He aha ka Guanidine: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Guanidine i kuhikuhi ʻia e mālama i kahi maʻi nāwaliwali o nā ʻiʻo i kapa ʻia ʻo Lambert-Eaton myasthenic syndrome (LEMS). Hoʻopilikia kēia maʻi i ka pilina ma waena o kou mau aʻalolo a me nā ʻiʻo, e hana ana i nā hana o kēlā me kēia lā e like me ka hele ʻana, ka piʻi ʻana i nā alapiʻi, a i ʻole ka paʻa ʻana i nā mea e manaʻo ʻole ai he paʻakikī.

ʻOiai ʻaʻole ʻo guanidine he inoa hale e like me nā lāʻau lapaʻau ʻē aʻe, he koho lapaʻau nui ia no ka poʻe e noho ana me nā maʻi neuromuscular kikoʻī. E noʻonoʻo iā ia he mea hana kūikawā e kōkua ana i ka hoʻihoʻi ʻana i kekahi o ke kamaʻilio ʻana ma waena o kāu ʻōnaehana nerve a me nā ʻiʻo ke hana ʻole kēlā pilina.

He aha ka Guanidine?

He lāʻau lapaʻau ʻo Guanidine e hana pono ana i nā hōʻailona uila ma waena o kou mau aʻalolo a me nā ʻiʻo. No ka papa o nā lāʻau lapaʻau e kōkua ana i ka hoʻomaikaʻi ʻana i ke kamaʻilio ʻana o ka nerve-muscle, ʻoiai ke keakea kekahi mau maʻi autoimmune i kēia kaʻina.

Ua hoʻohana ʻia kēia lāʻau lapaʻau i ka hana lapaʻau no nā makahiki he nui, ʻoiai ua manaʻo ʻia he lāʻau lapaʻau kūikawā ma mua o ka lāʻau lapaʻau laina mua. E noʻonoʻo kāu kauka iā guanidine ke hāʻawi ʻole nā ​​lāʻau lapaʻau ʻē aʻe i ka hōʻoluʻolu kūpono a i ʻole ke hana ʻana o kou kūlana kikoʻī i kahi koho kūpono.

No ke aha i hoʻohana ʻia ai ka Guanidine?

Hoʻonohonoho mua ʻia ʻo Guanidine no ka Lambert-Eaton myasthenic syndrome (LEMS), kahi maʻi autoimmune laha ʻole e pili ana i ka 1 i ka 100,000 poʻe. I ka LEMS, hoʻouka hewa kāu ʻōnaehana pale i nā kahawai calcium i loko o kou mau aʻalolo, e hoʻopilikia ana i nā hōʻailona e haʻi ana i kou mau ʻiʻo e ʻaelike.

I kekahi manawa, hiki i nā kauka ke noʻonoʻo i ka guanidine no nā maʻi ʻē aʻe e pili ana i ka nāwaliwali o nā ʻiʻo, ʻoiai ʻaʻole maʻamau kēia. Hiki i kēia mau mea ke komo i kekahi mau ʻano maʻi ʻiʻo kahi i hoʻopilikia ʻia ai ka pilina o ke aʻalolo-ʻiʻo, akā mālama ʻia kēlā mau hoʻohana ʻana no nā kūlana kikoʻī kahi i kūpono ʻole ai nā lāʻau lapaʻau ʻē aʻe.

He hana maikaʻi ka lāʻau lapaʻau no ka poʻe nona ka nāwaliwali o nā ʻiʻo e hoʻomaikaʻi iki me ka hoʻohana pinepine ʻana i nā ʻiʻo i hoʻopilikia ʻia. Inā ʻike ʻoe e maikaʻi iki ana kou ikaika i kou neʻe ʻana i ka lā, hiki i ka guanidine ke kōkua nui i kou kūlana.

Pehea ka hana ʻana o Guanidine?

Hana ʻo Guanidine ma ka hoʻonui ʻana i ka hoʻokuʻu ʻana o kahi mea kemika i kapa ʻia ʻo acetylcholine ma ka hui ma waena o kou mau aʻalolo a me nā ʻiʻo. E noʻonoʻo i ka acetylcholine e like me ke kī e wehe ai i ka ʻiʻo - ke lawa ʻole kāu, ʻaʻole hiki i kou mau ʻiʻo ke pane pono i nā hōʻailona aʻalolo.

Kōkua kēia lāʻau lapaʻau i kāu mau aʻalolo e hoʻokuʻu i ka acetylcholine hou aku, e hoʻoikaika ana i ka hōʻailona e hiki ana i kou mau ʻiʻo. E like me ka hoʻonui ʻana i ka leo ma kahi hōʻailona lekiō nāwaliwali i hiki iā ʻoe ke lohe maopopo i ke mele.

Ua manaʻo ʻia ʻo Guanidine he lāʻau lapaʻau ikaika ma ke ʻano o kāna hopena. ʻAʻole ikaika e like me kekahi mau lāʻau lapaʻau ʻē aʻe no ka nāwaliwali o nā ʻiʻo, akā hiki iā ia ke hāʻawi i ka hoʻomaikaʻi nui no ka nui o ka poʻe me LEMS, ʻoiai ke hui pū ʻia me nā lāʻau lapaʻau ʻē aʻe.

Pehea wau e lawe ai i ka Guanidine?

E hoʻomaka kāu kauka iā ʻoe ma kahi haʻahaʻa o ka guanidine a hoʻonui mālie iā ia ma muli o kāu pane. Hoʻomaka ka hapa nui o ka poʻe me 10-15 mg no ke kilokani o ke kaumaha o ke kino i kēlā me kēia lā, i māhele ʻia i loko o nā ʻāpana liʻiliʻi i ka lā.

Hiki iā ʻoe ke lawe i ka guanidine me ka ʻole o ka meaʻai, ʻoiai ʻo ka lawe ʻana me nā meaʻai e kōkua i ka hōʻemi ʻana i ka ʻōpū inā loaʻa iā ʻoe. ʻOi aku ka maikaʻi e hoʻokaʻawale i kāu mau ʻāpana i ka lā e mālama i nā pae paʻa i kāu ʻōnaehana.

Ma hope o ka ʻōlelo ʻana, he mea nui ka hoʻohālikelike ʻana me kēia lāʻau lapaʻau. E hoʻāʻo e lawe i kāu mau lāʻau i nā manawa like i kēlā me kēia lā, a mai haʻalele i nā lāʻau inā ʻoe e manaʻo maikaʻi ana. Aia ka ikaika o kou ʻiʻo i ka mālama ʻana i nā pae kūpono o ka lāʻau lapaʻau i loko o kou ʻōnaehana.

Pehea ka lōʻihi e lawe ai au i ka Guanidine?

He ʻokoʻa nui ka lōʻihi o ka mālama ʻana i ka guanidine mai kēlā me kēia kanaka a hilinaʻi i kou kūlana kumu. No ka maʻi myasthenic syndrome o Lambert-Eaton, pono ka nui o nā kānaka e lawe i ka guanidine no ka manawa lōʻihi e mālama i ko lākou ikaika ʻiʻo a me ka hana.

E nānā kāu kauka i kāu pane ʻana i ka lāʻau lapaʻau i nā pule a i nā mahina. ʻIke kekahi poʻe i ka hoʻomaikaʻi ʻana i loko o nā lā, aʻo nā mea ʻē aʻe e pono paha i kekahi mau pule e ʻike i nā pōmaikaʻi piha.

He mea nui nā koho ukali maʻamau no ka mea pono kāu kauka e loiloi i ka pono o ka lāʻau lapaʻau a nānā i nā hopena ʻaoʻao. Mai hooki i ka lawe ʻana i ka guanidine me ka ʻole e kūkākūkā me kāu mea mālama ola, no ka mea, hiki i kēia ke alakaʻi i ka hoʻi ʻana mai o ka nāwaliwali o ka ʻiʻo.

He aha nā hopena ʻaoʻao o Guanidine?

E like me nā lāʻau lapaʻau a pau, hiki i ka guanidine ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole i ʻike nā mea a pau iā lākou. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hoʻokaʻaʻike aku ai i kāu kauka.

ʻO nā hopena ʻaoʻao maʻamau e maʻalahi a hoʻomaikaʻi pinepine i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau:

• Nausea a i ʻole ka ʻōpū
• Pāpaʻa a i ʻole nā ​​pahu palupalu
• ʻO ka ʻūlū a i ʻole ka māmā
• ʻO ka ʻili a i ʻole ka ʻili
• Poʻo
• Luhi a i ʻole ka manaʻo luhi ʻole

Hoʻoponopono maʻamau kēia mau hopena ʻaoʻao maʻamau i loko o kekahi mau lā a i nā pule i ka wā e maʻa ai kou kino i ka lāʻau lapaʻau. Inā mau lākou a lilo i mea pilikia, hiki i kāu kauka ke hoʻoponopono i kāu mahele a i ʻole ka manawa e kōkua ai e hōʻemi iā lākou.

ʻOi aku ka pilikia o nā hopena ʻaoʻao, akā pono e mālama koke ʻia e ke kauka. Pākuʻi ʻia kēia mau mea i nā hopena maʻi nui, nā loli nui i ka puʻuwai, a i ʻole nā hōʻailona o nā pilikia o ka puʻupaʻa e like me nā loli i nā ʻano mimi a i ʻole ka pehu ʻana o kou mau wāwae a me nā wāwae.

Hiki nō hoʻi i kekahi poʻe ke ʻike i nā hopena laha ʻole akā hopohopo e like me ka ʻūlū ʻana o nā ʻiʻo, ka huikau, a i ʻole ka pilikia o ka hanu ʻana. ʻOiai ʻaʻole maʻamau kēia mau mea, he mea nui e ʻike i ka hiki i ka mālama olakino wikiwiki ke hoʻoponopono pono i kēia mau pilikia.

ʻO wai ka mea ʻaʻole pono e lawe i ka Guanidine?

Pono kekahi poʻe e pale i ka guanidine a i ʻole e hoʻohana me ka akahele. E nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana i kēia lāʻau lapaʻau e hōʻoia i ka palekana iā ʻoe.

Pono ka poʻe me nā pilikia nui o ka puʻupaʻa e pale i ka guanidine, no ka mea, ua hana ʻia ka lāʻau lapaʻau ma o nā puʻupaʻa. Inā loaʻa iā ʻoe ka maʻi puʻupaʻa, pono kāu kauka e nānā pono iā ʻoe a i ʻole e noʻonoʻo i nā lāʻau lapaʻau ʻē aʻe.

Eia kekahi, ʻaʻole kūpono paha ka guanidine inā loaʻa iā ʻoe kekahi mau maʻi puʻuwai, ʻo ia hoʻi nā mea e pili ana i nā puʻuwai puʻuwai ʻole. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka hana o ka puʻuwai, no laila e loiloi kāu kauka i kou olakino cardiovascular ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau.

Pono nā wahine hāpai a me nā wahine e hānai ana i ka waiū e kūkākūkā pono i nā pilikia a me nā pōmaikaʻi me kā lākou mea mālama ola, no ka mea, he palena ka ʻike e pili ana i ka palekana o ka guanidine i ka wā hāpai a me ka hānai ʻana.

Nā inoa inoa o Guanidine

Loaʻa ka Guanidine ma lalo o nā inoa inoa like ʻole, ʻoiai ʻokoʻa ka loaʻa ʻana ma kēlā me kēia ʻāina. Ma kekahi mau wahi, hiki iā ʻoe ke ʻike ʻia e like me Guanidine HCl a i ʻole ma lalo o nā inoa inoa lāʻau lapaʻau.

Hiki i kāu kauka lapaʻau ke kōkua iā ʻoe e ʻike i ka inoa kikoʻī a i ʻole ka mana generic i loaʻa ma kou wahi. Noho like ka mea hana ikaika me ka mea hana, ʻoiai e ʻike paha kekahi poʻe e pane iki ana i nā formulations like ʻole.

Nā koho ʻē aʻe o Guanidine

Inā ʻaʻole kūpono ʻo guanidine iā ʻoe a i ʻole ʻaʻole e hāʻawi i ke kōkua kūpono, aia kekahi mau lapaʻau ʻē aʻe no ka maʻi myasthenic syndrome ʻo Lambert-Eaton a me nā maʻi like.

ʻO 3,4-diaminopyridine (3,4-DAP) ka mea i manaʻo pinepine ʻia he lapaʻau mua no LEMS a ʻoi aku ka maikaʻi ma mua o guanidine no nā kānaka he nui. Hana like kēia lāʻau lapaʻau akā ʻoi aku ka liʻiliʻi o nā hopena ʻaoʻao a me ka ʻae maikaʻi.

Hiki nō hoʻi i nā lapaʻau immunosuppressive e like me prednisone, azathioprine, a i ʻole mycophenolate ke koho, ʻoiai inā he mea nui ka autoimmune i kou maʻi. Hana kēia mau lāʻau lapaʻau ma ka hoʻemi ʻana i ka hoʻouka ʻana o ka ʻōnaehana pale i kāu mau pilina nerve-muscle.

I kekahi mau hihia, hiki ke ʻōlelo ʻia ka hoʻololi plasma a i ʻole nā lapaʻau immunoglobulin intravenous (IVIG), ʻoiai i nā wā e ʻoi aku ka nui o nā hōʻailona.

Ua ʻoi aku ka maikaʻi o Guanidine ma mua o 3,4-Diaminopyridine?

Ua manaʻo ʻia ʻo 3,4-diaminopyridine (3,4-DAP) ʻoi aku ka maikaʻi ma mua o guanidine no ka mālama ʻana i ka maʻi myasthenic syndrome ʻo Lambert-Eaton. Manaʻo ka hapa nui o nā alakaʻi lapaʻau i ka 3,4-DAP ma ke ʻano he lapaʻau koho mua no ka mea e hāʻawi maʻamau i ka hoʻomaikaʻi ʻana i nā hōʻailona me ka liʻiliʻi o nā hopena ʻaoʻao.

Eia naʻe, hiki nō i ka guanidine ke waiwai no ka poʻe i pane ʻole i ka 3,4-DAP a i ʻole hiki ʻole ke ʻae i kāna mau hopena ʻaoʻao. Hiki i kekahi poʻe ke pane maikaʻi i ka guanidine, ʻo ia ke kumu he mea nui ka loaʻa ʻana o nā koho lapaʻau he nui.

E noʻonoʻo kāu kauka i kāu mau hōʻailona kikoʻī, ka mōʻaukala olakino, a me ka pane ʻana i nā lapaʻau ʻē aʻe i ka wā e hoʻoholo ai ma waena o kēia mau lāʻau lapaʻau. I kekahi manawa, ʻoi aku ka maikaʻi o ka hui ʻana i nā lapaʻau ʻelua ma nā ʻano haʻahaʻa ma mua o ka hoʻohana ʻana i kekahi.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Guanidine

He palekana anei ʻo Guanidine no ka poʻe me ka maʻi diabetes?

Hiki ke hoʻohana ʻia ʻo Guanidine i ka poʻe me ka maʻi diabetes, akā pono ia i ka nānā pono. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i nā pae kōpaʻa koko i kekahi poʻe, ʻoiai ʻaʻole maʻamau kēia.

E makemake kāu kauka e nānā pono i kou kōpaʻa koko ke hoʻomaka ʻoe i ka guanidine, ʻoiai inā he maʻi diabetes kou. E hōʻoia e haʻi aku i kāu mea mālama ola e pili ana i nā loli i kāu mau hiʻohiʻona kōpaʻa koko a i ʻole nā lāʻau lapaʻau diabetes.

He aha kaʻu e hana ai inā lawe hewa au i ka nui o ka Guanidine?

Inā lawe hewa ʻoe i ka guanidine ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka a i ʻole ke kikowaena manaʻo ʻawaʻawa. ʻO ka lawe ʻana i ka nui hiki ke hana i nā hopena ʻaoʻao koʻikoʻi me ka nausea koʻikoʻi, ka luaʻi ʻana, ka ʻū ʻana o ka ʻiʻo, a i ʻole nā pilikia o ka puʻuwai.

Mai ho'āʻo e hana iā ʻoe iho e luaʻi ke ʻole i kuhikuhi ʻia e kahi loea mālama ola. E mālama i ka hue lāʻau me ʻoe ke ʻimi nei i ke kōkua olakino i ʻike pono nā mea mālama ola i ke ʻano a me ka nui āu i lawe ai.

He aha kaʻu e hana ai inā haʻalele au i kahi mahele o Guanidine?

Inā haʻalele ʻoe i kahi mahele o ka guanidine, e lawe koke iā ia ke hoʻomanaʻo ʻoe, ke ʻole kokoke ka manawa no kāu mahele i hoʻonohonoho ʻia. I kēlā hihia, e lele i ka mahele i haʻalele ʻia a hoʻomau me kāu papa manawa maʻamau.

Mai lawe i kahi mahele pālua e hana ai no ka mea i haʻalele ʻia, no ka mea, hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao. Inā poina pinepine ʻoe i nā mahele, e noʻonoʻo e hoʻonohonoho i nā mea hoʻomanaʻo kelepona a i ʻole ka hoʻohana ʻana i kahi mea hoʻonohonoho pila e kōkua iā ʻoe e noho ma ke ala.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Guanidine?

Pono ʻoe e hooki i ka lawe ʻana i ka guanidine ma lalo o ka mālama ʻana a kāu kauka. No ka hapa nui o ka poʻe me ka maʻi myasthenic syndrome ʻo Lambert-Eaton, ʻo ka hooki ʻana i ka lāʻau lapaʻau e hoʻihoʻi i ka nāwaliwali o ka ʻiʻo.

Hiki i kāu kauka ke ʻōlelo e hōʻemi mālie i kāu mahele ma mua o ka hooki ʻana i ka manawa koke. Kōkua kēia ala i ka hōʻemi ʻana i ka pilikia o nā hōʻailona haʻalele a hiki iā ʻoe ke nānā i ke ʻano o ka pane ʻana o kou kino i nā mahele haʻahaʻa.

Hiki iaʻu ke kalaiwa i ka wā e lawe ana i ka Guanidine?

Hiki i ka Guanidine ke hana i ka dizziness a i ʻole ka luhi i kekahi poʻe, hiki ke hoʻopilikia i kou hiki ke kalaiwa palekana. Ke hoʻomaka mua ʻoe e lawe i ka lāʻau lapaʻau, he mea naʻauao e pale i ke kalaiwa ʻana a hiki i kou ʻike ʻana i ke ʻano o ka hopena iā ʻoe.

Ma hope o kou noho ʻana ma kahi maʻamau paʻa no kekahi manawa a ʻaʻole i ʻike i ka wili a i ʻole nā hopena ʻē aʻe e hopohopo nei, hiki i ka hapa nui o nā kānaka ke kalaiwa maʻamau. Eia naʻe, e hoʻohana mau i kou manaʻo a mai kalaiwa inā ʻaʻole ʻoe e maikaʻi a i ʻole e luhi ʻole.