala me kāu papa hana lapaʻau.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Goserelin?

Pono ʻoe e hooki i ka lapaʻau goserelin ke hoʻoholo kāu kauka he palekana a kūpono ke hana pēlā. Aia ka hoʻoholo i kāu kūlana kikoʻī, nā pahuhopu lapaʻau, a me ka maikaʻi o kāu pane ʻana i ka lāʻau lapaʻau.

No ka lapaʻau maʻi ʻaʻai, ʻo ka hooki ʻana i ka wā mua e ʻae ai i ka maʻi ʻaʻai e ulu a i ʻole e hoʻi mai. E nānā mau kāu oncologist i kou kūlana a e hoʻoholo i ka lōʻihi o ka lapaʻau e pili ana i kāu holomua a me ke olakino holoʻokoʻa.

No nā kūlana e like me ka endometriosis, ua hoʻoholo mua ʻia ka lōʻihi o ka lapaʻau, akā hiki i kāu kauka ke hoʻoponopono iā ia e pili ana i ka maikaʻi o kou ʻae ʻana i ka lāʻau a me ka pane ʻana o kāu mau hōʻailona.

Mai hooki i ka lapaʻau goserelin ma kāu iho, ʻoiai inā e ʻike ana ʻoe i nā hopena ʻaoʻao. Akā, e kūkākūkā i kāu mau hopohopo me kāu mea mālama ola, nāna e kōkua i ka mālama ʻana i nā hopena ʻaoʻao a i ʻole e ʻimi i nā lāʻau lapaʻau ʻē aʻe inā pono.

Q5. Pehea ka lōʻihi o nā hopena ʻaoʻao ma hope o ka hooki ʻana iā Goserelin?

ʻO ka hapa nui o nā hopena ʻaoʻao goserelin he manawa pōkole a hoʻomaikaʻi mālie ma hope o kou hooki ʻana i ka lapaʻau. Hoʻomaka maʻamau kāu pae hormone i ka hoʻōla ʻana i loko o kekahi mau pule a i ʻole mau mahina ma hope o kāu lāʻau hope loa, a e mae nā hopena ʻaoʻao i ka wā e hoʻi ai nā hormones i ka maʻamau.

Hoʻomaikaʻi pinepine nā uila wela a me nā loli o ka naʻau i loko o 2-3 mau mahina o ka hooki ʻana i ka lapaʻau. Hiki i ka hana moe kolohe a me nā pae ikehu ke lawe i 3-6 mau mahina e hoʻōla piha ai, no ka mea, pono ke kino i ka manawa e hoʻomaka hou i ka hana hormone maʻamau.

Hiki i kekahi mau hopena, ʻo ka loli ʻana o ka iwi, ke lawe i ka manawa lōʻihi e hoʻohuli a pono paha i ka lapaʻau hou. E nānā kāu kauka i kou hoʻōla ʻana a hiki ke ʻōlelo i nā mea hoʻohui a i ʻole nā ​​lāʻau lapaʻau ʻē aʻe e kōkua i ka hoʻihoʻi ʻana i kou olakino ma hope o ka lāʻau goserelin.

He ʻokoʻa ka manawa hoʻōla mai kēlā kanaka i kēia kanaka, a hiki i nā mea e like me ka makahiki, ke olakino holoʻokoʻa, a me ka lōʻihi o ka mālama ʻana ke hoʻopili i ka wikiwiki o kou hoʻi ʻana mai. E hoʻomanawanui me kou kino i ka wā e hoʻoponopono hou ai i nā pae hormone maʻamau.